Published in Proc Natl Acad Sci U S A on June 03, 2010
De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy. Nat Genet (2015) 1.98
Structural basis for gating charge movement in the voltage sensor of a sodium channel. Proc Natl Acad Sci U S A (2011) 1.68
Contributions of counter-charge in a potassium channel voltage-sensor domain. Nat Chem Biol (2011) 1.32
Control of a final gating charge transition by a hydrophobic residue in the S2 segment of a K+ channel voltage sensor. Proc Natl Acad Sci U S A (2011) 1.29
3(10) helices in channels and other membrane proteins. J Gen Physiol (2010) 1.24
Intermediate state trapping of a voltage sensor. J Gen Physiol (2012) 1.20
De novo protein structure determination from near-atomic-resolution cryo-EM maps. Nat Methods (2015) 1.05
R1 in the Shaker S4 occupies the gating charge transfer center in the resting state. J Gen Physiol (2011) 1.04
Structural correlates of selectivity and inactivation in potassium channels. Biochim Biophys Acta (2011) 1.04
Structural changes during HCN channel gating defined by high affinity metal bridges. J Gen Physiol (2012) 1.00
The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands. Cell Res (2013) 1.00
Modeling the binding of three toxins to the voltage-gated potassium channel (Kv1.3). Biophys J (2011) 0.99
Genetically encoding unnatural amino acids in neural stem cells and optically reporting voltage-sensitive domain changes in differentiated neurons. Stem Cells (2011) 0.99
Computational methods of studying the binding of toxins from venomous animals to biological ion channels: theory and applications. Physiol Rev (2013) 0.99
Nano-positioning system for structural analysis of functional homomeric proteins in multiple conformations. Structure (2012) 0.99
Tuning the voltage-sensor motion with a single residue. Biophys J (2012) 0.96
Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel. Elife (2014) 0.95
Voltage-dependent gating of HERG potassium channels. Front Pharmacol (2012) 0.93
A structural view of ligand-dependent activation in thermoTRP channels. Front Physiol (2014) 0.92
Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart. J Mol Biol (2014) 0.91
S3-S4 linker length modulates the relaxed state of a voltage-gated potassium channel. Biophys J (2013) 0.90
Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels. J Gen Physiol (2013) 0.89
New potential binding determinant for hERG channel inhibitors. Sci Rep (2016) 0.88
Molecular dynamics simulations of voltage-gated cation channels: insights on voltage-sensor domain function and modulation. Front Pharmacol (2012) 0.87
A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel. Nat Commun (2013) 0.87
Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain. J Mol Model (2012) 0.87
Structural basis of the selective block of Kv1.2 by maurotoxin from computer simulations. PLoS One (2012) 0.87
Moving gating charges through the gating pore in a Kv channel voltage sensor. Proc Natl Acad Sci U S A (2014) 0.87
The free energy barrier for arginine gating charge translation is altered by mutations in the voltage sensor domain. PLoS One (2012) 0.85
Normal mode analysis with molecular geometry restraints: bridging molecular mechanics and elastic models. Arch Biochem Biophys (2011) 0.85
Solid state NMR: The essential technology for helical membrane protein structural characterization. J Magn Reson (2013) 0.85
Gating currents from Kv7 channels carrying neuronal hyperexcitability mutations in the voltage-sensing domain. Biophys J (2012) 0.85
Regional flexibility in the S4-S5 linker regulates hERG channel closed-state stabilization. Pflugers Arch (2014) 0.84
Repolarizing cardiac potassium channels: multiple sites and mechanisms for CaMKII-mediated regulation. Heart Rhythm (2011) 0.84
The conserved phenylalanine in the K+ channel voltage-sensor domain creates a barrier with unidirectional effects. Biophys J (2013) 0.84
A conserved threonine in the S1-S2 loop of KV7.2 and K V7.3 channels regulates voltage-dependent activation. Pflugers Arch (2012) 0.82
Conserved gating elements in TRPC4 and TRPC5 channels. J Biol Chem (2013) 0.82
Interaction of diverse voltage sensor homologs with lipid bilayers revealed by self-assembly simulations. Biophys J (2011) 0.81
Molecular determinants of U-type inactivation in Kv2.1 channels. Biophys J (2011) 0.81
Molecular dynamics simulations of scorpion toxin recognition by the Ca(2+)-activated potassium channel KCa3.1. Biophys J (2013) 0.80
Voltage Sensing in Membranes: From Macroscopic Currents to Molecular Motions. J Membr Biol (2015) 0.80
Further advances in the production of membrane proteins in Pichia pastoris. Bioengineered (2013) 0.80
Shock Wave-Induced Damage of a Protein by Void Collapse. Biophys J (2016) 0.79
Predicting X-ray diffuse scattering from translation-libration-screw structural ensembles. Acta Crystallogr D Biol Crystallogr (2015) 0.79
Structure of potassium channels. Cell Mol Life Sci (2015) 0.79
Voltage gated ion channel function: gating, conduction, and the role of water and protons. Int J Mol Sci (2012) 0.79
Cysteines in the loop between IS5 and the pore helix of Ca(V)3.1 are essential for channel gating. Pflugers Arch (2010) 0.79
Free-energy landscape of ion-channel voltage-sensor-domain activation. Proc Natl Acad Sci U S A (2014) 0.78
Surface-Constrained 3D Reconstruction in Cryo-EM. Conf Rec Asilomar Conf Signals Syst Comput (2011) 0.78
Fine-tuning of voltage sensitivity of the Kv1.2 potassium channel by interhelix loop dynamics. J Biol Chem (2013) 0.78
Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain. Biochemistry (2015) 0.77
Proton channel models filling the gap between experimental data and the structural rationale. Channels (Austin) (2014) 0.77
PIM: phase integrated method for normal mode analysis of biomolecules in a crystalline environment. J Mol Biol (2013) 0.77
Designing a C84 fullerene as a specific voltage-gated sodium channel blocker. Nanoscale Res Lett (2013) 0.77
Mechanisms of activation of voltage-gated potassium channels. Acta Naturae (2014) 0.77
In silico modeling of the pore region of a KCNQ4 missense mutant from a patient with hearing loss. BMC Res Notes (2012) 0.77
Voltage sensor gating charge transfer in a hERG potassium channel model. Biophys J (2014) 0.76
Kv Channel S1-S2 Linker Working as a Binding Site of Human β-Defensin 2 for Channel Activation Modulation. J Biol Chem (2015) 0.76
Binding of hanatoxin to the voltage sensor of Kv2.1. Toxins (Basel) (2012) 0.76
Expression, crystallization and preliminary X-ray analysis of rice L-galactose dehydrogenase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.76
Computational Studies of Venom Peptides Targeting Potassium Channels. Toxins (Basel) (2015) 0.76
fSUB: normal mode analysis with flexible substructures. J Phys Chem B (2012) 0.76
Modeling of the Binding of Peptide Blockers to Voltage-Gated Potassium Channels: Approaches and Evidence. Acta Naturae (2016) 0.75
Caution is required in interpretation of mutations in the voltage sensing domain of voltage gated channels as evidence for gating mechanisms. Int J Mol Sci (2015) 0.75
Dominant KCNA2 mutation causes episodic ataxia and pharmacoresponsive epilepsy. Neurology (2016) 0.75
Predicting a double mutant in the twilight zone of low homology modeling for the skeletal muscle voltage-gated sodium channel subunit beta-1 (Nav1.4 β1). Comput Struct Biotechnol J (2015) 0.75
Upward movement of IS4 and IIIS4 is a rate-limiting stage in Cav1.2 activation. Pflugers Arch (2016) 0.75
The activity of prolactin releasing peptide correlates with its helicity. Biopolymers (2013) 0.75
The open gate of the K(V)1.2 channel: quantum calculations show the key role of hydration. Biophys J (2014) 0.75
Disulfide mapping the voltage-sensing mechanism of a voltage-dependent potassium channel. Sci Rep (2016) 0.75
The First Extracellular Linker Is Important for Several Aspects of the Gating Mechanism of Human TRPA1 Channel. Front Mol Neurosci (2017) 0.75
IBiSA_Tools: A Computational Toolkit for Ion-Binding State Analysis in Molecular Dynamics Trajectories of Ion Channels. PLoS One (2016) 0.75
A conserved pre-block interaction motif regulates potassium channel activation and N-type inactivation. PLoS One (2013) 0.75
Normal mode dynamics of voltage-gated K(+) channels: gating principle, opening mechanism, and inhibition. J Comput Neurosci (2014) 0.75
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science (2005) 17.70
X-ray structure of a voltage-dependent K+ channel. Nature (2003) 14.50
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature (2007) 12.35
Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel. Neuron (1996) 8.20
Contribution of the S4 segment to gating charge in the Shaker K+ channel. Neuron (1996) 8.11
Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science (2005) 7.82
The size of gating charge in wild-type and mutant Shaker potassium channels. Science (1992) 6.42
A proton pore in a potassium channel voltage sensor reveals a focused electric field. Nature (2004) 5.66
Shaker potassium channel gating. II: Transitions in the activation pathway. J Gen Physiol (1994) 4.98
The moving parts of voltage-gated ion channels. Q Rev Biophys (1998) 4.46
Usefulness and limitations of normal mode analysis in modeling dynamics of biomolecular complexes. Structure (2005) 3.85
A gating charge transfer center in voltage sensors. Science (2010) 3.60
Closing in on the resting state of the Shaker K(+) channel. Neuron (2007) 3.49
How does voltage open an ion channel? Annu Rev Cell Dev Biol (2006) 3.05
Potassium channels. FEBS Lett (2003) 2.58
On the use of normal modes in thermal parameter refinement: theory and application to the bovine pancreatic trypsin inhibitor. Acta Crystallogr A (1990) 2.04
Potassium channels and the atomic basis of selective ion conduction (Nobel Lecture). Angew Chem Int Ed Engl (2004) 1.64
How far will you go to sense voltage? Neuron (2005) 1.61
Specificity of charge-carrying residues in the voltage sensor of potassium channels. J Gen Physiol (2004) 1.60
Refinement of protein dynamic structure: normal mode refinement. Proc Natl Acad Sci U S A (1990) 1.54
Normal mode refinement of anisotropic thermal parameters for a supramolecular complex at 3.42-A crystallographic resolution. Proc Natl Acad Sci U S A (2007) 1.52
Voltage-gated potassium channels: from hyperexcitability to excitement. FEBS Lett (1999) 1.43
Extent of voltage sensor movement during gating of shaker K+ channels. Neuron (2008) 1.42
Normal-mode refinement of anisotropic thermal parameters for potassium channel KcsA at 3.2 A crystallographic resolution. Structure (2007) 1.20
K+ channel blockers: novel tools to inhibit T cell activation leading to specific immunosuppression. Curr Pharm Des (2006) 1.03
Atomic constraints between the voltage sensor and the pore domain in a voltage-gated K+ channel of known structure. J Gen Physiol (2008) 1.02
Structural improvement of unliganded simian immunodeficiency virus gp120 core by normal-mode-based X-ray crystallographic refinement. Acta Crystallogr D Biol Crystallogr (2009) 0.98
Allowed N-glycosylation sites on the Kv1.2 potassium channel S1-S2 linker: implications for linker secondary structure and the glycosylation effect on channel function. Biochem J (2003) 0.91
Application of normal-mode refinement to X-ray crystal structures at the lower resolution limit. Acta Crystallogr D Biol Crystallogr (2009) 0.89
The Kv1.2 potassium channel: the position of an N-glycan on the extracellular linkers affects its protein expression and function. Brain Res (2008) 0.85
Band gap fluorescence from individual single-walled carbon nanotubes. Science (2002) 5.34
WormBase: a multi-species resource for nematode biology and genomics. Nucleic Acids Res (2004) 4.14
WormBase: a comprehensive data resource for Caenorhabditis biology and genomics. Nucleic Acids Res (2005) 3.82
Experimental verification of conformational variation of human fatty acid synthase as predicted by normal mode analysis. Structure (2004) 2.30
How to describe protein motion without amino acid sequence and atomic coordinates. Proc Natl Acad Sci U S A (2002) 2.06
The crystal structure of murine p97/VCP at 3.6A. J Struct Biol (2003) 1.98
A normal mode analysis of structural plasticity in the biomolecular motor F(1)-ATPase. J Mol Biol (2004) 1.92
Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system. Cell Metab (2006) 1.76
GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes. Proc Natl Acad Sci U S A (2011) 1.69
Structure of the s5a:k48-linked diubiquitin complex and its interactions with rpn13. Mol Cell (2009) 1.57
Conformational pathways in the gating of Escherichia coli mechanosensitive channel. Proc Natl Acad Sci U S A (2002) 1.56
The role of shape in determining molecular motions. Biophys J (2005) 1.53
Normal mode refinement of anisotropic thermal parameters for a supramolecular complex at 3.42-A crystallographic resolution. Proc Natl Acad Sci U S A (2007) 1.52
OPUS-PSP: an orientation-dependent statistical all-atom potential derived from side-chain packing. J Mol Biol (2007) 1.48
Evolutionary trends of A(H1N1) influenza virus hemagglutinin since 1918. PLoS One (2009) 1.40
DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a. Proc Natl Acad Sci U S A (2003) 1.39
Domain movements in human fatty acid synthase by quantized elastic deformational model. Proc Natl Acad Sci U S A (2002) 1.38
Motions and negative cooperativity between p97 domains revealed by cryo-electron microscopy and quantised elastic deformational model. J Mol Biol (2003) 1.36
An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic. J Clin Invest (2007) 1.34
A Structural-informatics approach for tracing beta-sheets: building pseudo-C(alpha) traces for beta-strands in intermediate-resolution density maps. J Mol Biol (2004) 1.34
OPUS-Ca: a knowledge-based potential function requiring only Calpha positions. Protein Sci (2007) 1.33
A New Method for Coarse-Grained Elastic Normal-Mode Analysis. J Chem Theory Comput (2006) 1.32
Conformational transition of amyloid beta-peptide. Proc Natl Acad Sci U S A (2005) 1.28
Ligand-free and -bound structures of the binding protein (LivJ) of the Escherichia coli ABC leucine/isoleucine/valine transport system: trajectory and dynamics of the interdomain rotation and ligand specificity. Biochemistry (2005) 1.26
Insulin as a physiological modulator of glucagon secretion. Am J Physiol Endocrinol Metab (2008) 1.26
Crystal structure of unliganded influenza B virus hemagglutinin. J Virol (2008) 1.24
Intrinsic flexibility and gating mechanism of the potassium channel KcsA. Proc Natl Acad Sci U S A (2002) 1.22
Normal-mode refinement of anisotropic thermal parameters for potassium channel KcsA at 3.2 A crystallographic resolution. Structure (2007) 1.20
Simulation via direct computation of partition functions. Phys Rev E Stat Nonlin Soft Matter Phys (2007) 1.17
The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis. Diabetes (2012) 1.16
A structural-informatics approach for mining beta-sheets: locating sheets in intermediate-resolution density maps. J Mol Biol (2003) 1.13
Differences in the neuronal stem cells survival, neuronal differentiation and neurological improvement after transplantation of neural stem cells between mild and severe experimental traumatic brain injury. J Med Invest (2006) 1.11
The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism. FASEB J (2003) 1.10
Structural basis for receptor specificity of influenza B virus hemagglutinin. Proc Natl Acad Sci U S A (2007) 1.10
Substructure synthesis method for simulating large molecular complexes. Proc Natl Acad Sci U S A (2002) 1.07
The eFIP system for text mining of protein interaction networks of phosphorylated proteins. Database (Oxford) (2012) 1.07
Refinement of F-actin model against fiber diffraction data by long-range normal modes. Biophys J (2004) 1.06
OPUS-Rota: a fast and accurate method for side-chain modeling. Protein Sci (2008) 1.06
Protein structural transitions and their functional role. Philos Trans A Math Phys Eng Sci (2005) 1.05
The unfolding action of GroEL on a protein substrate. Biophys J (2004) 1.04
Allosteric transition pathways in the lactose repressor protein core domains: asymmetric motions in a homodimer. Protein Sci (2003) 1.03
Transcription factors and genetic circuits orchestrating the complex, multilayered response of Clostridium acetobutylicum to butanol and butyrate stress. BMC Syst Biol (2013) 1.01
Simulation of F-actin filaments of several microns. Biophys J (2003) 1.01
The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion. J Biol Chem (2006) 1.01
Counting solutions for the N -queens and Latin-square problems by Monte Carlo simulations. Phys Rev E Stat Nonlin Soft Matter Phys (2009) 1.00
A minimalist network model for coarse-grained normal mode analysis and its application to biomolecular x-ray crystallography. Proc Natl Acad Sci U S A (2008) 0.99
Complete genome sequence of a Peste des petits ruminants virus recovered from wild bharal in Tibet, China. J Virol (2012) 0.98
The allosteric mechanism of yeast chorismate mutase: a dynamic analysis. J Mol Biol (2005) 0.98
Structural improvement of unliganded simian immunodeficiency virus gp120 core by normal-mode-based X-ray crystallographic refinement. Acta Crystallogr D Biol Crystallogr (2009) 0.98
Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions. J Biol Chem (2007) 0.97
Comparison of sampling efficiency between simulated tempering and replica exchange. J Chem Phys (2008) 0.97
Enhanced sampling and applications in protein folding in explicit solvent. J Chem Phys (2010) 0.97
Folding of small helical proteins assisted by small-angle X-ray scattering profiles. Structure (2005) 0.96
Conformational flexibility of pyruvate dehydrogenase complexes: a computational analysis by quantized elastic deformational model. J Mol Biol (2003) 0.95
Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines. Mol Cancer Res (2006) 0.95
Structural basis for the divergent evolution of influenza B virus hemagglutinin. Virology (2013) 0.94
Ubiquitin family proteins and their relationship to the proteasome: a structural perspective. Biochim Biophys Acta (2004) 0.94
Free energy landscape for the binding process of Huperzine A to acetylcholinesterase. Proc Natl Acad Sci U S A (2013) 0.93
Unfolding of heptameric co-chaperonin protein follows "fly casting" mechanism: observation of transient nonnative heptamer. J Am Chem Soc (2005) 0.92
Palmitate causes endoplasmic reticulum stress and apoptosis in human mesenchymal stem cells: prevention by AMPK activator. Endocrinology (2012) 0.91
The conformational coupling and translocation mechanism of vitamin B12 ATP-binding cassette transporter BtuCD. Biophys J (2007) 0.91
Determining protein topology from skeletons of secondary structures. J Mol Biol (2005) 0.91
Epac is involved in cAMP-stimulated proglucagon expression and hormone production but not hormone secretion in pancreatic alpha- and intestinal L-cell lines. Am J Physiol Endocrinol Metab (2008) 0.90
Molecular dynamics analysis of a buckyball-antibody complex. Proc Natl Acad Sci U S A (2002) 0.90
Folding helical proteins in explicit solvent using dihedral-biased tempering. Proc Natl Acad Sci U S A (2012) 0.89
Application of normal-mode refinement to X-ray crystal structures at the lower resolution limit. Acta Crystallogr D Biol Crystallogr (2009) 0.89
Theoretical analysis of twist/bend ratio and mechanical moduli of bacterial flagellar hook and filament. Biophys J (2004) 0.88
GABA coordinates with insulin in regulating secretory function in pancreatic INS-1 β-cells. PLoS One (2011) 0.88
The protective effect of peroxiredoxin II on oxidative stress induced apoptosis in pancreatic β-cells. Cell Biosci (2012) 0.88
Inhibitor discovery targeting the intermediate structure of beta-amyloid peptide on the conformational transition pathway: implications in the aggregation mechanism of beta-amyloid peptide. Biochemistry (2006) 0.88
Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands. Proteins (2008) 0.88
Diversifying selective pressure on influenza B virus hemagglutinin. J Med Virol (2009) 0.87
RLIMS-P 2.0: A Generalizable Rule-Based Information Extraction System for Literature Mining of Protein Phosphorylation Information. IEEE/ACM Trans Comput Biol Bioinform (2015) 0.87
POU homeodomain protein Oct-1 functions as a sensor for cyclic AMP. J Biol Chem (2009) 0.87
GLP-1(28-36) improves β-cell mass and glucose disposal in streptozotocin-induced diabetic mice and activates cAMP/PKA/β-catenin signaling in β-cells in vitro. Am J Physiol Endocrinol Metab (2013) 0.87
GABA protects human islet cells against the deleterious effects of immunosuppressive drugs and exerts immunoinhibitory effects alone. Transplantation (2013) 0.87
Eight genes expression patterns during visual system regeneration in Dugesia japonica. Gene Expr Patterns (2011) 0.86
Study of the surface structure of butterfly wings using the scanning electron microscopic moiré method. Appl Opt (2007) 0.86
Highly dispersible and stable copper terephthalate metal-organic framework-graphene oxide nanocomposite for an electrochemical sensing application. ACS Appl Mater Interfaces (2014) 0.85
Normal mode analysis with molecular geometry restraints: bridging molecular mechanics and elastic models. Arch Biochem Biophys (2011) 0.85
Increased beta-cell apoptosis and impaired insulin signaling pathway contributes to the onset of diabetes in OLETF rats. Cell Physiol Biochem (2008) 0.85
Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cells. J Endocrinol (2009) 0.84
Structural basis of actin filament nucleation by tandem W domains. Cell Rep (2013) 0.84
Gene tagging with engineered Ds elements in maize. Methods Mol Biol (2013) 0.84
Genome-wide polycomb target gene prediction in Drosophila melanogaster. Nucleic Acids Res (2012) 0.83
Enhanced sampling in generalized ensemble with large gap of sampling parameter: case study in temperature space random walk. J Chem Phys (2009) 0.83
Insulin treatment and high-fat diet feeding reduces the expression of three Tcf genes in rodent pancreas. J Endocrinol (2010) 0.83