Published in J Am Chem Soc on August 16, 2011
Click chemistry in complex mixtures: bioorthogonal bioconjugation. Chem Biol (2014) 1.40
Direct evidence of a dinuclear copper intermediate in Cu(I)-catalyzed azide-alkyne cycloadditions. Science (2013) 1.24
Bioorthogonal chemistry: strategies and recent developments. Chem Commun (Camb) (2013) 1.19
Monitoring dynamic glycosylation in vivo using supersensitive click chemistry. Bioconjug Chem (2014) 0.83
Kinetic and Spectroscopic Studies of Aerobic Copper(II)-Catalyzed Methoxylation of Arylboronic Esters and Insights into Aryl Transmetalation to Copper(II). Organometallics (2012) 0.78
Squish and CuAAC: additive-free covalent monolayers of discrete molecules in seconds. Langmuir (2013) 0.78
Click-chemistry approaches to π-conjugated polymers for organic electronics applications. Chem Sci (2016) 0.75
On the regioselectivity of the mononuclear copper-catalyzed cycloaddition of azide and alkynes (CuAAC). A quantum chemical topological study. J Mol Model (2014) 0.75
A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Angew Chem Int Ed Engl (2002) 24.12
Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. J Org Chem (2002) 13.76
The growing impact of click chemistry on drug discovery. Drug Discov Today (2003) 6.79
Cu-catalyzed azide-alkyne cycloaddition. Chem Rev (2008) 6.21
The growing applications of click chemistry. Chem Soc Rev (2007) 4.37
Analysis and optimization of copper-catalyzed azide-alkyne cycloaddition for bioconjugation. Angew Chem Int Ed Engl (2009) 3.81
Copper(I)-catalyzed synthesis of azoles. DFT study predicts unprecedented reactivity and intermediates. J Am Chem Soc (2005) 2.75
Copper-catalyzed azide-alkyne cycloaddition (CuAAC) and beyond: new reactivity of copper(I) acetylides. Chem Soc Rev (2010) 2.68
Mechanism of the ligand-free CuI-catalyzed azide-alkyne cycloaddition reaction. Angew Chem Int Ed Engl (2005) 2.62
A fluorogenic probe for the copper(I)-catalyzed azide-alkyne ligation reaction: modulation of the fluorescence emission via 3(n,pi)-1(pi,pi) inversion. J Am Chem Soc (2004) 2.37
1,3-dipolar cycloadditions of azides and alkynes: a universal ligation tool in polymer and materials science. Angew Chem Int Ed Engl (2007) 2.28
Acetylenic Coupling: A Powerful Tool in Molecular Construction. Angew Chem Int Ed Engl (2000) 1.73
Ligand-accelerated Cu-catalyzed azide-alkyne cycloaddition: a mechanistic report. J Am Chem Soc (2007) 1.72
Tailored ligand acceleration of the Cu-catalyzed azide-alkyne cycloaddition reaction: practical and mechanistic implications. J Am Chem Soc (2010) 1.56
On the role of metal contaminants in catalyses with FeCl3. Angew Chem Int Ed Engl (2009) 1.41
Copper-catalyzed aerobic oxidative functionalization of an arene C-H bond: evidence for an aryl-copper(III) intermediate. J Am Chem Soc (2010) 1.38
Click chemistry: function follows form. Chem Soc Rev (2010) 1.23
Hydroxylation of N-heterocycle ligands observed in two unusual mixed-valence Cu(I)/Cu(II) complexes. Angew Chem Int Ed Engl (2002) 1.19
Fluorometric assays for isozymes of human alcohol dehydrogenase. Anal Biochem (1989) 1.10
mu-Acetylide and mu-alkenylidene ligands in "click" triazole syntheses. Chem Commun (Camb) (2007) 1.08
Catalytic "active-metal" template synthesis of [2]rotaxanes, [3]rotaxanes, and molecular shuttles, and some observations on the mechanism of the cu(i)-catalyzed azide-alkyne 1,3-cycloaddition. J Am Chem Soc (2007) 1.00
Isolation of a copper(I) triazolide: a "click" intermediate. Angew Chem Int Ed Engl (2007) 0.93
Site-selective glycosylation of proteins: creating synthetic glycoproteins. Nat Protoc (2007) 0.92
Highly active copper-catalysts for azide-alkyne cycloaddition. Dalton Trans (2009) 0.91
Chelation-assisted, copper(II)-acetate-accelerated azide-alkyne cycloaddition. J Org Chem (2010) 0.91
Alkynylcopper(I) polymers and their use in a mechanistic study of alkyne-azide click reactions. Chem Commun (Camb) (2010) 0.90
Apparent copper(II)-accelerated azide-alkyne cycloaddition. Org Lett (2009) 0.90
An examination of the role of autocatalytic cycles in the chemistry of proposed primordial reactions. Angew Chem Int Ed Engl (2009) 0.88
Mixed-Valence Cu(I)-Cu(II) and Heterodimetallic Cu(I)-M(II) Bis(carboxylate-bridged) Complexes: Structural, Electrochemical, and Spectroscopic Investigations. Inorg Chem (1998) 0.88
Experimental evidence for the involvement of dinuclear alkynylcopper(I) complexes in alkyne-azide chemistry. Chemistry (2010) 0.87
[(NHC)2Cu]X complexes as efficient catalysts for azide-alkyne click chemistry at low catalyst loadings. Angew Chem Int Ed Engl (2008) 0.87
Cu(II)-hydrotalcite as an efficient heterogeneous catalyst for Huisgen [3+2] cycloaddition. Chemistry (2009) 0.85
Electrochemical applications. How click chemistry brought biomimetic models to the next level: electrocatalysis under controlled rate of electron transfer. Chem Soc Rev (2010) 0.84
Syntheses, crystal structures, and physical properties of dinuclear copper(I) and tetranuclear mixed-valence copper(I,II) complexes with hydroxylated bipyridyl-like ligands. Chemistry (2002) 0.82
1,3-Dipolar cycloaddition of organic azides to alkynes by a dicopper-substituted silicotungstate. J Am Chem Soc (2008) 0.79
Mechanistic insights into Cu(I)-catalyzed azide-alkyne "click" cycloaddition monitored by real time infrared spectroscopy. J Phys Chem A (2010) 0.78
Copper(I) alkynyl clusters, [Cu(x+y)(hfac)(x)(C[triple chemical bond]CR)(y)], with Cu(10)-Cu(12) cores. Chemistry (2006) 0.78
Structure determination of homoleptic AuI, AgI, and CuI aryl/alkylethynyl coordination polymers by X-ray powder diffraction. Chemistry (2005) 0.77
Century-known copper salt Cu(OAc)(OMe) proven to be a unique magnetic lattice composed of tetranuclear copper(II) species with a rare binding mode of the acetate anion. Inorg Chem (2003) 0.77
Tridentate complexes of 2,6-bis(4-substituted-1,2,3-triazol-1-ylmethyl)pyridine and its organic azide precursors: an application of the copper(II) acetate-accelerated azide-alkyne cycloaddition. Dalton Trans (2011) 0.76
Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS One (2011) 3.10
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. Proc Natl Acad Sci U S A (2012) 2.84
Flavonoids: promising anticancer agents. Med Res Rev (2003) 2.43
Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity (2013) 2.37
Adipose mitochondrial biogenesis is suppressed in db/db and high-fat diet-fed mice and improved by rosiglitazone. Diabetes (2007) 2.23
Prediction of yeast protein-protein interaction network: insights from the Gene Ontology and annotations. Nucleic Acids Res (2006) 1.93
Rho GTPase signaling activates microtubule severing to promote microtubule ordering in Arabidopsis. Curr Biol (2013) 1.83
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab (2013) 1.70
Compressed sensing based cone-beam computed tomography reconstruction with a first-order method. Med Phys (2010) 1.68
Comparison study of [18F]FAl-NOTA-PRGD2, [18F]FPPRGD2, and [68Ga]Ga-NOTA-PRGD2 for PET imaging of U87MG tumors in mice. Bioconjug Chem (2011) 1.56
A ROP GTPase signaling pathway controls cortical microtubule ordering and cell expansion in Arabidopsis. Curr Biol (2009) 1.55
Arabidopsis MICROTUBULE-ASSOCIATED PROTEIN18 functions in directional cell growth by destabilizing cortical microtubules. Plant Cell (2007) 1.51
308 nm photolysis of nitric acid in the gas phase, on aluminum surfaces, and on ice films. J Phys Chem A (2010) 1.49
A model for the preferential delivery of isoflurane to the spinal cord of the goat. Vet J (2010) 1.48
Mining new crystal protein genes from Bacillus thuringiensis on the basis of mixed plasmid-enriched genome sequencing and a computational pipeline. Appl Environ Microbiol (2012) 1.45
The performance of phase analysis of gated SPECT myocardial perfusion imaging in the presence of perfusion defects: a simulation study. J Nucl Cardiol (2011) 1.44
Terlipressin decreases vascular endothelial growth factor expression and improves oxygenation in patients with acute respiratory distress syndrome and shock. J Emerg Med (2012) 1.40
Water hyacinth in China: a sustainability science-based management framework. Environ Manage (2007) 1.38
The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Nat Cell Biol (2013) 1.35
miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat Cell Biol (2012) 1.34
Modulation of gamma-secretase specificity using small molecule allosteric inhibitors. Proc Natl Acad Sci U S A (2009) 1.34
Distribution, diversity, and potential mobility of extrachromosomal elements related to the Bacillus anthracis pXO1 and pXO2 virulence plasmids. Appl Environ Microbiol (2009) 1.29
{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE. J Biol Chem (2007) 1.27
eNOS deficiency predisposes podocytes to injury in diabetes. J Am Soc Nephrol (2012) 1.26
Scatter correction for full-fan volumetric CT using a stationary beam blocker in a single full scan. Med Phys (2011) 1.25
Boron-doped carbon nanotubes as metal-free electrocatalysts for the oxygen reduction reaction. Angew Chem Int Ed Engl (2011) 1.24
Why do pathological stage IA lung adenocarcinomas vary from prognosis?: a clinicopathologic study of 176 patients with pathological stage IA lung adenocarcinoma based on the IASLC/ATS/ERS classification. J Thorac Oncol (2013) 1.21
Shading correction for on-board cone-beam CT in radiation therapy using planning MDCT images. Med Phys (2010) 1.20
Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity. Cell Host Microbe (2008) 1.20
Complete genome sequence of Bacillus subtilis BSn5, an endophytic bacterium of Amorphophallus konjac with antimicrobial activity for the plant pathogen Erwinia carotovora subsp. carotovora. J Bacteriol (2011) 1.19
MDP25, a novel calcium regulatory protein, mediates hypocotyl cell elongation by destabilizing cortical microtubules in Arabidopsis. Plant Cell (2011) 1.19
Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates. J Med Chem (2012) 1.18
Accelerated barrier optimization compressed sensing (ABOCS) reconstruction for cone-beam CT: phantom studies. Med Phys (2012) 1.16
New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1. J Med Chem (2013) 1.16
An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes. Int J Biol Sci (2012) 1.15
An initial strategy for comparing proteins at the domain architecture level. Bioinformatics (2006) 1.14
Knockout of the AtCESA2 gene affects microtubule orientation and causes abnormal cell expansion in Arabidopsis. Plant Physiol (2006) 1.13
Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery. Biomaterials (2012) 1.13
Temporal trends in self-reported functional limitations and physical disability among the community-dwelling elderly population: the Framingham heart study. Am J Public Health (2008) 1.12
Quantitative cone-beam CT imaging in radiation therapy using planning CT as a prior: first patient studies. Med Phys (2012) 1.09
Scatter correction method for x-ray CT using primary modulation: phantom studies. Med Phys (2010) 1.09
Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes. Biomaterials (2012) 1.09
Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease. PLoS One (2009) 1.09
MicroPET imaging of integrin αvβ3 expressing tumors using 89Zr-RGD peptides. Mol Imaging Biol (2011) 1.08
Primary intrathoracic liposarcoma: a clinicopathologic study and prognostic analysis of 23 cases. J Cardiothorac Surg (2014) 1.08
The type II Arabidopsis formin14 interacts with microtubules and microfilaments to regulate cell division. Plant Cell (2010) 1.08
The effects of biotic and abiotic factors on the spatial heterogeneity of alpine grassland vegetation at a small scale on the Qinghai-Tibet Plateau (QTP), China. Environ Monit Assess (2013) 1.08
Diet quality and obesity in women: the Framingham Nutrition Studies. Br J Nutr (2009) 1.07
Rapid and simple one-step F-18 labeling of peptides. Bioconjug Chem (2011) 1.06
Nutritional risk and the metabolic syndrome in women: opportunities for preventive intervention from the Framingham Nutrition Study. Am J Clin Nutr (2006) 1.05
Multiferroic behavior associated with an order-disorder hydrogen bonding transition in metal-organic frameworks (MOFs) with the perovskite ABX3 architecture. J Am Chem Soc (2009) 1.05
Genomic binding profiling of the fission yeast stress-activated MAPK Sty1 and the bZIP transcriptional activator Atf1 in response to H2O2. PLoS One (2010) 1.04
Multimodality imaging of tumor response to doxil. Theranostics (2011) 1.03
Noninvasive monitoring of orthotopic glioblastoma therapy response using RGD-conjugated iron oxide nanoparticles. Biomaterials (2012) 1.02
Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9. J Lipid Res (2011) 1.01
Picomolar dichotomous activity of gnidimacrin against HIV-1. PLoS One (2011) 1.01
Early phase drug discovery: cheminformatics and computational techniques in identifying lead series. Bioorg Med Chem (2012) 1.00
Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors. Dev Biol (2012) 0.99
Intrathoracic giant pleural lipoma: case report and review of the literature. J Cardiothorac Surg (2013) 0.99
Highly sensitive fluorescent probes for zinc ion based on triazolyl-containing tetradentate coordination motifs. Org Lett (2007) 0.99
Diet and physical activity patterns of school-aged children. J Am Diet Assoc (2009) 0.99
High-grade transgenic somatic chimeras from chicken embryonic stem cells. Mech Dev (2005) 0.98
Three-dimensional anisotropic adaptive filtering of projection data for noise reduction in cone beam CT. Med Phys (2011) 0.98
Complete genome sequence of Bacillus thuringiensis serovar finitimus strain YBT-020. J Bacteriol (2011) 0.98
Noise reduction in low-dose x-ray fluoroscopy for image-guided radiation therapy. Int J Radiat Oncol Biol Phys (2009) 0.97
Region competition based active contour for medical object extraction. Comput Med Imaging Graph (2008) 0.97
Diet quality, physical activity, smoking status, and weight fluctuation are associated with weight change in women and men. J Nutr (2010) 0.97
N-Alkyl-PEI-functionalized iron oxide nanoclusters for efficient siRNA delivery. Small (2011) 0.97
Increased neural responses to unfairness in a loss context. Neuroimage (2013) 0.96
Crystalline Morphology and Polymorphic Phase Transitions in Electrospun Nylon 6 Nanofibers. Macromolecules (2007) 0.96
Multiplex imaging of an intracellular proteolytic cascade by using a broad-spectrum nanoquencher. Angew Chem Int Ed Engl (2012) 0.96
MYB97, MYB101 and MYB120 function as male factors that control pollen tube-synergid interaction in Arabidopsis thaliana fertilization. PLoS Genet (2013) 0.96
Anisotropic structure and transformation kinetics of vapor-deposited indomethacin glasses. J Phys Chem B (2010) 0.95
Tetra-aqua-bis[4-(imidazol-1-yl-κN)benzoato]manganese(II). Acta Crystallogr Sect E Struct Rep Online (2010) 0.95
Manipulating the power of an additional phase: a flower-like Au-Fe3O4 optical nanosensor for imaging protease expressions in vivo. ACS Nano (2011) 0.95
Evaluation of an [(18)F]AlF-NOTA Analog of Exendin-4 for Imaging of GLP-1 Receptor in Insulinoma. Theranostics (2012) 0.95
Role of ion-dipole interactions in nucleation of gamma poly(vinylidene fluoride) in the presence of graphene oxide during melt crystallization. J Phys Chem B (2012) 0.95
Effect of injection routes on the biodistribution, clearance, and tumor uptake of carbon dots. ACS Nano (2013) 0.95
Identification of two novel fibrinolytic enzymes from Bacillus subtilis QK02. Comp Biochem Physiol C Toxicol Pharmacol (2004) 0.95
Cucumber mosaic virus movement protein severs actin filaments to increase the plasmodesmal size exclusion limit in tobacco. Plant Cell (2010) 0.94
Effect of primer treatment on bonding of resin cements to zirconia ceramic. Dent Mater (2010) 0.94
Plasminogen activator inhibitor-1 regulates LPS-induced TLR4/MD-2 pathway activation and inflammation in alveolar macrophages. Inflammation (2015) 0.94
Longitudinal bioluminescence imaging of the dynamics of Doxorubicin induced apoptosis. Theranostics (2013) 0.93
New Methods for Labeling RGD Peptides with Bromine-76. Theranostics (2011) 0.93
Modality- and task-specific brain regions involved in Chinese lexical processing. J Cogn Neurosci (2009) 0.93
Hybrid ferritin nanoparticles as activatable probes for tumor imaging. Angew Chem Int Ed Engl (2011) 0.93
R-spondin 2 signalling mediates susceptibility to fatal infectious diarrhoea. Nat Commun (2013) 0.93
Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants. Bioorg Med Chem Lett (2012) 0.93
Dynamic epigenetic regulation of gene expression during the life cycle of malaria parasite Plasmodium falciparum. PLoS Pathog (2013) 0.93
Inverse planning for IMRT with nonuniform beam profiles using total-variation regularization (TVR). Med Phys (2011) 0.92
Early effects of mechanical ventilation on isotonic contractile properties and MAF-box gene expression in the diaphragm. J Appl Physiol (1985) (2005) 0.92
A facile, one-step nanocarbon functionalization for biomedical applications. Nano Lett (2012) 0.92
Genome sequence of poultry pathogen Riemerella anatipestifer strain RA-YM. J Bacteriol (2010) 0.91
A phase II study of paclitaxel and nedaplatin as front-line chemotherapy in Chinese patients with metastatic esophageal squamous cell carcinoma. World J Gastroenterol (2013) 0.91
Chelation-assisted, copper(II)-acetate-accelerated azide-alkyne cycloaddition. J Org Chem (2010) 0.91
Treatment of distal tibial shaft fractures by three different surgical methods: a randomized, prospective study. Int Orthop (2014) 0.91