Published in Hum Mol Genet on August 05, 2011
Emerging role of autophagy in kidney function, diseases and aging. Autophagy (2012) 1.43
Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease. J Clin Invest (2017) 1.38
Strategies targeting cAMP signaling in the treatment of polycystic kidney disease. J Am Soc Nephrol (2013) 1.33
Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease. J Clin Invest (2014) 1.24
Targeting the tumor microenvironment: JAK-STAT3 signaling. JAKSTAT (2013) 1.14
The STAT5 Inhibitor Pimozide Displays Efficacy in Models of Acute Myelogenous Leukemia Driven by FLT3 Mutations. Genes Cancer (2012) 1.05
Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer. Mol Cell Endocrinol (2013) 1.04
IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells. Proc Natl Acad Sci U S A (2014) 1.02
JAK inhibition and progressive kidney disease. Curr Opin Nephrol Hypertens (2015) 0.98
Screening approaches to generating STAT inhibitors: Allowing the hits to identify the targets. JAKSTAT (2012) 0.98
Polycystic kidney disease in 2011: Connecting the dots toward a polycystic kidney disease therapy. Nat Rev Nephrol (2011) 0.93
STAT signaling in the pathogenesis and treatment of myeloid malignancies. JAKSTAT (2012) 0.92
Regulation of STATs by polycystin-1 and their role in polycystic kidney disease. JAKSTAT (2013) 0.91
Primary cilia and kidney injury: current research status and future perspectives. Am J Physiol Renal Physiol (2013) 0.90
Vasopressin and disruption of calcium signalling in polycystic kidney disease. Nat Rev Nephrol (2015) 0.89
Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein. Hum Mol Genet (2014) 0.88
ALK Signaling and Target Therapy in Anaplastic Large Cell Lymphoma. Front Oncol (2012) 0.88
New treatments for autosomal dominant polycystic kidney disease. Br J Clin Pharmacol (2013) 0.85
Cutaneous plasmablastic lymphoma in an immunocompetent patient with long-term pyrimethamine use for essential thrombocythemia: a case report and literature review. Case Rep Hematol (2013) 0.85
Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening. J Transl Med (2012) 0.83
The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation. J Am Soc Nephrol (2014) 0.83
Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney Disease. J Am Soc Nephrol (2014) 0.80
Genetic Interactions of STAT3 and Anticancer Drug Development. Cancers (Basel) (2014) 0.79
Autophagy and Tubular Cell Death in the Kidney. Semin Nephrol (2016) 0.77
STAT3 Signaling in Polycystic Kidney Disease. Drug Discov Today Dis Mech (2013) 0.77
Experimental therapies and ongoing clinical trials to slow down progression of ADPKD. Curr Hypertens Rev (2013) 0.76
Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease. Dis Model Mech (2016) 0.75
Src family kinases in chronic kidney disease. Am J Physiol Renal Physiol (2017) 0.75
Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell (1996) 10.49
Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell (1996) 10.44
Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell (2008) 6.54
A road map for those who don't know JAK-STAT. Science (2002) 5.67
Autosomal dominant polycystic kidney disease. N Engl J Med (1993) 5.64
Everolimus in patients with autosomal dominant polycystic kidney disease. N Engl J Med (2010) 5.50
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A (2007) 4.77
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A (2006) 4.56
A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med (2007) 4.40
Sirolimus and kidney growth in autosomal dominant polycystic kidney disease. N Engl J Med (2010) 4.36
Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol (2003) 3.47
PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell (2002) 3.09
The evolution of signalling pathways in animal development. Nat Rev Genet (2003) 2.79
Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr Biol (2000) 2.70
Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res (2002) 2.41
A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy. Kidney Int (2010) 2.32
Genetic heterogeneity of polycystic kidney disease in Europe. Contrib Nephrol (1992) 2.14
Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects. Hum Mol Genet (2001) 2.09
Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice. Hum Mol Genet (2007) 2.03
Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol (2006) 1.95
Renal injury is a third hit promoting rapid development of adult polycystic kidney disease. Hum Mol Genet (2009) 1.94
FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. Genes Dev (1999) 1.94
Pkd1 inactivation induced in adulthood produces focal cystic disease. J Am Soc Nephrol (2008) 1.65
Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells. Am J Physiol Renal Physiol (2001) 1.57
Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways. Hum Mol Genet (2009) 1.53
Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3. Blood (2008) 1.53
Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis. Oncogene (2002) 1.47
A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium. Dev Cell (2003) 1.46
Rapamycin blocks tumor progression: unlinking immunosuppression from antitumor efficacy. Transplantation (2002) 1.33
JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion. Circulation (2001) 1.30
Mechanisms of progression in autosomal dominant polycystic kidney disease. Kidney Int Suppl (1997) 1.18
Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model. Am J Physiol Renal Physiol (2011) 1.17
Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases. Clin J Am Soc Nephrol (2010) 1.12
Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells. Biochem Biophys Res Commun (2007) 1.08
Localized JAK/STAT signaling is required for oriented cell rearrangement in a tubular epithelium. Development (2003) 1.08
Therapeutic mTOR inhibition in autosomal dominant polycystic kidney disease: What is the appropriate serum level? Am J Transplant (2010) 1.03
Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease. J Clin Invest (2010) 0.96
Pyrimethamine induces apoptosis of melanoma cells via a caspase and cathepsin double-edged mechanism. Cancer Res (2008) 0.94
Plasma pyrimethamine concentrations during long-term treatment for cerebral toxoplasmosis in patients with AIDS. Antimicrob Agents Chemother (1996) 0.91
Col2-Cre recombinase is co-expressed with endogenous type II collagen in embryonic renal epithelium and drives development of polycystic kidney disease following inactivation of ciliary genes. Matrix Biol (2008) 0.91
Signal transduction and transcriptional adaptation in embryonic heart development and during myocardial hypertrophy. Mol Cell Biochem (1999) 0.87
Inflammatory cytokine profile in autosomal dominant polycystic kidney disease. Contrib Nephrol (1997) 0.80
Evaluation of the effect of pyrimethamine, an anti-malarial drug, on HIV-1 replication. Virus Res (2010) 0.77
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet (2003) 13.33
Pten regulates neuronal arborization and social interaction in mice. Neuron (2006) 6.11
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med (2005) 6.04
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood (2006) 4.46
The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. J Clin Invest (2011) 4.41
A test of climate, sun, and culture relationships from an 1810-year Chinese cave record. Science (2008) 3.94
Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. J Clin Invest (2008) 3.59
Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene. Cancer Discov (2011) 3.45
Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation (2008) 3.33
Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate. Nature (2010) 3.19
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation (2009) 2.77
Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis. Kidney Int (2012) 2.74
Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis. EMBO J (2003) 2.69
Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases. Sci Signal (2010) 2.64
Experimental model for paroxysmal atrial fibrillation arising at the pulmonary vein-atrial junctions. Heart Rhythm (2006) 2.63
Nomograms for predicting annual resolution rate of primary vesicoureteral reflux: results from 2,462 children. J Urol (2009) 2.59
Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A (2009) 2.54
Coupling of human immunodeficiency virus type 1 fusion to virion maturation: a novel role of the gp41 cytoplasmic tail. J Virol (2004) 2.47
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem (2003) 2.44
Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation (2011) 2.29
Characterization of cardiac tumors in children by cardiovascular magnetic resonance imaging: a multicenter experience. J Am Coll Cardiol (2011) 2.24
The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood (2011) 2.23
Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10. Science (2010) 2.21
Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Nat Genet (2013) 2.21
Differentiated kidney epithelial cells repair injured proximal tubule. Proc Natl Acad Sci U S A (2013) 2.11
Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation. Curr Biol (2010) 2.08
Safety and efficacy of a fish-oil-based fat emulsion in the treatment of parenteral nutrition-associated liver disease. Pediatrics (2008) 2.02
Structure-based design of novel inhibitors of the MDM2-p53 interaction. J Med Chem (2012) 2.01
Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor. Cancer Res (2006) 1.97
Polycystins and mechanosensation in renal and nodal cilia. Bioessays (2004) 1.96
Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol (2006) 1.95
Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer. J Clin Oncol (2009) 1.95
Renal injury is a third hit promoting rapid development of adult polycystic kidney disease. Hum Mol Genet (2009) 1.94
Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization. J Virol (2010) 1.92
Parenteral fish oil improves outcomes in patients with parenteral nutrition-associated liver injury. Ann Surg (2009) 1.90
Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res (2010) 1.88
Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat Cell Biol (2005) 1.88
Activity-dependent development of callosal projections in the somatosensory cortex. J Neurosci (2007) 1.87
Initial manifestations of frailty criteria and the development of frailty phenotype in the Women's Health and Aging Study II. J Gerontol A Biol Sci Med Sci (2008) 1.87
TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol Cell Biol (2007) 1.86
Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. J Virol (2002) 1.85
Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res (2005) 1.82
Aberrant regulation of planar cell polarity in polycystic kidney disease. J Am Soc Nephrol (2010) 1.81
Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia. Mol Cell Biol (2007) 1.81
CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy. Clin Cancer Res (2009) 1.80
STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypes. Sci Signal (2014) 1.79
Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy. Clin Cancer Res (2007) 1.78
Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells. Hepatology (2005) 1.78
Interactive atrial neural network: Determining the connections between ganglionated plexi. Heart Rhythm (2006) 1.76
Reciprocal effects of STAT5 and STAT3 in breast cancer. Mol Cancer Res (2009) 1.72
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab (2013) 1.70
Nek8 regulates the expression and localization of polycystin-1 and polycystin-2. J Am Soc Nephrol (2008) 1.70
Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latency. J Virol (2003) 1.70
Establishment of clonal colony-forming assay for propagation of pancreatic cancer cells with stem cell properties. Pancreas (2007) 1.68
Specification of Arabidopsis floral meristem identity by repression of flowering time genes. Development (2007) 1.68
Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. Mol Cell Biol (2003) 1.67
The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area. J Am Soc Nephrol (2004) 1.66
CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice. J Clin Invest (2009) 1.66
Pkd1 inactivation induced in adulthood produces focal cystic disease. J Am Soc Nephrol (2008) 1.65
A preeclampsia-like syndrome characterized by reversible hypertension and proteinuria induced by the multitargeted kinase inhibitors sunitinib and sorafenib. J Natl Cancer Inst (2008) 1.63
STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers. Clin Cancer Res (2011) 1.62
MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5. BMC Cancer (2012) 1.61
Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis. J Clin Invest (2015) 1.59
Alpha-actinin-4 is required for normal podocyte adhesion. J Biol Chem (2006) 1.58
Low serum micronutrient concentrations predict frailty among older women living in the community. J Gerontol A Biol Sci Med Sci (2006) 1.58
Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2. J Biol Chem (2002) 1.57
Pathophysiology of acute kidney injury to chronic kidney disease: maladaptive repair. Contrib Nephrol (2011) 1.57
The origin of interstitial myofibroblasts in chronic kidney disease. Pediatr Nephrol (2011) 1.55
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics (2013) 1.53
Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. J Biol Chem (2004) 1.53
Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3. Blood (2008) 1.53
Characterization and fate of telomerase-expressing epithelia during kidney repair. J Am Soc Nephrol (2011) 1.52
Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis. Cancer Res (2006) 1.52
Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II. Proc Natl Acad Sci U S A (2012) 1.51
The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells. Blood (2003) 1.51
The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells. Blood (2005) 1.51
Thoracic ossification of ligamentum flavum caused by skeletal fluorosis. Eur Spine J (2006) 1.50
Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury. J Am Soc Nephrol (2012) 1.48
Characterization of Ser338 phosphorylation for Raf-1 activation. J Biol Chem (2008) 1.48
Trends in resource utilization by children with neurological impairment in the United States inpatient health care system: a repeat cross-sectional study. PLoS Med (2012) 1.47
Perioperative risk factors for surgical complications in pediatric urology: a pilot study in preoperative risk assessment in children. Urology (2009) 1.44
Neuron-specific enolase-cre mouse line with cre activity in specific neuronal populations. Genesis (2006) 1.43
Global cytoskeletal control of mechanotransduction in kidney epithelial cells. Exp Cell Res (2004) 1.43
Gating of the polycystin ion channel signaling complex in neurons and kidney cells. FASEB J (2004) 1.43
Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis. J Clin Invest (2014) 1.40
Predictors of clinical outcomes and hospital resource use of children after tracheotomy. Pediatrics (2009) 1.40
Tunable bandgap in silicene and germanene. Nano Lett (2011) 1.39
Retracted Inhibition of rho-kinase by fasudil suppresses formation and progression of experimental abdominal aortic aneurysms. PLoS One (2013) 1.39
Solution structure and dynamics of the wild-type pseudoknot of human telomerase RNA. J Mol Biol (2008) 1.39
Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. J Neurosci (2008) 1.36
Origin of new cells in the adult kidney: results from genetic labeling techniques. Kidney Int (2010) 1.36
E. coli NusG inhibits backtracking and accelerates pause-free transcription by promoting forward translocation of RNA polymerase. J Mol Biol (2010) 1.36
Hedgehog-Gli pathway activation during kidney fibrosis. Am J Pathol (2012) 1.34
miR-9 and NFATc3 regulate myocardin in cardiac hypertrophy. J Biol Chem (2010) 1.34
Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis. J Neurosci (2012) 1.34
Autonomic mechanism to explain complex fractionated atrial electrograms (CFAE). J Cardiovasc Electrophysiol (2007) 1.30