Published in Science on May 31, 2002
Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells (2005) 6.72
Immunomodulatory functions of type I interferons. Nat Rev Immunol (2012) 3.73
STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J Neurosci (2008) 3.44
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature (2011) 3.18
Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded. Nat Rev Microbiol (2008) 3.01
UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. EMBO J (2006) 2.84
Retinoic acid-inducible gene I mediates early antiviral response and Toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells. J Virol (2006) 2.76
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein. J Virol (2003) 2.54
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A (2003) 2.12
Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities. J Virol (2009) 2.10
Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc Natl Acad Sci U S A (2003) 2.07
The Jak/STAT pathway is involved in synaptic plasticity. Neuron (2012) 2.02
The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene (2009) 1.97
The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor. J Biol Chem (2009) 1.92
Canonical and non-canonical JAK-STAT signaling. Trends Cell Biol (2008) 1.85
STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes. Proc Natl Acad Sci U S A (2005) 1.80
Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury. J Neurosci (2013) 1.79
Identification of the nuclear export signal and STAT-binding domains of the Nipah virus V protein reveals mechanisms underlying interferon evasion. J Virol (2004) 1.76
Reduction of Stat3 activity attenuates HIV-induced kidney injury. J Am Soc Nephrol (2009) 1.70
A cytomegaloviral protein reveals a dual role for STAT2 in IFN-{gamma} signaling and antiviral responses. J Exp Med (2005) 1.68
Gaussian process regression bootstrapping: exploring the effects of uncertainty in time course data. Bioinformatics (2009) 1.68
Inhibition of interferon signaling by rabies virus phosphoprotein P: activation-dependent binding of STAT1 and STAT2. J Virol (2006) 1.67
Intrinsic apoptotic pathways of gingival epithelial cells modulated by Porphyromonas gingivalis. Cell Microbiol (2007) 1.66
Attenuated rabies virus activates, while pathogenic rabies virus evades, the host innate immune responses in the central nervous system. J Virol (2005) 1.65
Transcriptional activation of alpha/beta interferon genes: interference by nonsegmented negative-strand RNA viruses. J Virol (2005) 1.64
In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration. Proc Natl Acad Sci U S A (2011) 1.59
Rabies virus P protein interacts with STAT1 and inhibits interferon signal transduction pathways. J Virol (2005) 1.58
The JAK-STAT signaling network in the human B-cell: an extreme signaling pathway analysis. Biophys J (2004) 1.55
A load driver device for engineering modularity in biological networks. Nat Biotechnol (2014) 1.53
Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNα via accelerating the degradation of its receptor. Blood (2011) 1.49
Retracted A Role for PPARgamma in the Regulation of Cytokines in Immune Cells and Cancer. PPAR Res (2008) 1.48
Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability. Nat Cell Biol (2008) 1.47
Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta. Mol Cell Biol (2004) 1.46
A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signaling. Proc Natl Acad Sci U S A (2006) 1.43
Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain. J Virol (2005) 1.42
MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop. Sci Signal (2011) 1.42
ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency. Virol J (2006) 1.41
Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3. Cancer Res (2008) 1.36
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway. J Virol (2004) 1.36
BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes. Mol Cell Biol (2013) 1.35
Survival strategy of obligately intracellular Ehrlichia chaffeensis: novel modulation of immune response and host cell cycles. Infect Immun (2004) 1.34
Tumor necrosis factor-alpha is produced by dying retinal neurons and is required for Muller glia proliferation during zebrafish retinal regeneration. J Neurosci (2013) 1.30
Apical role for BRG1 in cytokine-induced promoter assembly. Proc Natl Acad Sci U S A (2005) 1.30
Synergistic transcriptional activation of indoleamine dioxygenase by IFN-gamma and tumor necrosis factor-alpha. J Interferon Cytokine Res (2003) 1.29
Mechanisms regulating dendritic cell specification and development. Immunol Rev (2010) 1.26
Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells. Mol Cell Biol (2005) 1.25
BDNF selectively regulates GABAA receptor transcription by activation of the JAK/STAT pathway. Sci Signal (2008) 1.25
NF-kappaB and STAT3 signaling in glioma: targets for future therapies. Expert Rev Neurother (2010) 1.25
NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer. Protein Cell (2013) 1.25
Sensitivity analysis of intracellular signaling pathway kinetics predicts targets for stem cell fate control. PLoS Comput Biol (2007) 1.22
Effects of interferon-α/β on HBV replication determined by viral load. PLoS Pathog (2011) 1.22
Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling. J Immunol (2008) 1.22
Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis. Biochim Biophys Acta (2011) 1.22
Clinical update on cancer: molecular oncology of head and neck cancer. Cell Death Dis (2014) 1.22
Role of metazoan mediator proteins in interferon-responsive transcription. Mol Cell Biol (2003) 1.22
Src-dependent STAT-3-mediated expression of monocyte chemoattractant protein-1 is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration. J Biol Chem (2009) 1.20
Nutrigenetics and metabolic disease: current status and implications for personalised nutrition. Nutrients (2013) 1.20
Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3. Biochem J (2003) 1.20
Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells. Mol Cancer (2005) 1.18
Herpes simplex type I (HSV-1) infection of the nervous system: is an immune response a good thing? J Neuroimmunol (2009) 1.16
Stat3 defines three populations of Müller glia and is required for initiating maximal müller glia proliferation in the regenerating zebrafish retina. J Comp Neurol (2012) 1.15
Characterization of the amino acid residues of sendai virus C protein that are critically involved in its interferon antagonism and RNA synthesis down-regulation. J Virol (2004) 1.15
Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling. Mol Cell Biol (2009) 1.13
Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites. J Biol Chem (2009) 1.12
Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinase D2. Mol Cell Biol (2010) 1.10
Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor. J Biol Chem (2009) 1.09
Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Hum Mol Genet (2011) 1.09
Hope and fear for interferon: the receptor-centric outlook on the future of interferon therapy. J Interferon Cytokine Res (2013) 1.07
Stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells. PLoS One (2010) 1.07
Modulation of gamma interferon receptor 1 by Mycobacterium tuberculosis: a potential immune response evasive mechanism. Infect Immun (2007) 1.07
Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway. PLoS One (2012) 1.06
Interleukin-6 as a photoreceptor neuroprotectant in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci (2008) 1.06
Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1. Mol Cell Biol (2010) 1.05
Immune and inflammatory mechanisms in pulmonary arterial hypertension. Prog Cardiovasc Dis (2012) 1.03
Hyperactivated B cells in human inflammatory bowel disease. J Leukoc Biol (2009) 1.03
The involvement of JAK-STAT3 in cell motility, invasion, and metastasis. JAKSTAT (2014) 1.03
Simvastatin prevents and reverses depigmentation in a mouse model of vitiligo. J Invest Dermatol (2014) 1.03
Vorinostat positively regulates synaptic plasticity genes expression and spine density in HIV infected neurons: role of nicotine in progression of HIV-associated neurocognitive disorder. Mol Brain (2014) 1.02
Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage. PLoS One (2008) 1.02
6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells. Cancer Res (2011) 1.02
STAT3 and cardiac remodeling. Heart Fail Rev (2011) 1.01
A rapid simple approach to quantify chromosome conformation capture. Nucleic Acids Res (2009) 1.01
Tuning the orchestra: transcriptional pathways controlling axon regeneration. Front Mol Neurosci (2012) 1.00
White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol (2014) 1.00
Regulation of Innate Immune Responses by Bovine Herpesvirus 1 and Infected Cell Protein 0 (bICP0). Viruses (2009) 0.99
The production of CXCR3-agonistic chemokines by synovial fibroblasts from patients with rheumatoid arthritis. Rheumatol Int (2004) 0.99
Overexpression of miR -155 promotes proliferation and invasion of human laryngeal squamous cell carcinoma via targeting SOCS1 and STAT3. PLoS One (2013) 0.99
The schlafen family of proteins and their regulation by interferons. J Interferon Cytokine Res (2013) 0.99
Viral degradasome hijacks mitochondria to suppress innate immunity. Cell Res (2013) 0.99
Suppression of STAT-1 expression by human papillomaviruses is necessary for differentiation-dependent genome amplification and plasmid maintenance. J Virol (2011) 0.99
Patterns and functions of STAT activation during Drosophila embryogenesis. Mech Dev (2003) 0.99
Absent in Melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers. Oncogene (2011) 0.99
Direct, interferon-independent activation of the CXCL10 promoter by NF-κB and interferon regulatory factor 3 during hepatitis C virus infection. J Virol (2013) 0.98
Cross-talk between interferon-γ and hedgehog signaling regulates adipogenesis. Diabetes (2011) 0.98
Vascular endothelial growth factor-induced elimination of the type 1 interferon receptor is required for efficient angiogenesis. Blood (2011) 0.98
Immature monocyte derived dendritic cells gene expression profile in response to Virus-Like Particles stimulation. J Transl Med (2005) 0.98
Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor. J Biol Chem (2014) 0.97
Alteration of epileptogenesis genes. Neurotherapeutics (2009) 0.97
Signal transducers and activators of transcription 5 contributes to erythropoietin-mediated neuroprotection against hippocampal neuronal death after transient global cerebral ischemia. Neurobiol Dis (2006) 0.97
Cancer prevention and therapy through the modulation of the tumor microenvironment. Semin Cancer Biol (2015) 0.97
Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation. J Virol (2002) 2.68
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. EMBO Rep (2008) 2.65
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein. J Virol (2003) 2.54
Paramyxoviruses SV5 and HPIV2 assemble STAT protein ubiquitin ligase complexes from cellular components. Virology (2002) 2.50
RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2. J Virol (2006) 2.22
Selective STAT protein degradation induced by paramyxoviruses requires both STAT1 and STAT2 but is independent of alpha/beta interferon signal transduction. J Virol (2002) 2.08
Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc Natl Acad Sci U S A (2003) 2.07
STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling. J Virol (2003) 1.95
Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2. J Biol Chem (2009) 1.78
Identification of the nuclear export signal and STAT-binding domains of the Nipah virus V protein reveals mechanisms underlying interferon evasion. J Virol (2004) 1.76
STAT2 acts as a host range determinant for species-specific paramyxovirus interferon antagonism and simian virus 5 replication. J Virol (2002) 1.66
Effects of influenza A virus NS1 protein on protein expression: the NS1 protein enhances translation and is not required for shutoff of host protein synthesis. J Virol (2002) 1.63
Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation. J Virol (2003) 1.59
Negative regulation of cytoplasmic RNA-mediated antiviral signaling. Cytokine (2008) 1.54
A novel role for viral-defective interfering particles in enhancing dendritic cell maturation. J Immunol (2006) 1.51
Select paramyxoviral V proteins inhibit IRF3 activation by acting as alternative substrates for inhibitor of kappaB kinase epsilon (IKKe)/TBK1. J Biol Chem (2008) 1.45
Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain. J Virol (2005) 1.42
Regulating immune response using polyvalent nucleic acid-gold nanoparticle conjugates. Mol Pharm (2009) 1.40
Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. Mol Cell Biol (2006) 1.39
SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation. J Biol Chem (2003) 1.39
A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2. J Virol (2009) 1.38
Histone deacetylases as transcriptional activators? Role reversal in inducible gene regulation. Sci STKE (2005) 1.38
STAT2 is a primary target for measles virus V protein-mediated alpha/beta interferon signaling inhibition. J Virol (2008) 1.37
A conserved role for human Nup98 in altering chromatin structure and promoting epigenetic transcriptional memory. PLoS Biol (2013) 1.27
Role of metazoan mediator proteins in interferon-responsive transcription. Mol Cell Biol (2003) 1.22
A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response. J Biol Chem (2003) 1.21
Paramyxovirus disruption of interferon signal transduction: STATus report. J Interferon Cytokine Res (2009) 1.21
Host evasion by emerging paramyxoviruses: Hendra virus and Nipah virus v proteins inhibit interferon signaling. Viral Immunol (2004) 1.15
Activation of RIG-I-like receptor signal transduction. Crit Rev Biochem Mol Biol (2011) 1.13
Influenza A virus infection of human respiratory cells induces primary microRNA expression. J Biol Chem (2012) 1.06
Dissociation of paramyxovirus interferon evasion activities: universal and virus-specific requirements for conserved V protein amino acids in MDA5 interference. J Virol (2010) 1.06
Measles virus V protein inhibits p53 family member p73. J Virol (2006) 1.06
Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway. JAKSTAT (2013) 1.04
ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2). J Biol Chem (2012) 1.00
Mechanisms of Type I interferon cell signaling and STAT-mediated transcriptional responses. Mt Sinai J Med (2002) 0.96
Extensive cooperation of immune master regulators IRF3 and NFκB in RNA Pol II recruitment and pause release in human innate antiviral transcription. Cell Rep (2013) 0.96
Amino acid requirements for MDA5 and LGP2 recognition by paramyxovirus V proteins: a single arginine distinguishes MDA5 from RIG-I. J Virol (2012) 0.94
Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: Potent inhibition of histone deacetylases. Bioorg Med Chem (2006) 0.92
Henipavirus V protein association with Polo-like kinase reveals functional overlap with STAT1 binding and interferon evasion. J Virol (2008) 0.92
A point mutation, E95D, in the mumps virus V protein disengages STAT3 targeting from STAT1 targeting. J Virol (2009) 0.90
Impaired cellular responses to cytosolic DNA or infection with Listeria monocytogenes and vaccinia virus in the absence of the murine LGP2 protein. PLoS One (2011) 0.89
Enabled interferon signaling evasion in an immune-competent transgenic mouse model of parainfluenza virus 5 infection. Virology (2007) 0.89
Unexpected roles for deacetylation in interferon- and cytokine-induced transcription. J Interferon Cytokine Res (2005) 0.87
MicroRNA profiling of Sendai virus-infected A549 cells identifies miR-203 as an interferon-inducible regulator of IFIT1/ISG56. J Virol (2013) 0.81
Small RNA profiling of influenza A virus-infected cells identifies miR-449b as a regulator of histone deacetylase 1 and interferon beta. PLoS One (2013) 0.80
High-density nucleosome occupancy map of human chromosome 9p21-22 reveals chromatin organization of the type I interferon gene cluster. J Interferon Cytokine Res (2014) 0.76
Detection of activated STAT proteins. Methods Mol Biol (2013) 0.75