Published in N Engl J Med on August 11, 2011
Iron and cancer: more ore to be mined. Nat Rev Cancer (2013) 2.40
An update on iron chelation therapy. Blood Transfus (2012) 1.19
Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function. Cell Rep (2014) 0.99
The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway. Oncotarget (2014) 0.96
IRP2 regulates breast tumor growth. Cancer Res (2013) 0.94
Streptomyces malaysiense sp. nov.: A novel Malaysian mangrove soil actinobacterium with antioxidative activity and cytotoxic potential against human cancer cell lines. Sci Rep (2016) 0.88
Evaluation of Antioxidative and Cytotoxic Activities of Streptomyces pluripotens MUSC 137 Isolated from Mangrove Soil in Malaysia. Front Microbiol (2015) 0.86
Current Status of Hepatic Arterial Infusion Chemotherapy. Liver Cancer (2015) 0.85
Mechanisms of hepatocellular carcinoma and challenges and opportunities for molecular targeted therapy. World J Hepatol (2015) 0.84
Oxidative Stress and Liver Cancer: Etiology and Therapeutic Targets. Oxid Med Cell Longev (2016) 0.83
Zinc supplementation therapy improves the outcome of patients with chronic hepatitis C. J Clin Biochem Nutr (2012) 0.81
Histopathology of type C liver disease for determining hepatocellular carcinoma risk factors. World J Gastroenterol (2013) 0.80
Regulation of iron homeostasis by the p53-ISCU pathway. Sci Rep (2015) 0.79
Supportive therapies for prevention of hepatocellular carcinoma recurrence and preservation of liver function. World J Gastroenterol (2016) 0.79
Deferasirox, an oral iron chelator, prevents hepatocarcinogenesis and adverse effects of sorafenib. J Clin Biochem Nutr (2016) 0.78
The Eltrombopag antitumor effect on hepatocellular carcinoma. Int J Oncol (2015) 0.78
Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy. Pharmaceuticals (Basel) (2011) 0.78
ABCB6 mRNA and DNA methylation levels serve as useful biomarkers for prediction of early intrahepatic recurrence of hepatitis C virus-related hepatocellular carcinoma. Int J Oncol (2013) 0.76
Deferasirox, a novel oral iron chelator, shows antiproliferative activity against pancreatic cancer in vitro and in vivo. BMC Cancer (2016) 0.75
Oxidation-Induced Degradable Nanogels for Iron Chelation. Sci Rep (2016) 0.75
The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death. Sci Rep (2015) 0.75
Effects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma. World J Gastroenterol (2016) 0.75
Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4. J Exp Clin Cancer Res (2016) 0.75
Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet (2009) 14.16
Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology (2004) 3.43
Effect of vitamin K2 on the recurrence of hepatocellular carcinoma. Hepatology (2011) 3.00
Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy. Stem Cells (2006) 2.77
Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. Gastroenterology (2007) 2.09
An in vivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes. J Biochem (2003) 1.81
Prospective randomized study on the use of a computer-based endoscopic simulator for training in esophagogastroduodenoscopy. J Gastroenterol Hepatol (2008) 1.65
Hepatocellular carcinoma with nonalcoholic steatohepatitis. J Gastroenterol (2004) 1.55
General rules for recording endoscopic findings of esophagogastric varices (2nd edition). Dig Endosc (2010) 1.51
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean. PLoS One (2012) 1.44
Usefulness of magnifying endoscopy with narrow-band imaging for determining gastric tumor margin. J Gastroenterol Hepatol (2010) 1.38
Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein. Gastroenterology (2006) 1.29
Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry. Int J Oncol (2007) 1.22
Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. Biochem Biophys Res Commun (2004) 1.22
Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells. Life Sci (2005) 1.13
TWIST1 hypermethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer. Genes Chromosomes Cancer (2010) 1.10
A multicenter, open-label, dose-ranging study to exploratively evaluate the efficacy, safety, and dose-response of tolvaptan in patients with decompensated liver cirrhosis. J Gastroenterol (2010) 1.10
Usefulness of Sonazoid contrast-enhanced ultrasonography for hepatocellular carcinoma: comparison with pathological diagnosis and superparamagnetic iron oxide magnetic resonance images. J Gastroenterol (2009) 1.10
Proteomic profiling of heat shock protein 70 family members as biomarkers for hepatitis C virus-related hepatocellular carcinoma. Proteomics (2003) 1.07
Guideline on the use of new anticancer drugs for the treatment of Hepatocellular Carcinoma 2010 update. Hepatol Res (2012) 1.07
Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine. Int J Oncol (2007) 1.05
New method for detection of gastric cancer by hyperspectral imaging: a pilot study. J Biomed Opt (2013) 1.03
Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytes. Gastroenterology (2008) 1.02
Complications of radiofrequency ablation for hepatocellular carcinoma in a multicenter study: An analysis of 16 346 treated nodules in 13 283 patients. Hepatol Res (2012) 1.02
Dose-finding trial of tolvaptan in liver cirrhosis patients with hepatic edema: A randomized, double-blind, placebo-controlled trial. Hepatol Res (2013) 1.02
Development of cell therapy using autologous bone marrow cells for liver cirrhosis. Med Mol Morphol (2005) 1.02
Melanocortin 4 receptor-deficient mice as a novel mouse model of nonalcoholic steatohepatitis. Am J Pathol (2011) 1.01
Unilateral versus bilateral drainage using self-expandable metallic stent for unresectable hilar biliary obstruction. Dig Endosc (2010) 1.00
Increased expression of tumor necrosis factor-alpha messenger RNA in the intestinal mucosa of inflammatory bowel disease, particularly in patients with disease in the inactive phase. J Gastroenterol (2002) 1.00
Proteomic profiling of proteins decreased in hepatocellular carcinoma from patients infected with hepatitis C virus. Proteomics (2004) 1.00
ERCP using double-balloon endoscopes in patients with Roux-en-Y anastomosis. J Hepatobiliary Pancreat Surg (2009) 0.99
Stem cell therapy in chronic liver disease. Curr Opin Gastroenterol (2012) 0.98
Proteomic analysis of autoantibodies in patients with hepatocellular carcinoma. Proteomics (2006) 0.98
Contribution of knee adduction moment impulse to pain and disability in Japanese women with medial knee osteoarthritis. Clin Biomech (Bristol, Avon) (2010) 0.98
Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Hepatol Res (2015) 0.98
Risk factors for delayed bleeding from endoscopic submucosal dissection of gastric neoplasms. Scand J Gastroenterol (2012) 0.98
Prognostic factors in patients with advanced hepatocellular carcinoma receiving hepatic arterial infusion chemotherapy. J Gastroenterol (2005) 0.97
Advanced therapies using autologous bone marrow cells for chronic liver disease. Discov Med (2012) 0.96
Human homologue of maid is a useful marker protein in hepatocarcinogenesis. Gastroenterology (2005) 0.95
Successful retrieval of an impacted mechanical lithotripsy basket: a case report. Dig Endosc (2010) 0.95
Telmisartan prevents hepatic fibrosis and enzyme-altered lesions in liver cirrhosis rat induced by a choline-deficient L-amino acid-defined diet. Biochem Biophys Res Commun (2007) 0.94
Heat-shock protein 27 is phosphorylated in gemcitabine-resistant pancreatic cancer cells. Anticancer Res (2010) 0.94
Medaka as a model for human nonalcoholic steatohepatitis. Dis Model Mech (2010) 0.94
Double balloon endoscope facilitates endoscopic retrograde cholangiopancreatography in roux-en-y anastomosis patients. Dig Endosc (2010) 0.92
Percutaneous radiofrequency ablation with cooled electrodes combined with hepatic arterial balloon occlusion in hepatocellular carcinoma. J Gastroenterol (2005) 0.92
Study on the colonoscopic features of GVHD enteritis that developed after hematopoietic stem cell transplantation. Hepatogastroenterology (2007) 0.92
Autologous bone marrow infusion activates the progenitor cell compartment in patients with advanced liver cirrhosis. Cell Transplant (2010) 0.92
Lesson from the GFP/CCl4 model--translational research project: the development of cell therapy using autologous bone marrow cells in patients with liver cirrhosis. J Hepatobiliary Pancreat Surg (2005) 0.91
Does chromoendoscopy improve the colonoscopic adenoma detection rate? Hepatogastroenterology (2011) 0.91
Herbal medicine Inchin-ko-to (TJ-135) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. J Hepatol (2003) 0.91
The efficacy of ursodeoxycholic acid and bezafibrate combination therapy for primary biliary cirrhosis: A prospective, multicenter study. Hepatol Res (2008) 0.91
Bortezomib induces tumor-specific cell death and growth inhibition in hepatocellular carcinoma and improves liver fibrosis. J Gastroenterol (2012) 0.90
Senescence marker protein 30 (SMP30)/regucalcin (RGN) expression decreases with aging, acute liver injuries and tumors in zebrafish. Biochem Biophys Res Commun (2011) 0.90
[A case of enteric muco-submucosal elongated polyp]. Nihon Shokakibyo Gakkai Zasshi (2012) 0.89
Leptin receptor-deficient Zucker (fa/fa) rat retards the development of pig serum-induced liver fibrosis with Kupffer cell dysfunction. Life Sci (2003) 0.89
Usefulness of ultraslim endoscopy with flexible spectral imaging color enhancement for detection of gastric neoplasm: a preliminary study. J Gastrointest Cancer (2013) 0.89
The expanding role of fish models in understanding non-alcoholic fatty liver disease. Dis Model Mech (2013) 0.88
Medaka fish, Oryzias latipes, as a model for human obesity-related glomerulopathy. Biochem Biophys Res Commun (2013) 0.88
Elevated levels of circulating cell-free DNA in the blood of patients with hepatitis C virus-associated hepatocellular carcinoma. Anticancer Res (2007) 0.88
Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer. J Transl Med (2014) 0.88
The effect of a late evening snack in patients with liver cirrhosis. Hepatol Res (2005) 0.87
Identification of up- and down-regulated proteins in gemcitabine-resistant pancreatic cancer cells using two-dimensional gel electrophoresis and mass spectrometry. Anticancer Res (2010) 0.87
L-cysteine administration prevents liver fibrosis by suppressing hepatic stellate cell proliferation and activation. Biochem Biophys Res Commun (2003) 0.87
Potential therapeutic application of intravenous autologous bone marrow infusion in patients with alcoholic liver cirrhosis. Stem Cells Dev (2011) 0.87
Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation. Cell Tissue Res (2011) 0.86
Clinical characteristics of patients who developed hepatocellular carcinoma after hepatitis C virus eradication with interferon therapy: current status in Japan. Intern Med (2013) 0.86
Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon-tetrachloride-induced liver fibrosis in mice. Cell Tissue Res (2006) 0.86
Helicobacter pylori CagA inhibits endocytosis of cytotoxin VacA in host cells. Dis Model Mech (2010) 0.86
Efficient detection of hepatocellular carcinoma by a hybrid blood test of epigenetic and classical protein markers. Clin Chim Acta (2010) 0.86
Cytokine-dependent anti-viral role of CD4-positive T cells in therapeutic vaccination against chronic hepatitis B viral infection. J Med Virol (2003) 0.86
Relation between serum levels of cell-free DNA and inflammation status in hepatitis C virus-related hepatocellular carcinoma. Oncol Rep (2008) 0.86
Predictors of the Effect of Tolvaptan on the Prognosis of Cirrhosis. Intern Med (2016) 0.86
Canine mesenchymal stem cells show antioxidant properties against thioacetamide-induced liver injury in vitro and in vivo. Hepatol Res (2013) 0.86