Published in Bioorg Med Chem on July 21, 2011
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Recent advances in design, synthesis and biological activity of aminoalkylsulfonates and sulfonamidopeptides. Curr Med Chem (2004) 1.16
Discovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2,4-dione inhibitors of MurD ligase. J Med Chem (2010) 1.15
Synthesis and biological evaluation of (6- and 7-phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1. J Med Chem (2010) 1.10
Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections. J Antimicrob Chemother (2004) 1.08
The target of daptomycin is absent from Escherichia coli and other gram-negative pathogens. Antimicrob Agents Chemother (2012) 1.06
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Functional and biochemical analysis of the Chlamydia trachomatis ligase MurE. J Bacteriol (2009) 0.98
Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds. ChemMedChem (2011) 0.97
Biological properties of novel antistaphylococcal quinoline-indole agents. Antimicrob Agents Chemother (2003) 0.97
Functional and biochemical analysis of Chlamydia trachomatis MurC, an enzyme displaying UDP-N-acetylmuramate:amino acid ligase activity. J Bacteriol (2003) 0.97
Characterization of global patterns and the genetics of fusidic acid resistance. Clin Infect Dis (2011) 0.97
Biochemical characterisation of the chlamydial MurF ligase, and possible sequence of the chlamydial peptidoglycan pentapeptide stem. Arch Microbiol (2012) 0.96
The silver cation (Ag+): antistaphylococcal activity, mode of action and resistance studies. J Antimicrob Chemother (2012) 0.95
Structural and functional characterization of enantiomeric glutamic acid derivatives as potential transition state analogue inhibitors of MurD ligase. J Mol Biol (2007) 0.95
XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity. J Antimicrob Chemother (2009) 0.95
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Discovery of novel benzene 1,3-dicarboxylic acid inhibitors of bacterial MurD and MurE ligases by structure-based virtual screening approach. Bioorg Med Chem Lett (2009) 0.92
Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme. J Med Chem (2008) 0.92
5-Benzylidenethiazolidin-4-ones as multitarget inhibitors of bacterial Mur ligases. ChemMedChem (2010) 0.91
Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. Antimicrob Agents Chemother (2008) 0.90
Escherichia coli mutators present an enhanced risk for emergence of antibiotic resistance during urinary tract infections. Antimicrob Agents Chemother (2004) 0.89
Phosphorylated hydroxyethylamines as novel inhibitors of the bacterial cell wall biosynthesis enzymes MurC to MurF. Bioorg Chem (2009) 0.88
Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis. J Med Chem (2014) 0.88
False positives in the early stages of drug discovery. Curr Med Chem (2010) 0.87
New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria. PLoS One (2011) 0.87
Purification and biochemical characterization of Mur ligases from Staphylococcus aureus. Biochimie (2010) 0.87
Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB). Bioorg Med Chem Lett (2009) 0.87
Furanyl-rhodanines are unattractive drug candidates for development as inhibitors of bacterial RNA polymerase. Antimicrob Agents Chemother (2010) 0.87
Diazenedicarboxamides as inhibitors of D-alanine-D-alanine ligase (Ddl). Bioorg Med Chem Lett (2007) 0.86
Cinnamic acids as new inhibitors of 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3). Mol Cell Endocrinol (2005) 0.86
Assessment of a microplate method for determining the post-antibiotic effect in Staphylococcus aureus and Escherichia coli. J Antimicrob Chemother (2004) 0.86
The distributed diagonal force decomposition method for parallelizing molecular dynamics simulations. J Comput Chem (2011) 0.86
Deletion of the multiple-drug efflux pump AcrAB in Escherichia coli prolongs the postantibiotic effect. Antimicrob Agents Chemother (2005) 0.85
Intrinsic novobiocin resistance in Staphylococcus saprophyticus. Antimicrob Agents Chemother (2007) 0.85
Discovery of new inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurF by structure-based virtual screening. Bioorg Med Chem (2009) 0.85
Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. Mol Cell Endocrinol (2008) 0.84
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Novel inhibitors of trihydroxynaphthalene reductase with antifungal activity identified by ligand-based and structure-based virtual screening. J Chem Inf Model (2011) 0.83
Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library. J Med Chem (2012) 0.83
Second-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acid. Eur J Med Chem (2011) 0.83
Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor. J Med Chem (2014) 0.83
Recent advances in the synthesis and applications of reduced amide pseudopeptides. Curr Med Chem (2009) 0.83
Structure-based design of a new series of D-glutamic acid based inhibitors of bacterial UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD). J Med Chem (2011) 0.83
Zeocin resistance suppresses mutation in hypermutable Escherichia coli. Microbiology (2003) 0.83
Structure-based function prediction of uncharacterized protein using binding sites comparison. PLoS Comput Biol (2013) 0.82
Activity of and development of resistance to corallopyronin A, an inhibitor of RNA polymerase. Antimicrob Agents Chemother (2011) 0.82
Exploration of the chemical space of novel naphthalene-sulfonamide and anthranilic Acid-based inhibitors of penicillin-binding proteins. Acta Chim Slov (2012) 0.82
Phytoestrogens as inhibitors of the human progesterone metabolizing enzyme AKR1C1. Mol Cell Endocrinol (2006) 0.82
Phosphinate inhibitors of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: L-lysine ligase (MurE). Arch Pharm (Weinheim) (2007) 0.82
Melanin is crucial for growth of the black yeast Hortaea werneckii in its natural hypersaline environment. Fungal Biol (2013) 0.81
Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety. PLoS One (2011) 0.81
Novel toll-like receptor 4 (TLR4) antagonists identified by structure- and ligand-based virtual screening. Eur J Med Chem (2013) 0.81
Population diversification in Staphylococcus aureus biofilms may promote dissemination and persistence. PLoS One (2013) 0.81
Antistaphylococcal activity of the novel cephalosporin CB-181963 (CAB-175). J Antimicrob Chemother (2005) 0.81
N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3. Bioorg Med Chem Lett (2012) 0.81
ENZO: a web tool for derivation and evaluation of kinetic models of enzyme catalyzed reactions. PLoS One (2011) 0.81
Cathepsin X cleavage of the beta2 integrin regulates talin-binding and LFA-1 affinity in T cells. J Leukoc Biol (2011) 0.80
Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF. Eur J Med Chem (2013) 0.80
Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase. Bioorg Med Chem Lett (2008) 0.80
Virtual screening for potential inhibitors of bacterial MurC and MurD ligases. J Mol Model (2011) 0.80
Lack of evidence for involvement of hypermutability in emergence of vancomycin-intermediate Staphylococcus aureus. Antimicrob Agents Chemother (2003) 0.80
2-Aminotetralones: novel inhibitors of MurA and MurZ. Bioorg Med Chem Lett (2008) 0.80
Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives. J Med Chem (2013) 0.80
6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase. PLoS One (2012) 0.80
Individual degrees of freedom and the solvation properties of water. J Chem Phys (2012) 0.80