Published in Antimicrob Agents Chemother on January 07, 2008
Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700). Antimicrob Agents Chemother (2009) 2.17
Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin. Antimicrob Agents Chemother (2009) 1.81
Resistance to linezolid caused by modifications at its binding site on the ribosome. Antimicrob Agents Chemother (2011) 1.70
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First report of Staphylococcal clinical isolates in Mexico with linezolid resistance caused by cfr: evidence of in vivo cfr mobilization. J Clin Microbiol (2010) 1.12
Structural basis for cross-resistance to ribosomal PTC antibiotics. Proc Natl Acad Sci U S A (2008) 1.04
Clonal dissemination of linezolid-resistant Staphylococcus haemolyticus exhibiting the G2576T mutation in the 23S rRNA gene in a tertiary care hospital in Brazil. Antimicrob Agents Chemother (2012) 1.03
Cfr-mediated linezolid-resistance among methicillin-resistant coagulase-negative staphylococci from infections of humans. PLoS One (2013) 1.03
Trends towards lower antimicrobial susceptibility and characterization of acquired resistance among clinical isolates of Brachyspira hyodysenteriae in Spain. Antimicrob Agents Chemother (2011) 0.98
Detection of a New cfr-Like Gene, cfr(B), in Enterococcus faecium Isolates Recovered from Human Specimens in the United States as Part of the SENTRY Antimicrobial Surveillance Program. Antimicrob Agents Chemother (2015) 0.97
Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance. Antimicrob Agents Chemother (2010) 0.96
Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus. Proc Natl Acad Sci U S A (2015) 0.94
The increase of methicillin-resistant Staphylococcus aureus (MRSA) and the presence of an unusual sequence type ST49 in slaughter pigs in Switzerland. BMC Vet Res (2011) 0.93
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Streptococcus sanguinis isolate displaying a phenotype with cross-resistance to several rRNA-targeting agents. J Clin Microbiol (2013) 0.90
In vitro resistance studies with bacteria that exhibit low mutation frequencies: prediction of "antimutant" linezolid concentrations using a mixed inoculum containing both susceptible and resistant Staphylococcus aureus. Antimicrob Agents Chemother (2014) 0.85
Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes. Antimicrob Agents Chemother (2008) 0.84
Decreased susceptibilities to Retapamulin, Mupirocin, and Chlorhexidine among Staphylococcus aureus isolates causing skin and soft tissue infections in otherwise healthy children. Antimicrob Agents Chemother (2014) 0.82
Mutations in the bacterial ribosomal protein l3 and their association with antibiotic resistance. Antimicrob Agents Chemother (2015) 0.80
Mutations within the rplD Gene of Linezolid-Nonsusceptible Streptococcus pneumoniae Strains Isolated in the United States. Antimicrob Agents Chemother (2014) 0.80
Ribosomal protein L3 mutations are associated with cfr-mediated linezolid resistance in clinical isolates of Staphylococcus cohnii. Curr Microbiol (2015) 0.77
The emergence of linezolid resistance among Enterococci in intestinal microbiota of treated patients is unrelated to individual pharmacokinetic characteristics. Antimicrob Agents Chemother (2014) 0.75
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The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics. Antimicrob Agents Chemother (2006) 3.94
Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. Mol Microbiol (2007) 3.47
The site of action of oxazolidinone antibiotics in living bacteria and in human mitochondria. Mol Cell (2007) 2.93
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Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin. Mol Microbiol (2004) 1.90
Single- and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and Streptococcus pyogenes. Antimicrob Agents Chemother (2006) 1.82
Response of Escherichia coli hypermutators to selection pressure with antimicrobial agents from different classes. J Antimicrob Chemother (2002) 1.57
Rapid orientated cloning in a shuttle vector allowing modulated gene expression in Bacillus subtilis. FEMS Microbiol Lett (2001) 1.44
Tiamulin resistance mutations in Escherichia coli. J Bacteriol (1982) 1.36
Resistance to the peptidyl transferase inhibitor tiamulin caused by mutation of ribosomal protein l3. Antimicrob Agents Chemother (2003) 1.32
Mutation frequencies for resistance to fusidic acid and rifampicin in Staphylococcus aureus. J Antimicrob Chemother (2001) 1.25
Selection of retapamulin, a novel pleuromutilin for topical use. Antimicrob Agents Chemother (2006) 1.22
Stepwise exposure of Staphylococcus aureus to pleuromutilins is associated with stepwise acquisition of mutations in rplC and minimally affects susceptibility to retapamulin. Antimicrob Agents Chemother (2007) 1.15
Interaction of pleuromutilin derivatives with the ribosomal peptidyl transferase center. Antimicrob Agents Chemother (2006) 1.12
Activity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant gram-positive cocci. Antimicrob Agents Chemother (2006) 1.07
Uptake of minocycline by Escherichia coli. J Antimicrob Chemother (1992) 0.87
Use of mutator strains for characterization of novel antimicrobial agents. Antimicrob Agents Chemother (2001) 0.82
Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy. Nat Genet (2008) 2.88
Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections. Nat Rev Microbiol (2011) 2.68
The isoleucyl-tRNA synthetase mutation V588F conferring mupirocin resistance in glycopeptide-intermediate Staphylococcus aureus is not associated with a significant fitness burden. J Antimicrob Chemother (2003) 1.72
Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents. Antimicrob Agents Chemother (2005) 1.71
Response of Escherichia coli hypermutators to selection pressure with antimicrobial agents from different classes. J Antimicrob Chemother (2002) 1.57
A fusidic acid-resistant epidemic strain of Staphylococcus aureus carries the fusB determinant, whereas fusA mutations are prevalent in other resistant isolates. Antimicrob Agents Chemother (2004) 1.52
In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis. J Antimicrob Chemother (2005) 1.47
Molecular basis of fusB-mediated resistance to fusidic acid in Staphylococcus aureus. Mol Microbiol (2006) 1.44
The activation peptide cleft exposed by thrombin cleavage of FXIII-A(2) contains a recognition site for the fibrinogen α chain. Blood (2013) 1.42
Analysis of mupirocin resistance and fitness in Staphylococcus aureus by molecular genetic and structural modeling techniques. Antimicrob Agents Chemother (2004) 1.39
Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques. J Antimicrob Chemother (2009) 1.35
pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases. J Am Chem Soc (2003) 1.32
Preclinical evaluation of novel antibacterial agents by microbiological and molecular techniques. Expert Opin Investig Drugs (2004) 1.31
Consequences of daptomycin-mediated membrane damage in Staphylococcus aureus. J Antimicrob Chemother (2008) 1.25
Dissecting structural and functional diversity of the lantibiotic mersacidin. Chem Biol (2009) 1.25
Comparison of assays for detection of agents causing membrane damage in Staphylococcus aureus. J Antimicrob Chemother (2004) 1.22
Insertional inactivation of mutS in Staphylococcus aureus reveals potential for elevated mutation frequencies, although the prevalence of mutators in clinical isolates is low. J Antimicrob Chemother (2002) 1.20
Anti-staphylococcal activity and mode of action of clofazimine. J Antimicrob Chemother (2004) 1.17
Determinants of hepatitis C virus p7 ion channel function and drug sensitivity identified in vitro. J Virol (2009) 1.10
Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections. J Antimicrob Chemother (2004) 1.08
The target of daptomycin is absent from Escherichia coli and other gram-negative pathogens. Antimicrob Agents Chemother (2012) 1.06
XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms. J Antimicrob Chemother (2010) 1.04
Structure-based discovery of antibacterial drugs. Nat Rev Microbiol (2010) 1.04
Increased mutability of Staphylococci in biofilms as a consequence of oxidative stress. PLoS One (2012) 1.03
The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors. Mol Microbiol (2009) 1.01
The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. Bioorg Med Chem Lett (2005) 1.00
Mechanisms of the post-antibiotic effects induced by rifampicin and gentamicin in Escherichia coli. J Antimicrob Chemother (2006) 0.99
Assay platform for clinically relevant metallo-β-lactamases. J Med Chem (2013) 0.99
Functional and biochemical analysis of the Chlamydia trachomatis ligase MurE. J Bacteriol (2009) 0.98
Biological properties of novel antistaphylococcal quinoline-indole agents. Antimicrob Agents Chemother (2003) 0.97
Functional and biochemical analysis of Chlamydia trachomatis MurC, an enzyme displaying UDP-N-acetylmuramate:amino acid ligase activity. J Bacteriol (2003) 0.97
Characterization of global patterns and the genetics of fusidic acid resistance. Clin Infect Dis (2011) 0.97
Biochemical characterisation of the chlamydial MurF ligase, and possible sequence of the chlamydial peptidoglycan pentapeptide stem. Arch Microbiol (2012) 0.96
The silver cation (Ag+): antistaphylococcal activity, mode of action and resistance studies. J Antimicrob Chemother (2012) 0.95
Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase. J Med Chem (2007) 0.95
XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity. J Antimicrob Chemother (2009) 0.95
Staphylococcus aureus biofilms promote horizontal transfer of antibiotic resistance. Antimicrob Agents Chemother (2013) 0.93
Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. J Med Chem (2009) 0.92
Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. Antimicrob Agents Chemother (2008) 0.90
Escherichia coli mutators present an enhanced risk for emergence of antibiotic resistance during urinary tract infections. Antimicrob Agents Chemother (2004) 0.89
Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB). Bioorg Med Chem Lett (2009) 0.87
Furanyl-rhodanines are unattractive drug candidates for development as inhibitors of bacterial RNA polymerase. Antimicrob Agents Chemother (2010) 0.87
Assessment of a microplate method for determining the post-antibiotic effect in Staphylococcus aureus and Escherichia coli. J Antimicrob Chemother (2004) 0.86
Diazenedicarboxamides as inhibitors of D-alanine-D-alanine ligase (Ddl). Bioorg Med Chem Lett (2007) 0.86
Structure-based design of anti-infectives. Ann N Y Acad Sci (2010) 0.86
The first de novo-designed antagonists of the human NK(2) receptor. J Med Chem (2005) 0.85
Intrinsic novobiocin resistance in Staphylococcus saprophyticus. Antimicrob Agents Chemother (2007) 0.85
Deletion of the multiple-drug efflux pump AcrAB in Escherichia coli prolongs the postantibiotic effect. Antimicrob Agents Chemother (2005) 0.85
Discovery of new inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurF by structure-based virtual screening. Bioorg Med Chem (2009) 0.85
Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases. J Med Chem (2012) 0.84
Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone. Cell Calcium (2011) 0.83
Zeocin resistance suppresses mutation in hypermutable Escherichia coli. Microbiology (2003) 0.83
Activity of and development of resistance to corallopyronin A, an inhibitor of RNA polymerase. Antimicrob Agents Chemother (2011) 0.82
9-Aminoacridine peptide derivatives as versatile reporter systems for use in fluorescence lifetime assays. Chem Commun (Camb) (2010) 0.82
A fluorescence lifetime-based assay for serine and threonine kinases that is suitable for high-throughput screening. Anal Biochem (2010) 0.82
Adenosine tetraphosphoadenosine drives a continuous ATP-release assay for aminoacyl-tRNA synthetases and other adenylate-forming enzymes. ACS Chem Biol (2013) 0.81
Antistaphylococcal activity of the novel cephalosporin CB-181963 (CAB-175). J Antimicrob Chemother (2005) 0.81
Population diversification in Staphylococcus aureus biofilms may promote dissemination and persistence. PLoS One (2013) 0.81
6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase. PLoS One (2012) 0.80
2-Aminotetralones: novel inhibitors of MurA and MurZ. Bioorg Med Chem Lett (2008) 0.80
Lack of evidence for involvement of hypermutability in emergence of vancomycin-intermediate Staphylococcus aureus. Antimicrob Agents Chemother (2003) 0.80
Further characterization of Bacillus subtilis antibiotic biosensors and their use for antibacterial mode-of-action studies. Antimicrob Agents Chemother (2011) 0.80
Adsorption and self-assembly of peptides on mica substrates. Angew Chem Int Ed Engl (2005) 0.80
A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH. Bioorg Med Chem Lett (2009) 0.79
Structure-based discovery of a family of synthetic cyclophilin inhibitors showing a cyclosporin-A phenotype in Caenorhabditis elegans. Biochem Biophys Res Commun (2007) 0.79
Computational methods to identify new antibacterial targets. Chem Biol Drug Des (2015) 0.78
Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor. Biochem Pharmacol (2011) 0.78
Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening. Bioorg Med Chem Lett (2009) 0.78
Discovery of new inhibitors of D-alanine:D-alanine ligase by structure-based virtual screening. J Med Chem (2008) 0.78
A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli. Angew Chem Int Ed Engl (2005) 0.78
Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp. ChemMedChem (2012) 0.77
Ellipticines and 9-acridinylamines as inhibitors of D-alanine:D-alanine ligase. Bioorg Med Chem (2011) 0.77
Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme MurD. Bioorg Med Chem Lett (2003) 0.77
Erratum: The First Small-Molecule Inhibitors of Members of the Ribonuclease E Family. Sci Rep (2015) 0.76
Synthesis and biological evaluation of N-acylhydrazones as inhibitors of MurC and MurD ligases. ChemMedChem (2008) 0.76
Evolution of extended-spectrum beta-lactamases in a MutS-deficient Pseudomonas aeruginosa hypermutator. J Antimicrob Chemother (2006) 0.75
Discovery of novel FabF ligands inspired by platensimycin by integrating structure-based design with diversity-oriented synthetic accessibility. Org Biomol Chem (2013) 0.75
A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT. Mol Membr Biol (2012) 0.75
Mecillinam has potent in vitro activity against Chlamydophila pneumoniae ATCC VR1310. J Antimicrob Chemother (2004) 0.75
Encapsulation of sodium alkyl sulfates by the cyclotriveratrylene-based, [Pd(6)L(8)](12+) stella octangula cage. Dalton Trans (2014) 0.75
Stereoselective palladium-catalyzed four-component cascade synthesis of pyrrolidinyl-, pyrazolidinyl-, and isoxazolidinyl isoquinolines. Angew Chem Int Ed Engl (2005) 0.75
Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design. J Med Chem (2013) 0.75
New Opportunities in the Structure-based Design of Anti-Protozoan Agents. Curr Top Med Chem (2017) 0.75
Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ). J Antimicrob Chemother (2010) 0.75
Identification of Receptor Tyrosine Kinase Inhibitors Using Cell Surface Biotinylation and Affinity Isolation. Methods Mol Biol (2015) 0.75