Published in Genome Med on August 23, 2011
Radiomics: Images Are More than Pictures, They Are Data. Radiology (2015) 1.68
Neurocognitive function after radiotherapy for paediatric brain tumours. Nat Rev Neurol (2012) 1.19
Radiation enteropathy--pathogenesis, treatment and prevention. Nat Rev Gastroenterol Hepatol (2014) 1.02
Radiation oncology in the era of precision medicine. Nat Rev Cancer (2016) 0.97
Chronic radiation-induced dermatitis: challenges and solutions. Clin Cosmet Investig Dermatol (2016) 0.91
Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. EBioMedicine (2016) 0.90
Supervised classification by filter methods and recursive feature elimination predicts risk of radiotherapy-related fatigue in patients with prostate cancer. Cancer Inform (2014) 0.88
Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity? Cancer Lett (2016) 0.85
Polymorphisms in DNA-repair genes in a cohort of prostate cancer patients from different areas in Spain: heterogeneity between populations as a confounding factor in association studies. PLoS One (2013) 0.81
Conditions for the generation of cytotoxic CD4(+) Th cells that enhance CD8(+) CTL-mediated tumor regression. Clin Transl Immunology (2016) 0.78
Polymorphic Variants in Oxidative Stress Genes and Acute Toxicity in Breast Cancer Patients Receiving Radiotherapy. Cancer Res Treat (2016) 0.77
Chronic radiation proctitis: tricks to prevent and treat. Int J Colorectal Dis (2015) 0.76
Mutations of the human interferon alpha-2b (hIFNα-2b) gene in cancer patients receiving radiotherapy. Am J Cancer Res (2015) 0.75
Exploiting biological and physical determinants of radiotherapy toxicity to individualize treatment. Br J Radiol (2015) 0.75
TNFSF10/TRAIL regulates human T4 effector memory lymphocyte radiosensitivity and predicts radiation-induced acute and subacute dermatitis. Oncotarget (2016) 0.75
Radiotherapy-Associated Long-term Modification of Expression of the Inflammatory Biomarker Genes ARG1, BCL2L1, and MYC. Front Immunol (2017) 0.75
Radiogenomics and radiotherapy response modeling. Phys Med Biol (2017) 0.75
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Action of x-rays on mammalian cells. J Exp Med (1956) 13.53
Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys (1991) 13.16
Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol (2011) 7.46
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev (2011) 5.60
Sensing and repairing DNA double-strand breaks. Carcinogenesis (2002) 5.52
Towards evidence-based guidelines for radiotherapy infrastructure and staffing needs in Europe: the ESTRO QUARTS project. Radiother Oncol (2005) 4.76
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet (2010) 4.42
Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity. Nature (1975) 4.30
Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial. Int J Radiat Oncol Biol Phys (2006) 3.79
Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nat Rev Cancer (2006) 3.65
Genome-based prediction of common diseases: advances and prospects. Hum Mol Genet (2008) 3.45
Radiation-induced bystander signalling in cancer therapy. Nat Rev Cancer (2009) 3.31
The role of double-strand break repair - insights from human genetics. Nat Rev Genet (2006) 3.25
Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. Curr Biol (1999) 2.98
The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer (2005) 2.92
Single nucleotide polymorphism at rs1982073:T869C of the TGFbeta 1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy. J Clin Oncol (2009) 2.75
Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC): an introduction to the scientific issues. Int J Radiat Oncol Biol Phys (2010) 2.32
Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy. Radiother Oncol (2007) 2.32
ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. EMBO J (2010) 2.27
Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes. Radiother Oncol (2003) 2.26
Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype. Nat Rev Cancer (2009) 2.13
Evidence behind use of intensity-modulated radiotherapy: a systematic review of comparative clinical studies. Lancet Oncol (2008) 2.00
Innovations in image-guided radiotherapy. Nat Rev Cancer (2007) 1.98
Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Genome Res (2010) 1.87
Image-guided radiotherapy: rationale, benefits, and limitations. Lancet Oncol (2006) 1.86
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proc Natl Acad Sci U S A (2007) 1.79
TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer. Radiother Oncol (2005) 1.78
Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition. J Clin Invest (2010) 1.74
Survey of the availability and use of advanced radiotherapy technology in the UK. Clin Oncol (R Coll Radiol) (2010) 1.73
Oxidative damage pathways in relation to normal tissue injury. Br J Radiol (2007) 1.69
ATM haplotypes and cellular response to DNA damage: association with breast cancer risk and clinical radiosensitivity. Cancer Res (2003) 1.64
TGFB1 single nucleotide polymorphisms are associated with adverse quality of life in prostate cancer patients treated with radiotherapy. Int J Radiat Oncol Biol Phys (2007) 1.64
No association between SNPs regulating TGF-β1 secretion and late radiotherapy toxicity to the breast: results from the RAPPER study. Radiother Oncol (2010) 1.63
An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome. DNA Repair (Amst) (2004) 1.60
Genetic predictors of long-term toxicities after radiation therapy for breast cancer. Int J Cancer (2008) 1.58
Different styles of image-guided radiotherapy. Semin Radiat Oncol (2007) 1.57
Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder. Am J Hum Genet (2009) 1.54
Apoptosis and mitotic cell death: their relative contributions to normal-tissue and tumour radiation response. Int J Radiat Biol (1997) 1.52
Heritability of cellular radiosensitivity: a marker of low-penetrance predisposition genes in breast cancer? Am J Hum Genet (1999) 1.51
Genetic variants and normal tissue toxicity after radiotherapy: a systematic review. Radiother Oncol (2009) 1.48
Normal tissue effects: reporting and analysis. Semin Radiat Oncol (2003) 1.44
Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma. Nat Med (2011) 1.42
Cellular radiosensitivity: how much better do we understand it? Int J Radiat Biol (2009) 1.40
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys (2010) 1.39
Cornelia de Lange syndrome mutations in SMC1A or SMC3 affect binding to DNA. Hum Mol Genet (2008) 1.37
Randomized controlled trial of forward-planned intensity modulated radiotherapy for early breast cancer: interim results at 2 years. Int J Radiat Oncol Biol Phys (2011) 1.34
Common statistical issues in genome-wide association studies: a review on power, data quality control, genotype calling and population structure. Curr Opin Lipidol (2008) 1.34
Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy. Cancer Epidemiol Biomarkers Prev (2003) 1.33
CD4 and CD8 T-lymphocyte apoptosis can predict radiation-induced late toxicity: a prospective study in 399 patients. Clin Cancer Res (2005) 1.32
Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy. Clin Cancer Res (2008) 1.30
Decreased pulmonary radiation resistance of manganese superoxide dismutase (MnSOD)-deficient mice is corrected by human manganese superoxide dismutase-Plasmid/Liposome (SOD2-PL) intratracheal gene therapy. Radiat Res (2000) 1.28
Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients. Clin Cancer Res (2005) 1.26
Genetic variation in normal tissue toxicity induced by ionizing radiation. Mutat Res (2008) 1.25
Genetic variations in DNA repair genes, radiosensitivity to cancer and susceptibility to acute tissue reactions in radiotherapy-treated cancer patients. Acta Oncol (2008) 1.24
Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer. Clin Cancer Res (2006) 1.24
Targeting the TGF-beta1 pathway to prevent normal tissue injury after cancer therapy. Oncologist (2010) 1.23
Establishment of a Radiogenomics Consortium. Int J Radiat Oncol Biol Phys (2010) 1.23
Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes. Int J Radiat Oncol Biol Phys (2009) 1.22
The late radiotherapy normal tissue injury phenotypes of telangiectasia, fibrosis and atrophy in breast cancer patients have distinct genotype-dependent causes. Br J Cancer (2007) 1.20
Radiation-sensitive genetically susceptible pediatric sub-populations. Pediatr Radiol (2008) 1.19
ATM protein kinase: the linchpin of cellular defenses to stress. Cell Mol Life Sci (2011) 1.17
Mutagen sensitivity has high heritability: evidence from a twin study. Cancer Res (2006) 1.16
Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer. Radiat Res (2008) 1.16
Association between genetic polymorphisms in the XRCC1, XRCC3, XPD, GSTM1, GSTT1, MSH2, MLH1, MSH3, and MGMT genes and radiosensitivity in breast cancer patients. Int J Radiat Oncol Biol Phys (2010) 1.14
Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients. Int J Radiat Biol (2003) 1.12
Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. PLoS One (2010) 1.12
Association between normal tissue complications after radiotherapy and polymorphic variations in TGFB1 and XRCC1 genes. Radiat Res (2010) 1.11
Genetic predictors of adverse radiotherapy effects: the Gene-PARE project. Int J Radiat Oncol Biol Phys (2006) 1.10
IL-17 receptor knockout mice have enhanced myelotoxicity and impaired hemopoietic recovery following gamma irradiation. J Immunol (2006) 1.09
Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity. Radiother Oncol (2010) 1.08
Initial slope of radiation survival curves is characteristic of the origin of primary and established cultures of human tumor cells and fibroblasts. Radiat Res (1987) 1.08
Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM--a study based on DNA from formalin fixed paraffin embedded tissue samples. Int J Radiat Biol (2006) 1.08
Normal tissue radiosensitivity--how important is it? Clin Oncol (R Coll Radiol) (1996) 1.06
Novel DNA sequence variants in the hHR21 DNA repair gene in radiosensitive cancer patients. Int J Radiat Oncol Biol Phys (2001) 1.05
Association of P53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy. Int J Radiat Oncol Biol Phys (2010) 1.04
Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer. Br J Cancer (2009) 1.03
The genomics revolution and radiotherapy. Clin Oncol (R Coll Radiol) (2007) 1.02
The effectiveness of radioactive iodine for treatment of low-risk thyroid cancer: a systematic analysis of the peer-reviewed literature from 1966 to April 2008. Thyroid (2010) 1.01
Relationship between early and late normal-tissue injury after postmastectomy radiotherapy. Radiother Oncol (1991) 1.01
Proton-beam vs intensity-modulated radiation therapy. Which is best for treating prostate cancer? Oncology (Williston Park) (2008) 1.01
Genetic predictors of acute toxicities related to radiation therapy following lumpectomy for breast cancer: a case-series study. Breast Cancer Res (2006) 1.01
G(2) chromosomal radiosensitivity in Danish survivors of childhood and adolescent cancer and their offspring. Br J Cancer (2005) 1.00
IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis. Clin Cancer Res (2008) 0.99
TGFbeta1 polymorphisms and late clinical radiosensitivity in patients treated for gynecologic tumors. Int J Radiat Oncol Biol Phys (2006) 0.99
Homology-directed repair is required for the development of radioresistance during S phase: interplay between double-strand break repair and checkpoint response. Radiat Res (2007) 0.98
Genome-wide association studies in pharmacogenomics: untapped potential for translation. Genome Med (2009) 0.98
Haplotype-based analysis of genes associated with risk of adverse skin reactions after radiotherapy in breast cancer patients. Int J Radiat Oncol Biol Phys (2007) 0.97
Postoperative proton radiotherapy for localized and locoregional breast cancer: potential for clinically relevant improvements? Int J Radiat Oncol Biol Phys (2009) 0.97
The heritability of G2 chromosomal radiosensitivity and its association with cancer in Danish cancer survivors and their offspring. Int J Radiat Biol (2010) 0.97
A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitivity in a patient with xeroderma pigmentosum. J Med Genet (2009) 0.96
Radiosensitivity, radiogenomics and RAPPER. Clin Oncol (R Coll Radiol) (2006) 0.96
Polymorphisms in genes related to oxidative stress (CAT, MnSOD, MPO, and eNOS) and acute toxicities from radiation therapy following lumpectomy for breast cancer. Clin Cancer Res (2006) 0.94
Genetic polymorphisms in the DNA double-strand break repair genes XRCC3, XRCC2, and NBS1 are not associated with acute side effects of radiotherapy in breast cancer patients. Cancer Epidemiol Biomarkers Prev (2006) 0.94
Clinical correlations between late normal tissue endpoints after radiotherapy: implications for predictive assays of radiosensitivity. Eur J Cancer (1993) 0.94
Evidence for significant heritability of apoptotic and cell cycle responses to ionising radiation. Hum Genet (2008) 0.93
Association between TP53 and p21 genetic polymorphisms and acute side effects of radiotherapy in breast cancer patients. Breast Cancer Res Treat (2005) 0.93
Sensitivity to low-dose/low-LET ionizing radiation in mammalian cells harboring mutations in succinate dehydrogenase subunit C is governed by mitochondria-derived reactive oxygen species. Radiat Res (2010) 0.93
The XRCC1 -77T->C variant: haplotypes, breast cancer risk, response to radiotherapy and the cellular response to DNA damage. Carcinogenesis (2006) 0.92
Heritability of baseline and induced micronucleus frequencies. Mutagenesis (2011) 0.92
Randomized controlled trial of intensity-modulated radiotherapy for early breast cancer: 5-year results confirm superior overall cosmesis. J Clin Oncol (2013) 2.41
Radiogenomics: the search for genetic predictors of radiotherapy response. Future Oncol (2014) 1.01
Conducting radiogenomic research--do not forget careful consideration of the clinical data. Radiother Oncol (2012) 0.92