Published in Chem Biol on August 26, 2011
Functional selectivity in CB(2) cannabinoid receptor signaling and regulation: implications for the therapeutic potential of CB(2) ligands. Mol Pharmacol (2011) 1.15
Divergent Reaction Pathways for Phenol Arylation by Arynes: Synthesis of Helicenes and 2-Arylphenols. Chem Sci (2013) 1.02
CB2 Cannabinoid receptors as a therapeutic target-what does the future hold? Mol Pharmacol (2014) 0.93
Lead discovery, chemistry optimization, and biological evaluation studies of novel biamide derivatives as CB2 receptor inverse agonists and osteoclast inhibitors. J Med Chem (2012) 0.89
Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55. ACS Med Chem Lett (2012) 0.86
Targeting cannabinoid receptor CB(2) in cardiovascular disorders: promises and controversies. Br J Pharmacol (2012) 0.86
Methylhonokiol attenuates neuroinflammation: a role for cannabinoid receptors? J Neuroinflammation (2012) 0.81
Functional Selectivity of CB2 Cannabinoid Receptor Ligands at a Canonical and Noncanonical Pathway. J Pharmacol Exp Ther (2016) 0.80
Role of cannabinoids in the regulation of bone remodeling. Front Endocrinol (Lausanne) (2012) 0.80
The natural product magnolol as a lead structure for the development of potent cannabinoid receptor agonists. PLoS One (2013) 0.80
Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development. Evid Based Complement Alternat Med (2015) 0.76
Antagonism of cannabinoid receptor 2 pathway suppresses IL-6-induced immunoglobulin IgM secretion. BMC Pharmacol Toxicol (2014) 0.76
Amelioration of Cognitive Dysfunction in APP/PS1 Double Transgenic Mice by Long-Term Treatment of 4-O-Methylhonokiol. Biomol Ther (Seoul) (2014) 0.76
4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation. J Neuroinflammation (2015) 0.75
Trisubstituted Sulfonamides: a New Chemotype for Development of Potent and Selective CB2 Receptor Inverse Agonists. ACS Med Chem Lett (2013) 0.75
4-O'-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice. J Mol Med (Berl) (2017) 0.75
Mitochondrial CB₁ receptors regulate neuronal energy metabolism. Nat Neurosci (2012) 2.15
Beta-caryophyllene is a dietary cannabinoid. Proc Natl Acad Sci U S A (2008) 1.97
Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science (2013) 1.97
Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects. J Biol Chem (2006) 1.54
An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region. J Med Chem (2003) 1.43
Cross-cultural comparisons of medicinal floras--what are the implications for bioprospecting? J Ethnopharmacol (2011) 1.38
Towards a new tuberculosis drug: pyridomycin - nature's isoniazid. EMBO Mol Med (2012) 1.36
Localisation of cannabinoid CB(1) receptor immunoreactivity in the guinea pig and rat myenteric plexus. J Comp Neurol (2002) 1.31
CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity. Mol Pharmacol (2012) 1.26
Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents. Nat Prod Rep (2007) 1.24
GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology (2008) 1.23
A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells. Br J Pharmacol (2010) 1.21
Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids. J Biol Chem (2011) 1.11
The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents. Angew Chem Int Ed Engl (2003) 1.09
Yucatec Mayan medicinal plants: evaluation based on indigenous uses. J Ethnopharmacol (2002) 1.06
In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens. Planta Med (2008) 1.02
The major central endocannabinoid directly acts at GABA(A) receptors. Proc Natl Acad Sci U S A (2011) 1.02
Structural basis of microtubule stabilization by laulimalide and peloruside A. Angew Chem Int Ed Engl (2014) 0.99
Synthesis of (-)-dactylolide and 13-desmethylene-(-)-dactylolide and their effects on tubulin. Org Lett (2010) 0.97
Patupilone (epothilone B, EPO906) inhibits growth and metastasis of experimental prostate tumors in vivo. Prostate (2005) 0.97
Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts. Int Immunopharmacol (2009) 0.96
Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors. J Biol Chem (2012) 0.96
Identification of serotonin 5-HT1A receptor partial agonists in ginger. Bioorg Med Chem (2010) 0.95
Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules. Chem Biol (2012) 0.95
Cannabinoid receptor ligands as potential anticancer agents--high hopes for new therapies? J Pharm Pharmacol (2009) 0.94
Quinolizidine alkaloids from the curare adjuvant Clathrotropis glaucophylla. Phytochemistry (2002) 0.94
Plant volatiles: production, function and pharmacology. Nat Prod Rep (2011) 0.93
Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis. J Immunol Methods (2011) 0.93
Catalytic selective cyclizations of aminocyclopropanes: formal synthesis of aspidospermidine and total synthesis of goniomitine. Angew Chem Int Ed Engl (2010) 0.92
Total synthesis of hypermodified epothilone analogs with potent in vitro antitumor activity. Org Lett (2008) 0.92
Evidence for bidirectional endocannabinoid transport across cell membranes. J Biol Chem (2012) 0.91
Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization. Acc Chem Res (2007) 0.91
Modulation of GABAA-receptors by honokiol and derivatives: subtype selectivity and structure-activity relationship. J Med Chem (2011) 0.89
Lead discovery, chemistry optimization, and biological evaluation studies of novel biamide derivatives as CB2 receptor inverse agonists and osteoclast inhibitors. J Med Chem (2012) 0.89
The state of the art of chemical biology. Chembiochem (2009) 0.88
Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections. J Med Chem (2010) 0.88
Conformational preferences of natural and C3-modified epothilones in aqueous solution. J Med Chem (2008) 0.88
Total synthesis of (-)-zampanolide and structure-activity relationship studies on (-)-dactylolide derivatives. Chemistry (2012) 0.87
The laulimalide family: total synthesis and biological evaluation of neolaulimalide, isolaulimalide, laulimalide and a nonnatural analogue. Chemistry (2009) 0.86
Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin. Biochem Pharmacol (2010) 0.86
RNA-Binding affinities and crystal structure of oligonucleotides containing five-atom amide-based backbone structures. Biochemistry (2006) 0.86
β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner. Free Radic Biol Med (2012) 0.85
Stereoselective synthesis of a monocyclic peloruside a analogue. Org Lett (2010) 0.85
Evaluation of novel epothilone analogues by means of a common pharmacophore and a QSAR pseudoreceptor model for taxanes and epothilones. ChemMedChem (2010) 0.85
Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching. Bioorg Med Chem Lett (2003) 0.84
Discovery of potent positive allosteric modulators of the α3β2 nicotinic acetylcholine receptor by a chemical space walk in ChEMBL. ACS Chem Neurosci (2014) 0.84
New natural noncannabinoid ligands for cannabinoid type-2 (CB2) receptors. J Recept Signal Transduct Res (2006) 0.84
Ginger phenylpropanoids inhibit IL-1beta and prostanoid secretion and disrupt arachidonate-phospholipid remodeling by targeting phospholipases A2. J Immunol (2011) 0.84
Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis. ACS Chem Biol (2014) 0.83
Highly potent modulation of GABA(A) receptors by valerenic acid derivatives. ChemMedChem (2010) 0.83
Diastereoselective titanium enolate aldol reaction for the total synthesis of epothilones. Org Lett (2002) 0.83
Structure-activity relationship studies on the macrolide exotoxin mycolactone of Mycobacterium ulcerans. PLoS Negl Trop Dis (2013) 0.82
Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. J Med Chem (2009) 0.81
A ring-closing metathesis-based approach to the synthesis of (+)-tetrabenazine. Org Lett (2012) 0.81
A ring-closing metathesis (RCM)-based approach to mycolactones A/B. Chemistry (2011) 0.81
Differential effects of natural product microtubule stabilizers on microtubule assembly: single agent and combination studies with taxol, epothilone B, and discodermolide. Chembiochem (2009) 0.81
Molecular docking and pharmacogenomics of vinca alkaloids and their monomeric precursors, vindoline and catharanthine. Biochem Pharmacol (2011) 0.81
Methylhonokiol attenuates neuroinflammation: a role for cannabinoid receptors? J Neuroinflammation (2012) 0.81
Total synthesis of the bacterial RNA polymerase inhibitor ripostatin B. Angew Chem Int Ed Engl (2012) 0.81
Cannabinoid receptor trafficking in peripheral cells is dynamically regulated by a binary biochemical switch. Biochem Pharmacol (2012) 0.81
Molecular recognition of epothilones by microtubules and tubulin dimers revealed by biochemical and NMR approaches. ACS Chem Biol (2014) 0.80
Total synthesis of the marine diterpenoid blumiolide C. Angew Chem Int Ed Engl (2008) 0.80
New cytotoxic saturated and unsaturated cyclohexanones from Anthemis maritima. Bioorg Med Chem Lett (2008) 0.80
Functionalization of β-caryophyllene generates novel polypharmacology in the endocannabinoid system. ACS Chem Biol (2014) 0.79
Contextual compound screening for improved therapeutic discovery. Chembiochem (2013) 0.79
A collection of robust organic synthesis reactions for in silico molecule design. J Chem Inf Model (2011) 0.79
Total synthesis of the tubulin inhibitor WF-1360F based on macrocycle formation through ring-closing alkyne metathesis. Angew Chem Int Ed Engl (2013) 0.78
Design, synthesis, and biological properties of highly potent epothilone B analogues. Angew Chem Int Ed Engl (2003) 0.78
Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides. J Nat Prod (2007) 0.78
Synthesis and biological activity of 7,8,9-trideoxy- and 7R desTHP-peloruside A. Chemistry (2013) 0.78
Structure-activity relationships in side-chain-modified epothilone analogues--how important is the position of the nitrogen atom? ChemMedChem (2006) 0.78
Total synthesis of the tiacumicin B (lipiarmycin A3/fidaxomicin) aglycone. Angew Chem Int Ed Engl (2014) 0.78
Epothilone analogues with benzimidazole and quinoline side chains: chemical synthesis, antiproliferative activity, and interactions with tubulin. Chemistry (2009) 0.78
Stereoselective synthesis, natural occurrence and CB(2) receptor binding affinities of alkylamides from herbal medicines such as Echinacea sp. Org Biomol Chem (2006) 0.78