Published in Bioorg Med Chem Lett on January 30, 2008
A redox economical synthesis of bioactive 6,12-guaianolides. Org Lett (2013) 0.83
Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. Bioorg Med Chem Lett (2011) 0.81
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Cross-cultural comparisons of medicinal floras--what are the implications for bioprospecting? J Ethnopharmacol (2011) 1.38
Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents. Nat Prod Rep (2007) 1.24
Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids. J Biol Chem (2011) 1.11
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In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens. Planta Med (2008) 1.02
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A comparison of medicinal plant use in Sardinia and Sicily-De Materia Medica revisited? J Ethnopharmacol (2008) 1.00
Mechanisms of osteoclastogenesis inhibition by a novel class of biphenyl-type cannabinoid CB(2) receptor inverse agonists. Chem Biol (2011) 0.99
Synthesis of (-)-dactylolide and 13-desmethylene-(-)-dactylolide and their effects on tubulin. Org Lett (2010) 0.97
Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts. Int Immunopharmacol (2009) 0.96
CO escape from myoglobin with metadynamics simulations. Proteins (2008) 0.96
Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors. J Biol Chem (2012) 0.96
Identification of serotonin 5-HT1A receptor partial agonists in ginger. Bioorg Med Chem (2010) 0.95
Quinolizidine alkaloids from the curare adjuvant Clathrotropis glaucophylla. Phytochemistry (2002) 0.94
Cannabinoid receptor ligands as potential anticancer agents--high hopes for new therapies? J Pharm Pharmacol (2009) 0.94
Plant volatiles: production, function and pharmacology. Nat Prod Rep (2011) 0.93
Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis. J Immunol Methods (2011) 0.93
Catalytic selective cyclizations of aminocyclopropanes: formal synthesis of aspidospermidine and total synthesis of goniomitine. Angew Chem Int Ed Engl (2010) 0.92
Total synthesis of hypermodified epothilone analogs with potent in vitro antitumor activity. Org Lett (2008) 0.92
Antiherpevirus activity of Artemisia arborescens essential oil and inhibition of lateral diffusion in Vero cells. Ann Clin Microbiol Antimicrob (2007) 0.92
Evidence for bidirectional endocannabinoid transport across cell membranes. J Biol Chem (2012) 0.91
Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization. Acc Chem Res (2007) 0.91
A novel dendrimeric peptide with antimicrobial properties: structure-function analysis of SB056. Biophys J (2012) 0.90
Metronidazole prodrugs: synthesis, physicochemical properties, stability, and ex vivo release studies. Eur J Med Chem (2011) 0.90
Lead discovery, chemistry optimization, and biological evaluation studies of novel biamide derivatives as CB2 receptor inverse agonists and osteoclast inhibitors. J Med Chem (2012) 0.89
Heme proteins: the role of solvent in the dynamics of gates and portals. J Am Chem Soc (2010) 0.89
Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections. J Med Chem (2010) 0.88
Conformational preferences of natural and C3-modified epothilones in aqueous solution. J Med Chem (2008) 0.88
Total synthesis of (-)-zampanolide and structure-activity relationship studies on (-)-dactylolide derivatives. Chemistry (2012) 0.87
The laulimalide family: total synthesis and biological evaluation of neolaulimalide, isolaulimalide, laulimalide and a nonnatural analogue. Chemistry (2009) 0.86
Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin. Biochem Pharmacol (2010) 0.86
Synthesis, characterization, antimicrobial activity and LPS-interaction properties of SB041, a novel dendrimeric peptide with antimicrobial properties. Peptides (2010) 0.86
Breathing motions of a respiratory protein revealed by molecular dynamics simulations. J Am Chem Soc (2009) 0.85
Stereoselective synthesis of a monocyclic peloruside a analogue. Org Lett (2010) 0.85
Cytotoxic phloroglucinols from the leaves of Myrtus communis. J Nat Prod (2012) 0.85
β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner. Free Radic Biol Med (2012) 0.85
Core-shell nano-architectures: the incorporation mechanism of hydrophobic nanoparticles into the aqueous core of a microemulsion. J Colloid Interface Sci (2013) 0.84
Discovery of potent positive allosteric modulators of the α3β2 nicotinic acetylcholine receptor by a chemical space walk in ChEMBL. ACS Chem Neurosci (2014) 0.84
Ginger phenylpropanoids inhibit IL-1beta and prostanoid secretion and disrupt arachidonate-phospholipid remodeling by targeting phospholipases A2. J Immunol (2011) 0.84
Structure-function relationship in a variant hemoglobin: a combined computational-experimental approach. Biophys J (2006) 0.83
Quercetin as the active principle of Hypericum hircinum exerts a selective inhibitory activity against MAO-A: extraction, biological analysis, and computational study. J Nat Prod (2006) 0.83
Phenolic constituents from Ephedra nebrodensis. Nat Prod Res (2005) 0.82
Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. Bioorg Med Chem Lett (2011) 0.81
Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. J Med Chem (2009) 0.81
Cannabinoid receptor trafficking in peripheral cells is dynamically regulated by a binary biochemical switch. Biochem Pharmacol (2012) 0.81
Extraction and characterization of a natural rubber from Euphorbia characias latex. Biopolymers (2012) 0.81
Molecular docking and pharmacogenomics of vinca alkaloids and their monomeric precursors, vindoline and catharanthine. Biochem Pharmacol (2011) 0.81
Floral markers of strawberry tree (Arbutus unedo L.) honey. J Agric Food Chem (2010) 0.81
Withania somnifera prevents acquisition and expression of morphine-elicited conditioned place preference. Behav Pharmacol (2013) 0.80
Design, synthesis, and biological evaluation of 1,3-diarylpropenones as dual inhibitors of HIV-1 reverse transcriptase. ChemMedChem (2014) 0.80
Total synthesis of the marine diterpenoid blumiolide C. Angew Chem Int Ed Engl (2008) 0.80
Functionalization of β-caryophyllene generates novel polypharmacology in the endocannabinoid system. ACS Chem Biol (2014) 0.79
Stereoselective synthesis, natural occurrence and CB(2) receptor binding affinities of alkylamides from herbal medicines such as Echinacea sp. Org Biomol Chem (2006) 0.78
Cytotoxic steroidal saponins from the rhizomes of Tacca integrifolia. Chem Biodivers (2010) 0.78
Identification of endocannabinoid system-modulating N-alkylamides from Heliopsis helianthoides var. scabra and Lepidium meyenii. J Nat Prod (2014) 0.78
An unexpected formation of the spectroscopic Cu(I)-semiquinone radical by xenon-induced self-catalysis of a copper quinoprotein. Biochimie (2006) 0.78
Epothilone analogues with benzimidazole and quinoline side chains: chemical synthesis, antiproliferative activity, and interactions with tubulin. Chemistry (2009) 0.78
Characterization of sodium dodecylsulphate and dodecylphosphocholine mixed micelles through NMR and dynamic light scattering. Magn Reson Chem (2013) 0.78
Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides. J Nat Prod (2007) 0.78
Synthesis and biological activity of 7,8,9-trideoxy- and 7R desTHP-peloruside A. Chemistry (2013) 0.78
Structure-activity relationships in side-chain-modified epothilone analogues--how important is the position of the nitrogen atom? ChemMedChem (2006) 0.78
Evidences of xenon-induced structural changes in the active site of cyano-metmyoglobins: a 1H NMR study. J Phys Chem B (2008) 0.77
The binding mode of side chain- and C3-modified epothilones to tubulin. ChemMedChem (2010) 0.77
Toward an improved structural model of the frog-skin antimicrobial peptide esculentin-1b(1-18). Biopolymers (2012) 0.77
The potential of 129Xe NMR relaxation measurements for the study of heme proteins. Chemphyschem (2002) 0.77
Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A. Bioorg Med Chem Lett (2009) 0.76
Topical anti-inflammatory activity of flavonoids and a new xanthone from Santolina insularis. Z Naturforsch C (2005) 0.76
Cytotoxic tirucallane triterpenoids from Melia azedarach fruits. Molecules (2010) 0.76
Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β2 subunit of GABAA receptors? PeerJ (2013) 0.76
An important lysine residue in copper/quinone-containing amine oxidases. FEBS J (2007) 0.76
Bioprospecting: evolutionary implications from a post-olmec pharmacopoeia and the relevance of widespread taxa. J Ethnopharmacol (2013) 0.76
Biodiversity and chemodiversity: future perspectives in bioprospecting. Curr Drug Targets (2011) 0.75
Methoxyflavones from Stachys glutinosa with binding affinity to opioid receptors: in silico, in vitro, and in vivo studies. J Nat Prod (2015) 0.75
Structural and Functional Characterization of a New Double Variant Haemoglobin (HbG-Philadelphia/Duarte α(2)β(2)). ISRN Hematol (2010) 0.75
N-Alkyl dien- and trienamides from the roots of Otanthus maritimus with binding affinity for opioid and cannabinoid receptors. Bioorg Med Chem (2013) 0.75
Cytotoxic diacetylenic spiroketal enol ethers from Plagius flosculosus. J Nat Prod (2006) 0.75
Design and synthesis of 12-aza-epothilones (azathilones)--"non-natural" natural products with potent anticancer activity. Angew Chem Int Ed Engl (2006) 0.75
Natural products as leads for anticancer drug discovery: discovery of new chemotypes of microtubule stabilizers through reengineering of the epothilone scaffold. Chimia (Aarau) (2010) 0.75
Lumichrome and phenyllactic acid as chemical markers of thistle (Galactites tomentosa Moench) honey. J Agric Food Chem (2010) 0.75
Mild synthetic approach to novel indole-1-carbinols and preliminary evaluation of their cytotoxicity in hepatocarcinoma cells. Arch Pharm (Weinheim) (2012) 0.75
New cytotoxic prenylated isoflavonoids from Bituminaria morisiana. Planta Med (2005) 0.75