Published in Free Radic Biol Med on August 10, 2011
A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition. Biochim Biophys Acta (2014) 0.84
Role of physiological levels of 4-hydroxynonenal on adipocyte biology: implications for obesity and metabolic syndrome. Free Radic Res (2012) 0.80
Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice. Front Mol Neurosci (2014) 0.80
Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging. J Gerontol A Biol Sci Med Sci (2014) 0.79
Proteasome Dysfunction Associated to Oxidative Stress and Proteotoxicity in Adipocytes Compromises Insulin Sensitivity in Human Obesity. Antioxid Redox Signal (2015) 0.78
TIPping the balance in adipogenesis: USP7-mediated stabilization of Tip60. Adipocyte (2014) 0.78
Molecular alterations induced by a high-fat high-fiber diet in porcine adipose tissues: variations according to the anatomical fat location. BMC Genomics (2016) 0.77
Implications of the colonic deposition of free hemoglobin-α chain: a previously unknown tissue by-product in inflammatory bowel disease. Inflamm Bowel Dis (2014) 0.76
18O-Tracer Metabolomics Reveals Protein Turnover and CDP-Choline Cycle Activity in Differentiating 3T3-L1 Pre-Adipocytes. PLoS One (2016) 0.75
Mechanisms underlying ubiquitination. Annu Rev Biochem (2001) 18.87
Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem (1996) 10.70
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol Endocrinol (2000) 4.25
Proteasomes: destruction as a programme. Trends Biochem Sci (1996) 3.15
Age-related changes in total and regional fat distribution. Ageing Res Rev (2009) 2.88
Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway. Diabetes (1999) 2.30
The proteasomal system. Mol Aspects Med (2009) 2.19
Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome. J Biol Chem (2002) 2.16
Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes. Diabetes (1998) 2.11
Oxidative stress is associated with adiposity and insulin resistance in men. J Clin Endocrinol Metab (2003) 1.92
Adipogenesis and aging: does aging make fat go MAD? Exp Gerontol (2002) 1.90
Protein homeostasis and aging: taking care of proteins from the cradle to the grave. J Gerontol A Biol Sci Med Sci (2009) 1.84
Protein homeostasis and aging: The importance of exquisite quality control. Ageing Res Rev (2010) 1.84
Aging in adipocytes: potential impact of inherent, depot-specific mechanisms. Exp Gerontol (2007) 1.81
Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome. J Biol Chem (1996) 1.75
4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules. J Biol Chem (1999) 1.74
Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPARgamma in adipocytes. J Biol Chem (2001) 1.61
The ubiquitin-mediated proteolytic pathway: mode of action and clinical implications. J Cell Biochem Suppl (2000) 1.61
The ubiquitin-proteasome system and its role in inflammatory and autoimmune diseases. Cell Mol Immunol (2006) 1.54
Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1. Mol Cell Biol (2002) 1.49
Possible involvement of proteasome inhibition in aging: implications for oxidative stress. Mech Ageing Dev (2000) 1.45
Decreased levels of proteasome activity and proteasome expression in aging spinal cord. Neuroscience (2000) 1.40
Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition. Mol Cell Biol (2000) 1.38
Protein degradation by the proteasome and its implications in aging. Ann N Y Acad Sci (2000) 1.33
The proteasome and its role in the degradation of oxidized proteins. IUBMB Life (2008) 1.32
Relationship between body composition changes and changes in physical function and metabolic risk factors in aging. Curr Opin Clin Nutr Metab Care (2005) 1.26
Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxy-2-nonenal cross-linked protein. FEBS Lett (1997) 1.25
Proteasome inhibition induces reversible impairments in protein synthesis. FASEB J (2006) 1.20
Oxidative stress-associated impairment of proteasome activity during ischemia-reperfusion injury. J Cereb Blood Flow Metab (2000) 1.18
Proteasomal defense of oxidative protein modifications. Antioxid Redox Signal (2006) 1.18
Increased adipose protein carbonylation in human obesity. Obesity (Silver Spring) (2011) 1.18
Redox homeostasis and cellular stress response in aging and neurodegeneration. Methods Mol Biol (2010) 1.18
Protein quality control in Alzheimer's disease by the ubiquitin proteasome system. Prog Neurobiol (2004) 1.10
Association of age with muscle mass, fat mass and fat distribution in non-diabetic haemodialysis patients. Nephrol Dial Transplant (2005) 1.08
Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis. PLoS One (2011) 1.05
High efficiency lipid-based siRNA transfection of adipocytes in suspension. PLoS One (2009) 1.02
Aging is associated with hypoxia and oxidative stress in adipose tissue: implications for adipose function. Am J Physiol Endocrinol Metab (2011) 0.97
Aging and dietary restriction alter proteasome biogenesis and composition in the brain and liver. Mech Ageing Dev (2009) 0.96
Contribution of adipose tissue to health span and longevity. Interdiscip Top Gerontol (2010) 0.95
Ubiquitin-proteasome pathway function is required for lens cell proliferation and differentiation. Invest Ophthalmol Vis Sci (2006) 0.94
Aging and dietary restriction effects on ubiquitination, sumoylation, and the proteasome in the heart. Mech Ageing Dev (2008) 0.93
Roles of proteasomes in cell growth. Mol Biol Rep (1995) 0.93
Inhibition of proteasome activity sensitizes dopamine neurons to protein alterations and oxidative stress. J Neural Transm (Vienna) (2004) 0.93
Studies on the activation by ATP of the 26 S proteasome complex from rat skeletal muscle. Biochem J (1995) 0.89
Roles of the ubiquitin-proteosome system in neurogenesis. Cell Cycle (2010) 0.89
Selective vulnerability of neurons to acute toxicity after proteasome inhibitor treatment: implications for oxidative stress and insolubility of newly synthesized proteins. Free Radic Biol Med (2010) 0.88
Dopamine induces proteasome inhibition in neural PC12 cell line. Free Radic Biol Med (2000) 0.87
Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen. FEBS Lett (2007) 0.87
The ubiquitin-proteasome pathway is a new partner for the control of insulin signaling. Curr Opin Clin Nutr Metab Care (2004) 0.87
Is insulin signaling molecules misguided in diabetes for ubiquitin-proteasome mediated degradation? Mol Cell Biochem (2005) 0.86
Comparison of rat liver and brain proteasomes for oxidative stress-induced inactivation: Influence of ageing and dietary restriction. Free Radic Res (2009) 0.86
Inhibition of human preadipocyte proteasomal activity by HIV protease inhibitors or specific inhibitor lactacystin leads to a defect in adipogenesis, which involves matrix metalloproteinase-9. J Pharmacol Exp Ther (2006) 0.85
The roles of ubiquitin and 26S proteasome in human obesity. Metabolism (2009) 0.84
Proteasome subunits mRNA expressions correlate with male BMI: implications for a role in obesity. Obesity (Silver Spring) (2009) 0.83
Proteasome activity correlates with male BMI and contributes to the differentiation of adipocyte in hADSC. Endocrine (2010) 0.83
The aggravating role of the ubiquitin-proteasome system in neurodegenerative disease. Biochem Soc Trans (2006) 0.79
The involvement of proteasome in myogenic differentiation of murine myocytes and human rhabdomyosarcoma cells. Int J Mol Med (1999) 0.79
Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity. Science (2004) 2.29
Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol (2009) 1.82
Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet. Neurobiol Dis (2009) 1.80
Ribosome dysfunction is an early event in Alzheimer's disease. J Neurosci (2005) 1.80
Redox-dependent modulation of aconitase activity in intact mitochondria. Biochemistry (2003) 1.73
Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria. J Biol Chem (2004) 1.62
Hypoxia-inducible factor-2alpha transactivates Abcg2 and promotes cytoprotection in cardiac side population cells. Circ Res (2008) 1.62
Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development. Dev Cell (2002) 1.58
RNA in brain disease: no longer just "the messenger in the middle". J Neuropathol Exp Neurol (2007) 1.57
Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice. Proc Natl Acad Sci U S A (2011) 1.56
Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses. Nat Neurosci (2011) 1.53
HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines. Glia (2006) 1.53
In silico cancer modeling: is it ready for prime time? Nat Clin Pract Oncol (2008) 1.52
Age-dependent declines in proteasome activity in the heart. Arch Biochem Biophys (2002) 1.52
Molecular footprints of domestication and improvement in soybean revealed by whole genome re-sequencing. BMC Genomics (2013) 1.46
Human cerebral neuropathology of Type 2 diabetes mellitus. Biochim Biophys Acta (2008) 1.46
High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling. J Neurochem (2010) 1.43
Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation. Am J Physiol Renal Physiol (2005) 1.43
Growth factor mediated assembly of cell receptor-responsive hydrogels. J Am Chem Soc (2007) 1.42
Intraretinal leakage and oxidation of LDL in diabetic retinopathy. Invest Ophthalmol Vis Sci (2008) 1.42
Heat stress-induced response of the proteomes of leaves from Salvia splendens Vista and King. Proteome Sci (2013) 1.41
Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice. Neurobiol Dis (2007) 1.40
Association of estrogen receptor gene polymorphisms with susceptibility to adolescent idiopathic scoliosis. Spine (Phila Pa 1976) (2006) 1.40
Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects. Proc Natl Acad Sci U S A (2011) 1.38
Indoor air pollution from coal combustion and the risk of neural tube defects in a rural population in Shanxi Province, China. Am J Epidemiol (2011) 1.36
Synaptic transport of human immunodeficiency virus-Tat protein causes neurotoxicity and gliosis in rat brain. J Neurosci (2003) 1.35
Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart. Free Radic Biol Med (2005) 1.35
Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation. Circ Res (2005) 1.34
A population-based case-control study of risk factors for neural tube defects in four high-prevalence areas of Shanxi province, China. Paediatr Perinat Epidemiol (2006) 1.33
Proteasome regulation of oxidative stress in aging and age-related diseases of the CNS. Antioxid Redox Signal (2006) 1.33
Obesity and vulnerability of the CNS. Biochim Biophys Acta (2008) 1.29
Proteasome inhibition alters neural mitochondrial homeostasis and mitochondria turnover. J Biol Chem (2004) 1.27
Simulating non-small cell lung cancer with a multiscale agent-based model. Theor Biol Med Model (2007) 1.25
Reversible redox-dependent modulation of mitochondrial aconitase and proteolytic activity during in vivo cardiac ischemia/reperfusion. Proc Natl Acad Sci U S A (2005) 1.24
Chronic exercise modulates RAS components and improves balance between pro- and anti-inflammatory cytokines in the brain of SHR. Basic Res Cardiol (2011) 1.24
NOX activity is increased in mild cognitive impairment. Antioxid Redox Signal (2010) 1.22
Morphine and HIV-Tat increase microglial-free radical production and oxidative stress: possible role in cytokine regulation. J Neurochem (2008) 1.22
Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease. Brain Res (2007) 1.21
Saturated long-chain fatty acids activate inflammatory signaling in astrocytes. J Neurochem (2012) 1.21
Extremely high prevalence of neural tube defects in a 4-county area in Shanxi Province, China. Birth Defects Res A Clin Mol Teratol (2006) 1.21
Morphine exacerbates HIV-1 Tat-induced cytokine production in astrocytes through convergent effects on [Ca(2+)](i), NF-kappaB trafficking and transcription. PLoS One (2008) 1.21
Decreased RNA, and increased RNA oxidation, in ribosomes from early Alzheimer's disease. Neurochem Res (2006) 1.21
Proteasome inhibition induces reversible impairments in protein synthesis. FASEB J (2006) 1.20
Inactivation of the proteasome by 4-hydroxy-2-nonenal is site specific and dependant on 20S proteasome subtypes. Arch Biochem Biophys (2006) 1.20
Mitochondrial protein oxidation and degradation in response to oxidative stress and aging. Exp Gerontol (2006) 1.20
Cytochrome c release and caspase activation after traumatic brain injury. Brain Res (2002) 1.20
Life Sciences and the web: a new era for collaboration. Mol Syst Biol (2008) 1.19
Protein oxidation and cellular homeostasis: Emphasis on metabolism. Biochim Biophys Acta (2006) 1.19
Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells. FASEB J (2004) 1.18
Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltaPKC during reperfusion. Cardiovasc Res (2009) 1.18
Autophagocytosis of mitochondria is prominent in Alzheimer disease. J Neuropathol Exp Neurol (2007) 1.18
Characterization of chronic low-level proteasome inhibition on neural homeostasis. J Neurochem (2003) 1.18
Incidence of cerebral hemorrhage in the Changsha community. A prospective study from 1986 to 2000. Cerebrovasc Dis (2004) 1.17
Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid. Biochemistry (2007) 1.17
Regulation of energy metabolism by inflammation: a feedback response in obesity and calorie restriction. Aging (Albany NY) (2010) 1.16
Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats. Biol Pharm Bull (2008) 1.15
The roles of annexins and alkaline phosphatase in mineralization process. Acta Biochim Pol (2003) 1.14
Rheological characterization of polysaccharide-poly(ethylene glycol) star copolymer hydrogels. Biomacromolecules (2005) 1.14
Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy (2007) 1.14
Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis. Free Radic Biol Med (2012) 1.13
Reversible inactivation of alpha-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status. Biochemistry (2003) 1.13
Oxidative damage precedes nitrative damage in adriamycin-induced cardiac mitochondrial injury. Toxicol Pathol (2004) 1.13
Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model. Nat Commun (2013) 1.12
Impact of opiate-HIV-1 interactions on neurotoxic signaling. J Neuroimmune Pharmacol (2006) 1.11
NADPH oxidase drives cytokine and neurotoxin release from microglia and macrophages in response to HIV-Tat. Antioxid Redox Signal (2009) 1.10
α-Ketoglutarate dehydrogenase: a mitochondrial redox sensor. Free Radic Res (2010) 1.10
Estrogen and brain inflammation: effects on microglial expression of MHC, costimulatory molecules and cytokines. J Neuroimmunol (2005) 1.10
Ump1 extends yeast lifespan and enhances viability during oxidative stress: central role for the proteasome? Free Radic Biol Med (2005) 1.10
A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitro. Planta Med (2006) 1.09
Role of the proteasome in protein oxidation and neural viability following low-level oxidative stress. FEBS Lett (2003) 1.09
Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin. J Biol Chem (2007) 1.09
High dietary fat selectively increases catalase expression within cardiac mitochondria. J Biol Chem (2012) 1.09
Cell-specific actions of HIV-Tat and morphine on opioid receptor expression in glia. J Neurosci Res (2008) 1.09
Proteolysis, free radicals, and aging. Free Radic Biol Med (2002) 1.09
Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion. Arch Biochem Biophys (2002) 1.09
Translocation of deltaPKC to mitochondria during cardiac reperfusion enhances superoxide anion production and induces loss in mitochondrial function. Arch Biochem Biophys (2005) 1.08
High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. J Biol Chem (2001) 1.07
Body mass index and the risk of dementia among Louisiana low income diabetic patients. PLoS One (2012) 1.07
Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI). Cardiovasc Diabetol (2007) 1.06
Polyglutamine expansion, protein aggregation, proteasome activity, and neural survival. J Biol Chem (2002) 1.06
Advancing cancer systems biology: introducing the Center for the Development of a Virtual Tumor, CViT. Cancer Inform (2007) 1.05
Mechanisms for countering oxidative stress and damage in retinal pigment epithelium. Int Rev Cell Mol Biol (2012) 1.05
Oxidative inactivation of the proteasome in Alzheimer's disease. Free Radic Res (2007) 1.04
CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates. J Neuroimmunol (2006) 1.04
Development of diet-induced insulin resistance in adult Drosophila melanogaster. Biochim Biophys Acta (2012) 1.04