Published in Proc Natl Acad Sci U S A on August 22, 2011
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol (2013) 4.16
Diagnostic potential of urinary α1-antitrypsin and apolipoprotein E in the detection of bladder cancer. J Urol (2012) 2.12
Apolipoprotein e sets the stage: response to injury triggers neuropathology. Neuron (2012) 1.46
ApoE and Aβ in Alzheimer's disease: accidental encounters or partners? Neuron (2014) 1.33
A multi-analyte assay for the non-invasive detection of bladder cancer. PLoS One (2012) 1.10
Hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry determine the interface and dynamics of apolipoprotein E oligomerization. Biochemistry (2011) 1.09
Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease. Proc Natl Acad Sci U S A (2012) 1.05
New insights into the determination of HDL structure by apolipoproteins: Thematic review series: high density lipoprotein structure, function, and metabolism. J Lipid Res (2012) 1.01
Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease. Alzheimers Res Ther (2013) 0.99
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Solution structure of the two RNA recognition motifs of hnRNP A1 using segmental isotope labeling: how the relative orientation between RRMs influences the nucleic acid binding topology. J Biomol NMR (2012) 0.97
Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis. Proc Natl Acad Sci U S A (2014) 0.94
Amphipathic α-helices in apolipoproteins are crucial to the formation of infectious hepatitis C virus particles. PLoS Pathog (2014) 0.93
The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation. Biochemistry (2014) 0.93
The extent of pyrene excimer fluorescence emission is a reflector of distance and flexibility: analysis of the segment linking the LDL receptor-binding and tetramerization domains of apolipoprotein E3. Biochemistry (2012) 0.92
Impact of apolipoprotein E on Alzheimer's disease. Curr Alzheimer Res (2013) 0.90
Interactions of metals and Apolipoprotein E in Alzheimer's disease. Front Aging Neurosci (2014) 0.88
Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies. Neurobiol Dis (2016) 0.87
Fluorescence analysis of the lipid binding-induced conformational change of apolipoprotein E4. Biochemistry (2012) 0.86
Biochemical and biophysical characterization of recombinant rat apolipoprotein E: similarities to human apolipoprotein E3. Arch Biochem Biophys (2012) 0.85
Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels. Arterioscler Thromb Vasc Biol (2013) 0.85
An apolipoprotein E4 fragment affects matrix metalloproteinase 9, tissue inhibitor of metalloproteinase 1 and cytokine levels in brain cell lines. Neuroscience (2012) 0.85
Concerning the structure of apoE. Protein Sci (2013) 0.84
Biophysical analysis of apolipoprotein E3 variants linked with development of type III hyperlipoproteinemia. PLoS One (2011) 0.83
Small-angle X-ray scattering of apolipoprotein A-IV reveals the importance of its termini for structural stability. J Biol Chem (2013) 0.83
Lipid-free Apolipoprotein A-I Structure: Insights into HDL Formation and Atherosclerosis Development. Arch Med Res (2015) 0.83
Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy. J Lipid Res (2012) 0.83
Role of apolipoprotein E in neurodegenerative diseases. Neuropsychiatr Dis Treat (2015) 0.83
Age, APOE and sex: Triad of risk of Alzheimer's disease. J Steroid Biochem Mol Biol (2016) 0.82
ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations. PLoS Comput Biol (2015) 0.81
ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease. Mol Neurodegener (2014) 0.80
Influence of domain stability on the properties of human apolipoprotein E3 and E4 and mouse apolipoprotein E. Biochemistry (2014) 0.79
Transcriptional regulation and its misregulation in Alzheimer's disease. Mol Brain (2013) 0.79
Molecular basis for increased risk for late-onset Alzheimer disease due to the naturally occurring L28P mutation in apolipoprotein E4. J Biol Chem (2014) 0.79
Global molecular analysis and APOE mutations in a cohort of autosomal dominant hypercholesterolemia patients in France. J Lipid Res (2016) 0.78
Fluorescence study of domain structure and lipid interaction of human apolipoproteins E3 and E4. Biochim Biophys Acta (2014) 0.78
Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia. J Lipid Res (2013) 0.78
ApoE: the role of conserved residues in defining function. Protein Sci (2014) 0.77
Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks. FEBS Lett (2016) 0.77
Completion of the Entire Hepatitis C Virus Life Cycle in Vero Cells Derived from Monkey Kidney. MBio (2016) 0.77
ApoE: In Vitro Studies of a Small Molecule Effector. Biochemistry (2016) 0.76
Understanding Dengue Virus Capsid Protein Interaction with Key Biological Targets. Sci Rep (2015) 0.76
A possible structural basis behind the pathogenic role of apolipoprotein E hereditary mutations associated with lipoprotein glomerulopathy. Clin Exp Nephrol (2013) 0.76
APOE genotype and stress response - a mini review. Lipids Health Dis (2016) 0.75
Allele-dependent thermodynamic and structural perturbations in ApoE variants associated with the correction of dyslipidemia and formation of spherical ApoE-containing HDL particles. Atherosclerosis (2012) 0.75
Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A (2017) 0.75
Novel susceptibility loci for Alzheimer's disease. Future Neurol (2015) 0.75
Probing the C-terminal domain of lipid-free apoA-I demonstrates the vital role of the H10B sequence repeat in HDL formation. J Lipid Res (2016) 0.75
Isoform and cell type-specific structure of Apolipoprotein E lipoparticles as revealed by a novel Forster Resonance Energy Transfer assay. J Biol Chem (2017) 0.75
Apolipoprotein E - A Multifunctional Protein with Implications in Various Pathologies as a Result of Its Structural Features. Comput Struct Biotechnol J (2017) 0.75
Swapping the N- and C-terminal domains of human apolipoprotein E3 and AI reveals insights into their structure/activity relationship. PLoS One (2017) 0.75
Automated NMR structure calculation with CYANA. Methods Mol Biol (2004) 9.31
Molecular genetics of the LDL receptor gene in familial hypercholesterolemia. Hum Mutat (1992) 4.48
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat Rev Neurosci (2009) 3.97
VADAR: a web server for quantitative evaluation of protein structure quality. Nucleic Acids Res (2003) 3.95
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Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science (1991) 3.42
Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E. J Lipid Res (1999) 2.39
Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Proc Natl Acad Sci U S A (2008) 2.38
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS. J Lipid Res (2008) 2.28
Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins. J Biol Chem (1996) 2.06
Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. J Biol Chem (1994) 2.04
The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments. J Biol Chem (1983) 1.75
Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains. J Biol Chem (1988) 1.72
Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains. J Biol Chem (1988) 1.57
The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor. J Lipid Res (2005) 1.57
Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease. J Biol Chem (2002) 1.54
Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholine. J Biol Chem (2005) 1.30
Helix orientation of the functional domains in apolipoprotein e in discoidal high density lipoprotein particles. J Biol Chem (2004) 1.22
A monomeric, biologically active, full-length human apolipoprotein E. Biochemistry (2007) 1.21
New insights into the heparan sulfate proteoglycan-binding activity of apolipoprotein E. J Biol Chem (2001) 1.17
RAP, a novel type of ER chaperone. Trends Cell Biol (1998) 1.13
Molecular mechanism of apolipoprotein E binding to lipoprotein particles. Biochemistry (2009) 1.11
Two-step mechanism of binding of apolipoprotein E to heparin: implications for the kinetics of apolipoprotein E-heparan sulfate proteoglycan complex formation on cell surfaces. J Biol Chem (2004) 1.11
Characterization of the heparin binding sites in human apolipoprotein E. J Biol Chem (2003) 1.10
Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain. Biochemistry (2003) 1.08
Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia. Nat Struct Biol (1996) 1.07
Lipid association-induced N- and C-terminal domain reorganization in human apolipoprotein E3. J Biol Chem (2001) 1.06
A unified scheme for initiation and conformational adaptation of human apolipoprotein E N-terminal domain upon lipoprotein binding and for receptor binding activity. J Biol Chem (2009) 1.03
Coaxing the LDL receptor family into the fold. Cell (2003) 1.02
Biophysical analysis of progressive C-terminal truncations of human apolipoprotein E4: insights into secondary structure and unfolding properties. Biochemistry (2008) 1.02
Impact of apolipoprotein E polymorphism on lipoproteins and risk of myocardial infarction. The ECTIM Study. Arterioscler Thromb (1994) 1.01
Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein. J Biochem (2002) 1.01
Effect of arginine 172 on the binding of apolipoprotein E to the low density lipoprotein receptor. J Biol Chem (2000) 1.01
Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein. Structure (1994) 0.96
A complete backbone spectral assignment of lipid-free human apolipoprotein E (apoE). Biomol NMR Assign (2008) 0.94
An efficient on-column expressed protein ligation strategy: application to segmental triple labeling of human apolipoprotein E3. Protein Sci (2008) 0.89
Two apolipoprotein E5 variants illustrate the importance of the position of additional positive charge on receptor-binding activity. J Lipid Res (1991) 0.89
Type 2 diabetes mellitus and its renal complications in relation to apolipoprotein E gene polymorphism. Transl Res (2008) 0.81
A segmental labeling strategy for unambiguous determination of domain-domain interactions of large multi-domain proteins. J Biomol NMR (2011) 0.80
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24
Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proc Natl Acad Sci U S A (2011) 3.80
Control of rice grain-filling and yield by a gene with a potential signature of domestication. Nat Genet (2008) 3.09
Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors. Cancer Discov (2014) 2.64
Antiretroviral therapy to prevent HIV transmission in serodiscordant couples in China (2003-11): a national observational cohort study. Lancet (2012) 2.41
N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking. J Neurosci (2008) 2.18
Myocardial ischemic memory imaging with molecular echocardiography. Circulation (2007) 2.13
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. Cell (2008) 1.97
Observation and tuning of hypersonic bandgaps in colloidal crystals. Nat Mater (2006) 1.96
Spatial analysis of malaria in Anhui province, China. Malar J (2008) 1.92
Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing. Proc Natl Acad Sci U S A (2007) 1.71
Practical protocols for production of very high yields of recombinant proteins using Escherichia coli. Protein Sci (2009) 1.69
Functional analysis of rice NPR1-like genes reveals that OsNPR1/NH1 is the rice orthologue conferring disease resistance with enhanced herbivore susceptibility. Plant Biotechnol J (2007) 1.66
Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells. Med Oncol (2009) 1.60
Complete genomic characterization of a pathogenic A.II strain of Francisella tularensis subspecies tularensis. PLoS One (2007) 1.31
A monomeric, biologically active, full-length human apolipoprotein E. Biochemistry (2007) 1.21
Silicon Wafer-Based Platinum Microelectrode Array Biosensor for Near Real-Time Measurement of Glutamate in Vivo. Sensors (Basel) (2008) 1.19
Ultrasound-targeted microbubble destruction to deliver siRNA cancer therapy. Cancer Res (2012) 1.18
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding. J Cell Sci (2005) 1.16
Permanent Genetic Resources added to Molecular Ecology Resources Database 1 May 2009-31 July 2009. Mol Ecol Resour (2009) 1.15
Genetic diversity of eukaryotic plankton assemblages in Eastern Tibetan Lakes differing by their salinity and altitude. Microb Ecol (2009) 1.11
Gene therapy of carcinoma using ultrasound-targeted microbubble destruction. Ultrasound Med Biol (2011) 1.09
Genome-wide association study identifies candidate genes that affect plant height in Chinese elite maize (Zea mays L.) inbred lines. PLoS One (2011) 1.06
Detection of intracellular iron by its regulatory effect. Am J Physiol Cell Physiol (2004) 1.06
Structural insights into a novel histone demethylase PHF8. Cell Res (2010) 1.05
NMR solution structure and dynamics of an exchangeable apolipoprotein, Locusta migratoria apolipophorin III. J Biol Chem (2003) 1.05
A unified scheme for initiation and conformational adaptation of human apolipoprotein E N-terminal domain upon lipoprotein binding and for receptor binding activity. J Biol Chem (2009) 1.03
Double-walled microspheres for the sustained release of a highly water soluble drug: characterization and irradiation studies. J Control Release (2002) 1.01
Effect of acoustic conditions on microbubble-mediated microvascular sonothrombolysis. Ultrasound Med Biol (2012) 1.01
Pre-treatment with IL-1β enhances the efficacy of MSC transplantation in DSS-induced colitis. Cell Mol Immunol (2012) 1.01
Robust prototypical anti-icing coatings with a self-lubricating liquid water layer between ice and substrate. ACS Appl Mater Interfaces (2013) 1.00
Elimination of in vivo cleavage between target protein and intein in the intein-mediated protein purification systems. Protein Expr Purif (2006) 1.00
Heterogeneity of archaeal and bacterial ammonia-oxidizing communities in Lake Taihu, China. Environ Microbiol Rep (2010) 0.99
A monomeric human apolipoprotein E carboxyl-terminal domain. Biochemistry (2004) 0.99
Effects of cyclen and cyclam on zinc(II)- and copper(II)-induced amyloid beta-peptide aggregation and neurotoxicity. Inorg Chem (2009) 0.99
Fabrication of novel comb-like Cu(2)O nanorod-based structures through an interface etching method and their application as ethanol sensors. Chem Commun (Camb) (2010) 0.99
Gibberellin homeostasis and plant height control by EUI and a role for gibberellin in root gravity responses in rice. Cell Res (2008) 0.98
New insights into mechanisms of sonothrombolysis using ultra-high-speed imaging. Ultrasound Med Biol (2013) 0.98
Engineering mouse apolipoprotein A-I into a monomeric, active protein useful for structural determination. Biochemistry (2005) 0.97
NKT cells are critical to initiate an inflammatory response after Pseudomonas aeruginosa ocular infection in susceptible mice. J Immunol (2007) 0.97
Characterization of bacterial communities associated with organic aggregates in a large, shallow, eutrophic freshwater lake (Lake Taihu, China). Microb Ecol (2009) 0.96
Bio-inspired strategies for anti-icing. ACS Nano (2014) 0.96
Selective detection of extracellular glutamate in brain tissue using microelectrode arrays coated with over-oxidized polypyrrole. Analyst (2007) 0.96
Effects of targeting moiety, linker, bifunctional chelator, and molecular charge on biological properties of 64Cu-labeled triphenylphosphonium cations. J Med Chem (2008) 0.96
MiR-27b targets LIMK1 to inhibit growth and invasion of NSCLC cells. Mol Cell Biochem (2014) 0.95
Anti-icing coating with an aqueous lubricating layer. ACS Appl Mater Interfaces (2014) 0.95
Molecular cloning and characterization of a heat shock protein 70 gene in swimming crab (Portunus trituberculatus). Fish Shellfish Immunol (2009) 0.95
A complete backbone spectral assignment of lipid-free human apolipoprotein E (apoE). Biomol NMR Assign (2008) 0.94
OsRAR1 and OsSGT1 physically interact and function in rice basal disease resistance. Mol Plant Microbe Interact (2008) 0.94
Mitigation effect of an FGF-2 peptide on acute gastrointestinal syndrome after high-dose ionizing radiation. Int J Radiat Oncol Biol Phys (2010) 0.93
Prognostic significance of miR-34a and its target proteins of FOXP1, p53, and BCL2 in gastric MALT lymphoma and DLBCL. Gastric Cancer (2013) 0.93
Apolipoprotein AI tertiary structures determine stability and phospholipid-binding activity of discoidal high-density lipoprotein particles of different sizes. Protein Sci (2009) 0.92
Organization of glucose-responsive systems and their properties. Chem Rev (2011) 0.92
Two Arabidopsis cytochrome P450 monooxygenases, CYP714A1 and CYP714A2, function redundantly in plant development through gibberellin deactivation. Plant J (2011) 0.91
MicroRNA-421 is a new potential diagnosis biomarker with higher sensitivity and specificity than carcinoembryonic antigen and cancer antigen 125 in gastric cancer. Biomarkers (2014) 0.90
Ultra-fast bright field and fluorescence imaging of the dynamics of micrometer-sized objects. Rev Sci Instrum (2013) 0.90
Assessment of heavy metal contamination in the sediments of Nansihu Lake Catchment, China. Environ Monit Assess (2009) 0.90
An efficient on-column expressed protein ligation strategy: application to segmental triple labeling of human apolipoprotein E3. Protein Sci (2008) 0.89
Targeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype. Mol Cancer Ther (2012) 0.89
Anti-icing surfaces based on enhanced self-propelled jumping of condensed water microdroplets. Chem Commun (Camb) (2013) 0.89
Tc-99m-N-MPO: novel cationic Tc-99m radiotracer for myocardial perfusion imaging. J Nucl Cardiol (2008) 0.89
Nasal chondromesenchymal hamartoma in young children: CT and MRI findings and review of the literature. World J Surg Oncol (2014) 0.88
The specific amino acid sequence between helices 7 and 8 influences the binding specificity of human apolipoprotein A-I for high density lipoprotein (HDL) subclasses: a potential for HDL preferential generation. J Biol Chem (2008) 0.88
Atomic-scale observation of lithiation reaction front in nanoscale SnO2 materials. ACS Nano (2013) 0.87
Conductivity of poly(pyrrole)-poly(styrene sulfonate) core-shell nanoparticles. Chemphyschem (2010) 0.87
Prognostic significance of the aggregative perivascular growth pattern of tumor cells in primary central nervous system diffuse large B-cell lymphoma. Neuro Oncol (2013) 0.86
Detection and identification of potential biomarkers of non-small cell lung cancer. Technol Cancer Res Treat (2009) 0.86
Structural characterization and antioxidant activities of polysaccharides extracted from Epimedium acuminatum. Carbohydr Polym (2012) 0.86
Productivity-diversity relationships in lake plankton communities. PLoS One (2011) 0.86
Surface study of apoB1694-1880, a sequence that can anchor apoB to lipoproteins and make it nonexchangeable. J Lipid Res (2009) 0.86
Ultrasound detection of myocardial ischemic memory using an E-selectin targeting peptide amenable to human application. Mol Imaging (2014) 0.85
Ofloxacin induces apoptosis in microencapsulated juvenile rabbit chondrocytes by caspase-8-dependent mitochondrial pathway. Toxicol Appl Pharmacol (2007) 0.85
Investigating the effects of solid surfaces on ice nucleation. Langmuir (2012) 0.85
Decreasing ammonium generation using hydrogenotrophic bacteria in the process of nitrate reduction by nanoscale zero-valent iron. Sci Total Environ (2009) 0.85
Comparison of acid degumming and enzymatic degumming process for Silybum marianum seed oil. J Sci Food Agric (2013) 0.84
Improvements of surgical techniques in a rat model of an orthotopic single lung transplant. Eur J Med Res (2013) 0.84
Anti-ice coating inspired by ice skating. Small (2014) 0.84
Accurate determination of the vapor-liquid-solid contact line tension and the viability of Young equation. Sci Rep (2013) 0.84
Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6. Structure (2011) 0.84
The relative ligand binding preference of the murine ileal lipid binding protein. Protein Expr Purif (2003) 0.84
Comparison of ascorbic acid biosynthesis in different tissues of three non-heading Chinese cabbage cultivars. Plant Physiol Biochem (2013) 0.83
Vascular endoluminal delivery of mesenchymal stem cells using acoustic radiation force. Tissue Eng Part A (2011) 0.83
Multiple calcifying fibrous pseudotumor of the bilateral pleura. Jpn J Clin Oncol (2010) 0.83
64Cu-labeled 2-(diphenylphosphoryl)ethyldiphenylphosphonium cations as highly selective tumor imaging agents: effects of linkers and chelates on radiotracer biodistribution characteristics. Bioconjug Chem (2008) 0.83
Rigid and flexible organic electrochemical transistor arrays for monitoring action potentials from electrogenic cells. Adv Healthc Mater (2014) 0.83
A complete NMR spectral assignment of the lipid-free mouse apolipoprotein A-I (apoAI) C-terminal truncation mutant, apoAI(1-216). Biomol NMR Assign (2007) 0.82
Soil bacterial communities shaped by geochemical factors and land use in a less-explored area, Tibetan Plateau. BMC Genomics (2013) 0.82
Suppression of toll-like receptor 2 expression inhibits the bioactivity of human hepatocellular carcinoma. Tumour Biol (2014) 0.82
NMR structure note: solution structure of the core domain of MESD that is essential for proper folding of LRP5/6. J Biomol NMR (2010) 0.82
High-generation second-order nonlinear optical (NLO) dendrimers: convenient synthesis by click chemistry and the increasing trend of NLO effects. Angew Chem Int Ed Engl (2010) 0.82
A complete backbone spectral assignment of human apolipoprotein AI on a 38 kDa prebetaHDL (Lp1-AI) particle. Biomol NMR Assign (2007) 0.82
Purely electric-field-driven perpendicular magnetization reversal. Nano Lett (2015) 0.82