PubRank

Victor L J Tybulewicz

Author PubWeight™ 92.37‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol 2010 4.26
2 Species-specific transcription in mice carrying human chromosome 21. Science 2008 4.03
3 An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science 2005 3.61
4 A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood 2005 2.90
5 CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand. Nat Immunol 2007 2.51
6 Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science 2003 2.46
7 Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol 2007 2.27
8 Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming. Science 2004 2.20
9 Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. J Biol Chem 2005 2.07
10 The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway. Immunity 2013 2.02
11 ERM proteins regulate cytoskeleton relaxation promoting T cell-APC conjugation. Nat Immunol 2004 1.99
12 NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. Nat Immunol 2003 1.89
13 Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse. Eur J Immunol 2003 1.88
14 Down syndrome--recent progress and future prospects. Hum Mol Genet 2009 1.85
15 Requirement for Rac1 in a K-ras induced lung cancer in the mouse. Cancer Res 2007 1.80
16 Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways. J Exp Med 2002 1.78
17 Beta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination. J Cell Biol 2007 1.77
18 Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome. Nature 2010 1.70
19 DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. Am J Hum Genet 2008 1.45
20 Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation. Immunity 2008 1.43
21 Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. J Biol Chem 2004 1.42
22 Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion. Immunity 2003 1.36
23 A critical role for Syk protein tyrosine kinase in Fc receptor-mediated antigen presentation and induction of dendritic cell maturation. J Immunol 2003 1.34
24 CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood 2011 1.30
25 Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. Nat Immunol 2002 1.29
26 Down syndrome: searching for the genetic culprits. Dis Model Mech 2011 1.28
27 Genomically humanized mice: technologies and promises. Nat Rev Genet 2011 1.18
28 Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome. Learn Mem 2008 1.18
29 Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen. Blood 2004 1.15
30 Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C. Blood 2002 1.15
31 Rac GTPases play critical roles in early T-cell development. Blood 2008 1.13
32 Function of the nucleotide exchange activity of vav1 in T cell development and activation. Sci Signal 2009 1.13
33 Functional analysis of activating receptor LMIR4 as a counterpart of inhibitory receptor LMIR3. J Biol Chem 2007 1.12
34 Crucial structural role for the PH and C1 domains of the Vav1 exchange factor. EMBO Rep 2008 1.11
35 Critical roles for Rac GTPases in T-cell migration to and within lymph nodes. Blood 2010 1.11
36 Itk controls the spatiotemporal organization of T cell activation. Sci Signal 2011 1.11
37 Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome. PLoS One 2013 1.10
38 Essential role of Rac1 and Rac3 GTPases in neuronal development. FASEB J 2009 1.10
39 Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome. Hum Mol Genet 2009 1.09
40 Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood 2010 1.08
41 Cutting edge: Rac GTPases sensitize activated T cells to die via Fas. J Immunol 2007 1.05
42 Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells. Blood 2007 1.04
43 A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival. J Exp Med 2010 0.97
44 Structural correlates of active-staining following magnetic resonance microscopy in the mouse brain. Neuroimage 2011 0.94
45 PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils. Blood 2010 0.91
46 The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome. Behav Brain Res 2010 0.91
47 Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells. J Biol Chem 2004 0.90
48 Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells. Immunity 2005 0.89
49 Syk-mediated translocation of PI3Kdelta to the leading edge controls lamellipodium formation and migration of leukocytes. PLoS One 2007 0.88
50 GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. Arterioscler Thromb Vasc Biol 2006 0.87
51 Altered regulation of tau phosphorylation in a mouse model of down syndrome aging. Neurobiol Aging 2011 0.85
52 Mechanism and function of Vav1 localisation in TCR signalling. J Cell Sci 2012 0.84
53 New approaches for modelling sporadic genetic disease in the mouse. Dis Model Mech 2009 0.84
54 Redundant role for Zap70 in B cell development and activation. Eur J Immunol 2008 0.83
55 Lymphocyte signaling: beyond knockouts. Nat Immunol 2009 0.83
56 Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome. Mol Cell Proteomics 2008 0.82
57 Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain. Hum Mol Genet 2013 0.82
58 Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down syndrome. PLoS One 2013 0.82
59 Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice. Proc Natl Acad Sci U S A 2012 0.82
60 The tyrosine kinase Syk is required for light chain isotype exclusion but dispensable for the negative selection of B cells. Eur J Immunol 2004 0.80
61 Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9. Eur J Immunol 2014 0.78
62 Characterization of the roles of Rac1 and Rac2 GTPases in lymphocyte development. Methods Enzymol 2008 0.77
63 Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21. J Biomed Res 2010 0.76
64 Mouse models of aneuploidy. ScientificWorldJournal 2012 0.76
65 Vav1 GEF activity is required for T cell mediated allograft rejection. Transpl Immunol 2012 0.76
66 Corrigendum: WNK1 kinase balances T cell adhesion versus migration in vivo. Nat Immunol 2017 0.75
67 Generation of a panel of antibodies against proteins encoded on human chromosome 21. J Negat Results Biomed 2010 0.75