Published in Dis Model Mech on September 01, 2011
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Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes. Dev Dyn (2004) 1.52
Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. J Neurosci (2007) 1.48
Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice. Proc Natl Acad Sci U S A (2006) 1.47
The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. J Neurosci (2009) 1.46
Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome. FASEB J (2008) 1.43
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Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells. J Neurosci (2010) 1.37
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Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. Neurosci Lett (2002) 1.33
Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome. Blood (2007) 1.33
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Change in the shape of dendritic spines caused by overexpression of drebrin in cultured cortical neurons. J Neurosci (1999) 1.24
Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome. Hum Mol Genet (2000) 1.23
Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current. J Neurophysiol (2006) 1.23
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A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome. Hum Mol Genet (2009) 1.20
Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome. Learn Mem (2008) 1.18
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Characterization of the cardiac phenotype in neonatal Ts65Dn mice. Dev Dyn (2008) 1.14
Variation in folate pathway genes contributes to risk of congenital heart defects among individuals with Down syndrome. Genet Epidemiol (2010) 1.14
Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse. Cardiovasc Res (2010) 1.13
Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome. Hum Mol Genet (2009) 1.09
Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome. J Neurochem (2006) 1.09
Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood (2010) 1.08
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Hematopoietic defects in the Ts1Cje mouse model of Down syndrome. Blood (2008) 1.07
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The use of mouse models to understand and improve cognitive deficits in Down syndrome. Dis Model Mech (2011) 1.05
Duplication of amyloid precursor protein (APP), but not prion protein (PRNP) gene is a significant cause of early onset dementia in a large UK series. Neurobiol Aging (2010) 1.04
The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development. Eur J Neurosci (2008) 1.04
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APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome. Hum Mol Genet (2011) 1.02
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Genetic analysis of Down syndrome-associated heart defects in mice. Hum Genet (2011) 0.97
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NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome. J Neurosci (2010) 0.93
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Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome. PLoS One (2013) 1.10
Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome. Hum Mol Genet (2009) 1.09
Cytoplasmic dynein heavy chain: the servant of many masters. Trends Neurosci (2013) 1.09
Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood (2010) 1.08
Cutting edge: Rac GTPases sensitize activated T cells to die via Fas. J Immunol (2007) 1.05
Is SOD1 loss of function involved in amyotrophic lateral sclerosis? Brain (2013) 1.05
A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis. Dis Model Mech (2011) 1.05
Quiet mutations in inbred strains of mice. Trends Mol Med (2007) 1.05
Modification of superoxide dismutase 1 (SOD1) properties by a GFP tag--implications for research into amyotrophic lateral sclerosis (ALS). PLoS One (2010) 1.05
Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells. Blood (2007) 1.04
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Cytoplasmic dynein could be key to understanding neurodegeneration. Genome Biol (2008) 1.02
Large-scale pathways-based association study in amyotrophic lateral sclerosis. Brain (2007) 0.98
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A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival. J Exp Med (2010) 0.97
The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12. Amyotroph Lateral Scler Other Motor Neuron Disord (2005) 0.95
Structural correlates of active-staining following magnetic resonance microscopy in the mouse brain. Neuroimage (2011) 0.94
Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice. Brain (2012) 0.94
Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition. Nat Commun (2013) 0.94
The phagocytic capacity of neurones. Eur J Neurosci (2007) 0.93
No association with common Caucasian genotypes in exons 8, 13 and 14 of the human cytoplasmic dynein heavy chain gene (DNCHC1) and familial motor neuron disorders. Amyotroph Lateral Scler Other Motor Neuron Disord (2003) 0.93
Identification and characterization of a novel mouse prion gene allele. Mamm Genome (2004) 0.92
Novel mouse model of autosomal semidominant adult hypophosphatasia has a splice site mutation in the tissue nonspecific alkaline phosphatase gene Akp2. J Bone Miner Res (2007) 0.91
The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome. Behav Brain Res (2010) 0.91
PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils. Blood (2010) 0.91
A motor-driven mechanism for cell-length sensing. Cell Rep (2012) 0.90
Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells. J Biol Chem (2004) 0.90
Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells. Immunity (2005) 0.89
Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse. J Neurosci (2011) 0.88