Published in J Biol Chem on June 05, 1990
Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem J (1998) 3.36
Identification of the SAAT gene involved in strawberry flavor biogenesis by use of DNA microarrays. Plant Cell (2000) 2.52
Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma. Neoplasia (2005) 1.62
Endogenous production of lipoic acid is essential for mouse development. Mol Cell Biol (2005) 1.49
Lipoic acid metabolism in Escherichia coli: sequencing and functional characterization of the lipA and lipB genes. J Bacteriol (1993) 1.43
Purification and properties of the lipoate protein ligase of Escherichia coli. Biochem J (1995) 1.43
The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes. Proc Natl Acad Sci U S A (2001) 1.40
Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. Biochim Biophys Acta (2009) 1.33
Principles of quasi-equivalence and Euclidean geometry govern the assembly of cubic and dodecahedral cores of pyruvate dehydrogenase complexes. Proc Natl Acad Sci U S A (1999) 1.31
The pyruvate dehydrogenase complexes: structure-based function and regulation. J Biol Chem (2014) 1.31
Molecular architecture and mechanism of an icosahedral pyruvate dehydrogenase complex: a multifunctional catalytic machine. EMBO J (2002) 1.30
Identification and molecular characterization of the Alcaligenes eutrophus H16 aco operon genes involved in acetoin catabolism. J Bacteriol (1991) 1.21
Lipoic acid synthesis and attachment in yeast mitochondria. J Biol Chem (2009) 1.18
Lipoic acid metabolism in microbial pathogens. Microbiol Mol Biol Rev (2010) 1.18
On the unique structural organization of the Saccharomyces cerevisiae pyruvate dehydrogenase complex. J Biol Chem (1997) 1.16
Structure and selectivity in post-translational modification: attaching the biotinyl-lysine and lipoyl-lysine swinging arms in multifunctional enzymes. EMBO J (1999) 1.16
Scavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparum. Mol Microbiol (2007) 1.14
Mutants of Escherichia coli K-12 that are resistant to a selenium analog of lipoic acid identify unknown genes in lipoate metabolism. Proc Natl Acad Sci U S A (1994) 1.11
Selective proteolysis of the protein X subunit of the bovine heart pyruvate dehydrogenase complex. Effects on dihydrolipoamide dehydrogenase (E3) affinity and enzymic properties of the complex. Biochem J (1991) 1.05
Biochemical and molecular characterization of the Clostridium magnum acetoin dehydrogenase enzyme system. J Bacteriol (1994) 1.04
Effects of insulin on the regulation of branched-chain alpha-keto acid dehydrogenase E1 alpha subunit gene expression. Biochem J (1996) 1.04
Biochemical and molecular characterization of the Alcaligenes eutrophus pyruvate dehydrogenase complex and identification of a new type of dihydrolipoamide dehydrogenase. J Bacteriol (1994) 1.03
Nonlinear relaxation dynamics in elastic networks and design principles of molecular machines. Proc Natl Acad Sci U S A (2007) 1.03
Global conformational change associated with the two-step reaction catalyzed by Escherichia coli lipoate-protein ligase A. J Biol Chem (2010) 1.03
Identification and molecular characterization of the aco genes encoding the Pelobacter carbinolicus acetoin dehydrogenase enzyme system. J Bacteriol (1994) 1.02
Three-dimensional structure of the truncated core of the Saccharomyces cerevisiae pyruvate dehydrogenase complex determined from negative stain and cryoelectron microscopy images. J Biol Chem (1992) 0.99
Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains. Structure (2008) 0.97
Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm). J Biol Chem (2009) 0.96
Evidence that pyruvate dehydrogenase kinase belongs to the ATPase/kinase superfamily. Biochem J (1999) 0.96
Molecular structure of a 9-MDa icosahedral pyruvate dehydrogenase subcomplex containing the E2 and E3 enzymes using cryoelectron microscopy. J Biol Chem (2005) 0.96
Reciprocal regulation of protein synthesis and carbon metabolism for thylakoid membrane biogenesis. PLoS Biol (2013) 0.95
Partial purification and characterization of the maize mitochondrial pyruvate dehydrogenase complex Plant Physiol (1998) 0.93
The autoimmunity of primary biliary cirrhosis and the clonal selection theory. Immunol Cell Biol (2010) 0.93
Biosynthesis of lipoic acid in Arabidopsis: cloning and characterization of the cDNA for lipoic acid synthase. Plant Physiol (1998) 0.91
Cloning and characterization of the dihydrolipoamide S-acetyltransferase subunit of the plastid pyruvate dehydrogenase complex (E2) from Arabidopsis. Plant Physiol (1999) 0.89
Gene preference in maple syrup urine disease. Am J Hum Genet (2000) 0.89
Expression, purification, and structural analysis of the trimeric form of the catalytic domain of the Escherichia coli dihydrolipoamide succinyltransferase. Protein Sci (2000) 0.88
Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins. Neurobiol Dis (2009) 0.88
Protein disorder is positively correlated with gene expression in Escherichia coli. J Proteome Res (2008) 0.86
A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain alpha-ketoacid dehydrogenase complex. EMBO J (2006) 0.86
Biotin and Lipoic Acid: Synthesis, Attachment, and Regulation. Ecosal Plus (2014) 0.86
Regulated production of free radicals by the mitochondrial electron transport chain: Cardiac ischemic preconditioning. Adv Drug Deliv Rev (2009) 0.85
Improvement of diffraction quality upon rehydration of dehydrated icosahedral Enterococcus faecalis pyruvate dehydrogenase core crystals. Protein Sci (1997) 0.85
Evidence for a catalytically and kinetically competent enzyme-substrate cross-linked intermediate in catalysis by lipoyl synthase. Biochemistry (2014) 0.85
Knockout studies reveal an important role of Plasmodium lipoic acid protein ligase A1 for asexual blood stage parasite survival. PLoS One (2009) 0.84
Sequences and expression of pyruvate dehydrogenase genes from Pseudomonas aeruginosa. J Bacteriol (1997) 0.84
Lipoylation of the E2 components of the 2-oxo acid dehydrogenase multienzyme complexes of Escherichia coli. Biochem J (1991) 0.84
Structure and function of the catalytic domain of the dihydrolipoyl acetyltransferase component in Escherichia coli pyruvate dehydrogenase complex. J Biol Chem (2014) 0.83
Interchain acetyl transfer in the E2 component of bacterial pyruvate dehydrogenase suggests a model with different roles for each chain in a trimer of the homooligomeric component. Biochemistry (2012) 0.82
Lipoic acid metabolism of Plasmodium--a suitable drug target. Curr Pharm Des (2012) 0.82
Thermodynamic analysis of the binding of component enzymes in the assembly of the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus. Protein Sci (2002) 0.81
Purification of the pyruvate dehydrogenase multienzyme complex of Zymomonas mobilis and identification and sequence analysis of the corresponding genes. J Bacteriol (1998) 0.81
Polymorphism of the yeast pyruvate carboxylase 2 gene and protein: effects on protein biotinylation. Biochem J (1995) 0.81
Pyruvate Dehydrogenase Kinases in the Nervous System: Their Principal Functions in Neuronal-glial Metabolic Interaction and Neuro-metabolic Disorders. Curr Neuropharmacol (2012) 0.80
An update on the role of mitochondrial α-ketoglutarate dehydrogenase in oxidative stress. Mol Cell Neurosci (2012) 0.80
1,3-Dinitrobenzene-induced metabolic impairment through selective inactivation of the pyruvate dehydrogenase complex. Toxicol Sci (2011) 0.80
The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase. Mol Biol Cell (2014) 0.79
Glucocorticoid regulation of branched-chain alpha-ketoacid dehydrogenase E2 subunit gene expression. Biochem J (2000) 0.79
Formation of N-hydroxy-N-arylacetamides from nitroso aromatic compounds by the mammalian pyruvate dehydrogenase complex. Biochem J (1993) 0.79
3D electron microscopy reveals the variable deposition and protein dynamics of the peripheral pyruvate dehydrogenase component about the core. Proc Natl Acad Sci U S A (2003) 0.79
Development of head organizer of the mouse embryo depends on a high level of mitochondrial metabolism. Dev Biol (2010) 0.78
Dissociation and unfolding of the pyruvate dehydrogenase complex by guanidinium chloride. Biochem J (1995) 0.78
Formation of reactive oxygen species by human and bacterial pyruvate and 2-oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components. Free Radic Biol Med (2015) 0.78
The amidase domain of lipoamidase specifically inactivates lipoylated proteins in vivo. PLoS One (2009) 0.77
Sequence-specific assignments of the inner lipoyl domain of human pyruvate dehydrogenase. J Biomol NMR (1997) 0.77
Identification of coding sequences from a freshly prepared Trypanosoma brucei brucei expression library by polymerase chain reaction. Int J Biochem Mol Biol (2013) 0.77
Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis. World J Gastroenterol (2010) 0.76
Interaction of glutaric aciduria type 1-related glutaryl-CoA dehydrogenase with mitochondrial matrix proteins. PLoS One (2014) 0.76
Mutations in the three Arabidopsis genes that encode the E2 subunit of the mitochondrial pyruvate dehydrogenase complex differentially affect enzymatic activity and plant growth. Plant Cell Rep (2015) 0.76
Transport of pyruvate into mitochondria is involved in methylmercury toxicity. Sci Rep (2016) 0.75
The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity. Cancer Metab (2017) 0.75
Amplification of USP13 drives ovarian cancer metabolism. Nat Commun (2016) 0.75
Change of gene expression on protein uptake composition and hindlimb-suspension in rat skeletal muscle. J Exerc Nutrition Biochem (2015) 0.75
Comparison of Metabolic Pathways in Escherichia coli by Using Genetic Algorithms. Comput Struct Biotechnol J (2015) 0.75
Investigating the Influence of MoS2 Nanosheets on E. coli from Metabolomics Level. PLoS One (2016) 0.75
Structural constraints of possible mechanisms of lactate dehydrogenase as shown by high resolution studies of the apoenzyme and a variety of enzyme complexes. Cold Spring Harb Symp Quant Biol (1972) 2.23
Structure-function relationships in lactate dehydrogenase. Proc Natl Acad Sci U S A (1973) 1.87
Crystal structure analysis and refinement at 2.5 A of hexameric C-phycocyanin from the cyanobacterium Agmenellum quadruplicatum. The molecular model and its implications for light-harvesting. J Mol Biol (1986) 1.50
Structure of mammalian ornithine decarboxylase at 1.6 A resolution: stereochemical implications of PLP-dependent amino acid decarboxylases. Structure (1999) 1.31
The structural and functional analysis of the hemoglobin D component from chicken. J Biol Chem (1999) 1.22
Crystallographic structure of a PLP-dependent ornithine decarboxylase from Lactobacillus 30a to 3.0 A resolution. J Mol Biol (1995) 1.18
Letter: Molecular symmetry axes and subunit interfaces in certain dehydrogenases. J Mol Biol (1973) 1.18
Subunit structure of dihydrolipoyl transacetylase component of pyruvate dehydrogenase complex from bovine heart. J Biol Chem (1981) 1.15
Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding. J Mol Biol (2000) 1.15
Crystal structure of 4-oxalocrotonate tautomerase inactivated by 2-oxo-3-pentynoate at 2.4 A resolution: analysis and implications for the mechanism of inactivation and catalysis. Biochemistry (1998) 1.04
A comparison of the structures of apo dogfish M4 lactate dehydrogenase and its ternary complexes. J Mol Biol (1976) 1.03
Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition. Biochemistry (1999) 1.03
Refined structure of the pyruvoyl-dependent histidine decarboxylase from Lactobacillus 30a. J Mol Biol (1993) 1.02
Structural motifs for pyridoxal-5'-phosphate binding in decarboxylases: an analysis based on the crystal structure of the Lactobacillus 30a ornithine decarboxylase. Protein Sci (1995) 1.02
Crystal structure of the truncated cubic core component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex. J Mol Biol (1998) 0.95
Structural analysis of monomeric hemichrome and dimeric cyanomet hemoglobins from Caudina arenicola. J Mol Biol (1995) 0.95
Comparisons of the low-resolution structures of ornithine decarboxylase by electron microscopy and X-ray crystallography: the utility of methylamine tungstate stain and Butvar support film in the study of macromolecules by transmission electron microscopy. J Electron Microsc Tech (1991) 0.94
Crystallization of a dihydrolipoyl transacetylase--dihydrolipoyl dehydrogenase subcomplex and its implications regarding the subunit structure of the pyruvate dehydrogenase complex from Escherichia coli. Biochem Biophys Res Commun (1979) 0.94
Pyruvoyl-dependent histidine decarboxylase. Active site structure and mechanistic analysis. J Biol Chem (1989) 0.94
Mechanism of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor: properties of the P1G, P1A, Y95F, and N97A mutants. Biochemistry (2000) 0.93
Structure determination of histidine decarboxylase from Lactobacillus 30a at 3.0 A resolution. J Mol Biol (1985) 0.89
Expression, purification, and structural analysis of the trimeric form of the catalytic domain of the Escherichia coli dihydrolipoamide succinyltransferase. Protein Sci (2000) 0.88
Crystallization of C-phycocyanin from the marine blue-green alga Agmenellum quadruplicatum. J Mol Biol (1977) 0.87
Crystallization and molecular symmetry of ornithine decarboxylase from Lactobacillus 30a. J Biol Chem (1989) 0.86
Three-dimensional structure of the Gly121Tyr dimeric form of ornithine decarboxylase from Lactobacillus 30a. Acta Crystallogr D Biol Crystallogr (1999) 0.84
Evidence for a multiple random coupling mechanism in the alpha-ketoglutarate dehydrogenase multienzyme complex of Escherichia coli: a computer model analysis. Proc Natl Acad Sci U S A (1983) 0.84
Crystallization of biosynthetic arginine decarboxylase from Escherichia coli. Acta Crystallogr D Biol Crystallogr (1994) 0.83
A computer model analysis of the active-site coupling mechanism in the pyruvate dehydrogenase multienzyme complex of Escherichia coli. Proc Natl Acad Sci U S A (1983) 0.83
Molecular orientation and position of the pig M4 and H4 isoenzymes of lactate dehydrogenase in their crystal cells. J Mol Biol (1973) 0.83
Purification and crystallization of NADP+-specific isocitrate dehydrogenase from Escherichia coli using polyethylene glycol. Biochim Biophys Acta (1977) 0.82
A low-resolution crystallographic study of porcine heart lactate dehydrogenase. J Mol Biol (1975) 0.81
Evolution of cooperativity in hemoglobins: what can invertebrate hemoglobins tell us? J Exp Zool (1998) 0.79
Novel subunit structure observed for noncooperative hemoglobin from Urechis caupo. J Biol Chem (1988) 0.78
Structure determination and refinement of homotetrameric hemoglobin from Urechis caupo at 2.5 A resolution. Acta Crystallogr B (1992) 0.78
The GTP effector site of ornithine decarboxylase from Lactobacillus 30a: kinetic and structural characterization. Biochemistry (1997) 0.77
Three-dimensional structure of a hemichrome hemoglobin from Caudina arenicola. Acta Crystallogr D Biol Crystallogr (1995) 0.76
Crystallization of a mammalian ornithine decarboxylase. Proteins (1996) 0.76
The purification of porcine heart lactate dehydrogenase by affinity chromatography. Biochim Biophys Acta (1974) 0.76
Dipotassium and sodium/potassium crystalline picrate complexes with the crown ether 6,7,9,10,12,13,20,21,23,24,26,27-dodecahydrodibenzo[b,n]-[1,4, 7,10,13,16,19,22]octaoxacyclotetracosin (dibenzo-24-crown-8). Acta Crystallogr B (1991) 0.75
Crystallization and subunit structure of histidine decarboxylase from Lactobacillus 30a. J Biol Chem (1981) 0.75
The quaternary structure of a unique phycobiliprotein: B-phycoerythrin from Porphyridium cruentum. Biochem Biophys Res Commun (1977) 0.75
Preliminary crystallographic data on monomeric and dimeric hemoglobins from the sea cucumber, Molpadia arenicola. J Biol Chem (1979) 0.75
X-ray structure determination of a dimeric hemoglobin from Caudina arenicola. Acta Crystallogr D Biol Crystallogr (1995) 0.75
Structural analysis of Urechis caupo hemoglobin. J Mol Biol (1994) 0.75