Published in J Cell Sci on September 06, 2011
Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking. J Cell Biol (2012) 1.10
Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease. Dis Model Mech (2013) 1.02
Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes. Mol Biol Cell (2013) 0.88
Motor and sensory neuropathy due to myelin infolding and paranodal damage in a transgenic mouse model of Charcot-Marie-Tooth disease type 1C. Hum Mol Genet (2013) 0.86
Protein misfolding and clearance in demyelinating peripheral neuropathies: Therapeutic implications. Commun Integr Biol (2012) 0.84
Loss of Fig4 in both Schwann cells and motor neurons contributes to CMT4J neuropathy. Hum Mol Genet (2014) 0.84
The Charcot Marie Tooth disease protein LITAF is a zinc-binding monotopic membrane protein. Biochem J (2016) 0.82
Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system. Cell Mol Life Sci (2014) 0.82
LITAF mutations associated with Charcot-Marie-Tooth disease 1C show mislocalization from the late endosome/lysosome to the mitochondria. PLoS One (2014) 0.81
Charcot-Marie-Tooth disease and intracellular traffic. Prog Neurobiol (2012) 0.81
Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia. Eur J Immunol (2014) 0.80
Cellular LITAF interacts with frog virus 3 75L protein and alters its subcellular localization. J Virol (2012) 0.78
Parkin Protects Against Misfolded SOD1 Toxicity by Promoting Its Aggresome Formation and Autophagic Clearance. Mol Neurobiol (2015) 0.78
Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS. PLoS Genet (2015) 0.77
PIG7 promotes leukemia cell chemosensitivity via lysosomal membrane permeabilization. Oncotarget (2016) 0.77
The different roles of selective autophagic protein degradation in mammalian cells. Oncotarget (2015) 0.77
Therapeutic implications of protein homeostasis in demyelinating peripheral neuropathies. Expert Rev Neurother (2012) 0.77
The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C. BMC Biol (2016) 0.75
SIMPLE: A new regulator of endosomal trafficking and signaling in health and disease. Commun Integr Biol (2013) 0.75
Negative regulation of Bmi-1 by AMPK and implication in cancer progression. Oncotarget (2016) 0.75
Autophagy as an Emerging Common Pathomechanism in Inherited Peripheral Neuropathies. Front Mol Neurosci (2017) 0.75
Charcot-Marie-Tooth disease type 1C: Clinical and electrophysiological findings for the c.334G>a (p.Gly112Ser) LITAF/SIMPLE mutation. Muscle Nerve (2017) 0.75
Improved prediction of signal peptides: SignalP 3.0. J Mol Biol (2004) 48.40
The HMMTOP transmembrane topology prediction server. Bioinformatics (2001) 12.57
SOSUI: classification and secondary structure prediction system for membrane proteins. Bioinformatics (1998) 11.91
The PredictProtein server. Nucleic Acids Res (2004) 10.89
Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol (2000) 9.40
Recognition of transmembrane helices by the endoplasmic reticulum translocon. Nature (2005) 7.72
Proteasomes and their kin: proteases in the machine age. Nat Rev Mol Cell Biol (2004) 5.14
Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases. Nat Cell Biol (2004) 4.63
Central pore residues mediate the p97/VCP activity required for ERAD. Mol Cell (2006) 4.56
Membrane insertion of a potassium-channel voltage sensor. Science (2005) 3.30
Opinion: What is the role of protein aggregation in neurodegeneration? Nat Rev Mol Cell Biol (2005) 3.18
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J Cell Biol (2007) 3.13
Prediction of potential GPI-modification sites in proprotein sequences. J Mol Biol (1999) 2.95
Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP. EMBO J (1994) 2.93
Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein. Hum Mol Genet (2003) 2.89
Overview of macroautophagy regulation in mammalian cells. Cell Res (2010) 2.68
How tails guide tail-anchored proteins to their destinations. Curr Opin Cell Biol (2007) 2.60
SNARE proteins are highly enriched in lipid rafts in PC12 cells: implications for the spatial control of exocytosis. Proc Natl Acad Sci U S A (2001) 2.48
Emerging role for autophagy in the removal of aggresomes in Schwann cells. J Neurosci (2003) 2.21
Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function. J Biol Chem (2003) 2.21
Thylakoid DeltapH-dependent precursor proteins bind to a cpTatC-Hcf106 complex before Tha4-dependent transport. J Cell Biol (2001) 2.17
Cytoplasmic dynein/dynactin mediates the assembly of aggresomes. Cell Motil Cytoskeleton (2002) 2.11
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas. Blood (2006) 2.10
Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice. J Neurosci (2010) 1.92
Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor. J Biol Chem (2000) 1.91
Mutation of a putative protein degradation gene LITAF/SIMPLE in Charcot-Marie-Tooth disease 1C. Neurology (2003) 1.74
Pathological consequences of VCP mutations on human striated muscle. Brain (2006) 1.68
Aggresome formation and neurodegenerative diseases: therapeutic implications. Curr Med Chem (2008) 1.68
Update on Charcot-Marie-Tooth disease. Curr Neurol Neurosci Rep (2011) 1.66
PMP22 accumulation in aggresomes: implications for CMT1A pathology. Neurobiol Dis (1999) 1.65
Targeting pathways of C-tail-anchored proteins. Biochim Biophys Acta (2010) 1.64
A pathway for cell wall anchorage of Saccharomyces cerevisiae alpha-agglutinin. Mol Cell Biol (1994) 1.61
Proteasome inhibition with bortezomib (PS-341): a phase I study with pharmacodynamic end points using a day 1 and day 4 schedule in a 14-day cycle. J Clin Oncol (2005) 1.50
Accumulation of peripheral myelin protein 22 in onion bulbs and Schwann cells of biopsied nerves from patients with Charcot-Marie-Tooth disease type 1A. Acta Neuropathol (1996) 1.46
SNIP, a novel SNAP-25-interacting protein implicated in regulated exocytosis. J Biol Chem (2000) 1.45
SIMPLE mutation analysis in dominant demyelinating Charcot-Marie-Tooth disease: three novel mutations. J Peripher Nerv Syst (2006) 1.38
Parkin-mediated ubiquitin signalling in aggresome formation and autophagy. Biochem Soc Trans (2010) 1.31
Quality control against misfolded proteins in the cytosol: a network for cell survival. J Biochem (2009) 1.31
Missense mutations in the SH3TC2 protein causing Charcot-Marie-Tooth disease type 4C affect its localization in the plasma membrane and endocytic pathway. Hum Mol Genet (2009) 1.29
Mistargeting of SH3TC2 away from the recycling endosome causes Charcot-Marie-Tooth disease type 4C. Hum Mol Genet (2009) 1.29
Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking. J Biol Chem (2002) 1.27
Dystonia-associated mutations cause premature degradation of torsinA protein and cell-type-specific mislocalization to the nuclear envelope. Hum Mol Genet (2008) 1.25
Alterations in degradative pathways and protein aggregation in a neuropathy model based on PMP22 overexpression. Neurobiol Dis (2005) 1.20
SNAP-23 and SNAP-25 are palmitoylated in vivo. Biochem Biophys Res Commun (1999) 1.19
SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation. Hum Mutat (2005) 1.18
The delivery of endocytosed cargo to lysosomes. Biochem Soc Trans (2009) 1.17
Receptor and membrane recycling can occur with unaltered efficiency despite dramatic Rab5(q79l)-induced changes in endosome geometry. J Biol Chem (2001) 1.16
SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease. J Neurosci Res (2005) 1.16
Aggresome formation in neuropathy models based on peripheral myelin protein 22 mutations. Neurobiol Dis (2002) 1.15
Protein lipid modifications in signaling and subcellular targeting. Curr Opin Plant Biol (2009) 1.11
Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes. Glia (2010) 1.09
Impaired intracellular trafficking is a common disease mechanism of PMP22 point mutations in peripheral neuropathies. Neurobiol Dis (1999) 1.08
Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage. Hum Mol Genet (2010) 1.08
GRIF1 binds Hrs and is a new regulator of endosomal trafficking. J Cell Sci (2006) 1.07
Impaired proteasome activity and accumulation of ubiquitinated substrates in a hereditary neuropathy model. J Neurochem (2005) 1.07
Transport of Trembler-J mutant peripheral myelin protein 22 is blocked in the intermediate compartment and affects the transport of the wild-type protein by direct interaction. J Neurosci (1999) 1.04
SIMPLE mutation in demyelinating neuropathy and distribution in sciatic nerve. Ann Neurol (2004) 1.03
Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis. J Biol Chem (2001) 1.02
Hereditary motor and sensory neuropathy caused by a novel mutation in LITAF. Neuromuscul Disord (2009) 1.01
Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking. J Mol Biol (2008) 0.99
Human and rat adult Schwann cell cultures: fast and efficient enrichment and highly effective non-viral transfection protocol. Nat Protoc (2007) 0.99
A new method of selecting Schwann cells from adult mouse sciatic nerve. J Neurosci Methods (2005) 0.96
Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis. J Biol Chem (2009) 0.96
Role of PSD95 in membrane association and catalytic activity of nNOSalpha in nitrergic varicosities in mice gut. Am J Physiol Gastrointest Liver Physiol (2009) 0.91
Phenotypic differences between peripheral myelin protein-22 (PMP22) and myelin protein zero (P0) mutations associated with Charcot-Marie-Tooth-related diseases. J Neuropathol Exp Neurol (2003) 0.91
Comparison of the glycosyl-phosphatidylinositol cleavage/attachment site between mammalian cells and parasitic protozoa. J Cell Sci (2000) 0.91
Molecular cloning and characterization of mouse LITAF cDNA: role in the regulation of tumor necrosis factor-alpha (TNF-alpha) gene expression. J Endotoxin Res (2004) 0.90
A conditional mutation affecting localization of the Menkes disease copper ATPase. Suppression by copper supplementation. J Biol Chem (2002) 0.89
The peripheral neuropathy-linked Trembler and Trembler-J mutant forms of peripheral myelin protein 22 are folding-destabilized. Biochemistry (2008) 0.89
S-100 protein and laminin: immunocytochemical markers for human Schwann cells in vitro. Exp Neurol (1986) 0.88
Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment. Oncogene (2010) 0.87
Clinical features and molecular modelling of novel MPZ mutations in demyelinating and axonal neuropathies. Eur J Hum Genet (2009) 0.86
Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma). Biochim Biophys Acta (2009) 0.84
Rat sperm 2B1 glycoprotein (PH20) contains a C-terminal sequence motif for attachment of a glycosyl phosphatidylinositol anchor. Effects of endoproteolytic cleavage on hyaluronidase activity. Biol Reprod (2000) 0.82
GGAing ubiquitin to the endosome. Nat Cell Biol (2004) 0.82
Expression of pig7 gene in acute leukemia and its potential to modulate the chemosensitivity of leukemic cells. Leuk Res (2009) 0.80
A high-dose bortezomib neuropathy with sensory ataxia and myelin involvement. J Neurol Sci (2007) 0.78
Effects of capping on the non-ionic detergent solubility of rat thymocyte glycoproteins. Eur J Cell Biol (1989) 0.77
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol (2007) 3.86
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J Cell Biol (2007) 3.13
Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J Biol Chem (2006) 2.50
Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. J Biol Chem (2004) 2.46
Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation. J Neurosci (2007) 2.44
Defining human ERAD networks through an integrative mapping strategy. Nat Cell Biol (2011) 2.28
Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function. J Biol Chem (2003) 2.21
Patlak plots of Gd-DTPA MRI data yield blood-brain transfer constants concordant with those of 14C-sucrose in areas of blood-brain opening. Magn Reson Med (2003) 2.20
High glucose-induced oxidative stress and mitochondrial dysfunction in neurons. FASEB J (2002) 2.18
Safety and prolonged activity of recombinant factor VIII Fc fusion protein in hemophilia A patients. Blood (2012) 2.17
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. Hum Mol Genet (2009) 2.10
Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking. Mol Biol Cell (2007) 1.75
Regulation of synaptophysin degradation by mammalian homologues of seven in absentia. J Biol Chem (2002) 1.74
Crystal structure of DJ-1/RS and implication on familial Parkinson's disease. FEBS Lett (2003) 1.73
MRI detects white matter reorganization after neural progenitor cell treatment of stroke. Neuroimage (2006) 1.69
Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum. Nat Struct Mol Biol (2011) 1.64
A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study. Breast Cancer Res (2012) 1.62
Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation. J Biol Chem (2002) 1.54
Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients. Int J Cancer (2009) 1.53
Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway. Autophagy (2007) 1.50
Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter. Mol Cell Biol (2008) 1.48
Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients. Blood (2011) 1.43
Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases. J Biol Chem (2005) 1.42
Investigation of neural progenitor cell induced angiogenesis after embolic stroke in rat using MRI. Neuroimage (2005) 1.41
A meta-analysis of evidences on XPC polymorphisms and lung cancer susceptibility. Tumour Biol (2013) 1.41
Superior effect of hypertonic saline over mannitol to attenuate cerebral edema in a rabbit bacterial meningitis model. Crit Care Med (2011) 1.40
Design of superior spider silk: from nanostructure to mechanical properties. Biophys J (2006) 1.38
Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death. Hum Mol Genet (2007) 1.33
Parkin-mediated ubiquitin signalling in aggresome formation and autophagy. Biochem Soc Trans (2010) 1.31
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc Natl Acad Sci U S A (2010) 1.30
Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment. Neoplasia (2009) 1.27
Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking. J Biol Chem (2002) 1.27
Multitargeted effects of statin-enhanced thrombolytic therapy for stroke with recombinant human tissue-type plasminogen activator in the rat. Circulation (2005) 1.26
Dystonia-associated mutations cause premature degradation of torsinA protein and cell-type-specific mislocalization to the nuclear envelope. Hum Mol Genet (2008) 1.25
Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats. J Cereb Blood Flow Metab (2008) 1.24
Angiogenesis detected after embolic stroke in rat brain using magnetic resonance T2*WI. Stroke (2008) 1.21
Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death. Diabetes (2004) 1.19
Integrin-linked kinase, a hypoxia-responsive molecule, controls postnatal vasculogenesis by recruitment of endothelial progenitor cells to ischemic tissue. Circulation (2006) 1.18
Tumor-activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients. J Immunol (2010) 1.16
Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor. Proc Natl Acad Sci U S A (2010) 1.13
Cloning of a novel pyrethroid-hydrolyzing carboxylesterase gene from Sphingobium sp. strain JZ-1 and characterization of the gene product. Appl Environ Microbiol (2009) 1.11
Corneal dystrophy-associated R124H mutation disrupts TGFBI interaction with Periostin and causes mislocalization to the lysosome. J Biol Chem (2009) 1.10
Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking. J Cell Biol (2012) 1.10
Quantitative evaluation of BBB permeability after embolic stroke in rat using MRI. J Cereb Blood Flow Metab (2005) 1.09
Integrated microRNA network analyses identify a poor-prognosis subtype of gastric cancer characterized by the miR-200 family. Clin Cancer Res (2013) 1.08
Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage. Hum Mol Genet (2010) 1.08
MRI evaluation of axonal reorganization after bone marrow stromal cell treatment of traumatic brain injury. NMR Biomed (2011) 1.08
Analysis of combined treatment of embolic stroke in rat with r-tPA and a GPIIb/IIIa inhibitor. J Cereb Blood Flow Metab (2005) 1.07
Nitric oxide-dependent proteasomal degradation of cytochrome P450 2B proteins. J Biol Chem (2007) 1.07
GRIF1 binds Hrs and is a new regulator of endosomal trafficking. J Cell Sci (2006) 1.07
Common genetic polymorphisms of microRNA biogenesis pathway genes and risk of breast cancer: a case-control study in Korea. Breast Cancer Res Treat (2011) 1.03
Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate. Mol Biol Cell (2012) 1.03
Tim-3 expression defines regulatory T cells in human tumors. PLoS One (2013) 1.02
Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking. J Mol Biol (2008) 0.99
Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. J Comp Neurol (2007) 0.99
Impact of myocardial infarct proteins and oscillating pressure on the differentiation of mesenchymal stem cells: effect of acute myocardial infarction on stem cell differentiation. Stem Cells (2008) 0.99
HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells. PLoS One (2008) 0.98
An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment. J Biol Chem (2007) 0.97
Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis. J Biol Chem (2009) 0.96
Mast cells expressing interleukin 17 in the muscularis propria predict a favorable prognosis in esophageal squamous cell carcinoma. Cancer Immunol Immunother (2013) 0.94
Ubiquitin C-terminal hydrolase l1 in tumorigenesis. Biochem Res Int (2012) 0.93
Interleukin-6 inhibits regulatory T cells and improves the proliferation and cytotoxic activity of cytokine-induced killer cells. J Immunother (2012) 0.93
Detection of BBB disruption and hemorrhage by Gd-DTPA enhanced MRI after embolic stroke in rat. Brain Res (2006) 0.93
Cerebral tissue repair and atrophy after embolic stroke in rat: a magnetic resonance imaging study of erythropoietin therapy. J Neurosci Res (2010) 0.93
Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. J Biol Chem (2009) 0.92
An alternate targeting pathway for procathepsin L in mouse fibroblasts. Traffic (2002) 0.91
Association of intra-tumoral infiltrating macrophages and regulatory T cells is an independent prognostic factor in gastric cancer after radical resection. Ann Surg Oncol (2011) 0.91
Validation of self-reported cancer incidence at follow-up in a prospective cohort study. Ann Epidemiol (2009) 0.91
Longitudinal magnetic resonance imaging of sildenafil treatment of embolic stroke in aged rats. Stroke (2011) 0.90
5-Aza-2'-deoxycytidine reactivates gene expression via degradation of pRb pocket proteins. FASEB J (2011) 0.90
SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells. Biochim Biophys Acta (2009) 0.89
Early prediction of gross hemorrhagic transformation by noncontrast agent MRI cluster analysis after embolic stroke in rat. Stroke (2005) 0.88
Association between the XRCC3 T241M polymorphism and head and neck cancer susceptibility: a meta-analysis of case-control studies. Asian Pac J Cancer Prev (2012) 0.87
The ubiquitin-proteasome system in spongiform degenerative disorders. Biochim Biophys Acta (2008) 0.86