Published in J Biol Chem on January 10, 2002
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J Cell Biol (2007) 3.13
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. Hum Mol Genet (2009) 2.10
Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking. Mol Biol Cell (2007) 1.75
SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Cell (2007) 1.60
A binding motif for Siah ubiquitin ligase. Proc Natl Acad Sci U S A (2003) 1.43
Rapid Ca2+-dependent decrease of protein ubiquitination at synapses. Proc Natl Acad Sci U S A (2003) 1.41
The ubiquitin ligase Siah2 and the hypoxia response. Mol Cancer Res (2009) 1.29
Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease. Proc Natl Acad Sci U S A (2004) 1.29
Ubiquitin homeostasis is critical for synaptic development and function. J Neurosci (2011) 1.26
Dystonia-associated mutations cause premature degradation of torsinA protein and cell-type-specific mislocalization to the nuclear envelope. Hum Mol Genet (2008) 1.25
Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina. Diabetes (2008) 1.19
Roles of ubiquitination at the synapse. Biochim Biophys Acta (2008) 1.19
The basis for selective E1-E2 interactions in the ISG15 conjugation system. J Biol Chem (2008) 1.17
Proteasome inhibition triggers activity-dependent increase in the size of the recycling vesicle pool in cultured hippocampal neurons. J Neurosci (2006) 1.15
Generation and analysis of Siah2 mutant mice. Mol Cell Biol (2003) 1.15
Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter. Proc Natl Acad Sci U S A (2004) 1.10
Seven in absentia homolog 1A mediates ubiquitination and degradation of group 1 metabotropic glutamate receptors. Proc Natl Acad Sci U S A (2004) 1.09
Fbxo45, a novel ubiquitin ligase, regulates synaptic activity. J Biol Chem (2009) 1.08
Synaptic vesicle protein trafficking at the glutamate synapse. Neuroscience (2008) 1.06
Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation. EMBO J (2013) 1.03
The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription. Mol Cell (2012) 1.03
The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases. Bioessays (2008) 1.01
Neuroprotective effects of lutein in the retina. Curr Pharm Des (2012) 1.01
The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration. Mol Neurodegener (2013) 1.01
Normal p53 function in primary cells deficient for Siah genes. Mol Cell Biol (2002) 0.99
Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14. Am J Physiol Cell Physiol (2011) 0.98
Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease. Free Radic Res (2010) 0.93
Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation. J Biol Chem (2009) 0.93
Molecular pathology of Lewy body diseases. Int J Mol Sci (2009) 0.93
Presynaptic silencing is an endogenous neuroprotectant during excitotoxic insults. Neurobiol Dis (2011) 0.92
Netrin induces down-regulation of its receptor, Deleted in Colorectal Cancer, through the ubiquitin-proteasome pathway in the embryonic cortical neuron. J Neurochem (2005) 0.92
Synaptic proteins are tonotopically graded in postnatal and adult type I and type II spiral ganglion neurons. J Comp Neurol (2011) 0.91
SIAH-1 interacts with the Kaposi's sarcoma-associated herpesvirus-encoded ORF45 protein and promotes its ubiquitylation and proteasomal degradation. J Virol (2007) 0.91
Coupled local translation and degradation regulate growth cone collapse. Nat Commun (2015) 0.90
Mediation of Af4 protein function in the cerebellum by Siah proteins. Proc Natl Acad Sci U S A (2004) 0.90
Seven in absentia proteins affect plant growth and nodulation in Medicago truncatula. Plant Physiol (2008) 0.90
Herpes simplex virus immediate-early protein ICP0 is targeted by SIAH-1 for proteasomal degradation. J Virol (2011) 0.88
MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens. PLoS One (2013) 0.86
A novel role for the immunoproteasome in retinal function. Invest Ophthalmol Vis Sci (2011) 0.83
Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons. PLoS One (2013) 0.83
PKC phosphorylation regulates mGluR5 trafficking by enhancing binding of Siah-1A. J Neurosci (2012) 0.82
Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system. Cell Mol Life Sci (2014) 0.82
Synaptojanin 1 is required for endolysosomal trafficking of synaptic proteins in cone photoreceptor inner segments. PLoS One (2014) 0.81
Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes. FEBS J (2009) 0.80
Regulation of synaptic activity by snapin-mediated endolysosomal transport and sorting. EMBO J (2015) 0.80
Distinct expression patterns of the E3 ligase SIAH-1 and its partner Kid/KIF22 in normal tissues and in the breast tumoral processes. J Exp Clin Cancer Res (2010) 0.80
Bassoon and piccolo regulate ubiquitination and link presynaptic molecular dynamics with activity-regulated gene expression. J Physiol (2016) 0.79
Membrane proteome analysis of cerulein-stimulated pancreatic acinar cells: implication for early event of acute pancreatitis. Gut Liver (2010) 0.78
E3 ubiquitin ligase Siah-1 downregulates synaptophysin expression under high glucose and hypoxia. Am J Transl Res (2015) 0.78
Subcellular localization of PMES-2 proteins regulated by their two cytoskeleton-associated domains. Cell Mol Neurobiol (2005) 0.78
Parkin Protects Against Misfolded SOD1 Toxicity by Promoting Its Aggresome Formation and Autophagic Clearance. Mol Neurobiol (2015) 0.78
Inhibition of synaptophysin ubiquitination may improve the intelligent drop due to high glucose and hypoxia. Int J Clin Exp Med (2014) 0.76
Proteomic study of retinal proteins associated with transcorneal electric stimulation in rats. J Ophthalmol (2015) 0.76
Organ of Corti explants direct tonotopically graded morphology of spiral ganglion neurons in vitro. J Comp Neurol (2015) 0.75
Splicing variants of porcine synphilin-1. Meta Gene (2015) 0.75
The iTRAPs: Guardians of Synaptic Vesicle Cargo Retrieval During Endocytosis. Front Synaptic Neurosci (2016) 0.75
The effects of proteasomal inhibition on synaptic proteostasis. EMBO J (2016) 0.75
Involvement of seven in absentia homolog-1 in ethanol-induced apoptosis in neural crest cells. Neurotoxicol Teratol (2014) 0.75
Recent insights on principles of synaptic protein degradation. F1000Res (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat Cell Biol (2003) 6.34
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol (2007) 3.86
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J Cell Biol (2005) 3.14
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J Cell Biol (2007) 3.13
Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J Biol Chem (2006) 2.50
Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. J Biol Chem (2004) 2.46
Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation. J Neurosci (2007) 2.44
Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function. J Biol Chem (2003) 2.21
Patlak plots of Gd-DTPA MRI data yield blood-brain transfer constants concordant with those of 14C-sucrose in areas of blood-brain opening. Magn Reson Med (2003) 2.20
Safety and prolonged activity of recombinant factor VIII Fc fusion protein in hemophilia A patients. Blood (2012) 2.17
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. Hum Mol Genet (2009) 2.10
Sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent macrophages. J Biol Chem (2006) 1.80
Brief report: increased apoptosis in advanced atherosclerotic lesions of Apoe-/- mice lacking macrophage Bcl-2. Arterioscler Thromb Vasc Biol (2008) 1.79
Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking. Mol Biol Cell (2007) 1.75
Crystal structure of DJ-1/RS and implication on familial Parkinson's disease. FEBS Lett (2003) 1.73
MRI detects white matter reorganization after neural progenitor cell treatment of stroke. Neuroimage (2006) 1.69
A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study. Breast Cancer Res (2012) 1.62
Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation. J Biol Chem (2002) 1.54
Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients. Int J Cancer (2009) 1.53
Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway. Autophagy (2007) 1.50
Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter. Mol Cell Biol (2008) 1.48
Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients. Blood (2011) 1.43
Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases. J Biol Chem (2005) 1.42
A meta-analysis of evidences on XPC polymorphisms and lung cancer susceptibility. Tumour Biol (2013) 1.41
Investigation of neural progenitor cell induced angiogenesis after embolic stroke in rat using MRI. Neuroimage (2005) 1.41
Superior effect of hypertonic saline over mannitol to attenuate cerebral edema in a rabbit bacterial meningitis model. Crit Care Med (2011) 1.40
Design of superior spider silk: from nanostructure to mechanical properties. Biophys J (2006) 1.38
Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death. Hum Mol Genet (2007) 1.33
Pivotal advance: macrophages become resistant to cholesterol-induced death after phagocytosis of apoptotic cells. J Leukoc Biol (2007) 1.33
Parkin-mediated ubiquitin signalling in aggresome formation and autophagy. Biochem Soc Trans (2010) 1.31
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc Natl Acad Sci U S A (2010) 1.30
Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment. Neoplasia (2009) 1.27
Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking. J Biol Chem (2002) 1.27
Multitargeted effects of statin-enhanced thrombolytic therapy for stroke with recombinant human tissue-type plasminogen activator in the rat. Circulation (2005) 1.26
Dystonia-associated mutations cause premature degradation of torsinA protein and cell-type-specific mislocalization to the nuclear envelope. Hum Mol Genet (2008) 1.25
Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats. J Cereb Blood Flow Metab (2008) 1.24
Angiogenesis detected after embolic stroke in rat brain using magnetic resonance T2*WI. Stroke (2008) 1.21
Integrin-linked kinase, a hypoxia-responsive molecule, controls postnatal vasculogenesis by recruitment of endothelial progenitor cells to ischemic tissue. Circulation (2006) 1.18
Tumor-activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients. J Immunol (2010) 1.16
TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells. Proc Natl Acad Sci U S A (2006) 1.16
Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages. Arterioscler Thromb Vasc Biol (2006) 1.14
Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor. Proc Natl Acad Sci U S A (2010) 1.13
Cloning of a novel pyrethroid-hydrolyzing carboxylesterase gene from Sphingobium sp. strain JZ-1 and characterization of the gene product. Appl Environ Microbiol (2009) 1.11
Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2. J Biol Chem (2007) 1.10
Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking. J Cell Biol (2012) 1.10
Quantitative evaluation of BBB permeability after embolic stroke in rat using MRI. J Cereb Blood Flow Metab (2005) 1.09
Integrated microRNA network analyses identify a poor-prognosis subtype of gastric cancer characterized by the miR-200 family. Clin Cancer Res (2013) 1.08
Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage. Hum Mol Genet (2010) 1.08
MRI evaluation of axonal reorganization after bone marrow stromal cell treatment of traumatic brain injury. NMR Biomed (2011) 1.08
GRIF1 binds Hrs and is a new regulator of endosomal trafficking. J Cell Sci (2006) 1.07
Analysis of combined treatment of embolic stroke in rat with r-tPA and a GPIIb/IIIa inhibitor. J Cereb Blood Flow Metab (2005) 1.07
Nitric oxide-dependent proteasomal degradation of cytochrome P450 2B proteins. J Biol Chem (2007) 1.07
Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways. J Cell Sci (2011) 1.04
Common genetic polymorphisms of microRNA biogenesis pathway genes and risk of breast cancer: a case-control study in Korea. Breast Cancer Res Treat (2011) 1.03
Tim-3 expression defines regulatory T cells in human tumors. PLoS One (2013) 1.02
Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking. J Mol Biol (2008) 0.99
Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. J Comp Neurol (2007) 0.99
Impact of myocardial infarct proteins and oscillating pressure on the differentiation of mesenchymal stem cells: effect of acute myocardial infarction on stem cell differentiation. Stem Cells (2008) 0.99
HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells. PLoS One (2008) 0.98
An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment. J Biol Chem (2007) 0.97
Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis. J Biol Chem (2009) 0.96
Mast cells expressing interleukin 17 in the muscularis propria predict a favorable prognosis in esophageal squamous cell carcinoma. Cancer Immunol Immunother (2013) 0.94
Ubiquitin C-terminal hydrolase l1 in tumorigenesis. Biochem Res Int (2012) 0.93
Interleukin-6 inhibits regulatory T cells and improves the proliferation and cytotoxic activity of cytokine-induced killer cells. J Immunother (2012) 0.93
Cerebral tissue repair and atrophy after embolic stroke in rat: a magnetic resonance imaging study of erythropoietin therapy. J Neurosci Res (2010) 0.93
Detection of BBB disruption and hemorrhage by Gd-DTPA enhanced MRI after embolic stroke in rat. Brain Res (2006) 0.93
Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. J Biol Chem (2009) 0.92
Association of intra-tumoral infiltrating macrophages and regulatory T cells is an independent prognostic factor in gastric cancer after radical resection. Ann Surg Oncol (2011) 0.91
An alternate targeting pathway for procathepsin L in mouse fibroblasts. Traffic (2002) 0.91
Validation of self-reported cancer incidence at follow-up in a prospective cohort study. Ann Epidemiol (2009) 0.91
Longitudinal magnetic resonance imaging of sildenafil treatment of embolic stroke in aged rats. Stroke (2011) 0.90
5-Aza-2'-deoxycytidine reactivates gene expression via degradation of pRb pocket proteins. FASEB J (2011) 0.90
Early prediction of gross hemorrhagic transformation by noncontrast agent MRI cluster analysis after embolic stroke in rat. Stroke (2005) 0.88
Association between the XRCC3 T241M polymorphism and head and neck cancer susceptibility: a meta-analysis of case-control studies. Asian Pac J Cancer Prev (2012) 0.87
Motor and sensory neuropathy due to myelin infolding and paranodal damage in a transgenic mouse model of Charcot-Marie-Tooth disease type 1C. Hum Mol Genet (2013) 0.86
The ubiquitin-proteasome system in spongiform degenerative disorders. Biochim Biophys Acta (2008) 0.86