Effect of efonidipine on TGF-β1-induced cardiac fibrosis through Smad2-dependent pathway in rat cardiac fibroblasts.

PubWeight™: 0.91‹?›

🔗 View Article (PMC 3230079)

Published in J Pharmacol Sci on September 07, 2011

Authors

Bai Lei1, Hirofumi Hitomi, Tatsuhiko Mori, Yukiko Nagai, Kazushi Deguchi, Hirohito Mori, Tsutomu Masaki, Daisuke Nakano, Hiroyuki Kobori, Yasushi Kitaura, Akira Nishiyama

Author Affiliations

1: Department of Pharmacology, Faculty of Medicine, Kagawa University, Japan.

Articles cited by this

Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature (2003) 20.48

Non-Smad TGF-beta signals. J Cell Sci (2005) 6.06

Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. Nature (1998) 3.77

Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family. Circ Res (1998) 2.49

Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest (2009) 2.46

Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family. J Neurosci (1999) 2.30

Reexpression of T-type Ca2+ channel gene and current in post-infarction remodeled rat left ventricle. Cardiovasc Res (2000) 1.72

T-type Ca2+ current is expressed in hypertrophied adult feline left ventricular myocytes. Circ Res (1993) 1.47

Gene expression pattern in biomechanically stretched cardiomyocytes: evidence for a stretch-specific gene program. Hypertension (2007) 1.38

Differential effects of transforming growth factor-beta 1 and phorbol myristate acetate on cardiac fibroblasts. Regulation of fibrillar collagen mRNAs and expression of early transcription factors. Circ Res (1991) 1.36

Expression of T-type Ca(2+) channels in ventricular cells from hypertrophied rat hearts. J Mol Cell Cardiol (1999) 1.32

Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart. Circ Res (2001) 1.28

T-type Ca2+ channel blockade prevents sudden death in mice with heart failure. Circulation (2009) 1.09

Cav3.2 subunit underlies the functional T-type Ca2+ channel in murine hearts during the embryonic period. Am J Physiol Heart Circ Physiol (2004) 1.08

TGF-beta1 calcium signaling in osteoblasts. J Cell Biochem (2007) 1.06

Pathophysiological significance of T-type Ca2+ channels: expression of T-type Ca2+ channels in fetal and diseased heart. J Pharmacol Sci (2005) 1.04

Transforming growth factor-beta 1 suppresses serum deprivation-induced death of A549 cells through differential effects on c-Jun and JNK activities. J Biol Chem (2000) 1.02

Transforming growth factor-beta1 up-regulation of human alpha(1)(I) collagen is mediated by Sp1 and Smad2 transacting factors. DNA Cell Biol (2009) 1.02

Angiotensin II increases collagen I expression via transforming growth factor-beta1 and extracellular signal-regulated kinase in cardiac fibroblasts. Eur J Pharmacol (2009) 0.99

Hypoxia regulates basal and induced DNA synthesis and collagen type I production in human cardiac fibroblasts: effects of transforming growth factor-beta1, thyroid hormone, angiotensin II and basic fibroblast growth factor. J Mol Cell Cardiol (1997) 0.97

Pathophysiological significance of T-type Ca2+ channels: role of T-type Ca2+ channels in renal microcirculation. J Pharmacol Sci (2005) 0.95

Association between transforming growth factor-beta(1) and left ventricular mass and diameter in hypertensive patients. J Am Soc Hypertens (2010) 0.94

Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability. Hypertension (2005) 0.93

Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts. Hypertension (2002) 0.91

Functional and molecular characterization of a T-type Ca(2+) channel during fetal and postnatal rat heart development. J Mol Cell Cardiol (2002) 0.91

Calcium channel diversity in the cardiovascular system. J Am Coll Cardiol (1996) 0.91

Low-threshold current is major calcium current in chick ventricle cells. Am J Physiol (1989) 0.90

Interferon-gamma enhances superoxide production in human mesangial cells via the JAK-STAT pathway. Kidney Int (2006) 0.90

Identification of R(-)-isomer of efonidipine as a selective blocker of T-type Ca2+ channels. Br J Pharmacol (2004) 0.88

Heterotrimeric G protein G alpha13-induced induction of cytokine mRNAs through two distinct pathways in cardiac fibroblasts. J Pharmacol Sci (2006) 0.87

Comparison of the effects of efonidipine and amlodipine on aldosterone in patients with hypertension. Hypertens Res (2007) 0.87

Regulation of proliferative response of cardiac fibroblasts by transforming growth factor-beta 1. J Mol Cell Cardiol (1996) 0.84

Cross talk among Smad, MAPK, and integrin signaling pathways enhances adventitial fibroblast functions activated by transforming growth factor-beta1 and inhibited by Gax. Arterioscler Thromb Vasc Biol (2008) 0.84

Pathophysiological significance of T-type Ca2+ channels: T-type Ca2+ channels and drug development. J Pharmacol Sci (2005) 0.83

Inhibitory effects of T/L-type calcium channel blockers on tubulointerstitial fibrosis in obstructed kidneys in rats. Urology (2010) 0.82

Long-term effect of efonidipine therapy on plasma aldosterone and left ventricular mass index in patients with essential hypertension. Hypertens Res (2009) 0.82

Effects of efonidipine hydrochloride on heart rate and circulatory changes due to stress. Clin Exp Hypertens (2009) 0.81

Beneficial effects of the dual L- and T-type Ca2+ channel blocker efonidipine on cardiomyopathic hamsters. Circ J (2007) 0.79

Articles by these authors

The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev (2007) 6.79

Regulation of intrarenal angiotensin II in hypertension. Hypertension (2002) 3.34

Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription. Mol Biol Cell (2009) 3.29

Urinary angiotensinogen as an indicator of intrarenal Angiotensin status in hypertension. Hypertension (2003) 2.99

Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension (2006) 2.89

Role of NAD(P)H oxidase- and mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II. Hypertension (2005) 2.67

Liver angiotensinogen is the primary source of renal angiotensin II. J Am Soc Nephrol (2012) 2.58

Enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats. Hypertension (2004) 2.54

Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature (2010) 2.46

The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase. J Biol Chem (2008) 2.40

Enhanced intrarenal angiotensinogen contributes to early renal injury in spontaneously hypertensive rats. J Am Soc Nephrol (2005) 2.30

Temporary angiotensin II blockade at the prediabetic stage attenuates the development of renal injury in type 2 diabetic rats. J Am Soc Nephrol (2005) 2.25

Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin. J Clin Invest (2004) 2.24

Bloc biopsy by using submucosal endoscopy with a mucosal flap method for gastric subepithelial tumor tissue sampling (with video). Gastrointest Endosc (2012) 2.15

Intrarenal angiotensin II and angiotensinogen augmentation in chronic angiotensin II-infused mice. Am J Physiol Renal Physiol (2008) 2.15

Intratubular renin-angiotensin system in hypertension. Hypertension (2011) 2.14

Comparison of central blood pressure and cardio-ankle vascular index for association with cardiac function in treated hypertensive patients. Hypertens Res (2009) 2.07

Oxidative stress and diabetic cardiovascular complications. Free Radic Biol Med (2005) 2.05

Regression of nephropathy developed in diabetes by (Pro)renin receptor blockade. J Am Soc Nephrol (2007) 2.04

Collecting duct renin is upregulated in both kidneys of 2-kidney, 1-clip goldblatt hypertensive rats. Hypertension (2008) 2.01

Novel sandwich ELISA for human angiotensinogen. Am J Physiol Renal Physiol (2007) 1.99

Enhancement of intrarenal angiotensinogen in Dahl salt-sensitive rats on high salt diet. Hypertension (2003) 1.89

Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats. J Am Soc Nephrol (2007) 1.87

AT1 receptor-mediated enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats. Am J Physiol Renal Physiol (2005) 1.84

Sustained renal interstitial macrophage infiltration following chronic angiotensin II infusions. Am J Physiol Renal Physiol (2006) 1.83

Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis. EMBO J (2002) 1.82

Efficacy and safety of over-the-scope clip: including complications after endoscopic submucosal dissection. World J Gastroenterol (2013) 1.80

Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models. J Biol Chem (2005) 1.77

Increased urinary excretion of angiotensinogen is associated with risk of chronic kidney disease. Nephrol Dial Transplant (2012) 1.75

Major role for ACE-independent intrarenal ANG II formation in type II diabetes. Am J Physiol Renal Physiol (2009) 1.75

Core protein of hepatitis C virus induces cardiomyopathy. Circ Res (2004) 1.73

Vascular endothelial growth factor-expressing mesenchymal stem cell transplantation for the treatment of acute myocardial infarction. Arterioscler Thromb Vasc Biol (2005) 1.73

Halting the interaction between vascular endothelial growth factor and its receptors attenuates liver carcinogenesis in mice. Hepatology (2004) 1.73

Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats. Hypertension (2004) 1.72

Glomerular angiotensinogen is induced in mesangial cells in diabetic rats via reactive oxygen species--ERK/JNK pathways. Hypertens Res (2010) 1.71

Modulation of Valpha19 NKT cell immune responses by alpha-mannosyl ceramide derivatives consisting of a series of modified sphingosines. Eur J Immunol (2007) 1.68

Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice. J Am Soc Nephrol (2006) 1.67

Role of activated intrarenal reactive oxygen species and renin-angiotensin system in IgA nephropathy model mice. Clin Exp Pharmacol Physiol (2009) 1.64

Intrarenal AT(1) receptor and ACE binding in ANG II-induced hypertensive rats. Am J Physiol Renal Physiol (2002) 1.59

Complement 3 activates the renal renin-angiotensin system by induction of epithelial-to-mesenchymal transition of the nephrotubulus in mice. Am J Physiol Renal Physiol (2013) 1.59

Contribution of reactive oxygen species to the pathogenesis of left ventricular failure in Dahl salt-sensitive hypertensive rats: effects of angiotensin II blockade. J Hypertens (2006) 1.59

Intrarenal angiotensin II and its contribution to the genesis of chronic hypertension. Curr Opin Pharmacol (2011) 1.58

The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo. Mol Cancer Ther (2012) 1.57

Steroid permeation into the artificial ulcer by combined steroid gel application and balloon dilatation: prevention of esophageal stricture. J Gastroenterol Hepatol (2013) 1.55

Cytomegalovirus-associated acute gastric mucosal lesion in an immunocompetent host. Intern Med (2009) 1.54

Pre-cutting using a noseless papillotome with independent lumens for contrast material and guidewire. J Gastroenterol Hepatol (2005) 1.53

Enhanced angiotensin receptor-associated protein in renal tubule suppresses angiotensin-dependent hypertension. Hypertension (2013) 1.52

Angiotensin II receptor blocker reduces oxidative stress and attenuates hypoxia-induced left ventricular remodeling in apolipoprotein E-knockout mice. Hypertens Res (2007) 1.51

Systemic candesartan reduces brain angiotensin II via downregulation of brain renin-angiotensin system. Hypertens Res (2009) 1.51

Enhanced expression of the S100A8/A9 complex in acute myocardial infarction patients. Circ J (2010) 1.51

Impact of outdoor temperature on prewaking morning surge and nocturnal decline in blood pressure in a Japanese population. Hypertens Res (2010) 1.50

The angiotensin II type 1 receptor blocker olmesartan preferentially improves nocturnal hypertension and proteinuria in chronic kidney disease. Hypertens Res (2012) 1.50

Multiphoton imaging of the glomerular permeability of angiotensinogen. J Am Soc Nephrol (2012) 1.48

Reduced expression of cell cycle regulator p18(INK4C) in human hepatocellular carcinoma. Hepatology (2004) 1.48

Mitochondria-derived reactive oxygen species and vascular MAP kinases: comparison of angiotensin II and diazoxide. Hypertension (2005) 1.47

Young Scholars Award Lecture: Intratubular angiotensinogen in hypertension and kidney diseases. Am J Hypertens (2006) 1.46

Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells. J Immunol (2004) 1.45

Angiotensin II type 1a receptor is involved in cell infiltration, cytokine production, and neovascularization in infarcted myocardium. Arterioscler Thromb Vasc Biol (2004) 1.45

Use of a whole blood rapid panel test for heart-type fatty acid-binding protein in patients with acute chest pain: comparison with rapid troponin T and myoglobin tests. Am J Med (2003) 1.44

Loss of the endothelial glycocalyx links albuminuria and vascular dysfunction. J Am Soc Nephrol (2012) 1.44

Increased urinary angiotensinogen is precedent to increased urinary albumin in patients with type 1 diabetes. Am J Med Sci (2009) 1.43

Pitavastatin reduces oxidative stress and attenuates intermittent hypoxia-induced left ventricular remodeling in lean mice. Hypertens Res (2010) 1.43

Angiotensin II shifts insulin signaling into vascular remodeling from glucose metabolism in vascular smooth muscle cells. Am J Hypertens (2011) 1.43

Esophageal function worsens with long duration of diabetes. J Gastroenterol (2008) 1.42

Effects of tempol on renal angiotensinogen production in Dahl salt-sensitive rats. Biochem Biophys Res Commun (2004) 1.41

Effects of diuretics on sodium-dependent glucose cotransporter 2 inhibitor-induced changes in blood pressure in obese rats suffering from the metabolic syndrome. J Hypertens (2016) 1.41

Aldosterone suppresses insulin signaling via the downregulation of insulin receptor substrate-1 in vascular smooth muscle cells. Hypertension (2007) 1.40

Involvement of activated prorenin in the pathogenesis of slowly progressive nephropathy in the non-clipped kidney of two kidney, one-clip hypertension. Hypertens Res (2010) 1.39

Costimulation with angiotensin II and interleukin 6 augments angiotensinogen expression in cultured human renal proximal tubular cells. Am J Physiol Renal Physiol (2008) 1.37

National survey of fulminant myocarditis in Japan: therapeutic guidelines and long-term prognosis of using percutaneous cardiopulmonary support for fulminant myocarditis (special report from a scientific committee). Circ J (2002) 1.36

Inducible deposition of the histone variant H3.3 in interferon-stimulated genes. J Biol Chem (2009) 1.36

Defining developmental potency and cell lineage trajectories by expression profiling of differentiating mouse embryonic stem cells. DNA Res (2008) 1.35

Cardiac oxidative stress in acute and chronic isoproterenol-infused rats. Cardiovasc Res (2005) 1.34

Sequential activation of the reactive oxygen species/angiotensinogen/renin-angiotensin system axis in renal injury of type 2 diabetic rats. Clin Exp Pharmacol Physiol (2008) 1.34

Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma. Int J Oncol (2008) 1.33

Urinary angiotensinogen reflects the activity of intrarenal renin-angiotensin system in patients with IgA nephropathy. Nephrol Dial Transplant (2010) 1.32

Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in rat mesangial cells. J Am Soc Nephrol (2005) 1.30