Protein-intrinsic and signaling network-based sources of resistance to EGFR- and ErbB family-targeted therapies in head and neck cancer.

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Published in Drug Resist Updat on September 14, 2011

Authors

Ranee Mehra1, Ilya G Serebriiskii, Roland L Dunbrack, Matthew K Robinson, Barbara Burtness, Erica A Golemis

Author Affiliations

1: Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

Associated clinical trials:

LUX-Head&Neck 1: A Phase III Trial of Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic (R/M) Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy | NCT01345682

LUX-Head&Neck 2: A Phase III Trial of Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy | NCT01345669

A Study of Dasatinib, Cetuximab and Radiation With or Without Cisplatin in HNSCC (Dasatinib) | NCT00882583

A Study of CP-751,871 in Patients With Recurrent Squamous Head and Neck Carcinoma | NCT00872404

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