Role of osteoclasts and interleukin-17 in the pathogenesis of rheumatoid arthritis: crucial 'human osteoclastology'.

PubWeight™: 0.83‹?›

🔗 View Article (PMID 21960179)

Published in J Bone Miner Metab on September 29, 2011

Authors

Shigeru Kotake1, Toru Yago, Manabu Kawamoto, Yuki Nanke

Author Affiliations

1: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan. skotake@ior.twmu.ac.jp

Articles cited by this

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol (2005) 30.22

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 27.17

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol (2007) 12.72

Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med (2001) 12.38

CD4+CD25high regulatory cells in human peripheral blood. J Immunol (2001) 11.25

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature (1999) 8.23

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest (1999) 7.66

T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature (2000) 6.49

Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med (2005) 6.37

TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest (2000) 5.78

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med (2006) 5.63

TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med (2007) 5.41

IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc Natl Acad Sci U S A (2003) 5.09

Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum (2004) 4.58

Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci U S A (1990) 4.40

Osteoblastic cells are involved in osteoclast formation. Endocrinology (1988) 4.37

T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med (2007) 3.29

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc Natl Acad Sci U S A (1993) 3.29

Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res Ther (2005) 3.17

LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheum (2010) 2.99

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res (1996) 2.86

Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology (1988) 2.60

A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. Nat Genet (2010) 2.34

Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection. J Clin Invest (2000) 2.32

Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis. Arthritis Rheum (2010) 2.29

Activated T lymphocytes support osteoclast formation in vitro. Biochem Biophys Res Commun (1999) 2.28

Role of Th17 cells in human autoimmune arthritis. Arthritis Rheum (2010) 2.25

IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest (2006) 2.15

Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection. Infect Immun (2007) 2.08

Autoimmune inflammation from the Th17 perspective. Autoimmun Rev (2006) 2.04

Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. J Exp Med (1997) 1.89

Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients. Arthritis Rheum (2001) 1.85

A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner. Arthritis Rheum (2009) 1.70

Modulation of osteoclast differentiation by local factors. Bone (1995) 1.47

Formation of multinucleated cells that respond to osteotropic hormones in long term human bone marrow cultures. Endocrinology (1987) 1.46

Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity. J Clin Invest (2001) 1.45

Calcitonin receptors as markers for osteoclastic differentiation: correlation between generation of bone-resorptive cells and cells that express calcitonin receptors in mouse bone marrow cultures. Endocrinology (1989) 1.44

IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res Ther (2007) 1.40

IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL. Eur J Immunol (2005) 1.34

The ratio of circulating osteoprotegerin to RANKL in early rheumatoid arthritis predicts later joint destruction. Arthritis Rheum (2006) 1.25

Identification and characterization of osteoclast-like cells and their progenitors in cultures of feline marrow mononuclear cells. J Cell Biol (1984) 1.22

Differential expression of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis. J Dent Res (2004) 1.21

Quantitative histologic studies on the pathogenesis of periarticular osteoporosis in rheumatoid arthritis. Arthritis Rheum (1985) 1.20

The molecular mechanism of osteoclastogenesis in rheumatoid arthritis. Arthritis Res (2002) 1.16

IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-alpha antibody: a novel mechanism of osteoclastogenesis by IL-17. J Cell Biochem (2009) 1.16

TGF-beta 1 and IFN-gamma direct macrophage activation by TNF-alpha to osteoclastic or cytocidal phenotype. J Immunol (2000) 1.05

Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin-15 on the cell surface and promote osteoclastogenesis in autologous monocytes. Arthritis Rheum (2006) 1.03

Interleukin-17 as a molecular target in immune-mediated arthritis: immunoregulatory properties of genetically modified murine dendritic cells that secrete interleukin-4. Arthritis Rheum (2007) 1.03

Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors. Bone (2008) 1.02

Prostaglandin E2 strongly inhibits human osteoclast formation. Endocrinology (2005) 1.01

Tumor necrosis factor-alpha mediates RANK ligand stimulation of osteoclast differentiation by an autocrine mechanism. J Cell Biochem (2001) 1.00

Bone resorption by tartrate-resistant acid phosphatase-positive multinuclear cells isolated from rheumatoid synovium. Br J Rheumatol (1996) 1.00

Th1 immune response promotes severe bone resorption caused by Porphyromonas gingivalis. Am J Pathol (2007) 1.00

Human Th17 cells: are they different from murine Th17 cells? Eur J Immunol (2009) 0.95

Granulocyte-macrophage colony-stimulating and binding activities of purified human urinary colony-stimulating factor to murine and human bone marrow cells. Blood (1982) 0.95

Bone resorption by cells isolated from rheumatoid synovium. Ann Rheum Dis (1992) 0.94

Expression of membrane-bound and soluble receptor activator of NF-kappaB ligand (RANKL) in human T cells. Immunol Lett (2004) 0.94

Cross-reactive adaptive immune response to oral commensal bacteria results in an induction of receptor activator of nuclear factor-kappaB ligand (RANKL)-dependent periodontal bone resorption in a mouse model. Oral Microbiol Immunol (2007) 0.93

T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. Bone (2009) 0.91

Generation of osteoclasts in vitro. J Cell Sci (1981) 0.91

Human osteoclastogenic T cells and human osteoclastology. Arthritis Rheum (2009) 0.89

Giant cells in arthritic synovium. Ann Rheum Dis (1993) 0.89

1,25-Dihydroxyvitamin D(3) and prostaglandin E(2) act directly on circulating human osteoclast precursors. Biochem Biophys Res Commun (1999) 0.89

High expression levels of receptor activator of nuclear factor-kappa B ligand associated with human chronic periodontitis are mainly secreted by CD4+ T lymphocytes. J Periodontol (2006) 0.88

The presence of a myeloid cell population showing strong reactivity with monoclonal antibody directed to difucosyl type 2 chain in epiphyseal bone marrow adjacent to joints affected with rheumatoid arthritis (RA) and its absence in the corresponding normal and non-RA bone marrow. J Rheumatol (1988) 0.87

Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet's disease before ocular attack: a possible predictive marker of ocular attack. Mod Rheumatol (2008) 0.85

Detection of myeloid precursors (granulocyte/macrophage colony forming units) in the bone marrow adjacent to rheumatoid arthritis joints. J Rheumatol (1992) 0.83

Geranylgeranylacetone, a non-toxic inducer of heat shock protein, induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Mod Rheumatol (2009) 0.83

Geranylgeranylacetone inhibits formation and function of human osteoclasts and prevents bone loss in tail-suspended rats and ovariectomized rats. Calcif Tissue Int (2005) 0.80

Upregulation of synoviocyte COX-2 through interactions with T lymphocytes: role of interleukin 17 and tumor necrosis factor-alpha. J Rheumatol (2004) 0.80

[Role of T-cell leukemia translocation-associated gene (TCTA) protein in human osteoclastogenesis]. Nihon Rinsho Meneki Gakkai Kaishi (2009) 0.77

Paracrine upregulation of monocyte cyclooxygenase-2 by mediators produced by T lymphocytes: role of interleukin 17 and interferon-gamma. J Rheumatol (2004) 0.76

Effects of NSAIDs on Differentiation and Function of Human and Murine Osteoclasts - Crucial 'Human Osteoclastology'. Pharmaceuticals (Basel) (2010) 0.75

Articles by these authors

Variations in the FTO gene are associated with severe obesity in the Japanese. J Hum Genet (2008) 2.03

Anti-C1q antibodies are associated with systemic lupus erythematosus global activity but not specifically with nephritis: a controlled study of 126 consecutive patients. Arthritis Rheum (2011) 1.62

Excessive production of IFN-gamma in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13B. J Immunol (2008) 1.56

IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res Ther (2007) 1.40

IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL. Eur J Immunol (2005) 1.34

Association of a functional polymorphism in the IRF5 region with systemic sclerosis in a Japanese population. Arthritis Rheum (2009) 1.19

Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. J Hum Genet (2009) 1.16

IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-alpha antibody: a novel mechanism of osteoclastogenesis by IL-17. J Cell Biochem (2009) 1.16

Intracellular IL-1alpha-binding proteins contribute to biological functions of endogenous IL-1alpha in systemic sclerosis fibroblasts. Proc Natl Acad Sci U S A (2006) 1.12

INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese. J Hum Genet (2008) 1.10

Association of the FAM167A-BLK region with systemic sclerosis. Arthritis Rheum (2010) 1.08

Large-scale single-nucleotide polymorphism (SNP) and haplotype analyses, using dense SNP Maps, of 199 drug-related genes in 752 subjects: the analysis of the association between uncommon SNPs within haplotype blocks and the haplotypes constructed with haplotype-tagging SNPs. Am J Hum Genet (2004) 1.07

Association of single-nucleotide polymorphisms in MTMR9 gene with obesity. Hum Mol Genet (2007) 1.03

Genetic variations and haplotypes of CYP2C19 in a Japanese population. Drug Metab Pharmacokinet (2005) 0.99

Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis. Clin Rheumatol (2007) 0.97

Genetic variations and haplotypes of UGT1A4 in a Japanese population. Drug Metab Pharmacokinet (2005) 0.97

Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences. J Hum Genet (2007) 0.96

Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population. J Hum Genet (2010) 0.95

Familial Mediterranean fever in three Japanese patients, and a comparison of the frequency of MEFV gene mutations in Japanese and Mediterranean populations. Mod Rheumatol (2007) 0.95

Risk factors associated with incident clinical vertebral and nonvertebral fractures in Japanese women with rheumatoid arthritis: a prospective 54-month observational study. J Rheumatol (2006) 0.92

Four novel defective alleles and comprehensive haplotype analysis of CYP2C9 in Japanese. Pharmacogenet Genomics (2006) 0.91

T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. Bone (2009) 0.91

Human osteoclastogenic T cells and human osteoclastology. Arthritis Rheum (2009) 0.89

The study of bone mineral density and bone turnover markers in postmenopausal women with active rheumatoid arthritis. Mod Rheumatol (2005) 0.89

Immunogenetic features in 120 Japanese patients with idiopathic inflammatory myopathy. J Rheumatol (2004) 0.89

Increased CD40 expression in skin fibroblasts from patients with systemic sclerosis (SSc): role of CD40-CD154 in the phenotype of SSc fibroblasts. Eur J Immunol (2003) 0.87

NOS2 polymorphisms associated with the susceptibility to pulmonary arterial hypertension with systemic sclerosis: contribution to the transcriptional activity. Arthritis Res Ther (2006) 0.87

Genetic variations of the ABC transporter gene ABCB11 encoding the human bile salt export pump (BSEP) in a Japanese population. Drug Metab Pharmacokinet (2009) 0.87

Attenuation of experimental autoimmune myositis by blocking ICOS-ICOS ligand interaction. J Immunol (2007) 0.86

Contribution of single nucleotide polymorphisms of the IL1A gene to the cleavage of precursor IL-1alpha and its transcription activity. Immunogenetics (2007) 0.85

Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. J Hum Genet (2009) 0.83

Interleukin-18 promoter polymorphisms in Japanese patients with rheumatoid arthritis: protective effect of the T allele and T/T genotype at rs360722. Mod Rheumatol (2011) 0.83

Geranylgeranylacetone, a non-toxic inducer of heat shock protein, induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Mod Rheumatol (2009) 0.83

Risk factors associated with incident fractures in Japanese men with rheumatoid arthritis: a prospective observational cohort study. J Bone Miner Metab (2008) 0.82

Single nucleotide polymorphisms of CD244 gene predispose to renal and neuropsychiatric manifestations with systemic lupus erythematosus. Mod Rheumatol (2010) 0.82

Genetic variations and haplotypes of ABCC2 encoding MRP2 in a Japanese population. Drug Metab Pharmacokinet (2008) 0.82

Interferon-induced helicase (IFIH1) polymorphism with systemic lupus erythematosus and dermatomyositis/polymyositis. Mod Rheumatol (2010) 0.82

Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus. Arthritis Res Ther (2007) 0.82

Ethnic differences of two non-synonymous single nucleotide polymorphisms in CDA gene. Drug Metab Pharmacokinet (2009) 0.81

A case of Mikulicz's disease, IgG4-related plasmacytic syndrome, successfully treated by corticosteroid and mizoribine, followed by mizoribine alone. Intern Med (2010) 0.80

Therapeutic efficacy of intravenous cyclophosphamide concomitant with moderate- to high-dose prednisolone in two patients with fasciitis panniculitis syndrome. Mod Rheumatol (2008) 0.80

Increased CD40 expression on articular chondrocytes from patients with rheumatoid arthritis: contribution to production of cytokines and matrix metalloproteinases. J Rheumatol (2004) 0.80

Amplification of the synovial inflammatory response through activation of mitogen-activated protein kinases and nuclear factor kappaB using ligation of CD40 on CD14+ synovial cells from patients with rheumatoid arthritis. Arthritis Rheum (2004) 0.80

Detection of six single-nucleotide polymorphisms associated with rheumatoid arthritis by a loop-mediated isothermal amplification method and an electrochemical DNA chip. Anal Chem (2007) 0.80

Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility in Japanese rheumatoid arthritis patients. Mod Rheumatol (2012) 0.79

Combining effects of polymorphism of tumor necrosis factor alpha 5'-flanking region and HLA-DRB1 on radiological progression in patients with rheumatoid arthritis. Mod Rheumatol (2008) 0.78

[Chlamydia-associated arthritis and enteropathic arthritis--two important spondyloarthritides]. Nihon Rinsho Meneki Gakkai Kaishi (2011) 0.78

The effects of disease modifying anti-rheumatic drugs on osteoclastogenesis and bone destruction in rheumatoid arthritis. Nihon Rinsho Meneki Gakkai Kaishi (2011) 0.78

Genetic variations and haplotype structures of the ABC transporter gene ABCC1 in a Japanese population. Drug Metab Pharmacokinet (2007) 0.78

A combinatorial haplotype of the UDP-glucuronosyltransferase 1A1 gene (#60-#IB) increases total bilirubin concentrations in Japanese volunteers. Clin Chem (2007) 0.77

Genetic variations of the AHR gene encoding aryl hydrocarbon receptor in a Japanese population. Drug Metab Pharmacokinet (2004) 0.77

Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population. Ann Rheum Dis (2012) 0.77

[Role of T-cell leukemia translocation-associated gene (TCTA) protein in human osteoclastogenesis]. Nihon Rinsho Meneki Gakkai Kaishi (2009) 0.77

[Serum markers of synovitis and bone metabolism in rheumatoid arthritis]. Clin Calcium (2009) 0.76

Activation of the activin A-ALK-Smad pathway in systemic sclerosis. J Autoimmun (2011) 0.76

Increased HGF and c-Met in muscle tissues of polymyositis and dermatomyositis patients: beneficial roles of HGF in muscle regeneration. Clin Immunol (2010) 0.76

Detection of IFN-γ+IL-17+ cells in salivary glands of patients with Sjögren's syndrome and Mikulicz's disease: Potential role of Th17•Th1 in the pathogenesis of autoimmune diseases. Nihon Rinsho Meneki Gakkai Kaishi (2016) 0.76

The role of T-cell leukemia translocation-associated gene protein in human tumorigenesis and osteoclastogenesis. J Biomed Biotechnol (2011) 0.75

Spinal tophaceous gout. Intern Med (2012) 0.75

Voltage-dependent anion channels (VDACs, porin) expressed in the plasma membrane regulate the differentiation and function of human osteoclasts. Cell Biol Int (2012) 0.75

Asymptomatic interstitial pneumonitis induced by bucillamine in a patient with rheumatoid arthritis. Mod Rheumatol (2005) 0.75

Bone erosion of the sternocostal joint in a patient with Behcet's disease. Nihon Rinsho Meneki Gakkai Kaishi (2009) 0.75

A case of Weber-Christian disease with later development of rheumatoid arthritis. Nihon Rinsho Meneki Gakkai Kaishi (2011) 0.75

Radiographic repair in three Japanese patients with rheumatoid arthritis treated with bucillamine. Mod Rheumatol (2009) 0.75

Efficacy of methotrexate in the treatment of a HLA-B27-positive Japanease patient with reactive arthritis. Nihon Rinsho Meneki Gakkai Kaishi (2010) 0.75

[A case of Sjögren syndrome suspected, rheumatoid arthritis and Behcet's disease complicated with cochlear nerve and trigeminal nerve disorders]. Nihon Rinsho Meneki Gakkai Kaishi (2012) 0.75

Human receptor activator of NF-κB ligand (RANKL) induces osteoclastogenesis of primates in vitro. In Vitro Cell Dev Biol Anim (2012) 0.75

Case of Chlamydia-associated arthritis. Nihon Rinsho Meneki Gakkai Kaishi (2009) 0.75

Tacrolimus potently inhibits human osteoclastogenesis induced by IL-17 from human monocytes alone and suppresses human Th17 differentiation. Cytokine (2012) 0.75

Clinical verification of a combination technology of a loop-mediated isothermal amplification method and an electrochemical DNA chip for personalized medicine. Clin Biochem (2009) 0.75

[An asymptomatic mother of cutaneous neonatal lupus child was diagnosed with Sjögren's syndrome suspected]. Nihon Rinsho Meneki Gakkai Kaishi (2010) 0.75

[Effects of biologic therapies on systemic osteoporosis in patients with rheumatoid arthritis]. Nihon Rinsho (2009) 0.75

[Secondary osteoporosis. Fractures in patients with rheumatoid arthritis]. Clin Calcium (2007) 0.75

Arterial Calcification Due to Deficiency of CD73 (ACDC) As One of Rheumatic Diseases Associated With Periarticular Calcification. J Clin Rheumatol (2015) 0.75

[Prospective cohort studies of incident fractures in patients with rheumatoid arthritis]. Nihon Rinsho (2007) 0.75