Published in PLoS One on September 23, 2011
DECKO: Single-oligo, dual-CRISPR deletion of genomic elements including long non-coding RNAs. BMC Genomics (2015) 1.45
Targeted RNA-sequencing with competitive multiplex-PCR amplicon libraries. PLoS One (2013) 1.03
The PLOS ONE synthetic biology collection: six years and counting. PLoS One (2012) 0.83
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature (1998) 72.56
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (2001) 57.23
In vitro selection of RNA molecules that bind specific ligands. Nature (1990) 30.19
Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing. Nat Biotechnol (2009) 27.17
A species of small antisense RNA in posttranscriptional gene silencing in plants. Science (1999) 19.34
Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer. Nat Biotechnol (2001) 14.57
Design of a novel globular protein fold with atomic-level accuracy. Science (2003) 13.06
Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase. Biochemistry (1988) 9.66
Light-generated oligonucleotide arrays for rapid DNA sequence analysis. Proc Natl Acad Sci U S A (1994) 9.59
Unlocking the potential of the human genome with RNA interference. Nature (2004) 6.70
Computational design of receptor and sensor proteins with novel functions. Nature (2003) 5.48
BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies. Nucleic Acids Res (2006) 4.93
Highly parallel genomic assays. Nat Rev Genet (2006) 4.24
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat Rev Drug Discov (2006) 4.03
Steric factors influencing hybridisation of nucleic acids to oligonucleotide arrays. Nucleic Acids Res (1997) 4.03
Encoded combinatorial chemistry. Proc Natl Acad Sci U S A (1992) 4.00
Synthesis of high-quality libraries of long (150mer) oligonucleotides by a novel depurination controlled process. Nucleic Acids Res (2010) 2.72
Applications of aptamers as sensors. Annu Rev Anal Chem (Palo Alto Calif) (2009) 2.45
Predicting sequence-dependent melting stability of short duplex DNA oligomers. Biopolymers (1997) 2.45
Design, synthesis and selection of DNA-encoded small-molecule libraries. Nat Chem Biol (2009) 2.08
Generation and screening of an oligonucleotide-encoded synthetic peptide library. Proc Natl Acad Sci U S A (1993) 1.81
Solid phase DNA amplification: characterisation of primer attachment and amplification mechanisms. Nucleic Acids Res (2000) 1.73
How to make a DNA chip. Angew Chem Int Ed Engl (2002) 1.68
Chemical and biochemical strategies for the randomization of protein encoding DNA sequences: library construction methods for directed evolution. Nucleic Acids Res (2004) 1.46
RNA interference in cancer. Biomol Eng (2006) 1.44
Encoded self-assembling chemical libraries. Nat Biotechnol (2004) 1.40
A multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemia. Nucleic Acids Res (2010) 1.22
Universal DNA tag systems: a combinatorial design scheme. J Comput Biol (2000) 1.16
An artificial cell-cycle inhibitor isolated from a combinatorial library. Proc Natl Acad Sci U S A (1998) 1.15
High-quality gene assembly directly from unpurified mixtures of microarray-synthesized oligonucleotides. Nucleic Acids Res (2010) 1.14
Strategies in the preparation of DNA oligonucleotide arrays for diagnostic applications. Curr Med Chem (2001) 1.10
POSaM: a fast, flexible, open-source, inkjet oligonucleotide synthesizer and microarrayer. Genome Biol (2004) 1.06
Computational design of Candida boidinii xylose reductase for altered cofactor specificity. Protein Sci (2009) 1.02
SNP genotyping by multiplexed solid-phase amplification and fluorescent minisequencing. Genome Res (2001) 0.98
Design, construction, and validation of a modular library of sequence diversity standards for polymerase chain reaction. Anal Biochem (2010) 0.83
A 10,000 member PNA-encoded peptide library for profiling tyrosine kinases. ACS Chem Biol (2007) 0.81
DNA-encoded chemical libraries. J Biotechnol (2006) 0.81
Estimating genetic variability in non-model taxa: a general procedure for discriminating sequence errors from actual variation. PLoS One (2010) 0.80
Steric effects and mass-transfer limitations surrounding amplification reactions on immobilized long and clinically relevant DNA templates. Langmuir (2009) 0.79
Integrated microfluidic biochips for DNA microarray analysis. Expert Rev Mol Diagn (2006) 0.79
Enhanced solid phase PCR: mechanisms to increase priming by solid support primers. Anal Biochem (2008) 0.76
An analysis of the feasibility of short read sequencing. Nucleic Acids Res (2005) 6.10
The global programme to eliminate lymphatic filariasis: health impact after 8 years. PLoS Negl Trop Dis (2008) 4.36
A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis. PLoS Negl Trop Dis (2012) 3.16
Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures. Nat Struct Mol Biol (2013) 2.09
Mass drug treatment for lymphatic filariasis and onchocerciasis. Trends Parasitol (2003) 1.92
Amide bond formation: beyond the myth of coupling reagents. Chem Soc Rev (2008) 1.91
Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development. Cell Res (2011) 1.76
Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism. Stem Cell Res (2010) 1.62
Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing. Environ Health Perspect (2010) 1.57
Transcending scale dependence in identifying habitat with resource selection functions. Ecol Appl (2012) 1.56
A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance. Curr Biol (2013) 1.54
A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host. Angew Chem Int Ed Engl (2002) 1.46
Decoding a PNA encoded peptide library by PCR: the discovery of new cell surface receptor ligands. Chem Biol (2011) 1.43
Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes. Part Fibre Toxicol (2011) 1.38
Lack of understanding of acute HIV infection among newly-infected persons-implications for prevention and public health: The NIMH Multisite Acute HIV Infection Study: II. AIDS Behav (2009) 1.37
Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs. Nanotoxicology (2011) 1.29
A controlled trial of methadone treatment combined with directly observed isoniazid for tuberculosis prevention in injection drug users. Drug Alcohol Depend (2002) 1.28
Palladium-mediated intracellular chemistry. Nat Chem (2011) 1.28
Developing high-fidelity hepatotoxicity models from pluripotent stem cells. Stem Cells Transl Med (2013) 1.27
Organotypic cultures as tools for functional screening in the CNS. Drug Discov Today (2005) 1.23
Assessing transmission of lymphatic filariasis using parasitologic, serologic, and entomologic tools after mass drug administration in American Samoa. Am J Trop Med Hyg (2009) 1.15
Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles. Toxicol Sci (2012) 1.14
Polymer microarrays for cellular adhesion. Chem Commun (Camb) (2006) 1.13
CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist. Cancer Res (2014) 1.12
Peptides for cell-selective drug delivery. Trends Pharmacol Sci (2012) 1.10
Factors influencing drug compliance in the mass drug administration programme against filariasis in the Western province of Sri Lanka. Trans R Soc Trop Med Hyg (2006) 1.05
Enzyme accessibility and solid supports: which molecular weight enzymes can be used on solid supports? An investigation using confocal Raman microscopy. Chemistry (2002) 1.03
Microarrays of over 2000 hydrogels--identification of substrates for cellular trapping and thermally triggered release. Biomaterials (2009) 1.01
Captured and cross-linked palladium nanoparticles. J Am Chem Soc (2006) 1.00
A thermoresponsive and chemically defined hydrogel for long-term culture of human embryonic stem cells. Nat Commun (2013) 0.98
Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles. Part Fibre Toxicol (2013) 0.96
L-arginyl-3,4-spermidine is neuroprotective in several in vitro models of neurodegeneration and in vivo ischaemia without suppressing synaptic transmission. Br J Pharmacol (2002) 0.95
Dunking doughnuts into cells--selective cellular translocation and in vivo analysis of polymeric micro-doughnuts. Chem Commun (Camb) (2008) 0.95
Microarray platforms for enzymatic and cell-based assays. Chem Soc Rev (2006) 0.92
Impact of two rounds of mass drug administration using diethylcarbamazine combined with albendazole on the prevalence of Brugia timori and of intestinal helminths on Alor Island, Indonesia. Filaria J (2005) 0.92
Synthesis, penetrability and intracellular targeting of fluorescein-tagged peptoids and peptide-peptoid hybrids. Bioorg Med Chem (2008) 0.91
DNA analysis by dynamic chemistry. Angew Chem Int Ed Engl (2010) 0.91
Full orthogonality between Dde and Fmoc: the direct synthesis of PNA--peptide conjugates. Org Lett (2004) 0.90
Investigation of microsphere-mediated cellular delivery by chemical, microscopic and gene expression analysis. Mol Biosyst (2009) 0.88
Revolutionizing Resin Handling for Combinatorial Synthesis. Angew Chem Int Ed Engl (2001) 0.88
Bead-based cellular analysis, sorting and multiplexing. Chembiochem (2005) 0.88
Microsphere-based real-time calcium sensing. Angew Chem Int Ed Engl (2006) 0.88
Development and bioorthogonal activation of palladium-labile prodrugs of gemcitabine. J Med Chem (2014) 0.88
Synthesis of polystyrene microspheres and functionalization with Pd(0) nanoparticles to perform bioorthogonal organometallic chemistry in living cells. Nat Protoc (2012) 0.88
Deciphering cellular morphology and biocompatibility using polymer microarrays. Biomed Mater (2008) 0.87
Tools for efficient high-throughput synthesis. Drug Discov Today (2007) 0.87
Polymer microarrays: identification of substrates for phagocytosis assays. Biomaterials (2006) 0.86
The role of translocation in recovery of woodland caribou populations. Conserv Biol (2010) 0.86
Surface functionalization affects the zeta potential, coronal stability and membranolytic activity of polymeric nanoparticles. Nanotoxicology (2013) 0.86
Multifunctionalized biocompatible microspheres for sensing. Ann N Y Acad Sci (2008) 0.85
A microarray approach to the identification of polyurethanes for the isolation of human skeletal progenitor cells and augmentation of skeletal cell growth. Biomaterials (2008) 0.85
The use of solid supports to generate nucleic acid carriers. Acc Chem Res (2012) 0.85
Degree of conversion and microhardness of TPO-containing resin-based composites cured by polywave and monowave LED units. J Dent (2012) 0.84
Inkjet fabrication of hydrogel microarrays using in situ nanolitre-scale polymerisation. Chem Commun (Camb) (2008) 0.84
Synthesis and evaluation of fluorescent probes for the detection of calpain activity. Anal Biochem (2003) 0.84
Parallel and multiplexed bead-based assays and encoding strategies. Comb Chem High Throughput Screen (2003) 0.83
Mechanism and structure-activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase. Bioorg Med Chem (2005) 0.83
Novel biochip platform for nucleic acid analysis. Sensors (Basel) (2012) 0.83
High-density polymer microarrays: identifying synthetic polymers that control human embryonic stem cell growth. Adv Healthc Mater (2013) 0.82
A role for intracellular calcium downstream of G-protein signaling in undifferentiated human embryonic stem cell culture. Stem Cell Res (2012) 0.82
Multi-modal molecular imaging approaches to detect primary cells in preclinical models. Faraday Discuss (2011) 0.82
Strategies for cell manipulation and skeletal tissue engineering using high-throughput polymer blend formulation and microarray techniques. Biomaterials (2010) 0.82
A highly sensitive fluorescent viscosity sensor. Bioorg Med Chem Lett (2012) 0.82
Microspheres as a vehicle for biomolecule delivery to neural stem cells. N Biotechnol (2009) 0.82
A 10,000 member PNA-encoded peptide library for profiling tyrosine kinases. ACS Chem Biol (2007) 0.81
Analysis of Giardia lamblia interactions with polymer surfaces using a microarray approach. Environ Sci Technol (2012) 0.81
The impact of combinatorial methodologies on medicinal chemistry. Curr Top Med Chem (2004) 0.81
Microsphere-based tracing and molecular delivery in embryonic stem cells. Biomaterials (2009) 0.81
Albendazole and its metabolites in the breast milk of lactating women following a single oral dose of albendazole. Br J Clin Pharmacol (2009) 0.81
Synthesis and cellular uptake of cell delivering PNA-peptide conjugates. Chem Commun (Camb) (2005) 0.80
Maintaining hepatic stem cell gene expression on biological and synthetic substrata. Biores Open Access (2012) 0.80
Solid supports for combinatorial chemistry. Curr Opin Chem Biol (2002) 0.80
A cooperative polymer-DNA microarray approach to biomaterial investigation. Lab Chip (2008) 0.80
Long-lasting reduction of Brugia timori microfilariae following a single dose of diethylcarbamazine combined with albendazole. Trans R Soc Trop Med Hyg (2004) 0.80
Dual colour, microarray-based, analysis of 10,000 protease substrates. Chem Commun (Camb) (2006) 0.80
Versatile biocompatible polymer hydrogels: scaffolds for cell growth. Angew Chem Int Ed Engl (2009) 0.79
Polymer resin library and the discovery of highly efficient polymer supported reagents and scavengers. Mol Divers (2005) 0.79
Entangled palladium nanoparticles in resin plugs. Chem Commun (Camb) (2007) 0.79
Fingerprinting polymer microarrays. Comb Chem High Throughput Screen (2009) 0.79
Solid-phase synthesis of 89 polyamine-based cationic lipids for DNA delivery to mammalian cells. Chemistry (2004) 0.79
Functional peptide arrays for high-throughput chemical biology based applications. Curr Opin Biotechnol (2007) 0.79
Screening of a combinatorial homing peptide library for selective cellular delivery. Angew Chem Int Ed Engl (2011) 0.79
Microsphere-based intracellular sensing of caspase-3/7 in apoptotic living cells. Macromol Biosci (2014) 0.79
Polymers for the rapid and effective activation and aggregation of platelets. Biomaterials (2011) 0.79
Screening for polymorphs on polymer microarrays. J Comb Chem (2008) 0.79
Microsphere-mediated protein delivery into cells. Chembiochem (2009) 0.79
Cell penetrable peptoid carrier vehicles: synthesis and evaluation. Chem Commun (Camb) (2003) 0.79
Which sites react first? Functional site distribution and kinetics on solid supports investigated using confocal Raman and fluorescence microscopy. J Comb Chem (2003) 0.78
Knocking (anti)-sense into cells: the microsphere approach to gene silencing. Bioconjug Chem (2009) 0.78
Laser printing mediated cell patterning. Chem Commun (Camb) (2009) 0.78
Tripod-like cationic lipids as novel gene carriers. J Med Chem (2008) 0.78
Very long-chain fatty tails for enhanced transfection. Org Biomol Chem (2008) 0.78
Microwave-assisted ester formation using O-alkylisoureas: a convenient method for the synthesis of esters with inversion of configuration. J Org Chem (2009) 0.78
Inkjet fabrication of polymer microarrays and grids--solving the evaporation problem. Chem Commun (Camb) (2008) 0.78
Targeting Cryptosporidium parvum capture. Water Res (2011) 0.78