Published in PLoS One on September 26, 2011
Association between the TLR2 Arg753Gln polymorphism and the risk of sepsis: a meta-analysis. Crit Care (2015) 1.12
Redox regulation of mitochondrial biogenesis. Free Radic Biol Med (2012) 1.11
Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes. Biochim Biophys Acta (2012) 1.10
Regulation of mitochondrial biogenesis and its intersection with inflammatory responses. Antioxid Redox Signal (2015) 0.94
Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology. Semin Immunopathol (2013) 0.93
Mitochondrial function and disturbances in the septic kidney. Semin Nephrol (2015) 0.88
A neonatal model of intravenous Staphylococcus epidermidis infection in mice <24 h old enables characterization of early innate immune responses. PLoS One (2012) 0.84
Mitochondrial dysfunction in inherited renal disease and acute kidney injury. Nat Rev Nephrol (2016) 0.84
Gestational exposure to a viral mimetic poly(i:C) results in long-lasting changes in mitochondrial function by leucocytes in the adult offspring. Mediators Inflamm (2013) 0.82
PGC-1α expression is increased in leukocytes in experimental acute pancreatitis. Inflammation (2014) 0.77
Transcriptomic effects of adenosine 2A receptor deletion in healthy and endotoxemic murine myocardium. Purinergic Signal (2016) 0.75
Cardiac Fibroblast Transcriptome Analyses Support a Role for Interferogenic, Profibrotic and Inflammatory Genes in Anti-SSA/Ro-Associated Congenital Heart Block. Am J Physiol Heart Circ Physiol (2017) 0.75
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature (2001) 25.15
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell (1999) 19.48
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 17.57
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity (1999) 17.40
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol (1999) 16.86
Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form. Anal Biochem (1991) 12.68
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol (2007) 12.00
TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature (2001) 11.84
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell (1998) 8.73
Blue native PAGE. Nat Protoc (2006) 8.04
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol (2003) 7.06
IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity (2002) 6.85
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol (2000) 6.61
Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev (2008) 6.57
Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science (2009) 6.07
LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med (2003) 5.97
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol (2006) 5.83
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol (2001) 5.27
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature (2008) 5.15
Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem (1997) 5.14
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol (2003) 4.94
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature (2002) 4.81
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med (2004) 4.64
MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity (2006) 4.28
The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest (2005) 3.99
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat Immunol (2009) 3.17
TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem (2003) 2.61
Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart. Genes Dev (2008) 2.58
Survival in critical illness is associated with early activation of mitochondrial biogenesis. Am J Respir Crit Care Med (2010) 2.48
Sepsis: definition, epidemiology, and diagnosis. BMJ (2007) 2.43
Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis. Am J Respir Crit Care Med (2007) 2.33
Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7. PLoS Pathog (2009) 1.95
PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons. J Biol Chem (2009) 1.78
Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli. FASEB J (2005) 1.72
Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis. Crit Care Clin (2001) 1.58
Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome. Mitochondrion (2004) 1.56
Dysregulation of mitochondrial dynamics and the muscle transcriptome in ICU patients suffering from sepsis induced multiple organ failure. PLoS One (2008) 1.52
Mechanism of I kappa B alpha binding to NF-kappa B dimers. J Biol Chem (2000) 1.33
TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker. J Immunol (2005) 1.33
Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression. Diabetes (2009) 1.31
Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments. PLoS One (2010) 1.28
Intracellular signaling molecules activated by Epstein-Barr virus for induction of interferon regulatory factor 7. J Virol (2001) 1.23
Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor. J Immunol (2008) 1.22
Competitive and noncompetitive inhibition of myocardial cytochrome C oxidase in sepsis. Shock (2004) 1.20
Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscess. Am J Pathol (2007) 1.16
Integrin-nucleated Toll-like receptor (TLR) dimerization reveals subcellular targeting of TLRs and distinct mechanisms of TLR4 activation and signaling. FEBS Lett (2002) 1.16
Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/gammac(null) mice: suppression by an inhibitor against NF-kappaB. J Virol (2003) 1.14
Regulation of IRF7 through cell type-specific protein stability. Biochem Biophys Res Commun (2006) 1.10
MyD88-dependent signals are essential for the host immune response in experimental brain abscess. J Immunol (2007) 1.10
Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription. J Mol Biol (2002) 1.09
Nuclear factor-kappaB activation in neonatal mouse lung protects against lipopolysaccharide-induced inflammation. Am J Respir Crit Care Med (2007) 1.07
Cytoplasmic domain-mediated dimerizations of toll-like receptor 4 observed by beta-lactamase enzyme fragment complementation. J Biol Chem (2003) 1.03
Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochondrial biogenesis. J Cell Sci (2010) 1.01
Differential regulation of the PGC family of genes in a mouse model of Staphylococcus aureus sepsis. PLoS One (2010) 0.97
Role of Toll-like receptors 2 and 4 in pulmonary inflammation and injury induced by pneumolysin in mice. PLoS One (2009) 0.96
Pretreatment with the Gram-positive bacterial cell wall molecule peptidoglycan improves bacterial clearance and decreases inflammation and mortality in mice challenged with Staphylococcus aureus. Crit Care Med (2008) 0.90
Toll-like receptor 4-dependent activation of myeloid dendritic cells by leukocidin of Staphylococcus aureus. Microbes Infect (2008) 0.90
Enhancement of macrophage stimulation by lipoteichoic acid and the costimulant hemoglobin is dependent on Toll-like receptors 2 and 4. Infect Immun (2007) 0.83
Poly (I:C) induced immune response in lymphoid tissues involves three sequential waves of type I IFN expression. Virology (2009) 0.82
Nitric oxide in the human respiratory cycle. Nat Med (2002) 4.50
Gene expression profiling of familial and sporadic interstitial pneumonia. Am J Respir Crit Care Med (2006) 3.32
Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circ Res (2008) 3.12
Practice recommendations in the diagnosis, management, and prevention of carbon monoxide poisoning. Am J Respir Crit Care Med (2012) 2.81
Survival in critical illness is associated with early activation of mitochondrial biogenesis. Am J Respir Crit Care Med (2010) 2.48
Retracted Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype. Am J Respir Crit Care Med (2012) 2.39
Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis. Am J Respir Crit Care Med (2007) 2.33
Concern TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation. Am J Respir Crit Care Med (2009) 2.07
The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy. J Clin Invest (2007) 1.98
Concern c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice. Am J Respir Crit Care Med (2011) 1.91
Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis. Am J Respir Crit Care Med (2012) 1.85
Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis. Cardiovasc Res (2004) 1.80
Reversible cardiac dysfunction associated with pandemic 2009 influenza A(H1N1). Chest (2010) 1.76
Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli. FASEB J (2005) 1.72
A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension. Proc Natl Acad Sci U S A (2005) 1.67
A new activating role for CO in cardiac mitochondrial biogenesis. J Cell Sci (2006) 1.64
Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1. J Biol Chem (2005) 1.60
Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. J Biol Chem (2011) 1.59
Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. J Neurosci (2008) 1.58
Rescue therapy in adult and pediatric patients with pH1N1 influenza infection: a tertiary center intensive care unit experience from April to October 2009. Crit Care Med (2010) 1.55
Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice. J Biol Chem (2009) 1.55
Central venous catheter integrity during mechanical power injection of iodinated contrast medium. Radiology (2009) 1.53
Chronic LPS inhalation causes emphysema-like changes in mouse lung that are associated with apoptosis. Am J Respir Cell Mol Biol (2008) 1.51
Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol (2008) 1.48
How do red blood cells dilate blood vessels? Circ Res (2004) 1.44
Hyperoxia-induced tissue hypoxia: a danger? Anesthesiology (2007) 1.44
Extracellular superoxide dismutase protects lung development in hyperoxia-exposed newborn mice. Am J Respir Crit Care Med (2002) 1.42
Oxalate deposition on asbestos bodies. Hum Pathol (2003) 1.42
Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1. J Biol Chem (2003) 1.42
Retracted Innate immune activation by inhaled lipopolysaccharide, independent of oxidative stress, exacerbates silica-induced pulmonary fibrosis in mice. PLoS One (2012) 1.41
Postlipopolysaccharide oxidative damage of mitochondrial DNA. Am J Respir Crit Care Med (2002) 1.38
Blockade of tissue factor: treatment for organ injury in established sepsis. Am J Respir Crit Care Med (2003) 1.38
Hedgehog controls hepatic stellate cell fate by regulating metabolism. Gastroenterology (2012) 1.36
Extracellular superoxide dismutase. Int J Biochem Cell Biol (2005) 1.34
Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure. Am J Physiol Lung Cell Mol Physiol (2005) 1.31
Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation. Trends Mol Med (2009) 1.29
Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide. Am J Respir Cell Mol Biol (2002) 1.25
Clara cells attenuate the inflammatory response through regulation of macrophage behavior. Am J Respir Cell Mol Biol (2009) 1.24
How do red blood cells cause hypoxic vasodilation? The SNO-hemoglobin paradigm. Am J Physiol Heart Circ Physiol (2006) 1.24
Inter-alpha-trypsin inhibitor attenuates complement activation and complement-induced lung injury. J Immunol (2007) 1.14
Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity. J Appl Physiol (1985) (2008) 1.14
Genetic basis of murine responses to hyperoxia-induced lung injury. Immunogenetics (2006) 1.13
Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity. J Biol Chem (2011) 1.12
CD14 is an essential mediator of LPS-induced airway disease. Am J Physiol Lung Cell Mol Physiol (2007) 1.11
Redox regulation of mitochondrial biogenesis. Free Radic Biol Med (2012) 1.11
Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes. Biochim Biophys Acta (2012) 1.10
Overexpression of extracellular superoxide dismutase decreases lung injury after exposure to oil fly ash. Am J Physiol Lung Cell Mol Physiol (2002) 1.10
Hyaluronan signaling during ozone-induced lung injury requires TLR4, MyD88, and TIRAP. PLoS One (2011) 1.09
Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice. Free Radic Biol Med (2012) 1.08
Iron increases expression of iron-export protein MTP1 in lung cells. Am J Physiol Lung Cell Mol Physiol (2002) 1.08
Carbon monoxide, oxidative stress, and mitochondrial permeability pore transition. Free Radic Biol Med (2005) 1.07
Regulation of the brain's vascular responses to oxygen. Circ Res (2002) 1.06
TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol (2005) 1.04
The iron cycle and oxidative stress in the lung. Free Radic Biol Med (2004) 1.04
The effect of toll-like receptors and toll-like receptor genetics in human disease. Annu Rev Med (2008) 1.03
Coagulation and inflammation in acute lung injury. Thromb Haemost (2002) 1.03
Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. Blood (2004) 1.02
Contraindications and safety of transbronchial lung biopsy via flexible bronchoscopy. A survey of pulmonologists and review of the literature. Respiration (2005) 1.02
Carbon monoxide actuates O(2)-limited heme degradation in the rat brain. Free Radic Biol Med (2004) 1.02
Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart. Circ Res (2010) 1.01
Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochondrial biogenesis. J Cell Sci (2010) 1.01
Transcriptional Regulation of SDHa flavoprotein by nuclear respiratory factor-1 prevents pseudo-hypoxia in aerobic cardiac cells. J Biol Chem (2008) 1.00
Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans. Am J Physiol Heart Circ Physiol (2009) 0.99
Staphylococcus aureus sepsis and mitochondrial accrual of the 8-oxoguanine DNA glycosylase DNA repair enzyme in mice. Am J Respir Crit Care Med (2010) 0.98
Differential regulation of the PGC family of genes in a mouse model of Staphylococcus aureus sepsis. PLoS One (2010) 0.97
S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery. Am J Physiol Lung Cell Mol Physiol (2005) 0.95
Ozone activates pulmonary dendritic cells and promotes allergic sensitization through a Toll-like receptor 4-dependent mechanism. J Allergy Clin Immunol (2010) 0.95
Discordant extracellular superoxide dismutase expression and activity in neonatal hyperoxic lung. Am J Respir Crit Care Med (2004) 0.95
Oxygenated water and athletic performance. JAMA (2003) 0.95
Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2002) 0.95
Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide. Am J Physiol Lung Cell Mol Physiol (2007) 0.94
Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study. Respir Res (2008) 0.94
Regulation of mitochondrial biogenesis and its intersection with inflammatory responses. Antioxid Redox Signal (2015) 0.94
Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation. J Immunol (2011) 0.93
Ambient ozone and pulmonary innate immunity. Immunol Res (2011) 0.93