Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion.

PubWeight™: 0.77‹?›

🔗 View Article (PMID 21971686)

Published in J Neurosci Res on October 04, 2011

Authors

Peter Röhnert1, Ulrich H Schröder, Iryna Ziabreva, Michael Täger, Klaus G Reymann, Frank Striggow

Author Affiliations

1: KeyNeurotek Pharmaceuticals AG, Magdeburg, Germany.

Articles by these authors

Microglia provide neuroprotection after ischemia. FASEB J (2006) 1.82

Mitochondrial changes within axons in multiple sclerosis. Brain (2009) 1.81

Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege. J Neurosci (2008) 1.73

Mitochondrial defects in acute multiple sclerosis lesions. Brain (2008) 1.69

Increased mitochondrial content in remyelinated axons: implications for multiple sclerosis. Brain (2011) 1.63

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis. Ann Neurol (2010) 1.60

Parkinson disease with dementia: comparing patients with and without Alzheimer pathology. Alzheimer Dis Assoc Disord (2009) 1.54

Neurogranin/RC3 enhances long-term potentiation and learning by promoting calcium-mediated signaling. J Neurosci (2004) 1.45

Induced tauopathy in a novel 3D-culture model mediates neurodegenerative processes: a real-time study on biochips. PLoS One (2012) 1.43

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors. Neurobiol Aging (2010) 1.32

Neuronal differentiation of transplanted embryonic stem cell-derived precursors in stroke lesions of adult rats. Brain (2006) 1.29

The pathologic cascade of cerebrovascular lesions in SHRSP: is erythrocyte accumulation an early phase? J Cereb Blood Flow Metab (2011) 1.20

Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc Natl Acad Sci U S A (2012) 1.11

Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation. J Neurosci (2011) 1.08

Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation. Neurobiol Dis (2006) 1.06

The specific FKBP38 inhibitor N-(N',N'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia. J Biol Chem (2006) 1.05

Aspirin reduces endothelial cell senescence. Biochem Biophys Res Commun (2005) 1.04

Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions. Clin Chem Lab Med (2009) 1.03

The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents. Neuropharmacology (2008) 1.01

Anti-inflammatory treatment with the p38 mitogen-activated protein kinase inhibitor SB239063 is neuroprotective, decreases the number of activated microglia and facilitates neurogenesis in oxygen-glucose-deprived hippocampal slice cultures. Eur J Pharmacol (2008) 0.99

The neuroprotective effect of bone marrow stem cells is not dependent on direct cell contact with hypoxic injured tissue. Exp Neurol (2008) 0.99

Protease-activated receptors in neuronal development, neurodegeneration, and neuroprotection: thrombin as signaling molecule in the brain. Neuroscientist (2004) 0.98

Determination of the therapeutic time window for human umbilical cord blood mononuclear cell transplantation following experimental stroke in rats. Cell Transplant (2011) 0.97

Low stability of Huntington muscle mitochondria against Ca2+ in R6/2 mice. Ann Neurol (2006) 0.97

A population of serum deprivation-induced bone marrow stem cells (SD-BMSC) expresses marker typical for embryonic and neural stem cells. Exp Cell Res (2008) 0.97

The regulation of OXPHOS by extramitochondrial calcium. Biochim Biophys Acta (2010) 0.96

Structural basis of β-amyloid-dependent synaptic dysfunctions. Angew Chem Int Ed Engl (2012) 0.96

Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses. Ann N Y Acad Sci (2007) 0.96

Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator. Eur J Pharmacol (2010) 0.96

Mitochondria and energetic depression in cell pathophysiology. Int J Mol Sci (2009) 0.95

Impaired regulation of brain mitochondria by extramitochondrial Ca2+ in transgenic Huntington disease rats. J Biol Chem (2008) 0.93

DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis. Front Biosci (2008) 0.93

Proliferating cells differentiate into neurons in the hippocampal CA1 region of gerbils after global cerebral ischemia. Neurosci Lett (2002) 0.93

Stases are associated with blood-brain barrier damage and a restricted activation of coagulation in SHRSP. J Neurol Sci (2012) 0.92

Expression of opioid receptor subtypes and their ligands in fibrillating human atria. Pacing Clin Electrophysiol (2005) 0.92

Assessment of neuroprotective effects of human umbilical cord blood mononuclear cell subpopulations in vitro and in vivo. Cell Transplant (2011) 0.92

Cytosolic Ca2+ regulates the energization of isolated brain mitochondria by formation of pyruvate through the malate-aspartate shuttle. Biochem J (2012) 0.91

Influence of EGF/bFGF treatment on proliferation, early neurogenesis and infarct volume after transient focal ischemia. Brain Res (2005) 0.91

Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment. Proc Natl Acad Sci U S A (2012) 0.91

Cholinergic neuronal deficits in CADASIL. Stroke (2006) 0.91

Effect of telmisartan on nitric oxide--asymmetrical dimethylarginine system: role of angiotensin II type 1 receptor gamma and peroxisome proliferator activated receptor gamma signaling during endothelial aging. Hypertension (2008) 0.90

Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice. Clin Chem Lab Med (2009) 0.90

Time-dependent segmentation of BrdU-signal leads to late detection problems in studies using BrdU as cell label or proliferation marker. J Neurosci Methods (2008) 0.89

Erythropoietin increases asymmetric dimethylarginine in endothelial cells: role of dimethylarginine dimethylaminohydrolase. J Am Soc Nephrol (2005) 0.88

Focal ischemia induces expression of protease-activated receptor1 (PAR1) and PAR3 on microglia and enhances PAR4 labeling in the penumbra. Brain Res (2006) 0.88

Anti-inflammatory treatment in oxygen-glucose-deprived hippocampal slice cultures is neuroprotective and associated with reduced cell proliferation and intact neurogenesis. Neurobiol Dis (2006) 0.88

Abeta mediated diminution of MTT reduction--an artefact of single cell culture? PLoS One (2008) 0.88

Novel aspects of cellular action of dipeptidyl peptidase IV/CD26. Biol Chem (2011) 0.87

Neurovascular pathophysiology in cerebral ischemia, dementia and the ageing brain - current trends in basic, translational and clinical research. Exp Transl Stroke Med (2012) 0.86

Assigning the phenotype of a natural regulatory T-cell to the human T-cell line, KARPAS-299. Int J Mol Med (2006) 0.85

Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence. Arterioscler Thromb Vasc Biol (2004) 0.85

No excess of mitochondrial DNA deletions within muscle in progressive multiple sclerosis. Mult Scler (2013) 0.85

Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke. Acta Neuropathol (2014) 0.84

Combining independent drug classes into superior, synergistically acting hybrid molecules. Angew Chem Int Ed Engl (2010) 0.84

Inhibition of Calpain Prevents N-Methyl-D-aspartate-Induced Degeneration of the Nucleus Basalis and Associated Behavioral Dysfunction. J Pharmacol Exp Ther (2008) 0.84

7-Hydroxylated epiandrosterone (7-OH-EPIA) reduces ischaemia-induced neuronal damage both in vivo and in vitro. Eur J Neurosci (2003) 0.84

Kidney pathology precedes and predicts the pathological cascade of cerebrovascular lesions in stroke prone rats. PLoS One (2011) 0.84

Rapid pacing of embryoid bodies impairs mitochondrial ATP synthesis by a calcium-dependent mechanism--a model of in vitro differentiated cardiomyocytes to study molecular effects of tachycardia. Biochim Biophys Acta (2006) 0.83

Effects of transient global ischaemia on freezing behaviour and activity in a context-dependent fear conditioning task--implications for memory investigations. Brain Res Bull (2011) 0.83

Clonally expanded mitochondrial DNA deletions within the choroid plexus in multiple sclerosis. Acta Neuropathol (2012) 0.83

bFGF and EGF modulate trauma-induced proliferation and neurogenesis in juvenile organotypic hippocampal slice cultures. Brain Res (2005) 0.83

Extracellular cysteines define ectopeptidase (APN, CD13) expression and function. Free Radic Biol Med (2002) 0.83

Divergent actions by inhibitors of DP IV and APN family enzymes on CD4+ Teff cell motility and functions. Immunobiology (2011) 0.82

Pattern of time-dependent reduction of histologically determined infarct volume after focal ischaemia in mice. Neurosci Lett (2007) 0.81

Protease-activated receptor-1 induces generation of new microglia in the dentate gyrus of traumatised hippocampal slice cultures. Neurosci Lett (2007) 0.81

Differential regulation of CXCL12 and PACAP mRNA expression after focal and global ischemia. Neuropharmacology (2009) 0.81

P2 receptor antagonist trinitrophenyl-adenosine-triphosphate protects hippocampus from oxygen and glucose deprivation cell death. J Pharmacol Exp Ther (2007) 0.81

An impedimetric microelectrode-based array sensor for label-free detection of tau hyperphosphorylation in human cells. Lab Chip (2009) 0.81

Detection of chronic sensorimotor impairments in the ladder rung walking task in rats with endothelin-1-induced mild focal ischemia. J Neurosci Methods (2004) 0.81

Group I metabotropic glutamate receptors interfere in different ways with pentylenetetrazole seizures, kindling, and kindling-related learning deficits. Naunyn Schmiedebergs Arch Pharmacol (2004) 0.81

Preconditioning with thrombin can be protective or worsen damage after endothelin-1-induced focal ischemia in rats. J Neurosci Res (2006) 0.80

The ATP-regulated K+-channel inhibitor HMR-1372 affects synaptic plasticity in hippocampal slices. Eur J Pharmacol (2004) 0.80

A novel organotypic tauopathy model on a new microcavity chip for bioelectronic label-free and real time monitoring. Biosens Bioelectron (2010) 0.80

Impedance spectroscopy based measurement system for quantitative and label-free real-time monitoring of tauopathy in hippocampal slice cultures. Biosens Bioelectron (2011) 0.80

Organotypic brain-slice cultures from adult rats: approaches for a prolonged culture time. Altern Lab Anim (2002) 0.80

Effect of L-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial cell aging. Biochem Biophys Res Commun (2006) 0.80

Inhibitors of cation-chloride-cotransporters affect hypoxic/hypoglycemic injury in hippocampal slices. Brain Res (2005) 0.80

Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation. Mol Cell Neurosci (2007) 0.79

The distribution pattern of pathology and cholinergic deficits in amygdaloid complex in Alzheimer's disease and dementia with Lewy bodies. Acta Neuropathol (2006) 0.79

Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation. Int Immunopharmacol (2006) 0.79

Thiol-inducing and immunoregulatory effects of flavonoids in peripheral blood mononuclear cells from patients with end-stage diabetic nephropathy. Free Radic Biol Med (2002) 0.79

Neural regeneration protein is a novel chemoattractive and neuronal survival-promoting factor. Exp Cell Res (2006) 0.79

Neuroprotective effects of the survival promoting peptide Y-P30. Eur J Pharmacol (2009) 0.79

Extramitochondrial Ca2+ in the nanomolar range regulates glutamate-dependent oxidative phosphorylation on demand. PLoS One (2009) 0.79

Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies. Acta Neuropathol Commun (2014) 0.79

Cortical serotonin 1A receptor levels are associated with depression in patients with dementia with Lewy bodies and Parkinson's disease dementia. Dement Geriatr Cogn Disord (2008) 0.79

Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13)--a novel approach for the treatment of inflammatory bowel disease. Int Immunopharmacol (2006) 0.79

Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia. J Neuroinflammation (2012) 0.78

6-Hydroxydopamine impairs mitochondrial function in the rat model of Parkinson's disease: respirometric, histological, and behavioral analyses. J Neural Transm (Vienna) (2014) 0.78

Preparation of a tissue-like cortical primary culture from embryonic rats using Matrigel and serum free Start V Medium. J Neurosci Methods (2006) 0.78

The Na+/H+ exchanger modulates long-term potentiation in rat hippocampal slices. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.78