CYP2C19 but not PON1 genetic variants influence clopidogrel pharmacokinetics, pharmacodynamics, and clinical efficacy in post-myocardial infarction patients.

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Published in Circ Cardiovasc Interv on October 04, 2011

Authors

Jean-Sébastien Hulot1, Jean-Philippe Collet, Guillaume Cayla, Johanne Silvain, Frédérick Allanic, Anne Bellemain-Appaix, Stuart A Scott, Gilles Montalescot

Author Affiliations

1: Université Pierre et Marie Curie-Paris 6, INSERM UMR S 956, Pharmacology Department, Pitié-Salpêtrière University Hospital, Paris, France.

Associated clinical trials:

Clopidogrel and Response Variability Investigation Study 2 (CLOVIS2) | NCT00822666

EValuation of REsidual Platelet REactivity After Acute Coronary Syndrome (ST+/ST-) in HIV (EVERE2ST-HIV) | NCT02380391

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