Published in J Biomed Biotechnol on October 03, 2011
Active roles of tumor stroma in breast cancer metastasis. Int J Breast Cancer (2012) 0.98
Improving prediction of prostate cancer recurrence using chemical imaging. Sci Rep (2015) 0.82
Non-receptor tyrosine kinase 2 reaches its lowest expression levels in human breast cancer during regional nodal metastasis. Clin Exp Metastasis (2011) 0.79
Analysis of tubulin alpha-1A/1B C-terminal tail post-translational poly-glutamylation reveals novel modification sites. J Proteome Res (2012) 0.76
A FTIR imaging characterization of fibroblasts stimulated by various breast cancer cell lines. PLoS One (2014) 0.76
Automated prostate tissue referencing for cancer detection and diagnosis. BMC Bioinformatics (2016) 0.75
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature (2007) 15.20
Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer (2004) 14.55
Molecular definition of breast tumor heterogeneity. Cancer Cell (2007) 12.67
Putting tumours in context. Nat Rev Cancer (2001) 12.37
IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature (2001) 11.03
TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science (2004) 10.23
Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med (2001) 9.99
Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell (2004) 9.41
Tumor-associated macrophages press the angiogenic switch in breast cancer. Cancer Res (2007) 3.49
Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics. Nat Rev Cancer (2006) 3.19
Know thy neighbor: stromal cells can contribute oncogenic signals. Curr Opin Genet Dev (2001) 3.12
Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. Cancer Res (2000) 3.06
Stromal cells can contribute oncogenic signals. Semin Cancer Biol (2001) 2.80
Steroid hormone receptors in breast cancer management. Breast Cancer Res Treat (1998) 2.42
Hormone receptors: their role in predicting prognosis and response to endocrine therapy. Semin Oncol (1978) 1.99
Do myoepithelial cells hold the key for breast tumor progression? J Mammary Gland Biol Neoplasia (2005) 1.91
Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. Mol Cell (2000) 1.91
Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression. Cancer Res (1995) 1.82
Tumors are unique organs defined by abnormal signaling and context. Semin Cancer Biol (2001) 1.61
Differential gene expression profile in breast cancer-derived stromal fibroblasts. Breast Cancer Res Treat (2007) 1.54
Cell clusters overlying focally disrupted mammary myoepithelial cell layers and adjacent cells within the same duct display different immunohistochemical and genetic features: implications for tumor progression and invasion. Breast Cancer Res (2003) 1.42
The significance of focal myoepithelial cell layer disruptions in human breast tumor invasion: a paradigm shift from the "protease-centered" hypothesis. Exp Cell Res (2004) 1.33
Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cells. Mol Endocrinol (2002) 1.30
Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the α-tubulin tyrosination cycle. Cancer Res (2011) 1.28
BRCA1 expression is not directly responsive to estrogen. Oncogene (1997) 1.24
Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell (2006) 1.24
Focal degeneration of aged or injured myoepithelial cells and the resultant auto-immunoreactions are trigger factors for breast tumor invasion. Med Hypotheses (2007) 1.08
Why are estrogen-receptor-negative breast cancers more aggressive than the estrogen-receptor-positive breast cancers? Invasion Metastasis (1995) 1.08
Predominant role of T cell receptor (TCR)-alpha chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system. J Exp Med (2002) 1.05
Inflammation and breast cancer. Microenvironmental factors regulating macrophage function in breast tumours: hypoxia and angiopoietin-2. Breast Cancer Res (2007) 1.04
Rudolf Virchow and modern aspects of tumor pathology. Pathol Res Pract (1988) 1.01
A clonal derivative of mammary epithelial cell line COMMA-D retains stem cell characteristics of unique morphological and functional heterogeneity. Exp Cell Res (1988) 0.94
A subset of in situ breast tumor cell clusters lacks expression of proliferation and progression related markers but shows signs of stromal and vascular invasion. Cancer Detect Prev (2005) 0.92
Tumor Suppressor RARRES1 Regulates DLG2, PP2A, VCP, EB1, and Ankrd26. J Cancer (2010) 0.90
Isoelectric point-based prefractionation of proteins from crude biological samples prior to two-dimensional gel electrophoresis. J Proteome Res (2005) 0.89
Alteration in protein expression in estrogen receptor alpha-negative human breast cancer tissues indicates a malignant and metastatic phenotype. Clin Exp Metastasis (2010) 0.85
Altered expression of the ZBRK1 gene in human breast carcinomas. J Pathol (2004) 0.84
Protein profiling of isolated leukocytes, myofibroblasts, epithelial, Basal, and endothelial cells from normal, hyperplastic, cancerous, and inflammatory human prostate tissues. J Cancer (2010) 0.81
The molecular basis of vitamin D receptor and beta-catenin crossregulation. Mol Cell (2006) 1.91
IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf. Mol Biol Cell (2003) 1.86
Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. Mol Cell Biol (2004) 1.80
Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155. Nat Med (2011) 1.79
Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology (2003) 1.62
Pathway-specific differences between tumor cell lines and normal and tumor tissue cells. Mol Cancer (2006) 1.51
Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor. Cell Res (2006) 1.51
Trans-repression of beta-catenin activity by nuclear receptors. J Biol Chem (2003) 1.37
The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene (2005) 1.35
The significance of focal myoepithelial cell layer disruptions in human breast tumor invasion: a paradigm shift from the "protease-centered" hypothesis. Exp Cell Res (2004) 1.33
Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells. J Biol Chem (2003) 1.31
Predicting new indications for approved drugs using a proteochemometric method. J Med Chem (2012) 1.29
Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the α-tubulin tyrosination cycle. Cancer Res (2011) 1.28
An alternatively spliced cadherin-11 enhances human breast cancer cell invasion. Cancer Res (2002) 1.26
G-DOC: a systems medicine platform for personalized oncology. Neoplasia (2011) 1.18
Wnt/beta-catenin and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix turnover. J Biol Chem (2009) 1.16
Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion. Cancer Res (2004) 1.13
Mechanical force modulates global gene expression and beta-catenin signaling in colon cancer cells. J Cell Sci (2007) 1.11
Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentials. Crit Rev Eukaryot Gene Expr (2011) 1.09
Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26. J Biol Chem (2002) 1.03
Cross-regulation of signaling pathways: an example of nuclear hormone receptors and the canonical Wnt pathway. Exp Cell Res (2010) 1.02
Genome-wide multi-omics profiling of colorectal cancer identifies immune determinants strongly associated with relapse. Front Genet (2013) 0.99
The role of cadherin, beta-catenin, and AP-1 in retinoid-regulated carcinoma cell differentiation and proliferation. J Biol Chem (2002) 0.99
ADAM19/adamalysin 19 structure, function, and role as a putative target in tumors and inflammatory diseases. Curr Pharm Des (2009) 0.98
The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling. J Biol Chem (2003) 0.98
Active roles of tumor stroma in breast cancer metastasis. Int J Breast Cancer (2012) 0.98
Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities. Biochem J (2004) 0.98
Methodology and applications of disease biomarker identification in human serum. Biomark Insights (2007) 0.97
Big data: the next frontier for innovation in therapeutics and healthcare. Expert Rev Clin Pharmacol (2014) 0.97
Control of TCF-4 expression by VDR and vitamin D in the mouse mammary gland and colorectal cancer cell lines. PLoS One (2009) 0.96
Post-transcriptional regulation of cadherin-11 expression by GSK-3 and beta-catenin in prostate and breast cancer cells. PLoS One (2009) 0.95
βII-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin. Hepatology (2015) 0.95
Enhancing QM/MM molecular dynamics sampling in explicit environments via an orthogonal-space-random-walk-based strategy. J Phys Chem B (2011) 0.95
Small molecule metabolite extraction strategy for improving LC/MS detection of cancer cell metabolome. J Biomol Tech (2011) 0.95
Anion exchange fractionation of serum proteins versus albumin elimination. Anal Biochem (2007) 0.93
A subset of in situ breast tumor cell clusters lacks expression of proliferation and progression related markers but shows signs of stromal and vascular invasion. Cancer Detect Prev (2005) 0.92
ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein. J Biol Chem (2011) 0.92
Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases. Inflamm Bowel Dis (2012) 0.92
Intracellular activation of human adamalysin 19/disintegrin and metalloproteinase 19 by furin occurs via one of the two consecutive recognition sites. J Biol Chem (2002) 0.91
Role of Sox-9, ER81 and VE-cadherin in retinoic acid-mediated trans-differentiation of breast cancer cells. PLoS One (2008) 0.91
Biomarkers of WNT signaling. Cancer Biomark (2007) 0.91
Differentially expressed transcripts and dysregulated signaling pathways and networks in African American breast cancer. PLoS One (2013) 0.90
RepurposeVS: A Drug Repurposing-Focused Computational Method for Accurate Drug-Target Signature Predictions. Comb Chem High Throughput Screen (2015) 0.90
Tumor Suppressor RARRES1 Regulates DLG2, PP2A, VCP, EB1, and Ankrd26. J Cancer (2010) 0.90
Metastasis suppressors in human benign prostate, intraepithelial neoplasia, and invasive cancer: their prospects as therapeutic agents. Med Res Rev (2011) 0.89
Isoelectric point-based prefractionation of proteins from crude biological samples prior to two-dimensional gel electrophoresis. J Proteome Res (2005) 0.89
Up-regulation of fibroblast growth factor-binding protein, by beta-catenin during colon carcinogenesis. Cancer Res (2003) 0.88
Expression of matrix metalloproteinase-26 and tissue inhibitor of metalloproteinase-4 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3. Mol Hum Reprod (2002) 0.88
Putative biomarkers and targets of estrogen receptor negative human breast cancer. Int J Mol Sci (2011) 0.85
Alteration in protein expression in estrogen receptor alpha-negative human breast cancer tissues indicates a malignant and metastatic phenotype. Clin Exp Metastasis (2010) 0.85
Autolytic processing at Glu586-Ser587 within the cysteine-rich domain of human adamalysin 19/disintegrin-metalloproteinase 19 is necessary for its proteolytic activity. J Biol Chem (2002) 0.85
Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies. Oncotarget (2014) 0.85
Retinoic acid mediates regulation of network formation by COUP-TFII and VE-cadherin expression by TGFbeta receptor kinase in breast cancer cells. PLoS One (2010) 0.85
Harnessing Polypharmacology with Computer-Aided Drug Design and Systems Biology. Curr Pharm Des (2016) 0.85
Inhibition of enzyme activity of and cell-mediated substrate cleavage by membrane type 1 matrix metalloproteinase by newly developed mercaptosulphide inhibitors. Biochem J (2005) 0.83
Drug repurposing: translational pharmacology, chemistry, computers and the clinic. Curr Top Med Chem (2013) 0.82
Protein profiling of isolated leukocytes, myofibroblasts, epithelial, Basal, and endothelial cells from normal, hyperplastic, cancerous, and inflammatory human prostate tissues. J Cancer (2010) 0.81
Calcium regulates tertiary structure and enzymatic activity of human endometase/matrilysin-2 and its role in promoting human breast cancer cell invasion. Biochem J (2007) 0.81
The balance of TCF7L2 variants with differential activities in Wnt-signaling is regulated by lithium in a GSK3beta-independent manner. Biochem Biophys Res Commun (2010) 0.80
Prefractionation enhances loading capacity and identification of basic proteins from human breast cancer tissues. Anal Biochem (2010) 0.80
Expression of adamalysin 19/ADAM19 in the endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy. Mol Hum Reprod (2005) 0.80
C-lysine conjugates: pH-controlled light-activated reagents for efficient double-stranded DNA cleavage with implications for cancer therapy. J Am Chem Soc (2009) 0.79
Non-receptor tyrosine kinase 2 reaches its lowest expression levels in human breast cancer during regional nodal metastasis. Clin Exp Metastasis (2011) 0.79
Quantitative measurement of human papillomavirus type 16 e5 oncoprotein levels in epithelial cell lines by mass spectrometry. J Virol (2012) 0.78
Expression of matrix metalloproteinase-26 in multiple human cancer tissues and smooth muscle cells. Ai Zheng (2009) 0.78
Spatio-temporal expression of matrix metalloproteinase-26 in human placental trophoblasts and fetal red cells during normal placentation. Biol Reprod (2004) 0.77
Characterization of the phosphoproteome in androgen-repressed human prostate cancer cells by Fourier transform ion cyclotron resonance mass spectrometry. J Proteome Res (2011) 0.77
Effects of detergents on catalytic activity of human endometase/matrilysin 2, a putative cancer biomarker. Anal Biochem (2009) 0.77
Developmental and hormonal regulation of meltrin beta (ADAM19) expression in mouse testes during embryonic and postnatal life. Life Sci (2006) 0.77
Identification of Potential Glycoprotein Biomarkers in Estrogen Receptor Positive (ER+) and Negative (ER-) Human Breast Cancer Tissues by LC-LTQ/FT-ICR Mass Spectrometry. J Cancer (2012) 0.77
Expression and implications of tissue inhibitor of metalloproteinases-4 in mouse embryo. Mol Hum Reprod (2003) 0.76
Protein engineering and properties of human metalloproteinase and thrombospondin 1. Biochem Biophys Res Commun (2002) 0.76
The Anti-inflammatory Role of Endometase/Matrilysin-2 in Human Prostate Cancer Cells. J Cancer (2013) 0.76
Drug repurposing a reality: from computers to the clinic. Expert Rev Clin Pharmacol (2013) 0.76
Analysis of tubulin alpha-1A/1B C-terminal tail post-translational poly-glutamylation reveals novel modification sites. J Proteome Res (2012) 0.76
Matrix metalloproteinase inhibitors based on the 3-mercaptopyrrolidine core. J Med Chem (2013) 0.76
Human coronary artery smooth muscle cell responses to bioactive polyelectrolyte multilayer interfaces. Biotechnol Res Int (2010) 0.75
Protein Signatures in Human MDA-MB-231 Breast Cancer Cells Indicating a More Invasive Phenotype Following Knockdown of Human Endometase/Matrilysin-2 by siRNA. J Cancer (2011) 0.75
Expression of tissue inhibitor of metalloproteinase-4 (TIMP-4) in endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy. Life Sci (2005) 0.75
In-silico fragment-based identification of novel angiogenesis inhibitors. Bioorg Med Chem Lett (2007) 0.75
Efficient soluble expression of secreted matrix metalloproteinase 26 in Brevibacillus choshinensis. Protein Expr Purif (2013) 0.75