Published in Bioorg Chem on September 21, 2011
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Fluorescent probes for investigation of isoprenoid configuration and size discrimination by bactoprenol-utilizing enzymes. Bioorg Med Chem (2013) 0.84
A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery. Chem Biol Drug Des (2014) 0.81
Synthesis and NMR characterization of (Z,Z,Z,Z,E,E,ω)-heptaprenol. J Am Chem Soc (2012) 0.81
A lettuce (Lactuca sativa) homolog of human Nogo-B receptor interacts with cis-prenyltransferase and is necessary for natural rubber biosynthesis. J Biol Chem (2014) 0.80
Species differences in alternative substrate utilization by the antibacterial target undecaprenyl pyrophosphate synthase. Biochemistry (2014) 0.78
Tuning the production of variable length, fluorescent polyisoprenoids using surfactant-controlled enzymatic synthesis. Biochemistry (2015) 0.77
Unwrapping bacteria. PLoS Genet (2014) 0.75
cis-Prenyltransferase: New Insights into Protein Glycosylation, Rubber Synthesis, and Human Diseases. J Biol Chem (2016) 0.75
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Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A (2007) 2.00
Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease. Chem Biol (2006) 1.63
Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem (2005) 1.62
Structural and functional analysis of three β-glucosidases from bacterium Clostridium cellulovorans, fungus Trichoderma reesei and termite Neotermes koshunensis. J Struct Biol (2010) 1.33
Mechanism of the maturation process of SARS-CoV 3CL protease. J Biol Chem (2005) 1.27
Small molecules targeting severe acute respiratory syndrome human coronavirus. Proc Natl Acad Sci U S A (2004) 1.25
Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds. J Biol Chem (2009) 1.23
DNA binding and degradation by the HNH protein ColE7. Structure (2004) 1.20
Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination. J Biol Chem (2006) 1.19
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem (2008) 1.18
Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate. Biochem Biophys Res Commun (2004) 1.16
Catalytic mechanism revealed by the crystal structure of undecaprenyl pyrophosphate synthase in complex with sulfate, magnesium, and triton. J Biol Chem (2003) 1.13
Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents. Bioorg Med Chem (2008) 1.10
Substrate binding mode and reaction mechanism of undecaprenyl pyrophosphate synthase deduced from crystallographic studies. Protein Sci (2004) 1.09
Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determination. J Biol Chem (2003) 1.08
Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters. Bioorg Med Chem (2005) 1.00
The zinc ion in the HNH motif of the endonuclease domain of colicin E7 is not required for DNA binding but is essential for DNA hydrolysis. Nucleic Acids Res (2002) 1.00
Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases. J Biomed Biotechnol (2008) 0.99
Synthesis and application of a fluorescent substrate analogue to study ligand interactions for undecaprenyl pyrophosphate synthase. J Am Chem Soc (2002) 0.97
Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation. Plant Cell (2010) 0.96
Intracellular beta-tubulin/chaperonin containing TCP1-beta complex serves as a novel chemotherapeutic target against drug-resistant tumors. Cancer Res (2009) 0.93
Probing the conformational change of Escherichia coli undecaprenyl pyrophosphate synthase during catalysis using an inhibitor and tryptophan mutants. J Biol Chem (2001) 0.91
Insight into the activation mechanism of Escherichia coli octaprenyl pyrophosphate synthase derived from pre-steady-state kinetic analysis. Biochim Biophys Acta (2002) 0.91
Identification of the active conformation and the importance of length of the flexible loop 72-83 in regulating the conformational change of undecaprenyl pyrophosphate synthase. Biochemistry (2003) 0.91
Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3'-digallate (TF3). Evid Based Complement Alternat Med (2005) 0.90
Mutations in the substrate entrance region of β-glucosidase from Trichoderma reesei improve enzyme activity and thermostability. Protein Eng Des Sel (2012) 0.90
One site mutation disrupts dimer formation in human DPP-IV proteins. J Biol Chem (2004) 0.90
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. J Med Chem (2007) 0.89
Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures. J Bacteriol (2005) 0.89
Construction and characterization of different fusion proteins between cellulases and β-glucosidase to improve glucose production and thermostability. Bioresour Technol (2010) 0.88
Probing electrostatic channeling in protozoal bifunctional thymidylate synthase-dihydrofolate reductase using site-directed mutagenesis. J Biol Chem (2003) 0.88
Mechanism of cis-prenyltransferase reaction probed by substrate analogues. Biochem Biophys Res Commun (2010) 0.88
Ligand specificities and structural requirements of two Tachypleus plasma lectins for bacterial trapping. Biochem J (2006) 0.87
Purification and characterization of human prolyl dipeptidase DPP8 in Sf9 insect cells. Protein Expr Purif (2004) 0.87
Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease. J Med Chem (2005) 0.87
Different reaction mechanisms for cis- and trans-prenyltransferases. Biochem Biophys Res Commun (2008) 0.87
Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthase. Biochem J (2005) 0.86
Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors. Bioorg Med Chem (2010) 0.86
Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery. Biochem Soc Trans (2011) 0.86
Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes. Angew Chem Int Ed Engl (2012) 0.86
Individual and common inhibitors of coronavirus and picornavirus main proteases. FEBS Lett (2009) 0.85
Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV. FEBS Lett (2004) 0.84
Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease. J Med Chem (2006) 0.84
Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies. J Clin Invest (2013) 0.83
The critical roles of polyamines in regulating ColE7 production and restricting ColE7 uptake of the colicin-producing Escherichia coli. J Biol Chem (2006) 0.83
Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. J Am Chem Soc (2014) 0.82
Novel small-molecule inhibitors of transmissible gastroenteritis virus. Antimicrob Agents Chemother (2007) 0.82
Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors. FEBS Lett (2007) 0.82
Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli. Acta Crystallogr D Biol Crystallogr (2003) 0.82
Parallel gene cloning and protein production in multiple expression systems. Biotechnol Prog (2009) 0.82
A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71. Anal Biochem (2007) 0.82
A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products. Biochemistry (2004) 0.82
Roles of amino acids in the Escherichia coli octaprenyl diphosphate synthase active site probed by structure-guided site-directed mutagenesis. Biochemistry (2012) 0.81
Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease. Bioorg Med Chem (2008) 0.81
Fluorescent substrate analog for monitoring chain elongation by undecaprenyl pyrophosphate synthase in real time. Anal Biochem (2011) 0.81
Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors. Chembiochem (2007) 0.80
Learning to predict expression efficacy of vectors in recombinant protein production. BMC Bioinformatics (2010) 0.80
Picornaviral 3C protease inhibitors and the dual 3C protease/coronaviral 3C-like protease inhibitors. Expert Opin Ther Pat (2010) 0.79
Reaction kinetic pathway of the recombinant octaprenyl pyrophosphate synthase from Thermotoga maritima: how is it different from that of the mesophilic enzyme. Biochim Biophys Acta (2002) 0.79
Combined experimental and theoretical study of long-range interactions modulating dimerization and activity of yeast geranylgeranyl diphosphate synthase. J Am Chem Soc (2009) 0.79
Undecaprenyl diphosphate synthase, a cis-prenyltransferase synthesizing lipid carrier for bacterial cell wall biosynthesis. Mol Membr Biol (2012) 0.79
Involvement of colicin in the limited protection of the colicin producing cells against bacteriophage. Biochem Biophys Res Commun (2004) 0.78
Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease. Bioorg Med Chem Lett (2010) 0.78
The catalytic roles of P185 and T188 and substrate-binding loop flexibility in 3α-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. PLoS One (2013) 0.77
Anti-SARS coronavirus agents: a patent review (2008 - present). Expert Opin Ther Pat (2013) 0.77
Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies. J Med Chem (2006) 0.76
Repression of btuB gene transcription in Escherichia coli by the GadX protein. BMC Microbiol (2011) 0.75
Conjugation of benzylvanillin and benzimidazole structure improves DNA binding with enhanced antileukemic properties. PLoS One (2013) 0.75
Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms. Proteins (2014) 0.75
Identification, synthesis, and evaluation of new neuraminidase inhibitors. Org Lett (2014) 0.75
Engineering a novel endopeptidase based on SARS 3CL(pro). Biotechniques (2009) 0.75
Control activity of yeast geranylgeranyl diphosphate synthase from dimer interface through H-bonds and hydrophobic interaction. Biochemistry (2013) 0.75
An E. coli lon mutant conferring partial resistance to colicin may reveal a novel role in regulating proteins involved in the translocation of colicin. Biochem Biophys Res Commun (2006) 0.75
Moiety-linkage map reveals selective nonbisphosphonate inhibitors of human geranylgeranyl diphosphate synthase. J Chem Inf Model (2013) 0.75