Published in Plant Cell on February 05, 2010
Terpene biosynthesis: modularity rules. Angew Chem Int Ed Engl (2011) 1.73
Terpenoid synthase structures: a so far incomplete view of complex catalysis. Nat Prod Rep (2012) 1.39
Terpene Specialized Metabolism in Arabidopsis thaliana. Arabidopsis Book (2011) 1.30
Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza. J Exp Bot (2012) 1.26
Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc Natl Acad Sci U S A (2013) 1.06
The biosynthetic origin of irregular monoterpenes in Lavandula: isolation and biochemical characterization of a novel cis-prenyl diphosphate synthase gene, lavandulyl diphosphate synthase. J Biol Chem (2013) 0.92
Structure and mechanism of an Arabidopsis medium/long-chain-length prenyl pyrophosphate synthase. Plant Physiol (2011) 0.91
Next generation sequencing unravels the biosynthetic ability of spearmint (Mentha spicata) peltate glandular trichomes through comparative transcriptomics. BMC Plant Biol (2014) 0.85
Competition between isoprene emission and pigment synthesis during leaf development in aspen. Plant Cell Environ (2013) 0.84
Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum. Sci Rep (2014) 0.82
Crystal structure of heterodimeric hexaprenyl diphosphate synthase from Micrococcus luteus B-P 26 reveals that the small subunit is directly involved in the product chain length regulation. J Biol Chem (2010) 0.81
Chrysanthemyl diphosphate synthase operates in planta as a bifunctional enzyme with chrysanthemol synthase activity. J Biol Chem (2014) 0.78
Killing cancer with platycodin D through multiple mechanisms. J Cell Mol Med (2015) 0.76
Overexpression of a synthetic insect-plant geranyl pyrophosphate synthase gene in Camelina sativa alters plant growth and terpene biosynthesis. Planta (2016) 0.76
Biotechnological production of limonene in microorganisms. Appl Microbiol Biotechnol (2016) 0.75
Multi-domain terpenoid cyclase architecture and prospects for proximity in bifunctional catalysis. Curr Opin Struct Biol (2016) 0.75
Structural and Chemical Biology of Terpenoid Cyclases. Chem Rev (2017) 0.75
Spearmint R2R3-MYB transcription factor MsMYB negatively regulates monoterpene production and suppresses the expression of geranyl diphosphate synthase large subunit (MsGPPS.LSU). Plant Biotechnol J (2017) 0.75
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis (1999) 45.01
Protein structure comparison by alignment of distance matrices. J Mol Biol (1993) 34.74
XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. J Struct Biol (1999) 17.84
Defensive function of herbivore-induced plant volatile emissions in nature. Science (2001) 8.57
The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature (2006) 6.00
The function of terpene natural products in the natural world. Nat Chem Biol (2007) 4.54
Cyanobacterial photosystem II at 2.9-A resolution and the role of quinones, lipids, channels and chloride. Nat Struct Mol Biol (2009) 4.29
Phase combination and cross validation in iterated density-modification calculations. Acta Crystallogr D Biol Crystallogr (1996) 4.15
Assessment of phase accuracy by cross validation: the free R value. Methods and applications. Acta Crystallogr D Biol Crystallogr (1993) 3.94
Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli. J Bacteriol (1990) 3.78
Designed divergent evolution of enzyme function. Nature (2006) 3.09
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc Natl Acad Sci U S A (2006) 2.73
Chimeras of two isoprenoid synthases catalyze all four coupling reactions in isoprenoid biosynthesis. Science (2007) 2.65
Structure, mechanism and function of prenyltransferases. Eur J Biochem (2002) 2.63
Crystallographic refinement of ligand complexes. Acta Crystallogr D Biol Crystallogr (2006) 2.47
Biosynthesis of plant volatiles: nature's diversity and ingenuity. Science (2006) 2.34
Volatile chemical cues guide host location and host selection by parasitic plants. Science (2006) 2.33
Regulation of product chain length by isoprenyl diphosphate synthases. Proc Natl Acad Sci U S A (1996) 2.13
Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis. J Biol Chem (2003) 2.06
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A (2007) 2.00
Unearthing the roots of the terpenome. Curr Opin Chem Biol (2008) 2.00
Biosynthesis of plant isoprenoids: perspectives for microbial engineering. Annu Rev Plant Biol (2009) 1.98
Enzymatic Aspects of Isoprenoid Chain Elongation. Chem Rev (1998) 1.97
Isoprenylated proteins. Cell Mol Life Sci (2006) 1.90
Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs. ChemMedChem (2006) 1.90
Developmental regulation of monoterpene biosynthesis in the glandular trichomes of peppermint. Plant Physiol (2000) 1.78
Chain elongation in the isoprenoid biosynthetic pathway. Curr Opin Chem Biol (1997) 1.78
Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases. Nat Chem Biol (2008) 1.77
Following evolution's lead to a single residue switch for diterpene synthase product outcome. Proc Natl Acad Sci U S A (2007) 1.64
Geranyl diphosphate synthase: cloning, expression, and characterization of this prenyltransferase as a heterodimer. Proc Natl Acad Sci U S A (1999) 1.61
(-)-Menthol biosynthesis and molecular genetics. Naturwissenschaften (2005) 1.50
Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design. Proteins (2006) 1.47
The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding. J Biol Chem (2006) 1.32
Formation of monoterpenes in Antirrhinum majus and Clarkia breweri flowers involves heterodimeric geranyl diphosphate synthases. Plant Cell (2004) 1.31
Chain-length determination mechanism of isoprenyl diphosphate synthases and implications for molecular evolution. Trends Biochem Sci (1999) 1.30
Organization of monoterpene biosynthesis in Mentha. Immunocytochemical localizations of geranyl diphosphate synthase, limonene-6-hydroxylase, isopiperitenol dehydrogenase, and pulegone reductase. Plant Physiol (2004) 1.27
Interaction with the small subunit of geranyl diphosphate synthase modifies the chain length specificity of geranylgeranyl diphosphate synthase to produce geranyl diphosphate. J Biol Chem (2001) 1.24
Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans. FEBS J (2005) 1.22
Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination. J Biol Chem (2006) 1.19
The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates. J Biol Chem (2007) 1.16
Purification and characterization of farnesyl diphosphate/geranylgeranyl diphosphate synthase. A thermostable bifunctional enzyme from Methanobacterium thermoautotrophicum. J Biol Chem (1993) 1.14
Farnesyl diphosphate synthase; regulation of product specificity. Acta Biochim Pol (2005) 1.11
Conversion of product specificity of archaebacterial geranylgeranyl-diphosphate synthase. Identification of essential amino acid residues for chain length determination of prenyltransferase reaction. J Biol Chem (1996) 1.11
Structure and reaction geometry of geranylgeranyl diphosphate synthase from Sinapis alba. Biochemistry (2006) 1.09
Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determination. J Biol Chem (2003) 1.08
Heterodimeric geranyl(geranyl)diphosphate synthase from hop (Humulus lupulus) and the evolution of monoterpene biosynthesis. Proc Natl Acad Sci U S A (2009) 1.06
Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components. J Biol Chem (1982) 1.05
Fission yeast decaprenyl diphosphate synthase consists of Dps1 and the newly characterized Dlp1 protein in a novel heterotetrameric structure. Eur J Biochem (2003) 1.05
Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis. Chem Biol (2008) 1.00
Cloning and characterization of two different types of geranyl diphosphate synthases from Norway spruce (Picea abies). Phytochemistry (2007) 1.00
A bifunctional geranyl and geranylgeranyl diphosphate synthase is involved in terpene oleoresin formation in Picea abies. Plant Physiol (2009) 0.99
Geranylgeranyl diphosphate synthase in fission yeast is a heteromer of farnesyl diphosphate synthase (FPS), Fps1, and an FPS-like protein, Spo9, essential for sporulation. Mol Biol Cell (2007) 0.97
Molecular cloning and nucleotide sequences of the genes for two essential proteins constituting a novel enzyme system for heptaprenyl diphosphate synthesis. J Biol Chem (1995) 0.92
An alternative mechanism of product chain-length determination in type III geranylgeranyl diphosphate synthase. Eur J Biochem (2003) 0.92
Heteromeric geranyl diphosphate synthase from mint: construction of a functional fusion protein and inhibition by bisphosphonate substrate analogs. Arch Biochem Biophys (2004) 0.92
Maize cDNAs expressed in endosperm encode functional farnesyl diphosphate synthase with geranylgeranyl diphosphate synthase activity. Plant Physiol (2006) 0.92
Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human. Biochim Biophys Acta (1999) 0.91
Characterization of a novel aphid prenyltransferase displaying dual geranyl/farnesyl diphosphate synthase activity. FEBS Lett (2008) 0.91
Essential protein factors for polyprenyl pyrophosphate synthetases. Separation of heptaprenyl pyrophosphate synthetase into two components. FEBS Lett (1983) 0.90
Two cistrons of the gerC operon of Bacillus subtilis encode the two subunits of heptaprenyl diphosphate synthase. J Bacteriol (1997) 0.90
Cloning and functional expression of a novel geranylgeranyl pyrophosphate synthase gene from Arabidopsis thaliana in Escherichia coli. Plant Cell Physiol (1997) 0.89
Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures. J Bacteriol (2005) 0.89
A novel homodimeric geranyl diphosphate synthase from the orchid Phalaenopsis bellina lacking a DD(X)2-4D motif. Plant J (2008) 0.89
Molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from Coleus forskohlii Briq. BMC Plant Biol (2004) 0.85
A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products. Biochemistry (2004) 0.82
Combined experimental and theoretical study of long-range interactions modulating dimerization and activity of yeast geranylgeranyl diphosphate synthase. J Am Chem Soc (2009) 0.79
Reaction kinetic pathway of the recombinant octaprenyl pyrophosphate synthase from Thermotoga maritima: how is it different from that of the mesophilic enzyme. Biochim Biophys Acta (2002) 0.79
The product chain length determination mechanism of type II geranylgeranyl diphosphate synthase requires subunit interaction. FEBS J (2008) 0.79
A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science (2008) 2.96
Structure, mechanism and function of prenyltransferases. Eur J Biochem (2002) 2.63
Right or left turn? RecA family protein filaments promote homologous recombination through clockwise axial rotation. Bioessays (2008) 2.05
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A (2007) 2.00
High-throughput screening of soluble recombinant proteins. Protein Sci (2002) 1.90
The cAMP receptor-like protein CLP is a novel c-di-GMP receptor linking cell-cell signaling to virulence gene expression in Xanthomonas campestris. J Mol Biol (2009) 1.78
Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J Am Chem Soc (2009) 1.75
Genomic and proteomic analysis of thirty-nine structural proteins of shrimp white spot syndrome virus. J Virol (2004) 1.65
Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease. Chem Biol (2006) 1.63
Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem (2005) 1.62
Precise mapping of increased sialylation pattern and the expression of acute phase proteins accompanying murine tumor progression in BALB/c mouse by integrated sera proteomics and glycomics. J Proteome Res (2008) 1.51
Phasevarions mediate random switching of gene expression in pathogenic Neisseria. PLoS Pathog (2009) 1.48
Identification of the nucleocapsid, tegument, and envelope proteins of the shrimp white spot syndrome virus virion. J Virol (2006) 1.42
Cysteine S-nitrosylation protects protein-tyrosine phosphatase 1B against oxidation-induced permanent inactivation. J Biol Chem (2008) 1.40
The refined crystal structure of an eel pout type III antifreeze protein RD1 at 0.62-A resolution reveals structural microheterogeneity of protein and solvation. Biophys J (2003) 1.36
Structural and functional analysis of three β-glucosidases from bacterium Clostridium cellulovorans, fungus Trichoderma reesei and termite Neotermes koshunensis. J Struct Biol (2010) 1.33
Discovery of virulence factors of pathogenic bacteria. Curr Opin Chem Biol (2008) 1.31
Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation. Proc Natl Acad Sci U S A (2004) 1.30
Mechanism of the maturation process of SARS-CoV 3CL protease. J Biol Chem (2005) 1.27
Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolution. J Biol Chem (2003) 1.26
Small molecules targeting severe acute respiratory syndrome human coronavirus. Proc Natl Acad Sci U S A (2004) 1.25
Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase. EMBO J (2006) 1.24
Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds. J Biol Chem (2009) 1.23
DNA binding and degradation by the HNH protein ColE7. Structure (2004) 1.20
Cloning, purification, crystallization and preliminary X-ray crystallographic analysis of XC847, a 3'-5' oligoribonuclease from Xanthomonas campestris. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 1.19
Crystal structures of the BlaI repressor from Staphylococcus aureus and its complex with DNA: insights into transcriptional regulation of the bla and mec operons. J Bacteriol (2005) 1.19
Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination. J Biol Chem (2006) 1.19
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem (2008) 1.18
White spot syndrome virus annexes a shrimp STAT to enhance expression of the immediate-early gene ie1. J Virol (2006) 1.17
White spot syndrome virus protein ICP11: A histone-binding DNA mimic that disrupts nucleosome assembly. Proc Natl Acad Sci U S A (2008) 1.16
Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate. Biochem Biophys Res Commun (2004) 1.16
Structure and properties of recombinant human pyridoxine 5'-phosphate oxidase. Protein Sci (2003) 1.14
Protein expression profiling of the shrimp cellular response to white spot syndrome virus infection. Dev Comp Immunol (2006) 1.14
Catalytic mechanism revealed by the crystal structure of undecaprenyl pyrophosphate synthase in complex with sulfate, magnesium, and triton. J Biol Chem (2003) 1.13
Self-cleavage of fusion protein in vivo using TEV protease to yield native protein. Protein Sci (2005) 1.13
Crystal structure of the left-handed archaeal RadA helical filament: identification of a functional motif for controlling quaternary structures and enzymatic functions of RecA family proteins. Nucleic Acids Res (2007) 1.12
Mechanism of action and inhibition of dehydrosqualene synthase. Proc Natl Acad Sci U S A (2010) 1.11
Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents. Bioorg Med Chem (2008) 1.10
Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design. J Biol Chem (2007) 1.10
Substrate binding mode and reaction mechanism of undecaprenyl pyrophosphate synthase deduced from crystallographic studies. Protein Sci (2004) 1.09
Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determination. J Biol Chem (2003) 1.08
Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. J Biol Chem (2007) 1.08
Unusual DNA duplex and hairpin motifs. Nucleic Acids Res (2003) 1.08
Crystal structure of the [Mg2+-(chromomycin A3)2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ion. Nucleic Acids Res (2004) 1.08
A modified protein precipitation procedure for efficient removal of albumin from serum. Electrophoresis (2005) 1.07
The many blades of the β-propeller proteins: conserved but versatile. Trends Biochem Sci (2011) 1.07
Crystal structures of the human SUMO-2 protein at 1.6 A and 1.2 A resolution: implication on the functional differences of SUMO proteins. Eur J Biochem (2004) 1.05
Early detection of antibodies against various structural proteins of the SARS-associated coronavirus in SARS patients. J Biomed Sci (2004) 1.02
Crystal structure of infectious bursal disease virus VP2 subviral particle at 2.6A resolution: implications in virion assembly and immunogenicity. J Struct Biol (2006) 1.01
Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters. Bioorg Med Chem (2005) 1.00
Crystal structure of D-aminoacylase from Alcaligenes faecalis DA1. A novel subset of amidohydrolases and insights into the enzyme mechanism. J Biol Chem (2002) 1.00
The zinc ion in the HNH motif of the endonuclease domain of colicin E7 is not required for DNA binding but is essential for DNA hydrolysis. Nucleic Acids Res (2002) 1.00
Insights into the alkyl peroxide reduction pathway of Xanthomonas campestris bacterioferritin comigratory protein from the trapped intermediate-ligand complex structures. J Mol Biol (2009) 0.99
The structure and inhibition of a GGDEF diguanylate cyclase complexed with (c-di-GMP)(2) at the active site. Acta Crystallogr D Biol Crystallogr (2011) 0.99
Crystal structure and substrate-binding mode of cellulase 12A from Thermotoga maritima. Proteins (2011) 0.99
Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases. J Biomed Biotechnol (2008) 0.99
Structures of Selenomonas ruminantium phytase in complex with persulfated phytate: DSP phytase fold and mechanism for sequential substrate hydrolysis. Structure (2004) 0.98
Structures, mechanisms and inhibitors of undecaprenyl diphosphate synthase: a cis-prenyltransferase for bacterial peptidoglycan biosynthesis. Bioorg Chem (2011) 0.98
Crystal structure of the hyperthermophilic archaeal DNA-binding protein Sso10b2 at a resolution of 1.85 Angstroms. J Bacteriol (2003) 0.98
Synthesis and application of a fluorescent substrate analogue to study ligand interactions for undecaprenyl pyrophosphate synthase. J Am Chem Soc (2002) 0.97
Protein S-thiolation by Glutathionylspermidine (Gsp): the role of Escherichia coli Gsp synthetASE/amidase in redox regulation. J Biol Chem (2010) 0.97
Structural study of TcaR and its complexes with multiple antibiotics from Staphylococcus epidermidis. Proc Natl Acad Sci U S A (2010) 0.96
Crystal structure of IcaR, a repressor of the TetR family implicated in biofilm formation in Staphylococcus epidermidis. Nucleic Acids Res (2008) 0.96