Published in PLoS Pathog on October 06, 2011
Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung. PLoS Pathog (2015) 1.48
Pulmonary-intestinal cross-talk in mucosal inflammatory disease. Mucosal Immunol (2011) 1.26
A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis. J Allergy Clin Immunol (2013) 1.16
Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung. Mucosal Immunol (2012) 1.04
Asthma microbiome studies and the potential for new therapeutic strategies. Curr Allergy Asthma Rep (2013) 0.97
Diversity of IL-17-producing T lymphocytes. Cell Mol Life Sci (2012) 0.91
Local IL-17A potentiates early neutrophil recruitment to the respiratory tract during severe RSV infection. PLoS One (2013) 0.91
Secondary electrospray ionization-mass spectrometry (SESI-MS) breathprinting of multiple bacterial lung pathogens, a mouse model study. J Appl Physiol (1985) (2013) 0.89
TLR2, but not TLR4, is required for effective host defence against Chlamydia respiratory tract infection in early life. PLoS One (2012) 0.85
Haemophilus influenzae responds to glucocorticoids used in asthma therapy by modulation of biofilm formation and antibiotic resistance. EMBO Mol Med (2015) 0.84
Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis. J Biol Chem (2014) 0.84
Elucidating novel disease mechanisms in severe asthma. Clin Transl Immunology (2016) 0.84
The Lung Immune Response to Nontypeable Haemophilus influenzae (Lung Immunity to NTHi). J Immunol Res (2015) 0.83
Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice. PLoS One (2012) 0.81
Nontypeable Haemophilus influenzae induces sustained lung oxidative stress and protease expression. PLoS One (2015) 0.80
Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease. Mucosal Immunol (2013) 0.79
Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette- smoke-induced lung inflammation in mice. Clin Sci (Lond) (2015) 0.79
From bedside to bench to clinic trials: identifying new treatments for severe asthma. Dis Model Mech (2013) 0.77
IL-17A and serum amyloid A are elevated in a cigarette smoke cessation model associated with the persistence of pigmented macrophages, neutrophils and activated NK cells. PLoS One (2014) 0.77
Characterization of a novel mouse model with genetic deletion of CD177. Protein Cell (2014) 0.77
Does IL-17 Respond to the Disordered Lung Microbiome and Contribute to the Neutrophilic Phenotype in Asthma? Mediators Inflamm (2016) 0.77
Dual effects of respiratory syncytial virus infections on airway inflammation by regulation of Th17/Treg responses in ovalbumin-challenged mice. Inflammation (2014) 0.76
High mobility group box 1: a novel mediator of Th2-type response-induced airway inflammation of acute allergic asthma. J Thorac Dis (2015) 0.76
Maturation of molybdoenzymes and its influence on the pathogenesis of non-typeable Haemophilus influenzae. Front Microbiol (2015) 0.76
Neonatal Streptococcus pneumoniae infection may aggravate adulthood allergic airways disease in association with IL-17A. PLoS One (2015) 0.76
Interleukin-22 protects against non-typeable Haemophilus influenzae infection: alteration during chronic obstructive pulmonary disease. Mucosal Immunol (2016) 0.75
Breathing Better Through Bugs: Asthma and the Microbiome. Yale J Biol Med (2016) 0.75
TLR2, TLR4 AND MyD88 Mediate Allergic Airway Disease (AAD) and Streptococcus pneumoniae-Induced Suppression of AAD. PLoS One (2016) 0.75
Early-Life Intranasal Colonization with Nontypeable Haemophilus influenzae Exacerbates Juvenile Airway Disease in Mice. Infect Immun (2016) 0.75
A Novel, Molybdenum-Containing Methionine Sulfoxide Reductase Supports Survival of Haemophilus influenzae in an In vivo Model of Infection. Front Microbiol (2016) 0.75
Biomarkers in the Management of Difficult Asthma. Curr Top Med Chem (2016) 0.75
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med (2005) 28.73
Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med (2001) 12.38
Asthma. N Engl J Med (2001) 8.73
Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med (2002) 6.48
IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol (2006) 5.27
Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med (2008) 4.95
Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med (1999) 4.75
Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med (2006) 4.38
IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J Immunol (2003) 4.13
Asthma: an epidemic of dysregulated immunity. Nat Immunol (2002) 4.00
IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol (2001) 3.91
Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am J Respir Cell Mol Biol (2003) 3.60
Non-eosinophilic asthma: importance and possible mechanisms. Thorax (2002) 3.53
Essential involvement of interleukin-8 (IL-8) in acute inflammation. J Leukoc Biol (1994) 3.35
Non-eosinophilic corticosteroid unresponsive asthma. Lancet (1999) 3.25
Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8. Chest (2001) 3.19
gammadelta T cells: an important source of IL-17. Curr Opin Immunol (2008) 3.03
Persistent colonization by Haemophilus influenzae in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2004) 2.96
Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J Allergy Clin Immunol (1995) 2.88
Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology (2006) 2.67
IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? Respir Res (2006) 2.66
Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax (2002) 2.63
IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice. Am J Respir Crit Care Med (2008) 2.62
An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. J Immunol (2007) 2.46
Th17 and natural Treg cell population dynamics in systemic lupus erythematosus. Arthritis Rheum (2009) 2.43
IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection. Microbes Infect (2006) 2.39
Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax (2007) 2.37
Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax (2006) 2.18
IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma. J Immunol (2008) 2.17
Modulation of dendritic cell trafficking to and from the airways. J Immunol (2006) 2.17
Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4. J Allergy Clin Immunol (2010) 2.02
The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated. Infect Immun (1995) 1.94
Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma. Eur Respir J (2002) 1.92
T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. Clin Exp Immunol (2009) 1.89
Respiratory infections caused by non-typeable Haemophilus influenzae. Curr Opin Infect Dis (2003) 1.89
Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein. Infect Immun (2005) 1.77
The role of rhinovirus in asthma exacerbations. J Allergy Clin Immunol (2005) 1.68
Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology. J Allergy Clin Immunol (2010) 1.66
Nontypeable Haemophilus influenzae: understanding virulence and commensal behavior. Trends Microbiol (2007) 1.64
Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma. J Immunol (2007) 1.60
Bacterial colonisation in patients with bronchiectasis: microbiological pattern and risk factors. Thorax (2002) 1.59
Assessment and evaluation of symptomatic steroid-naive asthmatics without sputum eosinophilia and their response to inhaled corticosteroids. Eur Respir J (2002) 1.59
Different inflammatory phenotypes in adults and children with acute asthma. Eur Respir J (2011) 1.50
Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses asthma-like responses via nitric oxide synthase 2 activity. J Immunol (2003) 1.46
Use of CpG oligonucleotides in treatment of asthma and allergic disease. Adv Drug Deliv Rev (2009) 1.14
Treatment of established asthma in a murine model using CpG oligodeoxynucleotides. Am J Physiol Lung Cell Mol Physiol (2002) 1.12
Cytokine/anti-cytokine therapy - novel treatments for asthma? Br J Pharmacol (2011) 1.11
New treatments for COPD. Nat Rev Drug Discov (2002) 1.09
Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease. Am J Respir Crit Care Med (2007) 1.09
CpG oligodeoxynucleotides can reverse Th2-associated allergic airway responses and alter the B7.1/B7.2 expression in a murine model of asthma. J Immunol (2000) 1.08
Peroxisome proliferator-activated receptor gamma agonist down-regulates IL-17 expression in a murine model of allergic airway inflammation. J Immunol (2009) 1.07
Different doses of lipopolysaccharides regulate the lung inflammation of asthmatic mice via TLR4 pathway in alveolar macrophages. J Asthma (2009) 1.07
Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells. Eur Respir J (2010) 1.04
IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages. J Immunol (2010) 1.02
Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease. J Immunol (2010) 1.00
Localization of human neutrophil interleukin-8 (CXCL-8) to organelle(s) distinct from the classical granules and secretory vesicles. J Leukoc Biol (2005) 1.00
Evidence of bacterial infection in acute exacerbations of chronic bronchitis. Semin Respir Infect (2000) 0.98
Steroid resistance in asthma: a major problem requiring novel solutions or a non-issue? Curr Opin Pharmacol (2004) 0.98
Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae. Vaccine (2007) 0.94
Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia. Free Radic Res (2010) 0.92
Exposure to endotoxins during sensitization prevents further endotoxin-induced exacerbation of airway inflammation in a mouse model of allergic asthma. Int Arch Allergy Immunol (2005) 0.90
Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease. Thorax (2010) 0.89
Chlamydia pneumoniae infection enhances cellular proliferation and reduces steroid responsiveness of human peripheral blood mononuclear cells via a tumor necrosis factor-alpha-dependent pathway. Clin Exp Allergy (2005) 0.86
Infectious Chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma. Pediatr Infect Dis J (2010) 0.85
The role of T regulatory cells in asthma. J Allergy Clin Immunol (2005) 0.83
Modulation of airway inflammation by Haemophilus influenzae isolates associated with chronic obstructive pulmonary disease exacerbation. Proc Am Thorac Soc (2006) 0.80
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med (2009) 9.38
Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial. Lancet (2012) 4.94
Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest (2003) 4.08
Eosinophils: biological properties and role in health and disease. Clin Exp Allergy (2008) 3.92
Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev (2014) 3.52
The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages. PLoS One (2010) 3.30
Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial. Lancet (2011) 3.21
Eosinophils: changing perspectives in health and disease. Nat Rev Immunol (2012) 2.69
Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology (2006) 2.67
Exhaled nitric oxide in pulmonary diseases: a comprehensive review. Chest (2010) 2.29
Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease. Proc Natl Acad Sci U S A (2009) 2.28
Eosinophil trafficking in allergy and asthma. J Allergy Clin Immunol (2007) 2.27
Cyclic alternating pattern in sleep and its relationship to creativity. Sleep Med (2011) 2.21
IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity. J Exp Med (2008) 2.19
Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax (2006) 2.18
Effects of anticytokine therapy in a mouse model of chronic asthma. Am J Respir Crit Care Med (2004) 2.15
Chemokines in asthma: cooperative interaction between chemokines and IL-13. J Allergy Clin Immunol (2003) 2.06
Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. J Exp Med (2002) 2.04
Clarithromycin targets neutrophilic airway inflammation in refractory asthma. Am J Respir Crit Care Med (2007) 1.91
Interferon-ε protects the female reproductive tract from viral and bacterial infection. Science (2013) 1.73
Interleukin-10 gene expression in acute virus-induced asthma. Am J Respir Crit Care Med (2005) 1.68
Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice. J Allergy Clin Immunol (2013) 1.67
Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15(S)-lipoxygenase: identification of a novel pathway for regulating allergic inflammation. J Immunol (2009) 1.67
Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology. J Allergy Clin Immunol (2010) 1.66
Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase. J Immunol (2004) 1.62
Investigation of the association between dietary intake, disease severity and airway inflammation in asthma. Respirology (2013) 1.60
Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples. J Allergy Clin Immunol (2011) 1.57
Immunological decision-making: how does the immune system decide to mount a helper T-cell response? Immunology (2007) 1.54
Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus. Blood (2007) 1.52
Laryngeal sensory dysfunction in laryngeal hypersensitivity syndrome. Respirology (2013) 1.48
The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma. Chest (2012) 1.48
Toll/IL-1 signaling is critical for house dust mite-specific helper T cell type 2 and type 17 [corrected] responses. Am J Respir Crit Care Med (2009) 1.47
Modeling allergic asthma in mice: pitfalls and opportunities. Am J Respir Cell Mol Biol (2002) 1.47
Regulation of microRNA by antagomirs: a new class of pharmacological antagonists for the specific regulation of gene function? Am J Respir Cell Mol Biol (2006) 1.47
Inhibition of house dust mite-induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment. J Allergy Clin Immunol (2011) 1.44
The "classical" ovalbumin challenge model of asthma in mice. Curr Drug Targets (2008) 1.42
Schistosoma mansoni infection in eosinophil lineage-ablated mice. Blood (2006) 1.42
Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness. J Immunol (2006) 1.40
Interventions for educating children who are at risk of asthma-related emergency department attendance. Cochrane Database Syst Rev (2009) 1.38
Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance. J Immunol (2007) 1.36
Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease. Nat Med (2007) 1.36
IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations. J Allergy Clin Immunol (2007) 1.34
Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev (2009) 1.32
NK cell deficiency predisposes to viral-induced Th2-type allergic inflammation via epithelial-derived IL-25. J Immunol (2010) 1.32
Transcutaneous immunization with combined cholera toxin and CpG adjuvant protects against Chlamydia muridarum genital tract infection. Infect Immun (2004) 1.30
Methods for the isolation and identification of Listeria spp. and Listeria monocytogenes: a review. FEMS Microbiol Rev (2004) 1.28
Inhaled corticosteroid doses in asthma: an evidence-based approach. Med J Aust (2003) 1.27
Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in mice. Am J Respir Crit Care Med (2003) 1.25
TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages. J Immunol (2008) 1.25
Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma. Am J Respir Crit Care Med (2005) 1.24
Impaired resistance in early secondary Nippostrongylus brasiliensis infections in mice with defective eosinophilopoeisis. Int J Parasitol (2007) 1.23
Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma. Am J Respir Cell Mol Biol (2008) 1.23
Airway hyperreactivity in exacerbation of chronic asthma is independent of eosinophilic inflammation. Am J Respir Cell Mol Biol (2006) 1.22
A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma. J Allergy Clin Immunol (2011) 1.22
Marked host specificity and lack of phylogeographic population structure of Campylobacter jejuni in wild birds. Mol Ecol (2013) 1.20
The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity. Nat Med (2013) 1.20
Maternal asthma is associated with reduced female fetal growth. Am J Respir Crit Care Med (2003) 1.20
Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma. J Pharmacol Exp Ther (2003) 1.20
The IL-3/IL-5/GM-CSF common receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation. J Immunol (2008) 1.19
Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9). Proc Natl Acad Sci U S A (2004) 1.18
A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis. J Allergy Clin Immunol (2013) 1.16
Chronic refractory cough as a sensory neuropathy: evidence from a reinterpretation of cough triggers. J Voice (2010) 1.15
Altered expression of microRNA in the airway wall in chronic asthma: miR-126 as a potential therapeutic target. BMC Pulm Med (2011) 1.14
Inflammometry: the current state of play. Thorax (2012) 1.14
S100A12 provokes mast cell activation: a potential amplification pathway in asthma and innate immunity. J Allergy Clin Immunol (2006) 1.14
Elevated expression of the NLRP3 inflammasome in neutrophilic asthma. Eur Respir J (2013) 1.14
Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity. J Allergy Clin Immunol (2003) 1.13
Emerging roles of pulmonary macrophages in driving the development of severe asthma. J Leukoc Biol (2012) 1.11
Understanding the mechanisms of viral induced asthma: new therapeutic directions. Pharmacol Ther (2008) 1.11
Cytokine/anti-cytokine therapy - novel treatments for asthma? Br J Pharmacol (2011) 1.11
Transgenic expression of bean alpha-amylase inhibitor in peas results in altered structure and immunogenicity. J Agric Food Chem (2005) 1.11
Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains. Respirology (2009) 1.10
Manipulating antioxidant intake in asthma: a randomized controlled trial. Am J Clin Nutr (2012) 1.10
Pregnant women have attenuated innate interferon responses to 2009 pandemic influenza A virus subtype H1N1. J Infect Dis (2012) 1.10
Interferon-gamma as a possible target in chronic asthma. Inflamm Allergy Drug Targets (2006) 1.10
Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease. Am J Respir Crit Care Med (2007) 1.09
Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice. Respir Res (2010) 1.07
Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma. Thorax (2012) 1.07
Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's disease. Mov Disord (2007) 1.06