Published in PLoS One on October 06, 2011
Matrine induces apoptosis in human acute myeloid leukemia cells via the mitochondrial pathway and Akt inactivation. PLoS One (2012) 1.21
Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation. Oncotarget (2014) 0.89
TRPC6 channel activation promotes neonatal glomerular mesangial cell apoptosis via calcineurin/NFAT and FasL/Fas signaling pathways. Sci Rep (2016) 0.77
The CNGRC-GG-D(KLAKLAK)2 peptide induces a caspase-independent, Ca2+-dependent death in human leukemic myeloid cells by targeting surface aminopeptidase N/CD13. Oncotarget (2016) 0.77
Tert-butylhydroquinone lowers blood pressure in AngII-induced hypertension in mice via proteasome-PTEN-Akt-eNOS pathway. Sci Rep (2016) 0.75
Novel cancer chemotherapy hits by molecular topology: dual Akt and Beta-catenin inhibitors. PLoS One (2015) 0.75
Targeting prohibitins induces apoptosis in acute myeloid leukemia cells. Oncotarget (2016) 0.75
Cellular survival: a play in three Akts. Genes Dev (1999) 17.05
Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol (1999) 6.62
Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci (1999) 4.42
NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood (1991) 4.30
Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. Biochem J (2005) 3.58
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood (2006) 3.13
Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J Biol Chem (1999) 2.52
Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice. Blood (2009) 2.42
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. Leukemia (2006) 2.28
Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy. Drug Resist Updat (2007) 2.21
Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition. PLoS Biol (2009) 2.15
Noxa: at the tip of the balance between life and death. Oncogene (2008) 2.09
Physiological regulation of Akt activity and stability. Am J Transl Res (2010) 1.95
The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo. Blood (2009) 1.83
Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin. Leukemia (2005) 1.67
PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect. Leukemia (2011) 1.59
Pathways to caspase activation. Cell Biol Int (2005) 1.50
Hyperforin inhibits P-gp and BCRP activities in chronic lymphocytic leukaemia cells and myeloid cells. Leuk Lymphoma (2007) 1.50
Anti-inflammatory compounds of plant origin. Part II. modulation of pro-inflammatory cytokines, chemokines and adhesion molecules. Planta Med (2004) 1.49
Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5. Blood (2008) 1.45
p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas. Mol Cancer Ther (2004) 1.40
Frequent mutations in the p53 gene in human myeloid leukemia cell lines. Blood (1992) 1.39
Targeting NF-kappaB in hematologic malignancies. Cell Death Differ (2006) 1.38
Bid: a Bax-like BH3 protein. Oncogene (2008) 1.38
Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia. Expert Opin Investig Drugs (2009) 1.36
Mechanisms of action of flavopiridol. Crit Rev Oncol Hematol (2001) 1.33
Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies. Leukemia (2010) 1.32
Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor kappa B (NF-kappaB). Planta Med (2003) 1.28
Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions. Mol Cancer Ther (2007) 1.24
Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias. Leukemia (2004) 1.24
Serine/threonine phosphatases in the DNA damage response and cancer. Oncogene (2010) 1.22
Targeted induction of apoptosis for cancer therapy: current progress and prospects. Trends Mol Med (2006) 1.21
Mammalian target of rapamycin as a therapeutic target in leukemia. Curr Mol Med (2005) 1.19
Ready for a comeback of natural products in oncology. Biochem Pharmacol (2008) 1.11
Changes in antigen expression on differentiating HL60 cells treated with dimethylsulphoxide, all-trans retinoic acid, alpha1,25-dihydroxyvitamin D3 or 12-O-tetradecanoyl phorbol-13-acetate. Leuk Res (1998) 1.08
Nuclear factor kB as a target for new drug development in myeloid malignancies. Haematologica (2007) 1.05
Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines. Eur J Pharm Biopharm (2003) 1.05
Interferons inhibit tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 activation via interferon regulatory factor-1 binding competition with NF-kappa B. J Biol Chem (2002) 1.04
Regulation of cell proliferation and survival: convergence of protein kinases and caspases. Biochim Biophys Acta (2009) 1.02
Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations. AAPS J (2009) 1.01
Flavopiridol: pleiotropic biological effects enhance its anti-cancer activity. Anticancer Drugs (2004) 0.98
Induction of apoptosis by esculetin in human leukemia U937 cells through activation of JNK and ERK. Toxicol Appl Pharmacol (2007) 0.97
Hyperforin: more than an antidepressant bioactive compound? Life Sci (2006) 0.96
Role of hyperforin in the pharmacological activities of St. John's Wort. CNS Drug Rev (2004) 0.94
Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain. Curr Med Chem (2011) 0.93
Mechanisms of differentiation of U937 leukemic cells induced by GM-CSF and 1,25(OH)2 vitamin D3. Leuk Res (1991) 0.90
Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet (2006) 0.90
Roles and regulation of the transcription factor CREB in pancreatic β -cells. Curr Mol Pharmacol (2011) 0.89
Bid stands at the crossroad of stress-response pathways. Curr Cancer Drug Targets (2010) 0.89
Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet. Arzneimittelforschung (2005) 0.88
Chemotherapy resistance in acute myeloid leukaemia. Best Pract Res Clin Haematol (2001) 0.88
The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice. Oncogene (2011) 0.86
Retinoid-induced activation of NF-kappaB in APL cells is not essential for granulocytic differentiation, but prolongs the life span of mature cells. Oncogene (2005) 0.86
Nuclear phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3-kinase, Akt, and PTen: emerging key regulators of anti-apoptotic signaling and carcinogenesis. Eur J Histochem (2007) 0.86
Hyperforin and aristoforin inhibit lymphatic endothelial cell proliferation in vitro and suppress tumor-induced lymphangiogenesis in vivo. Int J Cancer (2009) 0.85
The immunophenotype of acute myeloid leukemia: is there a relationship with prognosis? Blood Rev (2005) 0.85
Neurobiological effects of Hyperforin and its potential in Alzheimer's disease therapy. Curr Med Chem (2010) 0.85
Molecular bases of myelodysplastic syndromes: lessons from animal models. J Cell Physiol (2009) 0.85
Drug-induced Myc-mediated apoptosis of cancer cells is inhibited by stress protein Hsp70. Int J Cancer (2007) 0.84
Expressions of four major protein Ser/Thr phosphatases in human primary leukemic cells. Leukemia (1999) 0.83
TGF-beta 1-stimulated adhesion of human mononuclear phagocytes to fibronectin and laminin is abolished by IFN-gamma: dependence on alpha 5 beta 1 and beta 2 integrins. Exp Cell Res (1996) 0.83
Pro-apoptotic properties of hyperforin in leukemic cells from patients with B-cell chronic lymphocytic leukemia. Leukemia (2006) 0.83
Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo. Cell Mol Life Sci (2009) 0.83
Hyperforin, a new lead compound against the progression of cancer and leukemia? Leukemia (2006) 0.83
Prognostic value of immunophenotyping in elderly patients with acute myeloid leukemia: a single-institution experience. Cancer (2008) 0.83
Recent developments in acute myelogenous leukemia therapy. Oncologist (2007) 0.82
Matrix proteases, green tea, and St. John's wort: biomedical research catches up with folk medicine. Clin Chim Acta (2007) 0.82
Controversies in treatment of AML: case-based discussion. Hematology Am Soc Hematol Educ Program (2006) 0.81
Mechanisms of Hyperforin as an anti-angiogenic angioprevention agent. Eur J Cancer (2009) 0.80
P53 transcription-independent activity mediates selenite-induced acute promyelocytic leukemia NB4 cell apoptosis. BMB Rep (2008) 0.80
Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway. Chem Biol Interact (2011) 0.79
Noxa upregulation is associated with apoptosis of chronic lymphocytic leukemia cells induced by hyperforin but not flavopiridol. Leukemia (2008) 0.78
Effect of eluent pH on the HPLC-UV analysis of hyperforin from St. John's Wort (Hypericum perforatum L.). Phytochem Anal (2006) 0.76
Loss of the Bcl-2 phosphorylation loop domain is required to protect human myeloid leukemia cells from flavopiridol-mediated mitochondrial damage and apoptosis. Cancer Biol Ther (2002) 0.76
NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy. J Biol Chem (2006) 3.67
Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway. Blood (2003) 2.06
Characterization of microRNAs involved in embryonic stem cell states. Stem Cells Dev (2010) 1.62
microRNAs regulate human embryonic stem cell division. Cell Cycle (2009) 1.58
Hyperforin inhibits P-gp and BCRP activities in chronic lymphocytic leukaemia cells and myeloid cells. Leuk Lymphoma (2007) 1.50
Role of BAFF and APRIL in human B-cell chronic lymphocytic leukaemia. Immunology (2006) 1.30
Matrix metalloproteinase-9 silencing by RNA interference triggers the migratory-adhesive switch in Ewing's sarcoma cells. J Biol Chem (2003) 1.27
IFN-beta impairs superoxide-dependent parasite killing in human macrophages: evidence for a deleterious role of SOD1 in cutaneous leishmaniasis. J Immunol (2009) 1.26
MRP3, BCRP, and P-glycoprotein activities are prognostic factors in adult acute myeloid leukemia. Clin Cancer Res (2005) 1.15
Interferons inhibit tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 activation via interferon regulatory factor-1 binding competition with NF-kappa B. J Biol Chem (2002) 1.04
Regulation of autophagy by NFkappaB transcription factor and reactives oxygen species. Autophagy (2007) 0.99
Phase I studies of AVE9633, an anti-CD33 antibody-maytansinoid conjugate, in adult patients with relapsed/refractory acute myeloid leukemia. Invest New Drugs (2011) 0.99
Protein tyrosine kinase and p38 MAP kinase pathways are involved in stimulation of matrix metalloproteinase-9 by TNF-alpha in human monocytes. Immunol Lett (2006) 0.94
Re-establishment of a normal apoptotic process as a therapeutic approach in B-CLL. Curr Drug Targets Cardiovasc Haematol Disord (2003) 0.93
JC-1, a sensitive probe for a simultaneous detection of P-glycoprotein activity and apoptosis in leukemic cells. Cytometry B Clin Cytom (2006) 0.93
Analysis of resveratrol-induced apoptosis in human B-cell chronic leukaemia. Br J Haematol (2002) 0.91
ATRA-induced upregulation of Beclin 1 prolongs the life span of differentiated acute promyelocytic leukemia cells. Autophagy (2011) 0.90
Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells. FASEB J (2011) 0.89
ATP Binding Cassette transporters associated with chemoresistance: transcriptional profiling in extreme cohorts and their prognostic impact in a cohort of 281 acute myeloid leukemia patients. Haematologica (2011) 0.88
Inhibition of matrix metalloproteinase-9 by interferons and TGF-beta1 through distinct signalings accounts for reduced monocyte invasiveness. FEBS Lett (2005) 0.88
Development of potent and selective dipeptidyl peptidase II inhibitors. Bioorg Med Chem Lett (2002) 0.86
Comparative antiproliferative and apoptotic effects of resveratrol, epsilon-viniferin and vine-shots derived polyphenols (vineatrols) on chronic B lymphocytic leukemia cells and normal human lymphocytes. Leuk Lymphoma (2002) 0.86
Applying ecological and evolutionary theory to cancer: a long and winding road. Evol Appl (2012) 0.84
Stimulation of iNOS expression and apoptosis resistance in B-cell chronic lymphocytic leukemia (B-CLL) cells through engagement of Toll-like receptor 7 (TLR-7) and NF-kappaB activation. Nitric Oxide (2008) 0.84
Soluble endothelial protein C receptor (sEPCR) is likely a biomarker of cancer-associated hypercoagulability in human hematologic malignancies. Cancer Med (2012) 0.84
Flavones and polyphenols inhibit the NO pathway during apoptosis of leukemia B-cells. Leuk Res (2004) 0.83
Flexusines A and B and epimukulol from the soft coral Sarcophyton flexuosum. J Nat Prod (2008) 0.83
Flt3 internal tandem duplication and P-glycoprotein functionality in 171 patients with acute myeloid leukemia. Clin Cancer Res (2006) 0.82
gamma-Glutamyl transpeptidase expression in Ewing's sarcoma cells: up-regulation by interferons. Biochem J (2002) 0.82
Clinical and biological impact of TET2 mutations and expression in younger adult AML patients treated within the EORTC/GIMEMA AML-12 clinical trial. Ann Hematol (2014) 0.81
Structure-activity relationship and molecular mechanisms of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and its analogues. J Med Chem (2011) 0.81
Nestin expression in the retina of rats with inherited retinal degeneration. Exp Eye Res (2013) 0.81
Ad-IFN gamma induces antiproliferative and antitumoral responses in malignant mesothelioma. Clin Cancer Res (2002) 0.80
Allium compounds, dipropyl and dimethyl thiosulfinates as antiproliferative and differentiating agents of human acute myeloid leukemia cell lines. Biologics (2008) 0.80
p70S6 kinase is a target of the novel proteasome inhibitor 3,3'-diamino-4'-methoxyflavone during apoptosis in human myeloid tumor cells. Biochim Biophys Acta (2013) 0.80
Anthocyanin and flavonoid production from Perilla frutescens: pilot plant scale processing including cross-flow microfiltration and reverse osmosis. J Agric Food Chem (2006) 0.79
Analysis of the mechanisms of human cytotoxic T lymphocyte response inhibition by NO. Int Immunol (2002) 0.78
Therapeutic activity of two xanthones in a xenograft murine model of human chronic lymphocytic leukemia. J Hematol Oncol (2010) 0.78
Ptilomycalin D, a polycyclic guanidine alkaloid from the marine sponge Monanchora dianchora. J Nat Prod (2007) 0.78
Interactions between human monocytes and fibronectin are suppressed by interferons beta and gamma, but not alpha: correlation with Rho-paxillin signaling. Int J Mol Med (2002) 0.78
Hyperforin induces apoptosis of chronic lymphocytic leukemia cells through upregulation of the BH3-only protein Noxa. Int J Oncol (2011) 0.77
[Cell death signalling: recent advances and therapeutic application]. Bull Cancer (2005) 0.77
Prognostic impact of high ABC transporter activity in 111 adult acute myeloid leukemia patients with normal cytogenetics when compared to FLT3, NPM1, CEBPA and BAALC. Haematologica (2011) 0.77
4-arylcoumarin analogues of combretastatins stimulate apoptosis of leukemic cells from chronic lymphocytic leukemia patients. Exp Hematol (2008) 0.76
Flavopiridol-induced iNOS downregulation during apoptosis of chronic lymphocytic leukemia cells is caspase-dependent. Leuk Res (2007) 0.76
Acute myeloid leukemia in patients older than 75: prognostic impact of FLT3-ITD and NPM1 mutations. Leuk Lymphoma (2014) 0.76
Isolation and characterization of a new hispolone derivative from antioxidant extracts of Pistacia atlantica. Phytother Res (2009) 0.76
Chemotypes of Pistacia atlantica leaf essential oils from Algeria. Nat Prod Commun (2010) 0.75
Aldosterone and Vascular Mineralocorticoid Receptors in Murine Endotoxic and Human Septic Shock. Crit Care Med (2017) 0.75
The inducible NO synthase is downregulated during apoptosis of malignant cells from B-cell chronic lymphocytic leukemia induced by flavopiridol and polyphenols. Ann N Y Acad Sci (2003) 0.75
Oleodaphnoic acid and coriaceol, two new natural products from the stem bark of Wikstroemia coriacea. Molecules (2013) 0.75
A new acute lymphoblastic leukaemia cell line BEL-1 with t(4; 11) (q21; q23) chromosomal translocation and a unique aberrant p27 transcript. Br J Haematol (2004) 0.75
Chemical composition and antioxidant activity of seed oil of two Algerian date palm cultivars (Phoenix dactylifera). Nat Prod Commun (2014) 0.75
Synthesis and spectroscopic examination of various substituted 1,3-dibenzoylmethane, active agents for UVA/UVB photoprotection. J Photochem Photobiol B (2008) 0.75
The BH3-only protein Noxa is stimulated during apoptosis of chronic lymphocytic leukemia cells triggered by M2YN, a new plant-derived extract. Int J Oncol (2011) 0.75
Marine bifunctional sphingolipids from the sponge Oceanapia ramsayi. Molecules (2008) 0.75
Effect of Maturation Degree on Composition of Fatty Acids and Tocopherols of Fruit Oil from Pistacia atlantica Growing Wild in Algeria. Nat Prod Commun (2015) 0.75