Computational modeling of airway and pulmonary vascular structure and function: development of a "lung physiome".

PubWeight™: 0.81‹?›

🔗 View Article (PMC 3215333)

Published in Crit Rev Biomed Eng on January 01, 2011

Authors

Merryn Tawhai1, A Clark, G Donovan, K Burrowes

Author Affiliations

1: Auckland Bioengineering Institute, The University of Auckland, New Zealand.

Articles cited by this

Muscle structure and theories of contraction. Prog Biophys Biophys Chem (1957) 32.09

Self-organized patchiness in asthma as a prelude to catastrophic shifts. Nature (2005) 3.82

Regional distribution of inspired gas in the lung. J Appl Physiol (1966) 3.65

Morphometry of the human pulmonary acinus. Anat Rec (1988) 3.18

DISTRIBUTION OF BLOOD FLOW IN ISOLATED LUNG; RELATION TO VASCULAR AND ALVEOLAR PRESSURES. J Appl Physiol (1964) 2.89

SOME NEW FACTS ABOUT THE PULMONARY ARTERY AND ITS BRANCHING PATTERN. Clin Radiol (1965) 2.41

Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm. Am J Respir Crit Care Med (1999) 2.40

Models of the human bronchial tree. J Appl Physiol (1971) 2.34

THE PHYSIOLOGICAL PRINCIPLE OF MINIMUM WORK APPLIED TO THE ANGLE OF BRANCHING OF ARTERIES. J Gen Physiol (1926) 2.22

Counterpoint: Gravity is not the major factor determining the distribution of blood flow in the healthy human lung. J Appl Physiol (1985) (2008) 2.18

Cross-bridge phosphorylation and regulation of latch state in smooth muscle. Am J Physiol (1988) 2.10

Gravity is a minor determinant of pulmonary blood flow distribution. J Appl Physiol (1985) (1991) 2.03

CT-based geometry analysis and finite element models of the human and ovine bronchial tree. J Appl Physiol (1985) (2004) 2.02

Vertical gradients in regional lung density and perfusion in the supine human lung: the Slinky effect. J Appl Physiol (1985) (2007) 1.92

Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airways. Respir Physiol Neurobiol (2007) 1.78

Simulation of pulmonary air flow with a subject-specific boundary condition. J Biomech (2010) 1.54

Computational physiology and the Physiome Project. Exp Physiol (2004) 1.53

Effects of age on elastic moduli of human lungs. J Appl Physiol (1985) (2000) 1.52

A computational model for expiratory flow. J Appl Physiol Respir Environ Exerc Physiol (1982) 1.51

MCAT to XCAT: The Evolution of 4-D Computerized Phantoms for Imaging Research: Computer models that take account of body movements promise to provide evaluation and improvement of medical imaging devices and technology. Proc IEEE Inst Electr Electron Eng (2009) 1.49

Patient-specific finite element modeling of respiratory lung motion using 4D CT image data. Med Phys (2009) 1.48

Stresses, strains, and surface pressures in the lung caused by its weight. J Appl Physiol (1972) 1.44

Supine and prone differences in regional lung density and pleural pressure gradients in the human lung with constant shape. J Appl Physiol (1985) (2009) 1.43

A three-dimensional model of the human airway tree. J Appl Physiol (1985) (1999) 1.42

Generation of an anatomically based three-dimensional model of the conducting airways. Ann Biomed Eng (2000) 1.41

Computational fluid dynamics. IEEE Eng Med Biol Mag (2009) 1.41

Airway stability and heterogeneity in the constricted lung. J Appl Physiol (1985) (2001) 1.40

On intra- and intersubject variabilities of airflow in the human lungs. Phys Fluids (1994) (2009) 1.36

Anatomically based geometric modelling of the musculo-skeletal system and other organs. Biomech Model Mechanobiol (2003) 1.36

Computational fluid dynamics simulation of airflow and aerosol deposition in human lungs. Ann Biomed Eng (2003) 1.34

A vision and strategy for the virtual physiological human in 2010 and beyond. Philos Trans A Math Phys Eng Sci (2010) 1.33

Geometric modeling of the human torso using cubic hermite elements. Ann Biomed Eng (1997) 1.33

Smaller is better--but not too small: a physical scale for the design of the mammalian pulmonary acinus. Proc Natl Acad Sci U S A (2002) 1.31

The IUPS human Physiome Project. Pflugers Arch (2002) 1.25

Fractal properties of pulmonary blood flow: characterization of spatial heterogeneity. J Appl Physiol (1985) (1990) 1.25

Fractal modeling of pulmonary blood flow heterogeneity. J Appl Physiol (1985) (1991) 1.25

Application of an idealized model to morphometry of the mammalian tracheobronchial tree. Anat Rec (1978) 1.24

Morphometry of the small pulmonary arteries in man. Circ Res (1978) 1.24

Flow analyses in the lower airways: patient-specific model and boundary conditions. Med Eng Phys (2007) 1.22

A mathematical model of airway and pulmonary arteriole smooth muscle. Biophys J (2007) 1.19

Anatomically based finite element models of the human pulmonary arterial and venous trees including supernumerary vessels. J Appl Physiol (1985) (2005) 1.18

A multiscale, spatially distributed model of asthmatic airway hyper-responsiveness. J Theor Biol (2010) 1.18

Sliding characteristic and material compressibility of human lung: parametric study and verification. Med Phys (2009) 1.16

Improved measurements of shear modulus and pleural membrane tension of the lung. J Appl Physiol Respir Environ Exerc Physiol (1979) 1.16

In vitro validation of computational fluid dynamic simulation in human proximal airways with hyperpolarized 3He magnetic resonance phase-contrast velocimetry. J Appl Physiol (1985) (2007) 1.15

Stress transmission in the lung: pathways from organ to molecule. Annu Rev Physiol (2006) 1.15

Modeling of lung morphogenesis using fractal geometries. IEEE Trans Med Imaging (1988) 1.15

Gravity is an important but secondary determinant of regional pulmonary blood flow in upright primates. J Appl Physiol (1985) (1999) 1.14

Theory of sheet flow in lung alveoli. J Appl Physiol (1969) 1.12

Finite element displacement analysis of a lung. J Biomech (1972) 1.08

A model of the mechanics of airway narrowing. J Appl Physiol (1985) (1990) 1.07

Stratified distribution of blood flow in secondary lobule of the rat lung. J Appl Physiol (1967) 1.05

Computational modeling of RBC and neutrophil transit through the pulmonary capillaries. J Appl Physiol (1985) (2001) 1.04

Relation between structure, function, and imaging in a three-dimensional model of the lung. Ann Biomed Eng (2003) 1.02

New perspectives on the mechanical basis for airway hyperreactivity and airway hypersensitivity in asthma. J Appl Physiol (1985) (2006) 1.01

Computational predictions of pulmonary blood flow gradients: gravity versus structure. Respir Physiol Neurobiol (2005) 1.00

The interface between measurement and modeling of peripheral lung mechanics. Respir Physiol Neurobiol (2005) 0.99

Diameter, length and branching ratios in the bronchial tree. Respir Physiol (1976) 0.97

Integration from proteins to organs: the IUPS Physiome Project. Mech Ageing Dev (2005) 0.96

The interdependent contributions of gravitational and structural features to perfusion distribution in a multiscale model of the pulmonary circulation. J Appl Physiol (1985) (2011) 0.95

Contribution of serial and parallel microperfusion to spatial variability in pulmonary inter- and intra-acinar blood flow. J Appl Physiol (1985) (2010) 0.95

Modeling the dynamics of airway constriction: effects of agonist transport and binding. J Appl Physiol (1985) (2010) 0.93

Analysis of blood flow in cat's lung with detailed anatomical and elasticity data. J Appl Physiol Respir Environ Exerc Physiol (1983) 0.93

Elastic properties of air- and liquid-filled lung parenchyma. J Appl Physiol (1985) (1988) 0.91

An anatomically based patient-specific finite element model of patella articulation: towards a diagnostic tool. Biomech Model Mechanobiol (2005) 0.91

Vascular structure determines pulmonary blood flow distribution. News Physiol Sci (1999) 0.90

Investigation of the relative effects of vascular branching structure and gravity on pulmonary arterial blood flow heterogeneity via an image-based computational model. Acad Radiol (2005) 0.89

BIFURCATING DISTRIBUTIVE SYSTEM USING MONTE CARLO METHOD. Math Comput Model (1992) 0.89

Species-specific pulmonary arterial asymmetry determines species differences in regional pulmonary perfusion. Ann Biomed Eng (2009) 0.88

The role of airway epithelium in replenishment of evaporated airway surface liquid from the human conducting airways. Ann Biomed Eng (2010) 0.88

Model simulations of gas mixing and ventilation distribution in the human lung. J Appl Physiol (1985) (1990) 0.88

Endothelial control of vascular tone by nitric oxide and gap junctions: a haemodynamic perspective. Biorheology (2002) 0.87

Modeling RBC and neutrophil distribution through an anatomically based pulmonary capillary network. Ann Biomed Eng (2004) 0.86

Effect of heart weight on distribution of lung surface pressures in vertical dogs. J Appl Physiol (1985) (1986) 0.84

Characterising respiratory airway gas mixing using a lumped parameter model of the pulmonary acinus. Respir Physiol (2001) 0.84

Real-time simulation of 4D lung tumor radiotherapy using a breathing model. Med Image Comput Comput Assist Interv (2008) 0.84

Theoretical studies of gas mixing and ventilation distribution in the lung. Physiol Rev (1987) 0.82

Effects of anatomic variability on blood flow and pressure gradients in the pulmonary capillaries. J Appl Physiol (1985) (1997) 0.82

Effect of stratified inequality of blood flow on gas exchange in liquid-filled lungs. J Appl Physiol (1972) 0.82

Vascular impedance analysis in human pulmonary circulation. Biomed Sci Instrum (2006) 0.81

The circulation in the peripheral parts of the human lung. Dis Chest (1966) 0.80

The multiscale manifestations of airway smooth muscle contraction in the lung. J Appl Physiol (1985) (2010) 0.80

Comparison of theory and experiment in pulsatile flow in cat lung. Ann Biomed Eng (1998) 0.80

Airflow modeling of steady inspiration in two realistic proximal airway trees reconstructed from human thoracic tomodensitometric images. Comput Methods Biomech Biomed Engin (2005) 0.79

Flow and particle deposition patterns in a realistic human double bifurcation airway model. Inhal Toxicol (2007) 0.78

5-hydroxytryptamine- and U46619-mediated vasoconstriction in bovine pulmonary conventional and supernumerary arteries: effect of endogenous nitric oxide. Clin Sci (Lond) (2000) 0.76

Modeling respiratory motion for cancer radiation therapy based on patient-specific 4DCT data. Med Image Comput Comput Assist Interv (2009) 0.76

Articles by these authors

(truncated to the top 100)

Protective effect of breast feeding against infection. BMJ (1990) 5.88

Designing conditions for in vitro formation of amyloid protofilaments and fibrils. Proc Natl Acad Sci U S A (1999) 4.71

Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci U S A (1987) 4.19

Disease mapping models: an empirical evaluation. Disease Mapping Collaborative Group. Stat Med (2001) 2.88

Change in obstetric practice in response to fear of litigation in the British Isles. Lancet (1991) 2.78

Confirmatory assay increases specificity of the chlamydiazyme test for Chlamydia trachomatis infection of the cervix. J Clin Microbiol (1990) 2.65

Relation between early introduction of solid food to infants and their weight and illnesses during the first two years of life. BMJ (1993) 2.46

Declining T-cell immunity to influenza, 1977-82. Lancet (1983) 2.34

Quality of life measurements in patients with malignant disease: a review. J R Soc Med (1986) 2.28

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence? Diabetologia (2010) 2.21

Islet amyloid formed from diabetes-associated peptide may be pathogenic in type-2 diabetes. Lancet (1987) 2.15

The use of various handwashing agents to decontaminate gloved hands. Br Dent J (1989) 2.03

The management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunology. Allergy (2007) 1.91

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation. Diabetologia (2009) 1.87

The evidence for beta blockers in heart failure. BMJ (1999) 1.84

Efficacy and safety of high-dose peanut oral immunotherapy with factors predicting outcome. Clin Exp Allergy (2011) 1.81

Rapid reversal of hyperoxaluria in a rat model after probiotic administration of Oxalobacter formigenes. J Urol (2001) 1.74

The heart failure epidemic: exactly how big is it? Eur Heart J (2001) 1.73

Effect of smaller droplet size of dornase alfa on lung function in mild cystic fibrosis. Dornase Alfa Nebulizer Group. Pediatr Pulmonol (1998) 1.73

Analysis of pace-maker and repolarization currents in frog atrial muscle. J Physiol (1976) 1.72

Effector functions of a monoclonal aglycosylated mouse IgG2a: binding and activation of complement component C1 and interaction with human monocyte Fc receptor. Mol Immunol (1985) 1.68

Multivesicular exocytosis in rat pancreatic beta cells. Diabetologia (2011) 1.63

Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology. Biochim Biophys Acta (2001) 1.63

Oral androgens in the treatment of hypogonadal impotent men. J Urol (1994) 1.61

Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60

Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis. J Mol Biol (2001) 1.57

Immune-mediated reactions to althesin (alphaxalone). Br J Anaesth (1976) 1.56

Identification of the pace-maker current in frog atrium. J Physiol (1976) 1.56

A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)gammaa as a pancreatic beta cell-specific biomarker. Diabetologia (2010) 1.53

Do facial averageness and symmetry signal health? Evol Hum Behav (2001) 1.52

Functional health status levels of primary care patients. JAMA (1983) 1.52

Changes in blood flow close to subcutaneous insulin injection sites in stable and brittle diabetics. Diabetes (1983) 1.51

Reactogenicity and immunogenicity of inactivated influenza A (H1N1) virus vaccine in unprimed children. Report to the Medical Research Council Committee on influenza and other respiratory virus vaccines. J Biol Stand (1980) 1.48

The emergence of oseltamivir-resistant pandemic influenza A (H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, November-December, 2009. Euro Surveill (2010) 1.46

Randomized clinical trial of fluid and salt restriction compared with a controlled liberal regimen in elective gastrointestinal surgery. Br J Surg (2013) 1.46

Clinical studies of monovalent inactivated whole virus and subunit A/USSR/77 (H1N1) vaccine: serological responses and clinical reactions. J Biol Stand (1979) 1.45

Evaluation of Syva's enzyme immunoassay for the detection of Chlamydia trachomatis in urogenital specimens. Diagn Microbiol Infect Dis (1993) 1.42

Observation of a centrality-dependent dijet asymmetry in lead-lead collisions at sqrt[S(NN)] =2.76 TeV with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.41

Observation of B(0)(s)-->Psi(2S)Phi and measurement of the ratio of branching fractions Beta(B(0)(s)-->Psi(2S)Phi)/Beta(B(0)(s)-->J/PsiPhi). Phys Rev Lett (2006) 1.40

Measurement of dijet azimuthal decorrelations in pp collisions at sqrt(s)=7  TeV. Phys Rev Lett (2011) 1.39

Type II diabetes of early onset: a distinct clinical and genetic syndrome? Br Med J (Clin Res Ed) (1987) 1.39

Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro. Diabetologia (2005) 1.38

Attractiveness of facial averageness and symmetry in non-western cultures: in search of biologically based standards of beauty. Perception (2001) 1.37

Determination of the strange-quark density of the proton from ATLAS measurements of the W→ℓν and Z→ℓℓ cross sections. Phys Rev Lett (2012) 1.34

Reactogenicity and immunogenicity of whole and ether-Tween-split influenza A virus vaccines in volunteers. J Infect Dis (1978) 1.33

Molecular characterization of the alpha-glucosidase gene (malA) from the hyperthermophilic archaeon Sulfolobus solfataricus. J Bacteriol (1998) 1.33

Search for new particles in two-jet final states in 7 TeV proton-proton collisions with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.32

Precision top-quark mass measurement at CDF. Phys Rev Lett (2012) 1.30

Spectrum of spontaneous frameshift mutations. Sequences of bacteriophage T4 rII gene frameshifts. J Mol Biol (1986) 1.28

Observation of associated near-side and away-side long-range correlations in sqrt[s(NN)]=5.02 TeV proton-lead collisions with the ATLAS detector. Phys Rev Lett (2013) 1.27

Formation of amyloid fibrils by peptides derived from the bacterial cold shock protein CspB. Protein Sci (1999) 1.27

Preparation of synthetic human islet amyloid polypeptide (IAPP) in a stable conformation to enable study of conversion to amyloid-like fibrils. FEBS Lett (2000) 1.25

Inhibition of Neisseria gonorrhoeae by normal human saliva. Br J Vener Dis (1979) 1.23

Measurement of the cross section for prompt isolated diphoton production using the full CDF run II data sample. Phys Rev Lett (2013) 1.22

Systemic amyloidosis of beta 2-microglobulin type: a complication of long-term haemodialysis. J Clin Pathol (1987) 1.21

Autoscopic phenomena with seizures. Arch Neurol (1989) 1.20

Search for dark matter candidates and large extra dimensions in events with a photon and missing transverse momentum in pp collision data at sqrt[s]=7 TeV with the ATLAS detector. Phys Rev Lett (2013) 1.19

An agent possibly associated with swine dysentery. Vet Rec (1970) 1.19

The role of muscles in joint adaptation and degeneration. Langenbecks Arch Surg (2003) 1.19

Diabetes mellitus in Macaca mulatta monkeys is characterised by islet amyloidosis and reduction in beta-cell population. Diabetologia (1993) 1.18

Antibodies to Saccharomyces cerevisiae in patients with Crohn's disease and their possible pathogenic importance. Gut (1992) 1.16

Oxygen delivery from red cells. Biophys J (1985) 1.15

Estimating European admixture in African Americans by using microsatellites and a microsatellite haplotype (CD4/Alu). Hum Genet (1999) 1.14

Effect of pH and insulin on fibrillogenesis of islet amyloid polypeptide in vitro. Biochemistry (1995) 1.14

Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide. Proc Natl Acad Sci U S A (1994) 1.13

Search for a supersymmetric partner to the top quark in final states with jets and missing transverse momentum at sqrt[s] = 7 TeV with the ATLAS detector. Phys Rev Lett (2012) 1.13

Adamantanone as a probe for the dimensions and characteristics of the substrate binding pocket of certain alcohol dehydrogenases. Biochem Biophys Res Commun (1967) 1.13

Stereochemical aspects of the substrate specificity of horse liver alcohol dehydrogenase. Biochemistry (1965) 1.13

Measurement of the WW + WZ production cross section using the lepton + jets final state at CDF II. Phys Rev Lett (2010) 1.12

Peripheral blood and bone marrow abnormalities in patients with HIV related disease. Br J Haematol (1987) 1.12

The antimalarial agent mefloquine inhibits ATP-sensitive K-channels. Br J Pharmacol (2000) 1.11

First observation of the decay Bs0-->Ds-Ds+ and measurement of its branching ratio. Phys Rev Lett (2008) 1.11

Prevention and early intervention for depression in adolescence and early adult life. Eur Arch Psychiatry Clin Neurosci (1998) 1.11

Transvaginal electrical stimulation for female urinary incontinence. Am J Obstet Gynecol (1997) 1.09

Evidence for a particle produced in association with weak bosons and decaying to a bottom-antibottom quark pair in higgs boson searches at the tevatron. Phys Rev Lett (2012) 1.08

Measurement of sigma chi c2 B(chi c2-->J/psi gamma)/sigma chi c1 B(chi c1 -->J/psi gamma) in pp collisions at square root s=1.96 TeV. Phys Rev Lett (2007) 1.07

A comparison of live and inactivated influenza A (H1N1) virus vaccines. 1. Short-term immunity. J Hyg (Lond) (1983) 1.07

Search for tb resonances in proton-proton collisions at √s=7 TeV with the ATLAS detector. Phys Rev Lett (2012) 1.07

A comparison of live and inactivated influenza A (H1N1) virus vaccines. 2. Long-term immunity. J Hyg (Lond) (1983) 1.06

Precise measurement of the W-boson mass with the CDF II detector. Phys Rev Lett (2012) 1.06

Colonisation of dental units by water bacteria. Br Dent J (1973) 1.05

False-positive Chlamydiazyme results during urine sediment analysis due to bacterial urinary tract infections. J Clin Microbiol (1991) 1.05

Search for a light Higgs boson decaying to long-lived weakly interacting particles in proton-proton collisions at sqrt[s] = 7 TeV with the ATLAS detector. Phys Rev Lett (2012) 1.05

Interaction between specific fatty acids, GLP-1 and insulin secretion in humans. Diabetologia (2002) 1.04

Specific and common changes in Nicotiana benthamiana gene expression in response to infection by enveloped viruses. J Gen Virol (2005) 1.04

Direct measurement of the W production charge asymmetry in pp collisions at square root s=1.96 TeV. Phys Rev Lett (2009) 1.04

The post-translational processing and intracellular sorting of PC2 in the islets of Langerhans. J Biol Chem (1992) 1.04

A graded-dose study of inactivated, surface antigen influenza B vaccine in volunteers: reactogenicity, antibody response and protection to challenge virus infection. J Hyg (Lond) (1983) 1.03

Longevity of human islet α- and β-cells. Diabetes Obes Metab (2011) 1.03

Search for long-lived massive charged particles in 1.96 TeV pp collisions. Phys Rev Lett (2009) 1.03

Serum cartilage oligomeric matrix protein and clinical signs and symptoms of potential pre-radiographic hip and knee pathology. Osteoarthritis Cartilage (2002) 1.03

Fibrillar islet amyloid polypeptide (amylin) is internalised by macrophages but resists proteolytic degradation. Cell Tissue Res (1998) 1.03

Pacemaker current in frog atrium. Nat New Biol (1972) 1.03

Morphological and biochemical differentiation of three types of small oral spirochetes. J Bacteriol (1969) 1.02

Adherence therapy for medication non-compliant patients with hypertension: a randomised controlled trial. J Hum Hypertens (2011) 1.01

Phosphonoformate (foscarnet): a pilot study in AIDS and AIDS related complex. AIDS (1987) 1.01

An F-Box/WD40 repeat-containing protein important for Dictyostelium cell-type proportioning, slug behaviour, and culmination. Dev Biol (2000) 1.00

Amelioration of diabetes in nonobese diabetic mice with advanced disease by linomide-induced immunoregulation combined with Reg protein treatment. Endocrinology (1998) 1.00

Partner management for gonococcal and chlamydial infection: expansion of public health services to the private sector and expedited sex partner treatment through a partnership with commercial pharmacies. Sex Transm Dis (2001) 1.00

Observation of Bs(0)-Bs(0) oscillations. Phys Rev Lett (2006) 1.00