The role of microglia in the healthy brain.

PubWeight™: 2.94‹?› | Rank: Top 1%

🔗 View Article (PMID 22072657)

Published in J Neurosci on November 09, 2011

Authors

Marie-Ève Tremblay1, Beth Stevens, Amanda Sierra, Hiroaki Wake, Alain Bessis, Axel Nimmerjahn

Author Affiliations

1: Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA. tremblay2@wisc.edu

Associated clinical trials:

SEMA4D Blockade Safety and Brain Metabolic Activity in Alzheimer's Disease (AD) (SIGNAL-AD) | NCT04381468

Articles citing this

(truncated to the top 100)

Microglia: scapegoat, saboteur, or something else? Science (2013) 2.94

Glia and pain: is chronic pain a gliopathy? Pain (2013) 2.21

Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. PLoS Biol (2016) 2.15

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss. Neuron (2017) 2.03

Microglia are essential to masculinization of brain and behavior. J Neurosci (2013) 1.95

Microglia regulate the number of neural precursor cells in the developing cerebral cortex. J Neurosci (2013) 1.86

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro. Brain Behav Immun (2013) 1.66

Efficient derivation of microglia-like cells from human pluripotent stem cells. Nat Med (2016) 1.64

TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat Neurosci (2013) 1.56

Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology. J Neurosci (2012) 1.51

How do immune cells support and shape the brain in health, disease, and aging? J Neurosci (2013) 1.51

Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology. PLoS One (2013) 1.48

CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. EMBO Mol Med (2013) 1.42

Neuroinflammation and psychiatric illness. J Neuroinflammation (2013) 1.42

Microglia development and function. Annu Rev Immunol (2014) 1.41

Prolonged White Matter Inflammation After Cardiopulmonary Bypass and Circulatory Arrest in a Juvenile Porcine Model. Ann Thorac Surg (2015) 1.39

Norepinephrine: a neuromodulator that boosts the function of multiple cell types to optimize CNS performance. Neurochem Res (2012) 1.38

The immune system and developmental programming of brain and behavior. Front Neuroendocrinol (2012) 1.36

MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS. Glia (2012) 1.32

Microglia, seen from the CX3CR1 angle. Front Cell Neurosci (2013) 1.30

Microglial activation - tuning and pruning adult neurogenesis. Front Pharmacol (2012) 1.29

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion. J Neuroinflammation (2013) 1.29

New tools for studying microglia in the mouse and human CNS. Proc Natl Acad Sci U S A (2016) 1.28

Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice. J Neurosci Res (2013) 1.28

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis. Mol Psychiatry (2013) 1.26

Quantitating the subtleties of microglial morphology with fractal analysis. Front Cell Neurosci (2013) 1.26

Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone. J Neurosci (2014) 1.21

Sexual differentiation of the rodent brain: dogma and beyond. Front Neurosci (2012) 1.20

Microglia and spinal cord synaptic plasticity in persistent pain. Neural Plast (2013) 1.17

Functional diversity of microglia - how heterogeneous are they to begin with? Front Cell Neurosci (2013) 1.14

Development and functions of the choroid plexus-cerebrospinal fluid system. Nat Rev Neurosci (2015) 1.14

Rett syndrome: genes, synapses, circuits, and therapeutics. Front Psychiatry (2012) 1.14

Microglia in the TBI brain: The good, the bad, and the dysregulated. Exp Neurol (2015) 1.10

The brain's best friend: microglial neurotoxicity revisited. Front Cell Neurosci (2013) 1.09

The ischemic environment drives microglia and macrophage function. Front Neurol (2015) 1.09

Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior. Front Neurosci (2015) 1.08

Microglial diversity by responses and responders. Front Cell Neurosci (2014) 1.07

Surveillance, phagocytosis, and inflammation: how never-resting microglia influence adult hippocampal neurogenesis. Neural Plast (2014) 1.07

ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo. Sci Rep (2012) 1.06

Two-photon excitation STED microscopy in two colors in acute brain slices. Biophys J (2013) 1.04

Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link? Mol Neurobiol (2012) 1.04

Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury. J Clin Invest (2013) 1.02

Microglia: key elements in neural development, plasticity, and pathology. J Neuroimmune Pharmacol (2013) 1.02

Microglia across the lifespan: from origin to function in brain development, plasticity and cognition. J Physiol (2016) 1.02

Microglial dysregulation in psychiatric disease. Clin Dev Immunol (2013) 1.01

Sex, glia, and development: interactions in health and disease. Horm Behav (2012) 1.01

A polarizing question: do M1 and M2 microglia exist? Nat Neurosci (2016) 1.00

IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS. PLoS One (2012) 1.00

Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia. Biol Psychiatry (2013) 0.98

Inflammation and the two-hit hypothesis of schizophrenia. Neurosci Biobehav Rev (2013) 0.98

Acute and chronic stress-induced disturbances of microglial plasticity, phenotype and function. Curr Drug Targets (2013) 0.97

Brain dendritic cells: biology and pathology. Acta Neuropathol (2012) 0.96

The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders. J Neurosci (2013) 0.95

Accelerated microglial pathology is associated with Aβ plaques in mouse models of Alzheimer's disease. Aging Cell (2014) 0.94

Extracellular membrane vesicles and immune regulation in the brain. Front Physiol (2012) 0.94

Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice. Am J Pathol (2013) 0.93

Astroglial cradle in the life of the synapse. Philos Trans R Soc Lond B Biol Sci (2014) 0.93

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus. Nat Commun (2015) 0.92

Microglia/Macrophage Polarization After Experimental Intracerebral Hemorrhage. Transl Stroke Res (2015) 0.92

From the Cajal alumni Achúcarro and Río-Hortega to the rediscovery of never-resting microglia. Front Neuroanat (2015) 0.91

Glia and neurodevelopment: focus on fetal alcohol spectrum disorders. Front Pediatr (2014) 0.91

Systemic inflammation regulates microglial responses to tissue damage in vivo. Glia (2014) 0.90

The endocannabinoid system in normal and pathological brain ageing. Philos Trans R Soc Lond B Biol Sci (2012) 0.90

Age-dependent microglial activation in immature brains after hypoxia- ischemia. CNS Neurol Disord Drug Targets (2013) 0.89

Microglia and synapse: interactions in health and neurodegeneration. Neural Plast (2013) 0.89

Microglial control of neuronal activity. Front Cell Neurosci (2013) 0.89

Intravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation. Dis Model Mech (2014) 0.89

NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair? Free Radic Biol Med (2014) 0.89

HIV-1 target cells in the CNS. J Neurovirol (2014) 0.89

Microglial numbers attain adult levels after undergoing a rapid decrease in cell number in the third postnatal week. J Neuroimmunol (2014) 0.88

Anti-inflammatory effect of ginsenoside Rg5 in lipopolysaccharide-stimulated BV2 microglial cells. Int J Mol Sci (2013) 0.88

Estrogens, Neuroinflammation, and Neurodegeneration. Endocr Rev (2016) 0.87

Detection of microRNAs in microglia by real-time PCR in normal CNS and during neuroinflammation. J Vis Exp (2012) 0.87

Getting to the core of addiction: Hooking CB2 receptor into drug abuse? Nat Med (2012) 0.87

Metabolic reprograming of mononuclear phagocytes in progressive multiple sclerosis. Front Immunol (2015) 0.87

Activation of intrinsic immune responses and microglial phagocytosis in an ex vivo spinal cord slice culture model of West Nile virus infection. J Virol (2014) 0.86

Alzheimer's disease, neuroprotection, and CNS immunosenescence. Front Pharmacol (2012) 0.86

Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression. Elife (2016) 0.86

Microglia trigger astrocyte-mediated neuroprotection via purinergic gliotransmission. Sci Rep (2014) 0.85

Puberty and adolescence as a time of vulnerability to stressors that alter neurobehavioral processes. Front Neuroendocrinol (2013) 0.85

Can we talk about microglia without neurons? A discussion of microglial cell autonomous properties in culture. Front Cell Neurosci (2014) 0.85

Neural crest stem cells from dental tissues: a new hope for dental and neural regeneration. Stem Cells Int (2012) 0.85

Neuroimmune mechanisms of alcohol and drug addiction. Int Rev Neurobiol (2014) 0.84

A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone. J Neurosci (2015) 0.84

Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology. J Neuroinflammation (2015) 0.84

Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles. Int J Mol Sci (2016) 0.84

Effects of inflammation on stem cells: together they strive? EMBO Rep (2015) 0.84

Role of microglia in a mouse model of paediatric traumatic brain injury. Brain Behav Immun (2016) 0.83

Microglia Function in Central Nervous System Development and Plasticity. Cold Spring Harb Perspect Biol (2015) 0.83

Central nervous system myeloid cells as drug targets: current status and translational challenges. Nat Rev Drug Discov (2015) 0.83

EDITORIAL Neuroglia as a Central Element of Neurological Diseases: An Underappreciated Target for Therapeutic Intervention. Curr Neuropharmacol (2014) 0.83

Anti-inflammatory effects of α-galactosylceramide analogs in activated microglia: involvement of the p38 MAPK signaling pathway. PLoS One (2014) 0.83

Kalopanaxsaponin A Exerts Anti-Inflammatory Effects in Lipopolysaccharide-Stimulated Microglia via Inhibition of JNK and NF-κB/AP-1 Pathways. Biomol Ther (Seoul) (2013) 0.83

Short and long-term analysis and comparison of neurodegeneration and inflammatory cell response in the ipsilateral and contralateral hemisphere of the neonatal mouse brain after hypoxia/ischemia. Neurol Res Int (2012) 0.83

The anti-inflammatory role of tissue inhibitor of metalloproteinase-2 in lipopolysaccharide-stimulated microglia. J Neuroinflammation (2014) 0.83

A pilot open-label trial of minocycline in patients with autism and regressive features. J Neurodev Disord (2013) 0.82

Blue Light Modulates Murine Microglial Gene Expression in the Absence of Optogenetic Protein Expression. Sci Rep (2016) 0.82

Minocycline modulates human social decision-making: possible impact of microglia on personality-oriented social behaviors. PLoS One (2012) 0.82

An engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons. J Vis Exp (2014) 0.82

Fine-tuning the central nervous system: microglial modelling of cells and synapses. Philos Trans R Soc Lond B Biol Sci (2014) 0.82

Articles by these authors

Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron (2012) 5.84

Astrocytes promote myelination in response to electrical impulses. Neuron (2006) 4.23

Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo. Proc Natl Acad Sci U S A (2004) 3.78

Automated analysis of cellular signals from large-scale calcium imaging data. Neuron (2009) 3.51

High-speed, miniaturized fluorescence microscopy in freely moving mice. Nat Methods (2008) 3.50

A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression. EMBO J (2010) 3.18

NS21: re-defined and modified supplement B27 for neuronal cultures. J Neurosci Methods (2008) 2.68

Miniaturized integration of a fluorescence microscope. Nat Methods (2011) 2.63

Association between quality improvement for care transitions in communities and rehospitalizations among Medicare beneficiaries. JAMA (2013) 2.60

The complement system: an unexpected role in synaptic pruning during development and disease. Annu Rev Neurosci (2012) 2.53

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma. J Clin Invest (2011) 2.25

Miniaturized two-photon microscope based on a flexible coherent fiber bundle and a gradient-index lens objective. Opt Lett (2004) 2.24

Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice. J Neurosci (2002) 2.05

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission. Proc Natl Acad Sci U S A (2011) 2.03

Sindbis vector SINrep(nsP2S726): a tool for rapid heterologous expression with attenuated cytotoxicity in neurons. J Neurosci Methods (2004) 1.79

Inter-regional contribution of enhanced activity of the primary somatosensory cortex to the anterior cingulate cortex accelerates chronic pain behavior. J Neurosci (2011) 1.67

The "quad-partite" synapse: microglia-synapse interactions in the developing and mature CNS. Glia (2012) 1.59

TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat Neurosci (2013) 1.56

The complement cascade: Yin-Yang in neuroinflammation--neuro-protection and -degeneration. J Neurochem (2008) 1.48

Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor. J Neurosci (2008) 1.47

In vivo calcium imaging of circuit activity in cerebellar cortex. J Neurophysiol (2005) 1.45

Enhanced synaptic connectivity and epilepsy in C1q knockout mice. Proc Natl Acad Sci U S A (2010) 1.38

Distortion-free delivery of nanojoule femtosecond pulses from a Ti:sapphire laser through a hollow-core photonic crystal fiber. Opt Lett (2004) 1.36

The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia. Biol Psychiatry (2011) 1.36

A novel stem cell source for vasculogenesis in ischemia: subfraction of side population cells from dental pulp. Stem Cells (2008) 1.32

Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse. J Neurosci (2004) 1.29

Prenatal activation of microglia induces delayed impairment of glutamatergic synaptic function. PLoS One (2008) 1.13

Association of gephyrin with synaptic and extrasynaptic GABAA receptors varies during development in cultured hippocampal neurons. Mol Cell Neurosci (2003) 1.11

Physiological roles of microglia during development. J Neurochem (2011) 1.11

Synapse elimination during development and disease: immune molecules take centre stage. Biochem Soc Trans (2010) 1.10

Aromatase expression by reactive astroglia is neuroprotective. Ann N Y Acad Sci (2003) 1.09

Aromatase: a neuroprotective enzyme. Prog Neurobiol (2003) 1.05

Microglia and synapse interactions: fine tuning neural circuits and candidate molecules. Front Cell Neurosci (2013) 1.04

Clustering of neuronal K+-Cl- cotransporters in lipid rafts by tyrosine phosphorylation. J Biol Chem (2009) 1.04

Morphologically identified glycinergic synapses in the hippocampus. Mol Cell Neurosci (2004) 1.02

Functional imaging in freely moving animals. Curr Opin Neurobiol (2012) 1.01

The Down syndrome critical region regulates retinogeniculate refinement. J Neurosci (2011) 1.00

The challenge of connecting the dots in the B.R.A.I.N. Neuron (2013) 0.99

Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system. Curr Opin Neurobiol (2013) 0.97

The role of the classical complement cascade in synapse loss during development and glaucoma. Adv Exp Med Biol (2010) 0.97

Brain microglia express steroid-converting enzymes in the mouse. J Steroid Biochem Mol Biol (2008) 0.97

Gender differences across racial and ethnic groups in the quality of care for acute myocardial infarction and heart failure associated with comorbidities. Womens Health Issues (2006) 0.96

Sensory input regulates spatial and subtype-specific patterns of neuronal turnover in the adult olfactory bulb. J Neurosci (2011) 0.94

An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin-like growth factor-I in the dentate gyrus of adult female rat. Eur J Neurosci (2003) 0.94

The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice. Br J Pharmacol (2010) 0.91

Charge of the right brigade? Communities, coverage, and care for the uninsured. Health Aff (Millwood) (2006) 0.90

Microglial control of neuronal activity. Front Cell Neurosci (2013) 0.89

Neural stem cell deforestation as the main force driving the age-related decline in adult hippocampal neurogenesis. Behav Brain Res (2011) 0.89

GABA regulates the multidirectional tangential migration of GABAergic interneurons in living neonatal mice. PLoS One (2011) 0.86

Neuroscience. How many cell types does it take to wire a brain? Science (2011) 0.83

In vivo labeling of cortical astrocytes with sulforhodamine 101 (SR101). Cold Spring Harb Protoc (2012) 0.83

Two-photon imaging of microglia in the mouse cortex in vivo. Cold Spring Harb Protoc (2012) 0.81

Directed neural lineage differentiation of adult hippocampal progenitor cells via modulation of hippocampal cholinergic neurostimulating peptide precursor expression. Brain Res (2010) 0.81

Microglia express functional 11 beta-hydroxysteroid dehydrogenase type 1. Glia (2010) 0.81

Microglia shape corpus callosum axon tract fasciculation: functional impact of prenatal inflammation. Eur J Neurosci (2014) 0.81

The value of experience: differences in knowledge among Medicare beneficiaries. Inquiry (2005) 0.80

Metallothionein promotes regenerative axonal sprouting of dorsal root ganglion neurons after physical axotomy. Cell Mol Life Sci (2011) 0.80

Optical window preparation for two-photon imaging of microglia in mice. Cold Spring Harb Protoc (2012) 0.80

NOS2 expression is restricted to neurons in the healthy brain but is triggered in microglia upon inflammation. Glia (2014) 0.79

Glia: regulating synaptogenesis from multiple directions. Curr Biol (2012) 0.78

Nitric oxide regulates astrocyte maturation in the hippocampus: involvement of NOS2. Mol Cell Neurosci (2011) 0.78

A developmental perspective on adult hippocampal neurogenesis. Int J Dev Neurosci (2013) 0.78

Surgical implantation of a head plate in mice in preparation for in vivo two-photon imaging of microglia. Cold Spring Harb Protoc (2012) 0.78

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. PLoS Biol (2016) 0.77

Depletion of microglia from primary cellular cultures. Methods Mol Biol (2013) 0.76

Women Bound to be Active: one year follow-up to an innovative pilot intervention to increase physical activity and self-worth in women. Women Health (2009) 0.76

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. PLoS Biol (2016) 0.75

Suppression of astrocyte lineage in adult hippocampal progenitor cells expressing hippocampal cholinergic neurostimulating Peptide precursor in an in vivo ischemic model. Cell Transplant (2012) 0.75

DAP12 and CD11b contribute to the microglial-induced death of dopaminergic neurons in vitro but not in vivo in the MPTP mouse model of Parkinson's disease. J Neuroinflammation (2013) 0.75

All You Need Is Mentorship. Cell (2016) 0.75

BDNF occludes GABA receptor-mediated inhibition of GABA release in rat hippocampal CA1 pyramidal neurons. Eur J Neurosci (2006) 0.75

Beth Stevens. Lancet Neurol (2015) 0.75