Hypoxia induces angiogenic factors in brain microvascular endothelial cells.

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Published in Microvasc Res on November 10, 2011

Authors

J Luo1, J Martinez, X Yin, A Sanchez, D Tripathy, P Grammas

Author Affiliations

1: Garrison Institute on Aging, Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

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Reversibility of cerebral atrophy in anorexia nervosa and Cushing's syndrome. J Comput Assist Tomogr (1977) 1.27