Published in Nature on December 21, 2005
Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev (2010) 11.25
Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neurol (2009) 6.90
White matter in learning, cognition and psychiatric disorders. Trends Neurosci (2008) 4.72
Myelination and support of axonal integrity by glia. Nature (2010) 3.54
Vesicular release of glutamate from unmyelinated axons in white matter. Nat Neurosci (2007) 3.39
Pathogenesis of cerebral white matter injury of prematurity. Arch Dis Child Fetal Neonatal Ed (2008) 2.85
Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS Biol (2013) 2.61
Regulation of NMDA receptors by phosphorylation. Neuropharmacology (2007) 2.20
Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes. PLoS Biol (2013) 1.92
Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia. Brain Pathol (2008) 1.87
Oligodendrocytes: biology and pathology. Acta Neuropathol (2009) 1.81
Antenatal magnesium sulfate for the prevention of cerebral palsy in preterm infants less than 34 weeks' gestation: a systematic review and metaanalysis. Am J Obstet Gynecol (2009) 1.77
Excitability and synaptic communication within the oligodendrocyte lineage. J Neurosci (2010) 1.74
Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits. J Neurosci (2010) 1.72
Regulation of oligodendrocyte development and myelination by glucose and lactate. J Neurosci (2011) 1.67
Will the real multiple sclerosis please stand up? Nat Rev Neurosci (2012) 1.61
Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis. Ann Neurol (2010) 1.60
Activation of recombinant NR1/NR2C NMDA receptors. J Physiol (2008) 1.57
NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia. J Neurosci (2008) 1.55
Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis. Prog Neurobiol (2010) 1.54
The encephalopathy of prematurity--brain injury and impaired brain development inextricably intertwined. Semin Pediatr Neurol (2009) 1.51
Proton-gated Ca(2+)-permeable TRP channels damage myelin in conditions mimicking ischaemia. Nature (2016) 1.49
The developing oligodendrocyte: key cellular target in brain injury in the premature infant. Int J Dev Neurosci (2011) 1.46
Coherent anti-Stokes Raman scattering imaging of myelin degradation reveals a calcium-dependent pathway in lyso-PtdCho-induced demyelination. J Neurosci Res (2007) 1.39
Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation. Trends Mol Med (2010) 1.32
Neurotransmitter receptors in the life and death of oligodendrocytes. Neuroscience (2006) 1.24
Novel regional and developmental NMDA receptor expression patterns uncovered in NR2C subunit-beta-galactosidase knock-in mice. Mol Cell Neurosci (2007) 1.20
Excitotoxic damage to white matter. J Anat (2007) 1.19
NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination. J Neurosci (2011) 1.18
Ionic storm in hypoxic/ischemic stress: can opioid receptors subside it? Prog Neurobiol (2009) 1.18
Glutamate excitotoxicity inflicts paranodal myelin splitting and retraction. PLoS One (2009) 1.17
Neurobiology of injury to the developing brain. Nat Rev Neurol (2010) 1.16
Bone marrow stromal cells increase oligodendrogenesis after stroke. J Cereb Blood Flow Metab (2009) 1.15
Influence of the NR3A subunit on NMDA receptor functions. Prog Neurobiol (2010) 1.14
Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptors. Ann Neurol (2009) 1.14
A new mechanism of nervous system plasticity: activity-dependent myelination. Nat Rev Neurosci (2015) 1.13
Glutamate receptors on myelinated spinal cord axons: I. GluR6 kainate receptors. Ann Neurol (2009) 1.12
Glutamate and ATP signalling in white matter pathology. J Anat (2011) 1.11
Genome-wide association study of severity in multiple sclerosis. Genes Immun (2011) 1.10
Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matter. Glia (2008) 1.10
Opiate drug use and the pathophysiology of neuroAIDS. Curr HIV Res (2012) 1.07
Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. Brain (2010) 1.06
Oligovascular signaling in white matter stroke. Biol Pharm Bull (2009) 1.06
Synapses on NG2-expressing progenitors in the brain: multiple functions? J Physiol (2008) 1.03
Injury and differentiation following inhibition of mitochondrial respiratory chain complex IV in rat oligodendrocytes. Glia (2010) 1.01
Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes. Br J Pharmacol (2011) 1.01
Glutamate-mediated neuronal-glial transmission. J Anat (2007) 1.01
Pathophysiology of glia in perinatal white matter injury. Glia (2014) 1.00
Strategies for treatment in Alexander disease. Neurotherapeutics (2010) 0.98
Vesicular apparatus, including functional calcium channels, are present in developing rodent optic nerve axons and are required for normal node of Ranvier formation. J Physiol (2008) 0.98
MK801 attenuates secondary injury in a mouse experimental compression model of spinal cord trauma. BMC Neurosci (2011) 0.96
A novel hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonist prevents ischemic neuronal death. J Biol Chem (2012) 0.95
Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to experimental autoimmune encephalomyelitis or their normal development. J Neurosci (2012) 0.95
Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics. Brain (2014) 0.94
Oligodendrocytes changing the rules: action potentials in glia and oligodendrocytes controlling action potentials. Neuroscientist (2008) 0.94
Oligodendrocyte degeneration and recovery after focal cerebral ischemia. Neuroscience (2010) 0.94
The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes. Brain (2009) 0.94
Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor. Biochemistry (2009) 0.92
NMDA Receptors in Glial Cells: Pending Questions. Curr Neuropharmacol (2013) 0.92
Regulation of glutamate transport in developing rat oligodendrocytes. J Neurosci (2009) 0.92
Relapsing and progressive forms of multiple sclerosis: insights from pathology. Curr Opin Neurol (2014) 0.92
Complex interplay between glutamate receptors and intracellular Ca2+ stores during ischaemia in rat spinal cord white matter. J Physiol (2006) 0.91
Brain dysfunction in the era of combination antiretroviral therapy: implications for the treatment of the aging population of HIV-infected individuals. Curr Opin Investig Drugs (2010) 0.91
Ceftriaxone attenuates hypoxic-ischemic brain injury in neonatal rats. J Biomed Sci (2011) 0.91
Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist. Proc Natl Acad Sci U S A (2008) 0.91
Developmental expression of N-methyl-D-aspartate (NMDA) receptor subunits in human white and gray matter: potential mechanism of increased vulnerability in the immature brain. Cereb Cortex (2013) 0.91
Hypoxic injury of isolated axons is independent of ionotropic glutamate receptors. Neurobiol Dis (2006) 0.91
Chronic excitotoxin-induced axon degeneration in a compartmented neuronal culture model. ASN Neuro (2012) 0.91
The injured nervous system: a Darwinian perspective. Prog Neurobiol (2008) 0.90
Optic neuritis in neuromyelitis optica. Prog Retin Eye Res (2013) 0.90
Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway. ASN Neuro (2009) 0.90
Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Mol Pharmacol (2014) 0.89
Molecular mechanisms of acrolein-mediated myelin destruction in CNS trauma and disease. Free Radic Res (2015) 0.89
Experimental models for analysis of oligodendrocyte pathophysiology in stroke. Exp Transl Stroke Med (2009) 0.89
Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits. Proc Natl Acad Sci U S A (2008) 0.88
The receptor subunits generating NMDA receptor mediated currents in oligodendrocytes. J Physiol (2010) 0.88
ParaHaplo: A program package for haplotype-based whole-genome association study using parallel computing. Source Code Biol Med (2009) 0.88
Ionic regulation of cell volume changes and cell death after ischemic stroke. Transl Stroke Res (2013) 0.88
Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D. Neuropharmacology (2013) 0.87
Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity. Front Cell Dev Biol (2014) 0.87
Lactate transport and signaling in the brain: potential therapeutic targets and roles in body-brain interaction. J Cereb Blood Flow Metab (2014) 0.87
Dual-specific phosphatase-6 (Dusp6) and ERK mediate AMPA receptor-induced oligodendrocyte death. J Biol Chem (2011) 0.85
X-linked spinal muscular atrophy in mice caused by autonomous loss of ATP7A in the motor neuron. J Pathol (2015) 0.85
Adhesion and hemifusion of cytoplasmic myelin lipid membranes are highly dependent on the lipid composition. Biochim Biophys Acta (2011) 0.85
Demyelination as a rational therapeutic target for ischemic or traumatic brain injury. Exp Neurol (2015) 0.84
Roles of white matter in central nervous system pathophysiologies. ASN Neuro (2012) 0.83
Electrophysiological properties of NG2(+) cells: Matching physiological studies with gene expression profiles. Brain Res (2015) 0.83
Dietary pattern and risk of multiple sclerosis. Iran J Neurol (2012) 0.82
Glutamate transporter EAAT2 expression is up-regulated in reactive astrocytes in human periventricular leukomalacia. J Comp Neurol (2008) 0.82
The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration. J Cell Sci (2015) 0.82
Why do oligodendrocyte lineage cells express glutamate receptors? F1000 Biol Rep (2010) 0.82
Acrolein-mediated conduction loss is partially restored by K+ channel blockers. J Neurophysiol (2015) 0.81
Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes. Glia (2014) 0.81
Opposite roles of NMDA receptors in relapsing and primary progressive multiple sclerosis. PLoS One (2013) 0.81
Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors. Neuropharmacology (2013) 0.81
Oligogenesis and oligodendrocyte progenitor maturation vary in different brain regions and partially correlate with local angiogenesis after ischemic stroke. Transl Stroke Res (2011) 0.80
Identification of Bax-interacting proteins in oligodendrocyte progenitors during glutamate excitotoxicity and perinatal hypoxia-ischemia. ASN Neuro (2013) 0.80
In utero PCP exposure alters oligodendrocyte differentiation and myelination in developing rat frontal cortex. Brain Res (2008) 0.80
Adaptive myelination from fish to man. Brain Res (2015) 0.80
Serial analysis of gene expression. Science (1995) 60.15
Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature (1999) 19.34
Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med (1999) 14.30
Characterization of the yeast transcriptome. Cell (1997) 11.33
Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models. Acc Chem Res (2000) 10.78
The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med (1996) 10.62
A public database for gene expression in human cancers. Cancer Res (1999) 8.81
Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N Engl J Med (1995) 8.23
PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95
A new class of membrane-bound chemokine with a CX3C motif. Nature (1997) 7.87
NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell (1998) 7.58
Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. Science (1999) 7.51
14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell (1997) 7.20
Analysis of human transcriptomes. Nat Genet (1999) 6.14
The evolution of H5N1 influenza viruses in ducks in southern China. Proc Natl Acad Sci U S A (2004) 5.87
Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5. Science (1994) 5.47
Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature (2011) 5.41
Rapid evolution of male reproductive genes in the descent of man. Nature (2000) 5.33
Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development (1995) 5.18
Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome. Circulation (2000) 5.09
Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell (1998) 4.95
Ligand binding to integrins. J Biol Chem (2000) 4.94
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68
VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest (2000) 4.36
Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet (1999) 4.36
Design and performance testing of quantitative real time PCR assays for influenza A and B viral load measurement. J Clin Virol (2004) 4.28
Bone development. Annu Rev Cell Dev Biol (2000) 4.24
Delay or probability discounting in a model of impulsive behavior: effect of alcohol. J Exp Anal Behav (1999) 4.23
Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet (2000) 4.17
The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy. Nat Med (2000) 4.08
Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria. Science (1997) 4.07
Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol (2001) 4.06
Neuropathology of fragile X-associated tremor/ataxia syndrome (FXTAS). Brain (2005) 3.99
A quantum dot single-photon turnstile device. Science (2000) 3.89
DNA supercoiling promotes formation of a bent repression loop in lac DNA. J Mol Biol (1987) 3.81
Antibody-mediated clearance of alphavirus infection from neurons. Science (1991) 3.70
The genome reconstruction manager: a software environment for supporting high-throughput DNA sequencing. Genomics (1994) 3.69
Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J Am Chem Soc (1997) 3.69
Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. J Exp Med (1992) 3.63
TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion. EMBO J (1998) 3.49
HIV-1 drug resistance in newly infected individuals. JAMA (1999) 3.49
An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. Oncogene (2006) 3.48
Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J Biol Chem (2001) 3.38
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell (1995) 3.34
The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes. Proc Natl Acad Sci U S A (2000) 3.16
Multiple Morphologies of "Crew-Cut" Aggregates of Polystyrene-b-poly(acrylic acid) Block Copolymers. Science (1995) 3.16
Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy. J Virol (1999) 3.15
A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nat Med (1998) 3.15
The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci U S A (2000) 3.12
PUMA, a potent killer with or without p53. Oncogene (2008) 3.09
TraI, a LuxI homologue, is responsible for production of conjugation factor, the Ti plasmid N-acylhomoserine lactone autoinducer. Proc Natl Acad Sci U S A (1994) 3.08
Identification and classification of p53-regulated genes. Proc Natl Acad Sci U S A (1999) 3.07
Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res (2001) 2.98
BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Cell (2000) 2.94
Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5. J Biol Chem (1995) 2.93
Sustained photobiological hydrogen gas production upon reversible inactivation of oxygen evolution in the green alga Chlamydomonas reinhardtii. Plant Physiol (2000) 2.92
Hydrogen peroxide is involved in abscisic acid-induced stomatal closure in Vicia faba. Plant Physiol (2001) 2.91
NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. J Neurosci (2000) 2.87
Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia. Neuroscience (2001) 2.84
HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells. Leukemia (2010) 2.83
Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet (2000) 2.82
Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities. Nat Cell Biol (2001) 2.78
Cortical demyelination in PML and MS: Similarities and differences. Neurology (2008) 2.75
Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia. Clin Cancer Res (2000) 2.71
Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science (1999) 2.71
Paternal population history of East Asia: sources, patterns, and microevolutionary processes. Am J Hum Genet (2001) 2.71
A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex. Mol Cell Biol (2000) 2.70
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene (2007) 2.68
The intermediate endpoint effect in logistic and probit regression. Clin Trials (2007) 2.67
Adhesion formation after previous caesarean section-a meta-analysis and systematic review. BJOG (2010) 2.66
Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature (1994) 2.61
Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation. Mol Cell Biol (1994) 2.59
Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group. Blood (1999) 2.59
Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Proc Natl Acad Sci U S A (2001) 2.58
Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors. J Biol Chem (2001) 2.57
Atrial G protein-activated K+ channel: expression cloning and molecular properties. Proc Natl Acad Sci U S A (1993) 2.57
Sino-MONICA project: a collaborative study on trends and determinants in cardiovascular diseases in China, Part i: morbidity and mortality monitoring. Circulation (2001) 2.56
cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1. Mol Cell Biol (1992) 2.55
Use of MM-PBSA in reproducing the binding free energies to HIV-1 RT of TIBO derivatives and predicting the binding mode to HIV-1 RT of efavirenz by docking and MM-PBSA. J Am Chem Soc (2001) 2.55
Hormonal changes in the grains of rice subjected to water stress during grain filling. Plant Physiol (2001) 2.52
The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling. Genes Dev (1999) 2.52
Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther (2001) 2.51
Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model. J Allergy Clin Immunol (2001) 2.51
Effect of shipment, storage, anticoagulant, and cell separation on lymphocyte proliferation assays for human immunodeficiency virus-infected patients. Clin Diagn Lab Immunol (1998) 2.48
Genetic influence on the structural variations of the abnormal prion protein. Proc Natl Acad Sci U S A (2000) 2.46
HIV-1 subtype and second-receptor use. Nature (1996) 2.46
A rat model of focal embolic cerebral ischemia. Brain Res (1997) 2.44
Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection. Antimicrob Agents Chemother (1998) 2.44
Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons. J Neurosci (1998) 2.43
All-cause mortality and cardiovascular disease mortality in three American Indian populations, aged 45-74 years, 1984-1988. The Strong Heart Study. Am J Epidemiol (1998) 2.43
HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy. J Clin Invest (1999) 2.42
Biomarker risk assessment and bladder cancer detection in a cohort exposed to benzidine. J Natl Cancer Inst (2001) 2.41
Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. Osteoarthritis Cartilage (2010) 2.39
Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes. Physiol Genomics (2006) 2.38
Transfusion and alloimmunization in sickle cell disease. The Cooperative Study of Sickle Cell Disease. Blood (1990) 2.38
Pattern of marine mass extinction near the Permian-Triassic boundary in South China. Science (2000) 2.38