Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity.

PubWeight™: 1.10‹?› | Rank: Top 10%

🔗 View Article (PMC 4399559)

Published in Aging Cell on December 29, 2011

Authors

Yael H Edrey1, Diana Casper, Dorothee Huchon, James Mele, Jonathan A Gelfond, Deborah M Kristan, Eviatar Nevo, Rochelle Buffenstein

Author Affiliations

1: Department of Biology, The City College of New York, New York, NY 10031, USA.

Articles citing this

Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proc Natl Acad Sci U S A (2012) 1.18

The naked mole-rat response to oxidative stress: just deal with it. Antioxid Redox Signal (2012) 1.00

Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models. Oxid Med Cell Longev (2015) 0.92

Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer's disease. Neurobiol Aging (2013) 0.89

Comparative biology: Looking for a master switch. Nature (2012) 0.86

Regulation of Nrf2 signaling and longevity in naturally long-lived rodents. Proc Natl Acad Sci U S A (2015) 0.85

Family Wide Molecular Adaptations to Underground Life in African Mole-Rats Revealed by Phylogenomic Analysis. Mol Biol Evol (2015) 0.82

Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: comparative analysis using six species of Bathyergidae. J Comp Neurol (2012) 0.81

Protracted brain development in a rodent model of extreme longevity. Sci Rep (2015) 0.81

Adult neurogenesis and its anatomical context in the hippocampus of three mole-rat species. Front Neuroanat (2014) 0.80

Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates. Arch Biochem Biophys (2015) 0.79

IGF1R levels in the brain negatively correlate with longevity in 16 rodent species. Aging (Albany NY) (2013) 0.79

And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat. Am J Physiol Heart Circ Physiol (2014) 0.77

Alternative strategy for Alzheimer's disease: stress response triggers. Int J Alzheimers Dis (2012) 0.77

Extended Postnatal Brain Development in the Longest-Lived Rodent: Prolonged Maintenance of Neotenous Traits in the Naked Mole-Rat Brain. Front Neurosci (2016) 0.76

Determinants of rodent longevity in the chaperone-protein degradation network. Cell Stress Chaperones (2016) 0.76

Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan. Aging (Albany NY) (2016) 0.75

The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent. Pflugers Arch (2017) 0.75

Neuregulin-1β Regulates the migration of Different Neurochemical Phenotypic Neurons from Organotypically Cultured Dorsal Root Ganglion Explants. Cell Mol Neurobiol (2015) 0.75

Articles cited by this

APE: Analyses of Phylogenetics and Evolution in R language. Bioinformatics (2004) 39.31

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56

Overview of caloric restriction and ageing. Mech Ageing Dev (2005) 6.68

Using the Past to Predict the Present: Confidence Intervals for Regression Equations in Phylogenetic Comparative Methods. Am Nat (2000) 4.36

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A (1989) 4.17

Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nat Med (2006) 4.00

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family. Proc Natl Acad Sci U S A (1993) 3.36

Structure of the extracellular region of HER3 reveals an interdomain tether. Science (2002) 3.19

Life and death: metabolic rate, membrane composition, and life span of animals. Physiol Rev (2007) 3.05

The naked mole-rat: a new long-living model for human aging research. J Gerontol A Biol Sci Med Sci (2005) 2.28

Neu and its ligands: from an oncogene to neural factors. Bioessays (1993) 2.00

Changes in the structural complexity of the aged brain. Aging Cell (2007) 1.96

Rodent phylogeny revised: analysis of six nuclear genes from all major rodent clades. BMC Evol Biol (2009) 1.80

Multiple molecular evidences for a living mammalian fossil. Proc Natl Acad Sci U S A (2007) 1.74

Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber). Aging Cell (2010) 1.69

Phenotypic characterization of spatial cognition and social behavior in mice with 'knockout' of the schizophrenia risk gene neuregulin 1. Neuroscience (2007) 1.55

The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands. Biochim Biophys Acta (1998) 1.51

Evaluating the performance of a successive-approximations approach to parameter optimization in maximum-likelihood phylogeny estimation. Mol Biol Evol (2005) 1.42

Neuregulin-1 (NRG-1) mRNA and protein in the adult human brain. Neuroscience (2004) 1.40

Mitochondrial versus nuclear gene sequences in deep-level mammalian phylogeny reconstruction. Mol Biol Evol (2001) 1.38

Endocrine function and neurobiology of the longest-living rodent, the naked mole-rat. Exp Gerontol (2010) 1.37

ErbB transmembrane tyrosine kinase receptors are differentially expressed throughout the adult rat central nervous system. J Comp Neurol (2001) 1.36

The neuregulin signaling pathway and schizophrenia: from genes to synapses and neural circuits. Brain Res Bull (2010) 1.34

Neuregulins: versatile growth and differentiation factors in nervous system development and human disease. Brain Res Rev (2006) 1.32

Disparate patterns of age-related changes in lipid peroxidation in long-lived naked mole-rats and shorter-lived mice. Aging Cell (2006) 1.30

Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions. Brain Res (2009) 1.24

Oxidative stress in vascular senescence: lessons from successfully aging species. Front Biosci (2008) 1.24

Neuregulins and cancer. Clin Cancer Res (2008) 1.21

Mammalian evolution and the interphotoreceptor retinoid binding protein (IRBP) gene: convincing evidence for several superordinal clades. J Mol Evol (1996) 1.10

Neuregulin-1 and erbB4 immunoreactivity is associated with neuritic plaques in Alzheimer disease brain and in a transgenic model of Alzheimer disease. J Neuropathol Exp Neurol (2003) 1.10

The neurobiology of aging. Epilepsy Res (2005) 1.02

Localization of neuregulin-1alpha (heregulin-alpha) and one of its receptors, ErbB-4 tyrosine kinase, in developing and adult human brain. Brain Res Bull (2006) 1.01

Neurobiology: new order for thought disorders. Nature (2007) 0.92

Thermogenic changes with chronic cold exposure in the naked mole-rat (Heterocephalus glaber). Comp Biochem Physiol A Mol Integr Physiol (2002) 0.92

Correlations between neuronal loss, decrease of memory, and decrease expression of brain-derived neurotrophic factor in the gerbil hippocampus during normal aging. Exp Neurol (2006) 0.91

NRG1 and synaptic function in the CNS. Neuron (2007) 0.88

Neuregulin-1 prevents amyloid β-induced impairment of long-term potentiation in hippocampal slices via ErbB4. Neurosci Lett (2011) 0.84

Age-related changes of NGF, BDNF, parvalbumin and neuronal nitric oxide synthase immunoreactivity in the mouse hippocampal CA1 sector. Metab Brain Dis (2008) 0.78

Oxygen restriction of neonate rats elevates neuregulin-1alpha isoform levels: possible relationship to schizophrenia. Neurochem Int (2007) 0.77

Articles by these authors

Microsatellites within genes: structure, function, and evolution. Mol Biol Evol (2004) 5.01

Microsatellites: genomic distribution, putative functions and mutational mechanisms: a review. Mol Ecol (2002) 4.98

High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature (2013) 3.32

Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature (2011) 3.19

Life and death: metabolic rate, membrane composition, and life span of animals. Physiol Rev (2007) 3.05

Is the oxidative stress theory of aging dead? Biochim Biophys Acta (2009) 2.86

Identifying the fundamental units of bacterial diversity: a paradigm shift to incorporate ecology into bacterial systematics. Proc Natl Acad Sci U S A (2008) 2.44

High oxidative damage levels in the longest-living rodent, the naked mole-rat. Aging Cell (2006) 2.31

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. Proc Natl Acad Sci U S A (2009) 2.14

Overexpression of Mn superoxide dismutase does not increase life span in mice. J Gerontol A Biol Sci Med Sci (2009) 1.98

Multiple genetic processes result in heterogeneous rates of evolution within the major cluster disease resistance genes in lettuce. Plant Cell (2004) 1.94

Domestication quantitative trait loci in Triticum dicoccoides, the progenitor of wheat. Proc Natl Acad Sci U S A (2003) 1.92

Origin of sphinx, a young chimeric RNA gene in Drosophila melanogaster. Proc Natl Acad Sci U S A (2002) 1.92

Origin and evolution of circadian clock genes in prokaryotes. Proc Natl Acad Sci U S A (2003) 1.73

Neuroglobin and cytoglobin in search of their role in the vertebrate globin family. J Inorg Biochem (2005) 1.71

Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms. Aging Cell (2007) 1.69

Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber). Aging Cell (2010) 1.69

Effects of pulsed electromagnetic fields on interleukin-1 beta and postoperative pain: a double-blind, placebo-controlled, pilot study in breast reduction patients. Plast Reconstr Surg (2010) 1.61

Congruent mammalian trees from mitochondrial and nuclear genes using Bayesian methods. Mol Biol Evol (2003) 1.56

Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia. J Biol Chem (2003) 1.54

Adaptation and incipient sympatric speciation of Bacillus simplex under microclimatic contrast at "Evolution Canyons" I and II, Israel. Proc Natl Acad Sci U S A (2005) 1.50

Tibet is one of the centers of domestication of cultivated barley. Proc Natl Acad Sci U S A (2012) 1.48

Attenuation of interleukin-1beta by pulsed electromagnetic fields after traumatic brain injury. Neurosci Lett (2012) 1.47

Adenosine-to-inosine RNA editing shapes transcriptome diversity in primates. Proc Natl Acad Sci U S A (2010) 1.47

Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress. J Gerontol A Biol Sci Med Sci (2008) 1.43

Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation. Proc Natl Acad Sci U S A (2004) 1.41

Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau. Proc Natl Acad Sci U S A (2013) 1.40

Endocrine function and neurobiology of the longest-living rodent, the naked mole-rat. Exp Gerontol (2010) 1.37

Nrf2, a guardian of healthspan and gatekeeper of species longevity. Integr Comp Biol (2010) 1.34

Disparate patterns of age-related changes in lipid peroxidation in long-lived naked mole-rats and shorter-lived mice. Aging Cell (2006) 1.30

Oxidative stress in vascular senescence: lessons from successfully aging species. Front Biosci (2008) 1.24

Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat. Mech Ageing Dev (2005) 1.24

Quantum speciation in Aegilops: molecular cytogenetic evidence from rDNA cluster variability in natural populations. Proc Natl Acad Sci U S A (2004) 1.21

The oxidative stress theory of aging: embattled or invincible? Insights from non-traditional model organisms. Age (Dordr) (2008) 1.20

Vascular aging in the longest-living rodent, the naked mole rat. Am J Physiol Heart Circ Physiol (2007) 1.20

Comparison of endothelial function, O2-* and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice. Am J Physiol Heart Circ Physiol (2006) 1.19

Adaptive role of increased frequency of polypurine tracts in mRNA sequences of thermophilic prokaryotes. Proc Natl Acad Sci U S A (2004) 1.19

Are mice calorically restricted in nature? Aging Cell (2003) 1.19

The genetic basis of adaptive population differentiation: a quantitative trait locus analysis of fitness traits in two wild barley populations from contrasting habitats. Evolution (2004) 1.18

Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proc Natl Acad Sci U S A (2012) 1.18

A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice. Mech Ageing Dev (2003) 1.18

Adaptive melanin response of the soil fungus Aspergillus niger to UV radiation stress at "Evolution Canyon", Mount Carmel, Israel. PLoS One (2008) 1.17

Hypoxic stress tolerance of the blind subterranean mole rat: expression of erythropoietin and hypoxia-inducible factor 1 alpha. Proc Natl Acad Sci U S A (2004) 1.17

Activity of the En/Spm-like transposons in meiosis as a base for chromosome repatterning in a small, isolated, peripheral population of Aegilops speltoides Tausch. Chromosome Res (2004) 1.16

Analysis of simple sequence repeats (SSRs) in wild barley from the Fertile Crescent: associations with ecology, geography and flowering time. Plant Mol Biol (2002) 1.16

Anthracoidea caricis-meadii is a new North American smut fungus on Carex sect. Paniceae. Mycologia (2012) 1.15

An ATP-binding cassette subfamily G full transporter is essential for the retention of leaf water in both wild barley and rice. Proc Natl Acad Sci U S A (2011) 1.13

Successful aging and sustained good health in the naked mole rat: a long-lived mammalian model for biogerontology and biomedical research. ILAR J (2011) 1.13

Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax. Proc Natl Acad Sci U S A (2010) 1.10

Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat (Heterocephalus glaber): a comparative study using shotgun lipidomics. Exp Gerontol (2007) 1.09

RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice. PLoS One (2011) 1.08

PGE(2) receptor EP1 renders dopaminergic neurons selectively vulnerable to low-level oxidative stress and direct PGE(2) neurotoxicity. J Neurosci Res (2007) 1.06

Predictive validity of discriminant analysis for genetic data. Genetica (2003) 1.06

Oxygen and carbon dioxide fluctuations in burrows of subterranean blind mole rats indicate tolerance to hypoxic-hypercapnic stresses. Comp Biochem Physiol A Mol Integr Physiol (2005) 1.05

Oxidation-resistant membrane phospholipids can explain longevity differences among the longest-living rodents and similarly-sized mice. J Gerontol A Biol Sci Med Sci (2006) 1.04

Drosophila flies in "Evolution Canyon" as a model for incipient sympatric speciation. Proc Natl Acad Sci U S A (2006) 1.04

Extended longevity of wild-derived mice is associated with peroxidation-resistant membranes. Mech Ageing Dev (2006) 1.04

Prolonged longevity in naked mole-rats: age-related changes in metabolism, body composition and gastrointestinal function. Comp Biochem Physiol A Mol Integr Physiol (2002) 1.04

Stress resistance in the naked mole-rat: the bare essentials - a mini-review. Gerontology (2012) 1.03

Alternatively spliced Spalax heparanase inhibits extracellular matrix degradation, tumor growth, and metastasis. Proc Natl Acad Sci U S A (2009) 1.02

Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat. PLoS One (2012) 1.02

Patterns of thermal adaptation of Bacillus simplex to the microclimatically contrasting slopes of 'Evolution Canyons' I and II, Israel. Environ Microbiol (2007) 1.02

DNA repair efficiency and thermotolerance in Drosophila melanogaster from "Evolution Canyon". Mutagenesis (2004) 1.02

Increased blood vessel density provides the mole rat physiological tolerance to its hypoxic subterranean habitat. FASEB J (2005) 1.02

Adaptive climatic molecular evolution in wild barley at the Isa defense locus. Proc Natl Acad Sci U S A (2007) 1.02

The naked mole-rat response to oxidative stress: just deal with it. Antioxid Redox Signal (2012) 1.00

Genetic diversity revealed by single nucleotide polymorphism markers in a worldwide germplasm collection of durum wheat. Int J Mol Sci (2013) 1.00

A new alpha-proteobacterial clade of Bdellovibrio-like predators: implications for the mitochondrial endosymbiotic theory. Environ Microbiol (2006) 0.99

Ecological stress and sex evolution in soil microfungi. Proc Biol Sci (2003) 0.99

Discovery and assay of single-nucleotide polymorphisms in barley (Hordeum vulgare). Plant Mol Biol (2002) 0.98

The RNA-binding protein Musashi1 affects medulloblastoma growth via a network of cancer-related genes and is an indicator of poor prognosis. Am J Pathol (2012) 0.98

Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms. Carcinogenesis (2011) 0.97

Conditionally immortalized clonal cell lines from the mouse olfactory placode differentiate into olfactory receptor neurons. Mol Cell Neurosci (2002) 0.97

Long-term microclimatic stress causes rapid adaptive radiation of kaiABC clock gene family in a cyanobacterium, Nostoc linckia, from "Evolution Canyons" I and II, Israel. Proc Natl Acad Sci U S A (2002) 0.96

A MAPK gene from Dead Sea fungus confers stress tolerance to lithium salt and freezing-thawing: Prospects for saline agriculture. Proc Natl Acad Sci U S A (2005) 0.96

Possible incipient sympatric ecological speciation in blind mole rats (Spalax). Proc Natl Acad Sci U S A (2013) 0.96

Gene expression defines natural changes in mammalian lifespan. Aging Cell (2015) 0.96

Fungal substances as modulators of NF-kappaB activation pathway. Mol Biol Rep (2006) 0.95

Evolution of genomic diversity and sex at extreme environments: fungal life under hypersaline Dead Sea stress. Proc Natl Acad Sci U S A (2003) 0.95

Mammalian microevolution in action: adaptive edaphic genomic divergence in blind subterranean mole-rats. Proc Biol Sci (2004) 0.95

Blunted neuronal calcium response to hypoxia in naked mole-rat hippocampus. PLoS One (2012) 0.94

Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus. Am J Physiol Regul Integr Comp Physiol (2013) 0.94

Allelic diversity associated with aridity gradient in wild emmer wheat populations. Plant Cell Environ (2007) 0.93

p53--a key player in tumoral and evolutionary adaptation: a lesson from the Israeli blind subterranean mole rat. Cell Cycle (2005) 0.93

Bacterial distribution in the rhizosphere of wild barley under contrasting microclimates. PLoS One (2011) 0.92

Wild barley eibi1 mutation identifies a gene essential for leaf water conservation. Planta (2004) 0.92

Thermogenic changes with chronic cold exposure in the naked mole-rat (Heterocephalus glaber). Comp Biochem Physiol A Mol Integr Physiol (2002) 0.92

Genome diversity in wild grasses under environmental stress. Proc Natl Acad Sci U S A (2011) 0.91

nemy encodes a cytochrome b561 that is required for Drosophila learning and memory. Proc Natl Acad Sci U S A (2008) 0.91

Transposable elements in a marginal plant population: temporal fluctuations provide new insights into genome evolution of wild diploid wheat. Mob DNA (2010) 0.91

Is evolution of blind mole rats determined by climate oscillations? PLoS One (2012) 0.91

Circadian genes in a blind subterranean mammal III: molecular cloning and circadian regulation of cryptochrome genes in the blind subterranean mole rat, Spalax ehrenbergi superspecies. J Biol Rhythms (2004) 0.90

Adaptive microclimatic structural and expressional dehydrin 1 evolution in wild barley, Hordeum spontaneum, at 'Evolution Canyon', Mount Carmel, Israel. Mol Ecol (2009) 0.90

Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer's disease. Neurobiol Aging (2013) 0.89

Phylogenetic analyses unravel the evolutionary history of NAC proteins in plants. Evolution (2012) 0.89