Published in Carcinogenesis on March 09, 2011
Role of the Nrf2-ARE pathway in liver diseases. Oxid Med Cell Longev (2013) 1.07
Protective Effect of Punica granatum L. against Serum/Glucose Deprivation-Induced PC12 Cells Injury. Evid Based Complement Alternat Med (2013) 1.00
Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation. Breast Cancer Res Treat (2012) 0.96
A Review on Antihyperglycemic and Antihepatoprotective Activity of Eco-Friendly Punica granatum Peel Waste. Evid Based Complement Alternat Med (2013) 0.95
Phytoagents for cancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms. Oxid Med Cell Longev (2013) 0.92
Nutritional protective mechanisms against gut inflammation. J Nutr Biochem (2013) 0.92
Dietary regulation of Keap1/Nrf2/ARE pathway: focus on plant-derived compounds and trace minerals. Nutrients (2014) 0.87
Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/ β -Catenin Signaling Pathway. Evid Based Complement Alternat Med (2013) 0.87
Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene. Antioxid Redox Signal (2014) 0.86
Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application. J Nutr Metab (2015) 0.85
Punicalagin Induces Nrf2/HO-1 Expression via Upregulation of PI3K/AKT Pathway and Inhibits LPS-Induced Oxidative Stress in RAW264.7 Macrophages. Mediators Inflamm (2015) 0.85
Potential Effects of Pomegranate Polyphenols in Cancer Prevention and Therapy. Oxid Med Cell Longev (2015) 0.83
Dietary Natural Products for Prevention and Treatment of Liver Cancer. Nutrients (2016) 0.80
Deficient glutathione in the pathophysiology of mycotoxin-related illness. Toxins (Basel) (2014) 0.78
Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis. Nutr Cancer (2015) 0.77
Inhibitory Effects of Two Varieties of Tunisian Pomegranate (Punica granatum L.) Extracts on Gastrointestinal Transit in Rat. J Med Food (2015) 0.75
Pomegranate Intake Protects Against Genomic Instability Induced by Medical X-rays In Vivo in Mice. Nutr Cancer (2016) 0.75
Fabrication, optimization, and characterization of umbelliferone β-D-galactopyranoside-loaded PLGA nanoparticles in treatment of hepatocellular carcinoma: in vitro and in vivo studies. Int J Nanomedicine (2017) 0.75
Potential Antitumor Effects of Pomegranates and Its Ingredients. Pharmacogn Rev (2017) 0.75
Hepatocellular carcinoma: recent trends in the United States. Gastroenterology (2004) 5.90
Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem (2000) 5.38
Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal (2005) 4.20
Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nat Genet (2004) 3.97
Histochemical and ultrastructural demonstration of gamma-glutamyl transpeptidase activity. J Histochem Cytochem (1969) 3.91
Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J Ethnopharmacol (2006) 2.99
Hepatocellular carcinoma--epidemiological trends and risk factors. Dig Dis (2009) 2.82
In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem (2005) 2.71
Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J Nutr (2001) 2.70
Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway. Antioxid Redox Signal (2010) 2.45
Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern Med Rev (2008) 2.38
N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol Ther (1996) 2.24
Risk of bleeding with vascular endothelial growth factor receptor tyrosine-kinase inhibitors sunitinib and sorafenib: a systematic review and meta-analysis of clinical trials. Lancet Oncol (2009) 2.23
Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis. Biol Chem (2006) 2.07
Clonal adaptation during carcinogenesis. Biochem Pharmacol (1990) 2.04
The stages of initiation and promotion in hepatocarcinogenesis. Biochim Biophys Acta (1980) 1.94
Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clin Cancer Res (2006) 1.86
Hepatocarcinogenesis: a dynamic cellular perspective. Lab Invest (1987) 1.82
Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc Natl Acad Sci U S A (2005) 1.78
Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models. J Agric Food Chem (2002) 1.64
Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. Int J Cancer (2005) 1.63
Experimental models of hepatocellular carcinoma. J Hepatol (2008) 1.61
Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat (2002) 1.60
Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo. Cancer Res (2007) 1.54
Relevance of nitrosamines to human cancer. Carcinogenesis (1984) 1.51
Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. J Agric Food Chem (2007) 1.41
Mechanisms of combined action of different chemopreventive dietary compounds: a review. Eur J Nutr (2008) 1.41
Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice. Food Chem Toxicol (2006) 1.40
Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Cancer Res (2007) 1.38
Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism. Mol Cancer Ther (2008) 1.27
Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers. J Agric Food Chem (2006) 1.26
Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells. J Med Food (2004) 1.26
Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles. Proc Natl Acad Sci U S A (2008) 1.21
Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice. Carcinogenesis (2006) 1.17
Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci (2004) 1.16
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis. Chem Biol Interact (2008) 1.16
Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas. Gastroenterology (2004) 1.13
Effect of pomegranate (Punica granatum) juice intake on hepatic oxidative stress. Eur J Nutr (2007) 1.10
Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo. Int J Oncol (2008) 1.09
Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions. Invest New Drugs (2005) 1.06
Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis. Cancer Prev Res (Phila) (2010) 1.04
Oxidative stress in carcinogenesis. Correlation between lipid peroxidation and induction of preneoplastic lesions in rat hepatocarcinogenesis. Cancer Lett (2005) 1.03
Cancer chemoprevention by pomegranate: laboratory and clinical evidence. Nutr Cancer (2009) 1.01
Selected fruits reduce azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats. Food Chem Toxicol (2006) 0.97
Hepatoprotective role and antioxidant capacity of pomegranate (Punica granatum) flowers infusion against trichloroacetic acid-exposed in rats. Food Chem Toxicol (2008) 0.95
Why a pomegranate? BMJ (2000) 0.95
Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice. J Med Food (2003) 0.93
Critical parameters in the quantitation of the stages of initiation, promotion, and progression in one model of hepatocarcinogenesis in the rat. Toxicol Pathol (1989) 0.93
Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma. Cancer Lett (2008) 0.93
Inhibitory effect of vanadium on rat liver carcinogenesis initiated with diethylnitrosamine and promoted by phenobarbital. Br J Cancer (1995) 0.90
Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3-methylimidazo[4,5-f]quinoline. Cancer Sci (2007) 0.89
N-nitrosodimethylamine-mediated formation of oxidized and methylated dna bases in a cytochrome P450 2E1 expressing cell line. Chem Res Toxicol (2001) 0.86
Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats. J Nutr Biochem (2011) 0.86
Pomegranate juice effects on cytochrome P450S expression: in vivo studies. J Med Food (2007) 0.86
Pomegranate fruit extract impairs invasion and motility in human breast cancer. Integr Cancer Ther (2009) 0.82
Pomegranate (Punica granatum) seed linolenic acid isomers: concentration-dependent modulation of estrogen receptor activity. Endocr Res (2010) 0.82
Microsatellites within genes: structure, function, and evolution. Mol Biol Evol (2004) 5.01
Microsatellites: genomic distribution, putative functions and mutational mechanisms: a review. Mol Ecol (2002) 4.98
High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature (2013) 3.32
Identifying the fundamental units of bacterial diversity: a paradigm shift to incorporate ecology into bacterial systematics. Proc Natl Acad Sci U S A (2008) 2.44
Multiple genetic processes result in heterogeneous rates of evolution within the major cluster disease resistance genes in lettuce. Plant Cell (2004) 1.94
Domestication quantitative trait loci in Triticum dicoccoides, the progenitor of wheat. Proc Natl Acad Sci U S A (2003) 1.92
Origin of sphinx, a young chimeric RNA gene in Drosophila melanogaster. Proc Natl Acad Sci U S A (2002) 1.92
Origin and evolution of circadian clock genes in prokaryotes. Proc Natl Acad Sci U S A (2003) 1.73
Neuroglobin and cytoglobin in search of their role in the vertebrate globin family. J Inorg Biochem (2005) 1.71
Congruent mammalian trees from mitochondrial and nuclear genes using Bayesian methods. Mol Biol Evol (2003) 1.56
Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia. J Biol Chem (2003) 1.54
Adaptation and incipient sympatric speciation of Bacillus simplex under microclimatic contrast at "Evolution Canyons" I and II, Israel. Proc Natl Acad Sci U S A (2005) 1.50
Tibet is one of the centers of domestication of cultivated barley. Proc Natl Acad Sci U S A (2012) 1.48
Adenosine-to-inosine RNA editing shapes transcriptome diversity in primates. Proc Natl Acad Sci U S A (2010) 1.47
Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation. Proc Natl Acad Sci U S A (2004) 1.41
Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau. Proc Natl Acad Sci U S A (2013) 1.40
Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells. J Med Food (2004) 1.26
Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer. J Hepatol (2008) 1.25
Nucleolin links to arsenic-induced stabilization of GADD45alpha mRNA. Nucleic Acids Res (2006) 1.23
Quantum speciation in Aegilops: molecular cytogenetic evidence from rDNA cluster variability in natural populations. Proc Natl Acad Sci U S A (2004) 1.21
Adaptive role of increased frequency of polypurine tracts in mRNA sequences of thermophilic prokaryotes. Proc Natl Acad Sci U S A (2004) 1.19
The genetic basis of adaptive population differentiation: a quantitative trait locus analysis of fitness traits in two wild barley populations from contrasting habitats. Evolution (2004) 1.18
Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proc Natl Acad Sci U S A (2012) 1.18
Adaptive melanin response of the soil fungus Aspergillus niger to UV radiation stress at "Evolution Canyon", Mount Carmel, Israel. PLoS One (2008) 1.17
Hypoxic stress tolerance of the blind subterranean mole rat: expression of erythropoietin and hypoxia-inducible factor 1 alpha. Proc Natl Acad Sci U S A (2004) 1.17
Activity of the En/Spm-like transposons in meiosis as a base for chromosome repatterning in a small, isolated, peripheral population of Aegilops speltoides Tausch. Chromosome Res (2004) 1.16
Analysis of simple sequence repeats (SSRs) in wild barley from the Fertile Crescent: associations with ecology, geography and flowering time. Plant Mol Biol (2002) 1.16
Anthracoidea caricis-meadii is a new North American smut fungus on Carex sect. Paniceae. Mycologia (2012) 1.15
Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma. Cancer Treat Rev (2009) 1.13
An ATP-binding cassette subfamily G full transporter is essential for the retention of leaf water in both wild barley and rice. Proc Natl Acad Sci U S A (2011) 1.13
Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax. Proc Natl Acad Sci U S A (2010) 1.10
Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity. Aging Cell (2011) 1.10
Predictive validity of discriminant analysis for genetic data. Genetica (2003) 1.06
Oxygen and carbon dioxide fluctuations in burrows of subterranean blind mole rats indicate tolerance to hypoxic-hypercapnic stresses. Comp Biochem Physiol A Mol Integr Physiol (2005) 1.05
Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis. Cancer Prev Res (Phila) (2010) 1.04
Drosophila flies in "Evolution Canyon" as a model for incipient sympatric speciation. Proc Natl Acad Sci U S A (2006) 1.04
Alternatively spliced Spalax heparanase inhibits extracellular matrix degradation, tumor growth, and metastasis. Proc Natl Acad Sci U S A (2009) 1.02
Increased blood vessel density provides the mole rat physiological tolerance to its hypoxic subterranean habitat. FASEB J (2005) 1.02
DNA repair efficiency and thermotolerance in Drosophila melanogaster from "Evolution Canyon". Mutagenesis (2004) 1.02
Patterns of thermal adaptation of Bacillus simplex to the microclimatically contrasting slopes of 'Evolution Canyons' I and II, Israel. Environ Microbiol (2007) 1.02
Adaptive climatic molecular evolution in wild barley at the Isa defense locus. Proc Natl Acad Sci U S A (2007) 1.02
Suppression of the inflammatory cascade is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis. Pharm Res (2010) 1.00
Genetic diversity revealed by single nucleotide polymorphism markers in a worldwide germplasm collection of durum wheat. Int J Mol Sci (2013) 1.00
Ecological stress and sex evolution in soil microfungi. Proc Biol Sci (2003) 0.99
Discovery and assay of single-nucleotide polymorphisms in barley (Hordeum vulgare). Plant Mol Biol (2002) 0.98
TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals. J Mol Cell Cardiol (2012) 0.98
Long-term microclimatic stress causes rapid adaptive radiation of kaiABC clock gene family in a cyanobacterium, Nostoc linckia, from "Evolution Canyons" I and II, Israel. Proc Natl Acad Sci U S A (2002) 0.96
A MAPK gene from Dead Sea fungus confers stress tolerance to lithium salt and freezing-thawing: Prospects for saline agriculture. Proc Natl Acad Sci U S A (2005) 0.96
Possible incipient sympatric ecological speciation in blind mole rats (Spalax). Proc Natl Acad Sci U S A (2013) 0.96
Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry. Phytochemistry (2004) 0.95
Fungal substances as modulators of NF-kappaB activation pathway. Mol Biol Rep (2006) 0.95
Evolution of genomic diversity and sex at extreme environments: fungal life under hypersaline Dead Sea stress. Proc Natl Acad Sci U S A (2003) 0.95
Mammalian microevolution in action: adaptive edaphic genomic divergence in blind subterranean mole-rats. Proc Biol Sci (2004) 0.95
Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells. J Med Food (2004) 0.94
Incorporation of an internal ribosome entry site-dependent mechanism in arsenic-induced GADD45 alpha expression. Cancer Res (2007) 0.94
Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice. J Med Food (2003) 0.93
Allelic diversity associated with aridity gradient in wild emmer wheat populations. Plant Cell Environ (2007) 0.93
p53--a key player in tumoral and evolutionary adaptation: a lesson from the Israeli blind subterranean mole rat. Cell Cycle (2005) 0.93
Bacterial distribution in the rhizosphere of wild barley under contrasting microclimates. PLoS One (2011) 0.92
Resveratrol and liver disease: from bench to bedside and community. Liver Int (2010) 0.92
Wild barley eibi1 mutation identifies a gene essential for leaf water conservation. Planta (2004) 0.92
Transposable elements in a marginal plant population: temporal fluctuations provide new insights into genome evolution of wild diploid wheat. Mob DNA (2010) 0.91
nemy encodes a cytochrome b561 that is required for Drosophila learning and memory. Proc Natl Acad Sci U S A (2008) 0.91
Genome diversity in wild grasses under environmental stress. Proc Natl Acad Sci U S A (2011) 0.91
Is evolution of blind mole rats determined by climate oscillations? PLoS One (2012) 0.91
Circadian genes in a blind subterranean mammal III: molecular cloning and circadian regulation of cryptochrome genes in the blind subterranean mole rat, Spalax ehrenbergi superspecies. J Biol Rhythms (2004) 0.90
Adaptive microclimatic structural and expressional dehydrin 1 evolution in wild barley, Hordeum spontaneum, at 'Evolution Canyon', Mount Carmel, Israel. Mol Ecol (2009) 0.90
Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: role of nitric oxide and BK channels. Am J Physiol Heart Circ Physiol (2012) 0.90
Phylogenetic analyses unravel the evolutionary history of NAC proteins in plants. Evolution (2012) 0.89
Circadian genes in a blind subterranean mammal II: conservation and uniqueness of the three Period homologs in the blind subterranean mole rat, Spalax ehrenbergi superspecies. Proc Natl Acad Sci U S A (2002) 0.89
Adaptive evolution of heparanase in hypoxia-tolerant Spalax: gene cloning and identification of a unique splice variant. Proc Natl Acad Sci U S A (2005) 0.89
Microgeographic genome size differentiation of the carob tree, Ceratonia siliqua, at 'Evolution Canyon', Israel. Ann Bot (2004) 0.89
Spiny mice modulate eumelanin to pheomelanin ratio to achieve cryptic coloration in "evolution canyon," Israel. PLoS One (2010) 0.88
The disease resistance gene Dm3 is infrequent in natural populations of Lactuca serriola due to deletions and frequent gene conversions at the RGC2 locus. Plant J (2006) 0.88
Sympatric incipient speciation of spiny mice Acomys at "Evolution Canyon," Israel. Proc Natl Acad Sci U S A (2014) 0.88
Ontogenetic expression of erythropoietin and hypoxia-inducible factor-1 alpha genes in subterranean blind mole rats. FASEB J (2004) 0.88
Differences in spontaneous mutation frequencies as a function of environmental stress in soil fungi at "Evolution Canyon," Israel. Proc Natl Acad Sci U S A (2008) 0.88
Angiogenesis in hepatocellular carcinoma: a potential target for chemoprevention and therapy. Curr Cancer Drug Targets (2012) 0.88
The health benefits of blackcurrants. Food Funct (2012) 0.88
Multidimensional analysis of Drosophila wing variation in Evolution Canyon. J Genet (2008) 0.88
Genome differentiation of Drosophila melanogaster from a microclimate contrast in Evolution Canyon, Israel. Proc Natl Acad Sci U S A (2013) 0.87
Scorpion biodiversity and interslope divergence at "evolution canyon", lower Nahal Oren microsite, Mt. Carmel, Israel. PLoS One (2009) 0.87
Tibet as a potential domestication center of cultivated barley of China. PLoS One (2013) 0.87
Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis. Curr Pharm Biotechnol (2012) 0.87
A biogeographic view of Apodemus in Asia and Europe inferred from nuclear and mitochondrial gene sequences. Biochem Genet (2008) 0.87
Hereditary family signature of facial expression. Proc Natl Acad Sci U S A (2006) 0.87
Assortative mating in Drosophila adapted to a microsite ecological gradient. Behav Genet (2005) 0.87
Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer. Int J Cancer (2013) 0.87
Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/ β -Catenin Signaling Pathway. Evid Based Complement Alternat Med (2013) 0.87
Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats. J Nutr Biochem (2011) 0.86
Living with stress: regulation of antioxidant defense genes in the subterranean, hypoxia-tolerant mole rat, Spalax. Gene (2012) 0.86
Ancient diversity of splicing motifs and protein surfaces in the wild emmer wheat (Triticum dicoccoides) LR10 coiled coil (CC) and leucine-rich repeat (LRR) domains. Mol Plant Pathol (2011) 0.86
Adaptive response to DNA-damaging agents in natural Saccharomyces cerevisiae populations from "Evolution Canyon", Mt. Carmel, Israel. PLoS One (2009) 0.86