Published in Nat Methods on November 27, 2011
Ultrasensitive fluorescent proteins for imaging neuronal activity. Nature (2013) 12.01
Improving FRET dynamic range with bright green and red fluorescent proteins. Nat Methods (2012) 3.54
The microbial opsin family of optogenetic tools. Cell (2011) 2.94
Nanotools for neuroscience and brain activity mapping. ACS Nano (2013) 2.74
Single action potentials and subthreshold electrical events imaged in neurons with a fluorescent protein voltage probe. Neuron (2012) 2.68
High-fidelity optical reporting of neuronal electrical activity with an ultrafast fluorescent voltage sensor. Nat Neurosci (2014) 2.53
All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins. Nat Methods (2014) 2.41
Multi-electrode array technologies for neuroscience and cardiology. Nat Nanotechnol (2013) 2.03
Genetically targeted optical electrophysiology in intact neural circuits. Cell (2013) 1.90
Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons. Nat Commun (2014) 1.75
Imaging neural spiking in brain tissue using FRET-opsin protein voltage sensors. Nat Commun (2014) 1.73
Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation. Nat Methods (2012) 1.65
Genetically encoded optical indicators for the analysis of neuronal circuits. Nat Rev Neurosci (2012) 1.46
Closed-loop and activity-guided optogenetic control. Neuron (2015) 1.42
Palette of fluorinated voltage-sensitive hemicyanine dyes. Proc Natl Acad Sci U S A (2012) 1.41
Physical principles for scalable neural recording. Front Comput Neurosci (2013) 1.40
Methods for the directed evolution of proteins. Nat Rev Genet (2015) 1.38
Mechanism of voltage-sensitive fluorescence in a microbial rhodopsin. Proc Natl Acad Sci U S A (2013) 1.33
A fluorescent, genetically-encoded voltage probe capable of resolving action potentials. PLoS One (2012) 1.31
Design and generation of recombinant rabies virus vectors. Nat Protoc (2013) 1.27
Simultaneous imaging of neural activity in three dimensions. Front Neural Circuits (2014) 1.27
Enhanced Archaerhodopsin Fluorescent Protein Voltage Indicators. PLoS One (2013) 1.27
Cardiac optogenetics. Am J Physiol Heart Circ Physiol (2013) 1.24
Two-photon voltage imaging using a genetically encoded voltage indicator. Sci Rep (2013) 1.20
Bright and fast multicoloured voltage reporters via electrochromic FRET. Nat Commun (2014) 1.18
Temporal dynamics of microbial rhodopsin fluorescence reports absolute membrane voltage. Biophys J (2014) 1.16
Optical mapping of optogenetically shaped cardiac action potentials. Sci Rep (2014) 1.16
Optical neural interfaces. Annu Rev Biomed Eng (2014) 1.15
Rapid cellular phenotyping of human pluripotent stem cell-derived cardiomyocytes using a genetically encoded fluorescent voltage sensor. Stem Cell Reports (2014) 1.11
Fluorescent protein voltage probes derived from ArcLight that respond to membrane voltage changes with fast kinetics. PLoS One (2013) 1.11
Genetically engineered fluorescent voltage reporters. ACS Chem Neurosci (2012) 1.09
Imaging the response of the retina to electrical stimulation with genetically encoded calcium indicators. J Neurophysiol (2013) 1.03
Improved detection of electrical activity with a voltage probe based on a voltage-sensing phosphatase. J Physiol (2013) 1.01
Monitoring activity in neural circuits with genetically encoded indicators. Front Mol Neurosci (2014) 0.97
Screening fluorescent voltage indicators with spontaneously spiking HEK cells. PLoS One (2013) 0.97
Simultaneous mapping of membrane voltage and calcium in zebrafish heart in vivo reveals chamber-specific developmental transitions in ionic currents. Front Physiol (2014) 0.94
Directed evolution of a far-red fluorescent rhodopsin. Proc Natl Acad Sci U S A (2014) 0.94
Design and development of genetically encoded fluorescent sensors to monitor intracellular chemical and physical parameters. Biophys Rev (2016) 0.94
Control and plasticity of the presynaptic action potential waveform at small CNS nerve terminals. Neuron (2014) 0.94
Improved PeT molecules for optically sensing voltage in neurons. J Am Chem Soc (2015) 0.93
Hybrid multiphoton volumetric functional imaging of large-scale bioengineered neuronal networks. Nat Commun (2014) 0.92
Probing neuronal activities with genetically encoded optical indicators: from a historical to a forward-looking perspective. Pflugers Arch (2012) 0.92
Synthetic nanoelectronic probes for biological cells and tissues. Annu Rev Anal Chem (Palo Alto Calif) (2013) 0.92
Exploration of genetically encoded voltage indicators based on a chimeric voltage sensing domain. Front Mol Neurosci (2014) 0.91
Hybrid voltage sensor imaging of electrical activity from neurons in hippocampal slices from transgenic mice. J Neurophysiol (2012) 0.91
Two-photon compatibility and single-voxel, single-trial detection of subthreshold neuronal activity by a two-component optical voltage sensor. PLoS One (2012) 0.90
Nano-Bioelectronics. Chem Rev (2015) 0.90
Super-resolution 2-photon microscopy reveals that the morphology of each dendritic spine correlates with diffusive but not synaptic properties. Front Neuroanat (2014) 0.89
Optrodes for combined optogenetics and electrophysiology in live animals. Neurophotonics (2015) 0.89
Designs and sensing mechanisms of genetically encoded fluorescent voltage indicators. Curr Opin Chem Biol (2015) 0.88
Fluorescence spectroscopy of rhodopsins: insights and approaches. Biochim Biophys Acta (2013) 0.88
The active-zone protein Munc13 controls the use-dependence of presynaptic voltage-gated calcium channels. Elife (2015) 0.88
Tools, methods, and applications for optophysiology in neuroscience. Front Mol Neurosci (2013) 0.88
Two-photon scanning microscopy of in vivo sensory responses of cortical neurons genetically encoded with a fluorescent voltage sensor in rat. Front Neural Circuits (2012) 0.88
Molecular tools and approaches for optogenetics. Biol Psychiatry (2012) 0.88
Conformational changes in the archaerhodopsin-3 proton pump: detection of conserved strongly hydrogen bonded water networks. J Biol Phys (2011) 0.88
A Bright and Fast Red Fluorescent Protein Voltage Indicator That Reports Neuronal Activity in Organotypic Brain Slices. J Neurosci (2016) 0.88
Single-trial imaging of spikes and synaptic potentials in single neurons in brain slices with genetically encoded hybrid voltage sensor. J Neurophysiol (2014) 0.88
Flash memory: photochemical imprinting of neuronal action potentials onto a microbial rhodopsin. J Am Chem Soc (2014) 0.87
Capturing structure and function in an embryonic heart with biophotonic tools. Front Physiol (2014) 0.87
Mechanistic studies of the genetically encoded fluorescent protein voltage probe ArcLight. PLoS One (2014) 0.87
Voltage imaging to understand connections and functions of neuronal circuits. J Neurophysiol (2016) 0.86
Imaging neuronal populations in behaving rodents: paradigms for studying neural circuits underlying behavior in the mammalian cortex. J Neurosci (2013) 0.86
Using injectoporation to deliver genes to mechanosensory hair cells. Nat Protoc (2014) 0.86
Toward microendoscopy-inspired cardiac optogenetics in vivo: technical overview and perspective. J Biomed Opt (2014) 0.86
Computer-generated holography enhances voltage dye fluorescence discrimination in adjacent neuronal structures. Neurophotonics (2015) 0.86
Single-molecule fluorimetry and gating currents inspire an improved optical voltage indicator. Elife (2015) 0.85
Running in reverse: rhodopsins sense voltage. Nat Methods (2011) 0.85
Genetic dissection of GABAergic neural circuits in mouse neocortex. Front Cell Neurosci (2014) 0.84
Revealing the secrets of neuronal circuits with recombinant rabies virus technology. Front Neural Circuits (2013) 0.84
Monitoring brain activity with protein voltage and calcium sensors. Sci Rep (2015) 0.84
Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and Voltage Fluorescent Reporters. Stem Cell Reports (2015) 0.84
Molecular neuroanatomy: a generation of progress. Trends Neurosci (2013) 0.83
Three-dimensional mapping and regulation of action potential propagation in nanoelectronics-innervated tissues. Nat Nanotechnol (2016) 0.83
Optical Tools to Investigate Cellular Activity in the Intestinal Wall. J Neurogastroenterol Motil (2015) 0.83
Archaerhodopsin voltage imaging: synaptic calcium and BK channels stabilize action potential repolarization at the Drosophila neuromuscular junction. J Neurosci (2014) 0.83
Photoreceptor engineering. Front Mol Biosci (2015) 0.83
Two-Photon Lifetime Imaging of Voltage Indicating Proteins as a Probe of Absolute Membrane Voltage. Biophys J (2015) 0.82
Optogenetics: Turning the Microscope on Its Head. Biophys J (2016) 0.82
Genetically Encoded Voltage Indicators: Opportunities and Challenges. J Neurosci (2016) 0.82
Imaging activity in astrocytes and neurons with genetically encoded calcium indicators following in utero electroporation. Front Mol Neurosci (2015) 0.82
Pado, a fluorescent protein with proton channel activity can optically monitor membrane potential, intracellular pH, and map gap junctions. Sci Rep (2016) 0.81
Rational design of a colorimetric pH sensor from a soluble retinoic acid chaperone. J Am Chem Soc (2013) 0.81
Optogenetic Monitoring of Synaptic Activity with Genetically Encoded Voltage Indicators. Front Synaptic Neurosci (2016) 0.80
Toward Better Genetically Encoded Sensors of Membrane Potential. Trends Neurosci (2016) 0.80
Genetically Targeted All-Optical Electrophysiology with a Transgenic Cre-Dependent Optopatch Mouse. J Neurosci (2016) 0.80
Comparative performance of a genetically-encoded voltage indicator and a blue voltage sensitive dye for large scale cortical voltage imaging. Front Cell Neurosci (2015) 0.80
Developing Fast Fluorescent Protein Voltage Sensors by Optimizing FRET Interactions. PLoS One (2015) 0.80
A neuron-based screening platform for optimizing genetically-encoded calcium indicators. PLoS One (2013) 0.80
Recent advances in engineering microbial rhodopsins for optogenetics. Curr Opin Struct Biol (2015) 0.80
Microbial rhodopsins: wide distribution, rich diversity and great potential. Biophys Physicobiol (2015) 0.80
Fast state-space methods for inferring dendritic synaptic connectivity. J Comput Neurosci (2014) 0.80
Large-scale imaging in small brains. Curr Opin Neurobiol (2015) 0.80
Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels. Elife (2016) 0.79
Route to genetically targeted optical electrophysiology: development and applications of voltage-sensitive fluorescent proteins. Neurophotonics (2015) 0.79
Fluorescence imaging in the last two decades. Microscopy (Oxf) (2013) 0.78
Near-IR resonance Raman spectroscopy of archaerhodopsin 3: effects of transmembrane potential. J Phys Chem B (2012) 0.78
Drugging Membrane Protein Interactions. Annu Rev Biomed Eng (2016) 0.78
Genetically Encoded Voltage Indicators in Circulation Research. Int J Mol Sci (2015) 0.77
Is realistic neuronal modeling realistic? J Neurophysiol (2016) 0.77
Environmental genome shotgun sequencing of the Sargasso Sea. Science (2004) 45.23
Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci (2005) 28.08
A guide to choosing fluorescent proteins. Nat Methods (2005) 18.55
Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. Nat Methods (2009) 13.39
Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system. Nature (2007) 12.76
High-performance genetically targetable optical neural silencing by light-driven proton pumps. Nature (2010) 8.37
The development and application of optogenetics. Annu Rev Neurosci (2011) 6.84
Light scattering and birefringence changes during nerve activity. Nature (1968) 4.65
Reversible dissociation of the purple complex in bacteriorhodopsin and identification of 13-cis and all-trans-retinal as its chromophores. Eur J Biochem (1973) 3.70
Automated analysis of cellular signals from large-scale calcium imaging data. Neuron (2009) 3.51
A genetically encoded optical probe of membrane voltage. Neuron (1997) 3.35
Changes in fluorescence, turbidity, and birefringence associated with nerve excitation. Proc Natl Acad Sci U S A (1968) 3.25
Electrical spiking in Escherichia coli probed with a fluorescent voltage-indicating protein. Science (2011) 3.09
Imaging brain electric signals with genetically targeted voltage-sensitive fluorescent proteins. Nat Methods (2010) 2.90
Electrophysiology in the age of light. Nature (2009) 2.90
Improving membrane voltage measurements using FRET with new fluorescent proteins. Nat Methods (2008) 2.74
Bacteriorhodopsin. Annu Rev Physiol (2004) 2.61
Imaging voltage in neurons. Neuron (2011) 2.54
Binding of all-trans-retinal to the purple membrane. Evidence for cooperativity and determination of the extinction coefficient. Biochemistry (1979) 2.27
The spatio-temporal characteristics of action potential initiation in layer 5 pyramidal neurons: a voltage imaging study. J Physiol (2011) 1.93
Evolution of the archaeal rhodopsins: evolution rate changes by gene duplication and functional differentiation. J Mol Biol (1999) 1.83
Inversion of proton translocation in bacteriorhodopsin mutants D85N, D85T, and D85,96N. Biophys J (1994) 1.63
Submillisecond optical reporting of membrane potential in situ using a neuronal tracer dye. J Neurosci (2009) 1.54
Rational optimization and imaging in vivo of a genetically encoded optical voltage reporter. J Neurosci (2008) 1.32
Persistent neuronal labeling by retrograde fluorescent tracers: a comparison between Fast Blue, Fluoro-Gold and various dextran conjugates. J Neurosci Methods (1997) 1.29
Wide-field and two-photon imaging of brain activity with voltage- and calcium-sensitive dyes. Philos Trans R Soc Lond B Biol Sci (2009) 1.12
Electric-field-induced Schiff-base deprotonation in D85N mutant bacteriorhodopsin. Proc Natl Acad Sci U S A (1996) 1.06
Crystal structure of the Anabaena sensory rhodopsin transducer. J Mol Biol (2006) 1.00
Conformational changes detected in a sensory rhodopsin II-transducer complex. J Biol Chem (2003) 0.99
Chromophore of sensory rhodopsin II from Halobacterium halobium. Biochemistry (1992) 0.98
First steps of retinal photoisomerization in proteorhodopsin. Biophys J (2006) 0.92
Second-harmonic generation imaging of membrane potential with photon counting. Microsc Microanal (2008) 0.92
Optical recording of electrical activity in guinea-pig enteric networks using voltage-sensitive dyes. J Vis Exp (2009) 0.89
Voltage signals of individual Purkinje cell dendrites in rat cerebellar slices. Neurosci Lett (1997) 0.86
Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells. Proc Natl Acad Sci U S A (2007) 3.11
Electrical spiking in Escherichia coli probed with a fluorescent voltage-indicating protein. Science (2011) 3.09
Making microtubules and mitotic spindles in cells without functional centrosomes. Curr Biol (2006) 2.70
All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins. Nat Methods (2014) 2.41
Enhanced enantioselectivity in excitation of chiral molecules by superchiral light. Science (2011) 1.76
Optical chirality and its interaction with matter. Phys Rev Lett (2010) 1.72
Limits on fluorescence detected circular dichroism of single helicene molecules. J Phys Chem A (2009) 1.58
Mechanism of voltage-sensitive fluorescence in a microbial rhodopsin. Proc Natl Acad Sci U S A (2013) 1.33
Surface plasmon resonance enhanced magneto-optics (SuPREMO): Faraday rotation enhancement in gold-coated iron oxide nanocrystals. Nano Lett (2009) 1.26
The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells. J Cell Biol (2009) 1.20
Electrokinetic trapping at the one nanometer limit. Proc Natl Acad Sci U S A (2011) 1.17
Convex lens-induced confinement for imaging single molecules. Anal Chem (2010) 1.06
Assessing historical fish community composition using surveys, historical collection data, and species distribution models. PLoS One (2011) 1.03
Single-molecule fluorescence imaging of processive myosin with enhanced background suppression using linear zero-mode waveguides (ZMWs) and convex lens induced confinement (CLIC). Opt Express (2013) 1.01
Mapping nanomagnetic fields using a radical pair reaction. Nano Lett (2011) 0.89
Flash memory: photochemical imprinting of neuronal action potentials onto a microbial rhodopsin. J Am Chem Soc (2014) 0.87
Ultrasensitive measurements of microbial rhodopsin photocycles using photochromic FRET. Photochem Photobiol (2011) 0.87
Hardware-based anti-Brownian electrokinetic trap (ABEL trap) for single molecules: Control loop simulations and application to ATP binding stoichiometry in multi-subunit enzymes. Proc SPIE Int Soc Opt Eng (2008) 0.87
Optical imaging through scattering media via magnetically modulated fluorescence. Opt Express (2010) 0.84
Anti-Brownian traps for studies on single molecules. Methods Enzymol (2010) 0.84
Mass action at the single-molecule level. J Am Chem Soc (2012) 0.84
Euler buckling and nonlinear kinking of double-stranded DNA. Nucleic Acids Res (2013) 0.83
Local geometry of electromagnetic fields and its role in molecular multipole transitions. J Phys Chem B (2011) 0.81
Can Species Distribution Models Aid Bioassessment when Reference Sites are Lacking? Tests Based on Freshwater Fishes. Environ Manage (2015) 0.78
Two-photon imaging of a magneto-fluorescent indicator for 3D optical magnetometry. Opt Express (2015) 0.78
Redox site-mediated charge transport in a Hg-SAM//Ru(NH(3))(6)(3+/2+)//SAM-Hg junction with a dynamic interelectrode separation: compatibility with redox cycling and electron hopping mechanisms. J Am Chem Soc (2009) 0.78
Carbon nanotubes provide a charge. Science (2003) 0.77
Measuring membrane voltage with microbial rhodopsins. Methods Mol Biol (2014) 0.76
Optimal tracking of a Brownian particle. Opt Express (2012) 0.75
Chirality-dependent friction of bulk molecular solids. Langmuir (2014) 0.75