Published in Anal Chem on December 21, 2011
Absolute quantification by droplet digital PCR versus analog real-time PCR. Nat Methods (2013) 3.63
Development and evaluation of a next-generation digital PCR diagnostic assay for ocular Chlamydia trachomatis infections. J Clin Microbiol (2013) 2.46
Comparison of droplet digital PCR to real-time PCR for quantitative detection of cytomegalovirus. J Clin Microbiol (2012) 2.39
Comparison of microfluidic digital PCR and conventional quantitative PCR for measuring copy number variation. Nucleic Acids Res (2012) 1.97
Digital genomic quantification of tumor-infiltrating lymphocytes. Sci Transl Med (2013) 1.72
Quantitative analysis of food and feed samples with droplet digital PCR. PLoS One (2013) 1.69
Low-level detection and quantitation of cellular HIV-1 DNA and 2-LTR circles using droplet digital PCR. J Virol Methods (2012) 1.65
A p53 enhancer region regulates target genes through chromatin conformations in cis and in trans. Genes Dev (2013) 1.62
Identification of chromosomally integrated human herpesvirus 6 by droplet digital PCR. Clin Chem (2014) 1.48
Comparison of droplet digital PCR and seminested real-time PCR for quantification of cell-associated HIV-1 RNA. PLoS One (2014) 1.40
Low copy target detection by Droplet Digital PCR through application of a novel open access bioinformatic pipeline, 'definetherain'. J Virol Methods (2014) 1.34
Increased frequency of de novo copy number variants in congenital heart disease by integrative analysis of single nucleotide polymorphism array and exome sequence data. Circ Res (2014) 1.32
Digital droplet PCR (ddPCR) for the precise quantification of human T-lymphotropic virus 1 proviral loads in peripheral blood and cerebrospinal fluid of HAM/TSP patients and identification of viral mutations. J Neurovirol (2014) 1.22
DNA copy number concentration measured by digital and droplet digital quantitative PCR using certified reference materials. Anal Bioanal Chem (2015) 1.16
Evaluation of digital PCR for absolute RNA quantification. PLoS One (2013) 1.13
Absolute determination of single-stranded and self-complementary adeno-associated viral vector genome titers by droplet digital PCR. Hum Gene Ther Methods (2014) 1.08
One-step RT-droplet digital PCR: a breakthrough in the quantification of waterborne RNA viruses. Anal Bioanal Chem (2013) 1.07
Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain. Aging Cell (2013) 1.05
Quantitative telomerase enzyme activity determination using droplet digital PCR with single cell resolution. Nucleic Acids Res (2014) 1.04
Impact of variance components on reliability of absolute quantification using digital PCR. BMC Bioinformatics (2014) 1.01
Evaluation of droplet digital PCR for characterizing plasmid reference material used for quantifying ammonia oxidizers and denitrifiers. Anal Bioanal Chem (2014) 1.01
CANOES: detecting rare copy number variants from whole exome sequencing data. Nucleic Acids Res (2014) 1.00
Digital quantitation of potential therapeutic target RNAs. Nucleic Acid Ther (2013) 0.99
Comparison of four digital PCR platforms for accurate quantification of DNA copy number of a certified plasmid DNA reference material. Sci Rep (2015) 0.98
Quantification of Plasma miRNAs by Digital PCR for Cancer Diagnosis. Biomark Insights (2013) 0.96
Digital PCR modeling for maximal sensitivity, dynamic range and measurement precision. PLoS One (2015) 0.94
The potential impact of droplet microfluidics in biology. Anal Chem (2013) 0.94
Analysis of β-cell death in type 1 diabetes by droplet digital PCR. Endocrinology (2014) 0.93
Diagnostic and prognostic microRNAs in the serum of breast cancer patients measured by droplet digital PCR. Biomark Res (2015) 0.90
DNA extract characterization process for microbial detection methods development and validation. BMC Res Notes (2012) 0.89
Mutant HSPB1 overexpression in neurons is sufficient to cause age-related motor neuronopathy in mice. Neurobiol Dis (2012) 0.88
Killer-cell Immunoglobulin-like Receptor gene linkage and copy number variation analysis by droplet digital PCR. Genome Med (2014) 0.88
Ultra-sensitive droplet digital PCR for detecting a low-prevalence somatic GNAQ mutation in Sturge-Weber syndrome. Sci Rep (2016) 0.87
Quantitative analysis of pork and chicken products by droplet digital PCR. Biomed Res Int (2014) 0.87
Mapping the deletion endpoints in individuals with 22q11.2 deletion syndrome by droplet digital PCR. BMC Med Genet (2014) 0.87
A comparison between droplet digital and quantitative PCR in the analysis of bacterial 16S load in lung tissue samples from control and COPD GOLD 2. PLoS One (2014) 0.87
Digital detection of endonuclease mediated gene disruption in the HIV provirus. Sci Rep (2016) 0.86
Amylase activity is associated with AMY2B copy numbers in dog: implications for dog domestication, diet and diabetes. Anim Genet (2014) 0.85
Germline copy number variations associated with breast cancer susceptibility in a Japanese population. Tumour Biol (2012) 0.85
Genome aberrations in canine mammary carcinomas and their detection in cell-free plasma DNA. PLoS One (2013) 0.84
The contribution of alu elements to mutagenic DNA double-strand break repair. PLoS Genet (2015) 0.84
12p microRNA expression in fibroblast cell lines from probands with Pallister-Killian syndrome. Chromosome Res (2014) 0.84
Creating biocompatible oil-water interfaces without synthesis: direct interactions between primary amines and carboxylated perfluorocarbon surfactants. Anal Chem (2013) 0.84
Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention. Sci Transl Med (2015) 0.83
Mucosal effects of tenofovir 1% gel. Elife (2015) 0.83
A highly sensitive and specific method for the screening detection of genetically modified organisms based on digital PCR without pretreatment. Sci Rep (2015) 0.83
Development of droplet digital PCR for the detection of Babesia microti and Babesia duncani. Exp Parasitol (2014) 0.83
Diet adaptation in dog reflects spread of prehistoric agriculture. Heredity (Edinb) (2016) 0.82
Assessment of the real-time PCR and different digital PCR platforms for DNA quantification. Anal Bioanal Chem (2015) 0.82
Droplet digital PCR quantifies host inflammatory transcripts in feces reliably and reproducibly. Cell Immunol (2016) 0.82
SOX2 expression is regulated by BRAF and contributes to poor patient prognosis in colorectal cancer. PLoS One (2014) 0.82
Standard free droplet digital polymerase chain reaction as a new tool for the quality control of high-capacity adenoviral vectors in small-scale preparations. Hum Gene Ther Methods (2015) 0.82
Comparison of Droplet Digital PCR and qPCR for the Quantification of Shiga Toxin-Producing Escherichia coli in Bovine Feces. Toxins (Basel) (2016) 0.81
Early Initiation of Antiretroviral Therapy Can Functionally Control Productive HIV-1 Infection in Humanized-BLT Mice. J Acquir Immune Defic Syndr (2015) 0.81
The effect of input DNA copy number on genotype call and characterising SNP markers in the humpback whale genome using a nanofluidic array. PLoS One (2012) 0.81
Evaluation of the performance of quantitative detection of the Listeria monocytogenes prfA locus with droplet digital PCR. Anal Bioanal Chem (2016) 0.81
A comparison of DNA methylation specific droplet digital PCR (ddPCR) and real time qPCR with flow cytometry in characterizing human T cells in peripheral blood. Epigenetics (2014) 0.80
Detection and quantification of chimerism by droplet digital PCR. Chimerism (2013) 0.80
Cyst Fluid Telomerase Activity Predicts the Histologic Grade of Cystic Neoplasms of the Pancreas. Clin Cancer Res (2016) 0.80
Fundamentals of multiplexing with digital PCR. Biomol Detect Quantif (2016) 0.80
Activating ESR1 Mutations Differentially Impact the Efficacy of ER Antagonists. Cancer Discov (2016) 0.80
Development of NIST standard reference material 2373: Genomic DNA standards for HER2 measurements. Biomol Detect Quantif (2016) 0.79
Quantification of HEV RNA by Droplet Digital PCR. Viruses (2016) 0.78
Bacterial Profiling Reveals Novel "Ca. Neoehrlichia", Ehrlichia, and Anaplasma Species in Australian Human-Biting Ticks. PLoS One (2015) 0.78
Tracing the expression of circular RNAs in human pre-implantation embryos. Genome Biol (2016) 0.78
Somatic Variants in the Human Lens Epithelium: A Preliminary Assessment. Invest Ophthalmol Vis Sci (2016) 0.78
A Novel Pretreatment-Free Duplex Chamber Digital PCR Detection System for the Absolute Quantitation of GMO Samples. Int J Mol Sci (2016) 0.78
Evidence of convergent evolution in humans and macaques supports an adaptive role for copy number variation of the β-defensin-2 gene. Genome Biol Evol (2014) 0.78
Maternal germline-specific genes in the Asian malaria mosquito Anopheles stephensi: characterization and application for disease control. G3 (Bethesda) (2014) 0.78
Gene expression changes in immune response pathways following oral administration of tetrabromobisphenol A (TBBPA) in female Wistar Han rats. Toxicol Lett (2017) 0.77
Arabidopsis thaliana population analysis reveals high plasticity of the genomic region spanning MSH2, AT3G18530 and AT3G18535 genes and provides evidence for NAHR-driven recurrent CNV events occurring in this location. BMC Genomics (2016) 0.77
A comparison between quantitative PCR and droplet digital PCR technologies for circulating microRNA quantification in human lung cancer. BMC Biotechnol (2016) 0.77
Comparison of Droplet Digital PCR and Quantitative PCR Assays for Quantitative Detection of Xanthomonas citri Subsp. citri. PLoS One (2016) 0.77
Validation of Reference Genes for Relative Quantitative Gene Expression Studies in Cassava (Manihot esculenta Crantz) by Using Quantitative Real-Time PCR. Front Plant Sci (2016) 0.77
Dietary Variation and Evolution of Gene Copy Number among Dog Breeds. PLoS One (2016) 0.77
Estimation of allele-specific Ace-1 duplication in insecticide-resistant Anopheles mosquitoes from West Africa. Malar J (2015) 0.77
Applicability of digital PCR to the investigation of pediatric-onset genetic disorders. Biomol Detect Quantif (2016) 0.77
Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations. Oncotarget (2016) 0.77
Multiplex quantification of four DNA targets in one reaction with Bio-Rad droplet digital PCR system for GMO detection. Sci Rep (2016) 0.77
Mitochondrial DNA exhibits resistance to induced point and deletion mutations. Nucleic Acids Res (2016) 0.76
Absolute quantification reveals the stable transmission of a high copy number variant linked to autoinflammatory disease. BMC Genomics (2016) 0.76
Parallelized ultra-high throughput microfluidic emulsifier for multiplex kinetic assays. Biomicrofluidics (2015) 0.76
Mosaic ratio quantification of isochromosome 12p in Pallister-Killian syndrome using droplet digital PCR. Mol Genet Genomic Med (2016) 0.76
Bead mediated separation of microparticles in droplets. PLoS One (2017) 0.75
Digital PCR using micropatterned superporous absorbent array chips. Analyst (2016) 0.75
Differences in AMY1 Gene Copy Numbers Derived from Blood, Buccal Cells and Saliva Using Quantitative and Droplet Digital PCR Methods: Flagging the Pitfall. PLoS One (2017) 0.75
Lignin-degrading peroxidases in white-rot fungus Trametes hirsuta 072. Absolute expression quantification of full multigene family. PLoS One (2017) 0.75
Quantification of Hepatitis E Virus in Naturally-Contaminated Pig Liver Products. Front Microbiol (2016) 0.75
Droplet digital PCR analysis of NOTCH1 gene mutations in chronic lymphocytic leukemia. Oncotarget (2016) 0.75
Postnatal and non-invasive prenatal detection of β-thalassemia mutations based on Taqman genotyping assays. PLoS One (2017) 0.75
The variations of IL-23R are associated with susceptibility and severe clinical forms of pulmonary tuberculosis in Chinese Uygurs. BMC Infect Dis (2015) 0.75
Synthetic certified DNA reference material for analysis of human erythropoietin transgene and transcript in gene doping and gene therapy. Gene Ther (2016) 0.75
Inter-laboratory assessment of different digital PCR platforms for quantification of human cytomegalovirus DNA. Anal Bioanal Chem (2017) 0.75
An international comparability study on quantification of mRNA gene expression ratios: CCQM-P103.1. Biomol Detect Quantif (2016) 0.75
Application of Droplet Digital PCR for Estimating Vector Copy Number States in Stem Cell Gene Therapy. Hum Gene Ther Methods (2016) 0.75
Diagnostic utility of droplet digital PCR for HIV reservoir quantification. J Virus Erad (2016) 0.75
Intronless WNT10B-short variant underlies new recurrent allele-specific rearrangement in acute myeloid leukaemia. Sci Rep (2016) 0.75
Accurate quantification of supercoiled DNA by digital PCR. Sci Rep (2016) 0.75
Detection and Enumeration of Spore-Forming Bacteria in Powdered Dairy Products. Front Microbiol (2017) 0.75
Aneuploidy screening of embryonic stem cell clones by metaphase karyotyping and droplet digital polymerase chain reaction. BMC Cell Biol (2016) 0.75
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High-throughput droplet digital PCR system for absolute quantitation of DNA copy number. Anal Chem (2011) 10.11
Quantitation of targets for PCR by use of limiting dilution. Biotechniques (1992) 4.65
Digital PCR for the molecular detection of fetal chromosomal aneuploidy. Proc Natl Acad Sci U S A (2007) 3.13
Mathematical analysis of copy number variation in a DNA sample using digital PCR on a nanofluidic device. PLoS One (2008) 2.79
Evaluation of digital PCR for absolute DNA quantification. Anal Chem (2011) 2.34
Taking qPCR to a higher level: Analysis of CNV reveals the power of high throughput qPCR to enhance quantitative resolution. Methods (2010) 2.27
Quantitative and sensitive detection of rare mutations using droplet-based microfluidics. Lab Chip (2011) 2.26
Single molecule detection in nanofluidic digital array enables accurate measurement of DNA copy number. Anal Bioanal Chem (2009) 2.10
Megapixel digital PCR. Nat Methods (2011) 1.94
Comparison of methods for accurate quantification of DNA mass concentration with traceability to the international system of units. Anal Chem (2010) 1.61
Quantifying EGFR alterations in the lung cancer genome with nanofluidic digital PCR arrays. Clin Chem (2010) 1.53
High-throughput droplet digital PCR system for absolute quantitation of DNA copy number. Anal Chem (2011) 10.11
Absolute quantification by droplet digital PCR versus analog real-time PCR. Nat Methods (2013) 3.63
The effect of geographical scale of sampling on DNA barcoding. Syst Biol (2012) 2.22
On-chip, real-time, single-copy polymerase chain reaction in picoliter droplets. Anal Chem (2007) 2.18
Single molecule detection in nanofluidic digital array enables accurate measurement of DNA copy number. Anal Bioanal Chem (2009) 2.10
Comparison of methods for accurate quantification of DNA mass concentration with traceability to the international system of units. Anal Chem (2010) 1.61
Second-generation blood tests to detect erythropoietin abuse by athletes. Haematologica (2003) 1.49
Multiplexed target detection using DNA-binding dye chemistry in droplet digital PCR. Anal Chem (2013) 1.35
A comparative study of submicron particle sizing platforms: accuracy, precision and resolution analysis of polydisperse particle size distributions. J Colloid Interface Sci (2013) 1.19
Determining transport efficiency for the purpose of counting and sizing nanoparticles via single particle inductively coupled plasma mass spectrometry. Anal Chem (2011) 1.13
Absolute quantification of genetically modified MON810 maize (Zea mays L.) by digital polymerase chain reaction. Anal Bioanal Chem (2009) 1.13
Tissue distribution of inhaled micro- and nano-sized cerium oxide particles in rats: results from a 28-day exposure study. Toxicol Sci (2012) 1.09
Autonomous detection of aerosolized Bacillus anthracis and Yersinia pestis. Anal Chem (2003) 1.08
Droplet digital PCR measurement of HER2 copy number alteration in formalin-fixed paraffin-embedded breast carcinoma tissue. Clin Chem (2013) 1.01
Single particle inductively coupled plasma-mass spectrometry: a performance evaluation and method comparison in the determination of nanoparticle size. Environ Sci Technol (2012) 0.99
Digital polymerase chain reaction measured pUC19 marker as calibrant for HPLC measurement of DNA quantity. Anal Chem (2013) 0.95
Environmental monitoring for biological threat agents using the autonomous pathogen detection system with multiplexed polymerase chain reaction. Anal Chem (2008) 0.94
Potential use of gene transfer in athletic performance enhancement. Mol Ther (2007) 0.94
Subpicometer length measurement using heterodyne laser interferometry and all-digital rf phase meters. Opt Lett (2010) 0.94
Effect of sustained elevated temperature prior to amplification on template copy number estimation using digital polymerase chain reaction. Analyst (2010) 0.92
Developing strategies for detection of gene doping. J Gene Med (2008) 0.90
Measurement of absolute copy number variation reveals association with essential hypertension. BMC Med Genomics (2014) 0.90
A multiplex real-time reverse transcription polymerase chain reaction assay for detection and differentiation of Bluetongue virus and Epizootic hemorrhagic disease virus serogroups. J Vet Diagn Invest (2009) 0.84
Linearization and minimization of cyclic error with heterodyne laser interferometry. Opt Lett (2012) 0.83
The effect of input DNA copy number on genotype call and characterising SNP markers in the humpback whale genome using a nanofluidic array. PLoS One (2012) 0.81
An international comparability study on quantification of total methyl cytosine content. Anal Biochem (2008) 0.80
Improved detection of transgene and nonviral vectors in blood. Hum Gene Ther Methods (2013) 0.80
Enhanced permanganate chemiluminescence. Analyst (2010) 0.80
Inkjet-printed gold nanoparticle chemiresistors: influence of film morphology and ionic strength on the detection of organics dissolved in aqueous solution. Anal Chim Acta (2008) 0.78
In search of a chemiluminescence 1,4-dioxy biradical. J Am Chem Soc (2009) 0.78
Multiplexed molecular assay for rapid exclusion of foot-and-mouth disease. J Virol Methods (2008) 0.78
A review of the detection, fate and effects of engineered nanomaterials in wastewater treatment plants. Water Sci Technol (2013) 0.77
Detection and identification of multiple genetically modified events using DNA insert fingerprinting. Anal Bioanal Chem (2009) 0.77
Multiplexed detection of antibodies to nonstructural proteins of foot-and-mouth disease virus. Anal Chem (2006) 0.77
Addition of gold nanoparticles to real-time PCR: effect on PCR profile and SYBR Green I fluorescence. Anal Bioanal Chem (2008) 0.77
A study of comparability in amplified fragment length polymorphism profiling using a simple model system. Electrophoresis (2007) 0.76
Control of excitation and quenching in multi-colour electrogenerated chemiluminescence systems through choice of co-reactant. Chemistry (2014) 0.76
Development of reference ranges in elite athletes for markers of altered erythropoiesis. Haematologica (2002) 0.76
A tiered approach. Nat Nanotechnol (2013) 0.75
Kinetics and selectivity of permanganate chemiluminescence: a study of hydroxyl and amino disubstituted benzene positional isomers. Anal Chim Acta (2011) 0.75
Toward metrological traceability for DNA fragment ratios in GM quantification. 1. Effect of DNA extraction methods on the quantitative determination of Bt176 corn by real-time PCR. J Agric Food Chem (2007) 0.75
A standard additions method reduces inhibitor-induced bias in quantitative real-time PCR. Anal Bioanal Chem (2011) 0.75
Finite element analysis of guided waves in fluid-filled corrugated pipes. J Acoust Soc Am (2007) 0.75
Studies on the mechanism of the peroxyoxalate chemiluminescence reaction: part 2. Further identification of intermediates using 2D EXSY 13C nuclear magnetic resonance spectroscopy. Anal Chim Acta (2008) 0.75
DNA methylation ratio variability may impede clinical application of cancer diagnostic markers. Anal Bioanal Chem (2014) 0.75
Autocatalytic nature of permanganate oxidations exploited for highly sensitive chemiluminescence detection. Anal Chem (2010) 0.75
Toward a multiplexed serotyping immunoassay for foot-and-mouth disease virus. J Vet Diagn Invest (2007) 0.75
Quantification of nanoparticle concentration in colloidal suspensions by a non-destructive optical method. Nanotechnology (2017) 0.75