SOX2 expression is regulated by BRAF and contributes to poor patient prognosis in colorectal cancer.

PubWeight™: 0.82‹?›

🔗 View Article (PMC 4092103)

Published in PLoS One on July 10, 2014

Authors

Ida V Lundberg1, Anna Löfgren Burström1, Sofia Edin1, Vincy Eklöf1, Åke Öberg2, Roger Stenling1, Richard Palmqvist1, Maria L Wikberg1

Author Affiliations

1: Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.
2: Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå, Sweden.

Articles cited by this

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51

A genetic model for colorectal tumorigenesis. Cell (1990) 44.37

An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet (2008) 17.67

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet (2006) 13.63

Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev (2003) 12.38

High-throughput droplet digital PCR system for absolute quantitation of DNA copy number. Anal Chem (2011) 10.11

Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer (2010) 8.55

CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut (2008) 6.26

Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers. Cancer Res (2005) 5.68

Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res (2007) 5.54

Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science (2013) 4.42

Evaluation of a droplet digital polymerase chain reaction format for DNA copy number quantification. Anal Chem (2011) 4.14

The Raf/MEK/ERK pathway: new concepts of activation. Biol Cell (2001) 3.08

The sox family of transcription factors: versatile regulators of stem and progenitor cell fate. Cell Stem Cell (2013) 2.97

Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases. Clin Cancer Res (2010) 2.95

The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status. Clin Cancer Res (2010) 2.23

Detection of BRAF V600E mutation in colorectal cancer: comparison of automatic sequencing and real-time chemistry methodology. J Mol Diagn (2006) 2.11

Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer. Mod Pathol (2007) 2.09

Expression of the SRY-related HMG box protein SOX2 in human gastric carcinoma. Int J Oncol (2004) 1.79

BRAFV600E: implications for carcinogenesis and molecular therapy. Mol Cancer Ther (2011) 1.77

Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer. Br J Cancer (2011) 1.69

Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas. Oncogene (2011) 1.66

Histopathologic evaluation of stepwise progression of pancreatic carcinoma with immunohistochemical analysis of gastric epithelial transcription factor SOX2: comparison of expression patterns between invasive components and cancerous or nonneoplastic intraductal components. Pancreas (2006) 1.53

The multiple roles for Sox2 in stem cell maintenance and tumorigenesis. Cell Signal (2013) 1.52

KRAS-mutation status in relation to colorectal cancer survival: the joint impact of correlated tumour markers. Br J Cancer (2013) 1.41

Roles of fibroblast growth factor receptors in carcinogenesis. Mol Cancer Res (2010) 1.41

The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer. Br J Cancer (2013) 1.33

Silencing SOX2 induced mesenchymal-epithelial transition and its expression predicts liver and lymph node metastasis of CRC patients. PLoS One (2012) 1.31

SOX2 contributes to melanoma cell invasion. Lab Invest (2011) 1.21

ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS (2010) 1.17

Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions. Int J Cancer (2008) 1.16

Elevated expression of SOX2 and FGFR1 in correlation with poor prognosis in patients with small cell lung cancer. Int J Clin Exp Pathol (2013) 1.04

Reciprocal relationship in gene expression between FGFR1 and FGFR3: implication for tumorigenesis. Oncogene (2005) 1.01

Overexpression of the fibroblast growth factor receptor-1 gene correlates with liver metastasis in colorectal cancer. Oncol Rep (2009) 0.98

A tumorigenic MLL-homeobox network in human glioblastoma stem cells. Cancer Res (2012) 0.96

Predictive value of Sox2 expression in transurethral resection specimens in patients with T1 bladder cancer. Med Oncol (2013) 0.94

SOX2 expression and prognostic significance in ovarian carcinoma. Int J Gynecol Pathol (2013) 0.93

SOX2 overexpression correlates with poor prognosis in laryngeal squamous cell carcinoma. Auris Nasus Larynx (2013) 0.93

SOX2 targets fibronectin 1 to promote cell migration and invasion in ovarian cancer: new molecular leads for therapeutic intervention. OMICS (2013) 0.88

SOX2 gene expression in normal human thymus and thymoma. Clin Exp Med (2010) 0.79