Published in Circulation on December 05, 2011
The Rotterdam Study: 2014 objectives and design update. Eur J Epidemiol (2013) 2.56
Genetic variants at chromosome 9p21 and risk of first versus subsequent coronary heart disease events: a systematic review and meta-analysis. J Am Coll Cardiol (2014) 1.61
The Rotterdam Study: 2016 objectives and design update. Eur J Epidemiol (2015) 1.61
Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries. Arterioscler Thromb Vasc Biol (2015) 1.54
Retracted Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction. PLoS One (2013) 1.45
Molecular imaging of atherosclerosis for improving diagnostic and therapeutic development. Circ Res (2012) 1.29
Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation. Arterioscler Thromb Vasc Biol (2012) 1.12
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genet (2016) 1.08
Genetic analysis for a shared biological basis between migraine and coronary artery disease. Neurol Genet (2015) 1.08
Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study. Circulation (2013) 1.03
Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. J Am Coll Cardiol (2013) 1.02
Genetics of coronary artery disease. Circulation (2013) 1.00
Genetics of coronary artery calcification among African Americans, a meta-analysis. BMC Med Genet (2013) 0.99
Risk loci for coronary artery calcification replicated at 9p21 and 6q24 in the Heinz Nixdorf Recall Study. BMC Med Genet (2013) 0.95
Genetic pathways of vascular calcification. Trends Cardiovasc Med (2012) 0.94
Analysis of common and coding variants with cardiovascular disease in the Diabetes Heart Study. Cardiovasc Diabetol (2014) 0.94
Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding. PLoS Genet (2015) 0.94
Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes. Hum Mol Genet (2013) 0.93
Population ancestry and genetic risk for diabetes and kidney, cardiovascular, and bone disease: modifiable environmental factors may produce the cures. Am J Kidney Dis (2013) 0.93
From genotype to phenotype in human atherosclerosis--recent findings. Curr Opin Lipidol (2013) 0.93
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest (2016) 0.93
Current Applications of Genetic Risk Scores to Cardiovascular Outcomes and Subclinical Phenotypes. Curr Epidemiol Rep (2015) 0.91
Genome-wide association study of gene by smoking interactions in coronary artery calcification. PLoS One (2013) 0.90
Mechanisms of ectopic calcification: implications for diabetic vasculopathy. Cardiovasc Diagn Ther (2015) 0.89
Genome-wide association studies of late-onset cardiovascular disease. J Mol Cell Cardiol (2015) 0.89
Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort). J Am Coll Cardiol (2013) 0.88
Apolipoprotein C3 genetic polymorphisms are associated with lipids and coronary artery disease in a Chinese population. Lipids Health Dis (2014) 0.87
HDL-3 is a superior predictor of carotid artery disease in a case-control cohort of 1725 participants. J Am Heart Assoc (2014) 0.87
Molecular genetics of coronary artery disease. J Hum Genet (2015) 0.87
Genetic Variant at the GLUL Locus Predicts All-Cause Mortality in Patients With Type 2 Diabetes. Diabetes (2015) 0.85
Integrative DNA, RNA, and protein evidence connects TREML4 to coronary artery calcification. Am J Hum Genet (2014) 0.85
Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction. PLoS One (2014) 0.85
Relationship between CYP17A1 genetic polymorphism and coronary artery disease in a Chinese Han population. Lipids Health Dis (2015) 0.83
Polygenic Risk Score Identifies Subgroup with Higher Burden of Atherosclerosis and Greater Relative Benefit from Statin Therapy in the Primary Prevention Setting. Circulation (2017) 0.82
Coronary artery calcium distributions in older persons in the AGES-Reykjavik study. Eur J Epidemiol (2012) 0.82
Towards a molecular systems model of coronary artery disease. Curr Cardiol Rep (2014) 0.82
TLR3 deficiency protects against collagen degradation and medial destruction in murine atherosclerotic plaques. Atherosclerosis (2013) 0.81
Association of COL4A1 genetic polymorphisms with coronary artery disease in Uygur population in Xinjiang, China. Lipids Health Dis (2013) 0.81
Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1. Atherosclerosis (2016) 0.80
The relationship between serum hypoxia-inducible factor 1α and coronary artery calcification in asymptomatic type 2 diabetic patients. Cardiovasc Diabetol (2014) 0.80
The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression. PLoS One (2015) 0.80
Common genetic variants and subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis (2015) 0.80
Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study. Atherosclerosis (2013) 0.80
The rs12526453 Polymorphism in an Intron of the PHACTR1 Gene and Its Association with 5-Year Mortality of Patients with Myocardial Infarction. PLoS One (2015) 0.80
Matrix gla protein gene polymorphism is associated with increased coronary artery calcification progression. Arterioscler Thromb Vasc Biol (2013) 0.79
From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease. Circ Res (2016) 0.79
Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis. Data Brief (2016) 0.78
The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts. Age (Dordr) (2013) 0.78
Admixture mapping of coronary artery calcification in African Americans from the NHLBI family heart study. BMC Genet (2015) 0.77
Proteomic Biomarkers Panel: New Insights in Chronic Kidney Disease. Dis Markers (2016) 0.76
Next frontiers in the genetic epidemiology of Alzheimer's disease. Eur J Epidemiol (2012) 0.76
The relationship between diastolic blood pressure and coronary artery calcification is dependent on single nucleotide polymorphisms on chromosome 9p21.3. BMC Med Genet (2014) 0.76
Analysis of rs6725887 in the WD Repeat Protein 12 in Association with Coronary Artery Disease in Iranian Patients. Int J Mol Cell Med (2015) 0.75
Chronic kidney disease: the "perfect storm" of cardiometabolic risk illuminates genetic diathesis in cardiovascular disease. J Am Coll Cardiol (2013) 0.75
Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circ Cardiovasc Genet (2016) 0.75
A robust distribution-free test for genetic association studies of quantitative traits. Stat Appl Genet Mol Biol (2015) 0.75
Correlation of single nucleotide polymorphisms in the pregnancy-associated plasma protein-A gene with carotid plaques. BMC Cardiovasc Disord (2015) 0.75
Genetic Research and Women's Heart Disease: a Primer. Curr Atheroscler Rep (2016) 0.75
PHACTR1 and SLC22A3 gene polymorphisms are associated with reduced coronary artery disease risk in the male Chinese Han population. Oncotarget (2016) 0.75
CDKN2B methylation is associated with carotid artery calcification in ischemic stroke patients. J Transl Med (2016) 0.75
The 9p21 locus is associated with coronary artery disease and cardiovascular events in the presence (but not in the absence) of coronary calcification. PLoS One (2014) 0.75
Genetic loci associated with ideal cardiovascular health: A meta-analysis of genome-wide association studies. Am Heart J (2016) 0.75
PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population. Int J Environ Res Public Health (2016) 0.75
The cis and trans effects of the risk variants of coronary artery disease in the Chr9p21 region. BMC Med Genomics (2015) 0.75
Whole Exome Sequencing to Identify Genetic Variants Associated with Raised Atherosclerotic Lesions in Young Persons. Sci Rep (2017) 0.75
A variant in the osteoprotegerin gene is associated with coronary atherosclerosis in patients with rheumatoid arthritis: results from a candidate gene study. Int J Mol Sci (2015) 0.75
Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men. Arterioscler Thromb Vasc Biol (2017) 0.75
Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The ARIC Study (Atherosclerosis Risk in Communities). Arterioscler Thromb Vasc Biol (2017) 0.75
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol (1990) 28.97
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation (2007) 22.81
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
An investigation of coronary heart disease in families. The Framingham offspring study. Am J Epidemiol (1979) 18.84
Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med (2008) 18.34
SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics (2008) 15.77
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination. Am J Epidemiol (2007) 9.90
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet (2009) 8.42
Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. Am J Epidemiol (2007) 7.06
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet (2008) 6.72
An approach to longitudinal studies in a community: the Framingham Study. Ann N Y Acad Sci (1963) 6.29
New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet (2009) 5.12
2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation (2010) 4.56
Vascular adhesion molecules in atherosclerosis. Arterioscler Thromb Vasc Biol (2007) 3.83
Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature (2010) 3.77
Role of COL4A1 in small-vessel disease and hemorrhagic stroke. N Engl J Med (2006) 3.58
The Rotterdam Study: 2010 objectives and design update. Eur J Epidemiol (2009) 3.44
Multi-center genetic study of hypertension: The Family Blood Pressure Program (FBPP). Hypertension (2002) 3.32
Coronary calcification improves cardiovascular risk prediction in the elderly. Circulation (2005) 3.28
Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly. Science (2005) 2.92
Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. N Engl J Med (2003) 2.87
INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis. PLoS One (2009) 2.77
Unrecognized myocardial infarction: epidemiology, clinical characteristics, and the prognostic role of angina pectoris. The Reykjavik Study. Ann Intern Med (1995) 2.14
COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. N Engl J Med (2007) 2.02
Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. Proc Natl Acad Sci U S A (2004) 1.86
Parental occurrence of premature cardiovascular disease predicts increased coronary artery and abdominal aortic calcification in the Framingham Offspring and Third Generation cohorts. Circulation (2007) 1.75
American College of Cardiology/American Heart Association Expert Consensus Document on electron-beam computed tomography for the diagnosis and prognosis of coronary artery disease. J Am Coll Cardiol (2000) 1.64
Heritability of coronary artery calcium quantity measured by electron beam computed tomography in asymptomatic adults. Circulation (2002) 1.46
Concordance of coronary artery calcium estimates between MDCT and electron beam tomography. AJR Am J Roentgenol (2005) 1.27
COL4A1 is associated with arterial stiffness by genome-wide association scan. Circ Cardiovasc Genet (2009) 1.16
Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have an impact on aneurysmal expansion. Eur J Hum Genet (2008) 1.09
Association of genetic variation on chromosome 9p21.3 and arterial stiffness. J Intern Med (2008) 1.08
Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes. Atherosclerosis (2008) 1.04
Comparison of coronary artery calcium scores between electron beam computed tomography and 64-multidetector computed tomographic scanner. J Comput Assist Tomogr (2009) 1.00
Genetic risk for myocardial infarction determined by polymorphisms of candidate genes in a Japanese population. J Med Genet (2007) 0.95
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res (2010) 97.51
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet (2011) 59.36
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
The structure of haplotype blocks in the human genome. Science (2002) 50.88
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Heart disease and stroke statistics--2012 update: a report from the American Heart Association. Circulation (2011) 31.98
Heart disease and stroke statistics--2013 update: a report from the American Heart Association. Circulation (2012) 30.79
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Heart disease and stroke statistics--2011 update: a report from the American Heart Association. Circulation (2010) 30.07
Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Heart disease and stroke statistics--2014 update: a report from the American Heart Association. Circulation (2013) 28.02
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49
General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation (2008) 26.42
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Efficiency and power in genetic association studies. Nat Genet (2005) 25.56
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med (2006) 23.83
Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA (2004) 23.69
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Detecting recent positive selection in the human genome from haplotype structure. Nature (2002) 22.00
Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat Med (2002) 21.28
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet (2008) 20.73
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71
Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet (2008) 19.55
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med (2014) 18.12
GenABEL: an R library for genome-wide association analysis. Bioinformatics (2007) 18.10
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89