Robert W Sauerwein

Author PubWeight™ 141.06‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry. Nature 2002 5.48
2 Hitting hotspots: spatial targeting of malaria for control and elimination. PLoS Med 2012 4.68
3 Submicroscopic Plasmodium falciparum gametocyte densities frequently result in mosquito infection. Am J Trop Med Hyg 2007 4.20
4 High efficiency transfection of Plasmodium berghei facilitates novel selection procedures. Mol Biochem Parasitol 2005 3.95
5 Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparum. J Infect Dis 2006 3.17
6 Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study. Lancet 2011 2.98
7 A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites. J Biol Chem 2003 2.84
8 Plasmodium falciparum gametocyte carriage in asymptomatic children in western Kenya. Malar J 2004 2.84
9 Submicroscopic Plasmodium falciparum gametocyte carriage is common in an area of low and seasonal transmission in Tanzania. Trop Med Int Health 2007 2.69
10 The epidemiology of Plasmodium falciparum gametocytes: weapons of mass dispersion. Trends Parasitol 2006 2.53
11 Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells. Proc Natl Acad Sci U S A 2005 2.49
12 Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A. PLoS One 2009 2.49
13 Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging. PLoS One 2009 2.18
14 In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals. Antimicrob Agents Chemother 2010 2.15
15 The human malaria parasite Pfs47 gene mediates evasion of the mosquito immune system. Science 2013 2.15
16 Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity. PLoS Pathog 2008 1.98
17 Three members of the 6-cys protein family of Plasmodium play a role in gamete fertility. PLoS Pathog 2010 1.72
18 Testing vaccines in human experimental malaria: statistical analysis of parasitemia measured by a quantitative real-time polymerase chain reaction. Am J Trop Med Hyg 2004 1.65
19 No hearing loss associated with the use of artemether-lumefantrine to treat experimental human malaria. Trans R Soc Trop Med Hyg 2006 1.64
20 Correctly folded Pfs48/45 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in mice. Proc Natl Acad Sci U S A 2008 1.64
21 Comparison of clinical and parasitological data from controlled human malaria infection trials. PLoS One 2012 1.64
22 Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infection. J Infect Dis 2009 1.63
23 Plasmodium falciparum infection causes proinflammatory priming of human TLR responses. J Immunol 2007 1.63
24 Controlled human malaria infections by intradermal injection of cryopreserved Plasmodium falciparum sporozoites. Am J Trop Med Hyg 2012 1.62
25 Malaria transmission after artemether-lumefantrine and dihydroartemisinin-piperaquine: a randomized trial. J Infect Dis 2013 1.61
26 Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity. Proc Natl Acad Sci U S A 2013 1.57
27 Efficacy of preerythrocytic and blood-stage malaria vaccines can be assessed in small sporozoite challenge trials in human volunteers. J Infect Dis 2012 1.54
28 Dynamic histone H3 epigenome marking during the intraerythrocytic cycle of Plasmodium falciparum. Proc Natl Acad Sci U S A 2009 1.54
29 Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence. J Infect Dis 2013 1.52
30 Longevity and composition of cellular immune responses following experimental Plasmodium falciparum malaria infection in humans. PLoS Pathog 2011 1.51
31 Interferon-γ--central mediator of protective immune responses against the pre-erythrocytic and blood stage of malaria. J Leukoc Biol 2010 1.51
32 Plasmodium falciparum dhfr but not dhps mutations associated with sulphadoxine-pyrimethamine treatment failure and gametocyte carriage in northern Ghana. Trop Med Int Health 2005 1.46
33 Thrombocytopenia and release of activated von Willebrand Factor during early Plasmodium falciparum malaria. J Infect Dis 2007 1.42
34 Pfs47, paralog of the male fertility factor Pfs48/45, is a female specific surface protein in Plasmodium falciparum. Mol Biochem Parasitol 2006 1.42
35 Increased Plasmodium falciparum gametocyte production in mixed infections with P. malariae. Am J Trop Med Hyg 2008 1.35
36 Age-dependent distribution of Plasmodium falciparum gametocytes quantified by Pfs25 real-time QT-NASBA in a cross-sectional study in Burkina Faso. Am J Trop Med Hyg 2007 1.34
37 Malaria transmission-blocking antigen, Pfs230, mediates human red blood cell binding to exflagellating male parasites and oocyst production. Mol Microbiol 2006 1.33
38 The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer. Parasitol Int 2009 1.32
39 A randomized, placebo-controlled, double-blind trial on sulfadoxine-pyrimethamine alone or combined with artesunate or amodiaquine in uncomplicated malaria. Trop Med Int Health 2005 1.31
40 HGF/MET signalling protects Plasmodium-infected host cells from apoptosis. Cell Microbiol 2005 1.28
41 Responses to malarial antigens are altered in helminth-infected children. J Infect Dis 2009 1.26
42 A consultation on the optimization of controlled human malaria infection by mosquito bite for evaluation of candidate malaria vaccines. Vaccine 2012 1.25
43 Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes. PLoS One 2008 1.25
44 Expression of human CD81 differently affects host cell susceptibility to malaria sporozoites depending on the Plasmodium species. Cell Microbiol 2006 1.25
45 Cholesterol contributes to the organization of tetraspanin-enriched microdomains and to CD81-dependent infection by malaria sporozoites. J Cell Sci 2006 1.23
46 Malaria in Wanokaka and Loli sub-districts, West Sumba District, East Nusa Tenggara Province, Indonesia. Am J Trop Med Hyg 2006 1.20
47 Scavenger receptor BI boosts hepatocyte permissiveness to Plasmodium infection. Cell Host Microbe 2008 1.20
48 A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stages. Blood 2012 1.19
49 Mild increases in serum hepcidin and interleukin-6 concentrations impair iron incorporation in haemoglobin during an experimental human malaria infection. Br J Haematol 2009 1.19
50 Glutamate-rich protein (GLURP) induces antibodies that inhibit in vitro growth of Plasmodium falciparum in a phase 1 malaria vaccine trial. Vaccine 2006 1.16
51 Inhibitory effect of TNF-α on malaria pre-erythrocytic stage development: influence of host hepatocyte/parasite combinations. PLoS One 2011 1.12
52 Early interferon-gamma response against Plasmodium falciparum correlates with interethnic differences in susceptibility to parasitemia between sympatric Fulani and Dogon in Mali. J Infect Dis 2010 1.12
53 Assessing the adequacy of attenuation of genetically modified malaria parasite vaccine candidates. Vaccine 2012 1.11
54 Memory-like IFN-γ response by NK cells following malaria infection reveals the crucial role of T cells in NK cell activation by P. falciparum. Eur J Immunol 2010 1.10
55 Rapid onset of transmission-reducing antibodies in javanese migrants exposed to malaria in papua, indonesia. Am J Trop Med Hyg 2006 1.09
56 Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteers. PLoS One 2011 1.08
57 New approach for high-throughput screening of drug activity on Plasmodium liver stages. Antimicrob Agents Chemother 2006 1.08
58 The relevance and applicability of oocyst prevalence as a read-out for mosquito feeding assays. Sci Rep 2013 1.07
59 How malaria modulates memory: activation and dysregulation of B cells in Plasmodium infection. Trends Parasitol 2013 1.07
60 Antibodies to plant-produced Plasmodium falciparum sexual stage protein Pfs25 exhibit transmission blocking activity. Hum Vaccin 2011 1.06
61 Cross-species immunity in malaria vaccine development: two, three, or even four for the price of one? Infect Immun 2007 1.05
62 Plasmodium liver load following parenteral sporozoite administration in rodents. Vaccine 2012 1.04
63 Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy. Br J Haematol 2010 1.04
64 Long term protection after immunization with P. berghei sporozoites correlates with sustained IFNγ responses of hepatic CD8+ memory T cells. PLoS One 2012 1.04
65 Two Plasmodium 6-Cys family-related proteins have distinct and critical roles in liver-stage development. FASEB J 2014 1.04
66 NF135.C10: a new Plasmodium falciparum clone for controlled human malaria infections. J Infect Dis 2012 1.04
67 Seasonal patterns of Plasmodium falciparum gametocyte prevalence and density in a rural population of Burkina Faso. Acta Trop 2007 1.02
68 A plant-produced Pfs230 vaccine candidate blocks transmission of Plasmodium falciparum. Clin Vaccine Immunol 2011 1.01
69 Liver or blood-stage arrest during malaria sporozoite immunization: the later the better? Trends Parasitol 2013 1.00
70 Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of Anopheles mosquitoes. Eukaryot Cell 2013 0.98
71 Transmission of Plasmodium falciparum in urban Yaoundé, Cameroon, is seasonal and age-dependent. Trans R Soc Trop Med Hyg 2004 0.98
72 A plant-produced Pfs25 VLP malaria vaccine candidate induces persistent transmission blocking antibodies against Plasmodium falciparum in immunized mice. PLoS One 2013 0.97
73 Prevalence and severity of malnutrition in pre-school children in a rural area of western Kenya. Am J Trop Med Hyg 2003 0.96
74 Malaria infected mosquitoes express enhanced attraction to human odor. PLoS One 2013 0.94
75 Structure-activity-based design of a synthetic malaria peptide eliciting sporozoite inhibitory antibodies in a virosomal formulation. Chem Biol 2007 0.94
76 Submicroscopic gametocytes and the transmission of antifolate-resistant Plasmodium falciparum in Western Kenya. PLoS One 2009 0.92
77 BAFF and BAFF receptor levels correlate with B cell subset activation and redistribution in controlled human malaria infection. J Immunol 2014 0.92
78 Serious psychiatric symptoms after chloroquine treatment following experimental malaria infection. Ann Pharmacother 2005 0.91
79 Complement activation in experimental human malaria infection. Trans R Soc Trop Med Hyg 2007 0.91
80 Removal of heterologous sequences from Plasmodium falciparum mutants using FLPe-recombinase. PLoS One 2010 0.90
81 Reduction and enhancement of Plasmodium falciparum transmission by endemic human sera. Int J Parasitol 2006 0.90
82 A virosomal malaria peptide vaccine elicits a long-lasting sporozoite-inhibitory antibody response in a phase 1a clinical trial. PLoS One 2007 0.89
83 Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana. Malar J 2005 0.88
84 Efficacy of artemisinin-based combination therapy for treatment of persons with uncomplicated Plasmodium falciparum malaria in West Sumba District, East Nusa Tenggara Province, Indonesia, and genotypic profiles of the parasite. Am J Trop Med Hyg 2009 0.88
85 Bacterium-like particles as multi-epitope delivery platform for Plasmodium berghei circumsporozoite protein induce complete protection against malaria in mice. Malar J 2012 0.88
86 Identification of a major rif transcript common to gametocytes and sporozoites of Plasmodium falciparum. Malar J 2010 0.88
87 Seasonal distribution of anti-malarial drug resistance alleles on the island of Sumba, Indonesia. Malar J 2009 0.86
88 A novel plant-produced Pfs25 fusion subunit vaccine induces long-lasting transmission blocking antibody responses. Hum Vaccin Immunother 2014 0.86
89 Short report: Severe Plasmodium falciparum malaria in Cameroon: associated with the glutathione S-transferase M1 null genotype. Am J Trop Med Hyg 2006 0.86
90 Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver. J Immune Based Ther Vaccines 2011 0.79
91 Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity. Malar J 2014 0.79
92 Common genotypic polymorphisms in glutathione S-transferases in mild and severe falciparum malaria in Tanzanian children. Am J Trop Med Hyg 2009 0.78
93 The dog that did not bark: malaria vaccines without antibodies. Trends Parasitol 2007 0.78
94 Enhancement of naturally acquired immunity against malaria by drug use. J Med Microbiol 2012 0.78
95 Persistence of full-length caspase-12 and its relation to malaria in West and Central African populations. Eur Cytokine Netw 2010 0.78
96 Plasmodium berghei Δp52&p36 parasites develop independent of a parasitophorous vacuole membrane in Huh-7 liver cells. PLoS One 2012 0.78
97 Controlled human malaria infection trials: How tandems of trust and control construct scientific knowledge. Soc Stud Sci 2016 0.77
98 Influenza virosomes: a flu jab for malaria? Trends Parasitol 2008 0.77
99 Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature 2016 0.77
100 [On the way to eradicating malaria]. Ned Tijdschr Geneeskd 2012 0.75
101 Editorial: Malaria investments and activities: it is now! or never? Trop Med Int Health 2002 0.75
102 [Neuroschistosomiasis; an unexpected finding in a Dutch woman]. Ned Tijdschr Geneeskd 2009 0.75