Published in J Biol Chem on June 25, 1979
Purification to homogeneity and enzymological characterization of a functional covalent complex composed of cytochromes P-450 isozyme 2 and b5 from rabbit liver. Proc Natl Acad Sci U S A (1987) 0.85
The opposite effect of bivalent cations on cytochrome b5 reduction by NADH:cytochrome b5 reductase and NADPH:cytochrome c reductase. Biochem J (1988) 0.83
The inhibitory effect of halides and carboxylates on hepatic NADH: cytochrome b5 oxidoreductase. Biochem J (1985) 0.80
The Crystal Structure of an Integral Membrane Fatty Acid α-Hydroxylase. J Biol Chem (2015) 0.78
Camphor hydroxylase of Pseudomonas putida: vestiges of sequence homology in cytochrome P-450CAM, putidaredoxin, and related proteins. Proc Natl Acad Sci U S A (1984) 0.75
Reduction of iron and synthesis of protoheme by Spirillum itersonii and other organisms. J Bacteriol (1977) 3.39
A form of cytochrome b5 that contains an additional hydrophobic sequence of 40 amino acid residues. Proc Natl Acad Sci U S A (1971) 3.28
Purification and properties of rat liver microsomal stearyl coenzyme A desaturase. Proc Natl Acad Sci U S A (1974) 3.18
Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33. Nature (1995) 2.78
Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid. J Biol Chem (1976) 2.77
Identification of the NH2-terminal blocking group of NADH-cytochrome b5 reductase as myristic acid and the complete amino acid sequence of the membrane-binding domain. J Biol Chem (1984) 2.14
Construction and sequence of cDNA for rat liver stearyl coenzyme A desaturase. J Biol Chem (1986) 2.11
The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis. Nat Struct Biol (2001) 1.96
A form of reduced nicotinamide adenine dinucleotide-cytochrome b 5 reductase containing both the catalytic site and an additional hydrophobic membrane-binding segment. J Biol Chem (1973) 1.84
A R59W mutation in human protoporphyrinogen oxidase results in decreased enzyme activity and is prevalent in South Africans with variegate porphyria. Nat Genet (1996) 1.78
Bovine ferrochelatase. Kinetic analysis of inhibition by N-methylprotoporphyrin, manganese, and heme. J Biol Chem (1983) 1.78
The binding of cytochrome b 5 to liver microsomes. J Biol Chem (1972) 1.71
Organization of the terminal two enzymes of the heme biosynthetic pathway. Orientation of protoporphyrinogen oxidase and evidence for a membrane complex. J Biol Chem (1988) 1.61
Cytochrome b5 reduction by NADPH-cytochrome P-450 reductase. J Biol Chem (1979) 1.52
Formation and properties of 1000-A-diameter, single-bilayer phospholipid vesicles. Proc Natl Acad Sci U S A (1979) 1.52
Lipid-protein interactions in the reconstitution of the microsomal reduced nicotinamide adenine dinucleotide-cytochrome b 5 reductase system. J Biol Chem (1973) 1.49
Apparent dependence of interactions between cytochrome b5 and cytochrome b5 reductase upon translational diffusion in dimyristoyl lecithin liposomes. Proc Natl Acad Sci U S A (1975) 1.46
The binding of cytochrome b5 to phospholipid vesicles and biological membranes. Effect of orientation on intermembrane transfer and digestion by carboxypeptidase Y. J Biol Chem (1979) 1.36
Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription. Protein Sci (2001) 1.33
Orientation of ferrochelatase in bovine liver mitochondria. Biochemistry (1985) 1.32
Purification of cytochrome b5. Methods Enzymol (1978) 1.32
Intramembrane position of the fluorescent tryptophanyl residue in membrane-bound cytochrome b5. Biochemistry (1979) 1.32
The induction and characterization of rat liver stearyl-CoA desaturase mRNA. J Biol Chem (1985) 1.31
Differential interaction of porphyrins used in photoradiation therapy with ferrochelatase. Biochem J (1984) 1.30
Purification and characterization of murine protoporphyrinogen oxidase. Biochemistry (1987) 1.21
The restricted tryptic cleavage of cytochrome b5. J Biol Chem (1966) 1.20
Mouse protoporphyrinogen oxidase. Kinetic parameters and demonstration of inhibition by bilirubin. Biochem J (1988) 1.16
Intramembrane positions of membrane-bound chromophores determined by excitation energy transfer. Biochemistry (1979) 1.16
Human ferrochelatase: characterization of substrate-iron binding and proton-abstracting residues. Biochemistry (2001) 1.16
Orientation of the carboxyl and NH2 termini of the membrane-binding segment of cytochrome b5 on the same side of phospholipid bilayers. J Biol Chem (1981) 1.15
Expression of a cloned protoporphyrinogen oxidase. J Biol Chem (1994) 1.14
Expression of mammalian 5-aminolevulinate synthase in Escherichia coli. Overproduction, purification, and characterization. J Biol Chem (1993) 1.14
Human protoporphyrinogen oxidase: expression, purification, and characterization of the cloned enzyme. Protein Sci (1996) 1.13
Purification and characterization of the membrane-bound ferrochelatase from Spirillum itersonii. J Bacteriol (1977) 1.12
Site-directed mutagenesis and spectroscopic characterization of human ferrochelatase: identification of residues coordinating the [2Fe-2S] cluster. Biochemistry (1996) 1.10
Aerobic ferrisiderophore reductase assay and activity stain for native polyacrylamide gels. Anal Biochem (1983) 1.10
Purification and characterization of membrane-bound ferrochelatase from Rhodopseudomonas sphaeroides. J Biol Chem (1982) 1.09
Purification and characterization of mammalian and chicken ferrochelatase. Methods Enzymol (1986) 1.08
Function of the [2FE-2S] cluster in mammalian ferrochelatase: a possible role as a nitric oxide sensor. Biochemistry (1996) 1.08
Ferric iron reductase of Rhodopseudomonas sphaeroides. J Bacteriol (1985) 1.07
Ferrochelatase activity in wild-type and mutant strains of Spirillum itersonii. Solubilization with chaotropic reagents. Arch Biochem Biophys (1974) 1.07
In situ conversion of coproporphyrinogen to heme by murine mitochondria: terminal steps of the heme biosynthetic pathway. Protein Sci (1993) 1.06
Complete amino acid sequence of steer liver microsomal NADH-cytochrome b5 reductase. J Biol Chem (1985) 1.06
Identification of an FAD superfamily containing protoporphyrinogen oxidases, monoamine oxidases, and phytoene desaturase. Expression and characterization of phytoene desaturase of Myxococcus xanthus. J Biol Chem (1998) 1.05
A molecular defect in human protoporphyria. Am J Hum Genet (1992) 1.04
Evidence for randon distribution and translational movement of cytochrome b5 in endoplasmic reticulum. J Biol Chem (1974) 1.04
Heme biosynthesis in mammalian systems: evidence of a Schiff base linkage between the pyridoxal 5'-phosphate cofactor and a lysine residue in 5-aminolevulinate synthase. Protein Sci (1993) 1.04
Structural and functional properties of the membrane binding segment of cytochrome b5. J Biol Chem (1978) 1.04
Evidence that the fourth ligand to the [2Fe-2S] cluster in animal ferrochelatase is a cysteine. Characterization of the enzyme from Drosophila melanogaster. J Biol Chem (1998) 1.03
Siderophore utilization and iron uptake by Rhodopseudomonas sphaeroides. Arch Biochem Biophys (1984) 1.03
Multiple mechanisms for the regulation of haem synthesis during erythroid cell differentiation. Possible role for coproporphyrinogen oxidase. Biochem J (1991) 1.02
Regulation of heme biosynthesis in Escherichia coli. Arch Biochem Biophys (1995) 1.02
Purification and characterization of bacterial ferrochelatase. Methods Enzymol (1986) 1.01
Characterization of the interaction of amphipathic cytochrome b5 with stearyl coenzyme A desaturase and NADPH:cytochrome P-450 reductase. J Biol Chem (1980) 1.00
Proton magnetic resonance determination of the relative heme orientations in disordered native and reconstituted ferricytochrome b5. Assignment of heme resonances by deuterium labeling. J Biol Chem (1981) 1.00
The synthesis of murine ferrochelatase in vitro and in vivo. Biochem J (1988) 1.00
Membrane-bound respiratory of Spirillum itersonii. J Bacteriol (1976) 1.00
Human ferrochelatase: crystallization, characterization of the [2Fe-2S] cluster and determination that the enzyme is a homodimer. Biochim Biophys Acta (1999) 1.00
Cytochrome b5 and cytochrome b5 reductase-phospholipid vesicles. Intervesicle protein transfer and oreintation factors in protein-protein interactions. J Biol Chem (1977) 0.98
Role of tyrosyl and arginyl residues in rat liver microsomal stearylcoenzyme A desaturase. Biochemistry (1978) 0.97
Direct measurement of metal ion chelation in the active site of human ferrochelatase. Biochemistry (2007) 0.97
Purification of and kinetic studies on a cloned protoporphyrinogen oxidase from the aerobic bacterium Bacillus subtilis. Arch Biochem Biophys (1998) 0.95
Purification of stearyl-CoA desaturase from liver. Methods Enzymol (1978) 0.94
The interaction of NADH-cytochrome b5 reductase and cytochrome b5 bound to egg lecithin liposomes. J Biol Chem (1975) 0.93
Examination of the activity of carboxyl-terminal chimeric constructs of human and yeast ferrochelatases. Biochemistry (2000) 0.93
Protein and coenzyme interactions in the NADH-cytochrome b5 reductase system. Fed Proc (1966) 0.93
Correction of the amino acid sequence of calf liver microsomal cytochrome b5. J Biol Chem (1969) 0.92
Biphasic ordered induction of heme synthesis in differentiating murine erythroleukemia cells: role of erythroid 5-aminolevulinate synthase. Mol Cell Biol (1993) 0.91
Cloning, sequence, and expression of mouse protoporphyrinogen oxidase. Arch Biochem Biophys (1995) 0.91
Iron transport and its relation to heme biosynthesis in Rhodopseudomonas sphaeroides. J Bacteriol (1985) 0.91
The characterization and interconversions of two conformational states of cytochrome b5 reductase. J Biol Chem (1971) 0.91
Autosomal recessive erythropoietic protoporphyria in the United Kingdom: prevalence and relationship to liver disease. J Med Genet (2004) 0.91
Spectroscopic examination of the active site of bovine ferrochelatase. Biochemistry (1985) 0.90
Topography of the C terminus of cytochrome b5 tightly bound to dimyristoylphosphatidylcholine vesicles. J Biol Chem (1987) 0.90
Effect of sulfhydryl group modification on the activity of bovine ferrochelatase. J Biol Chem (1984) 0.90
The primary structure of the nonpolar segment of bovine cytochrome b5. J Biol Chem (1978) 0.90
Molecular characterization of homozygous variegate porphyria. Hum Mol Genet (1998) 0.89
Effect of cellular location on the function of ferrochelatase. J Biol Chem (1995) 0.89
Purification and characterization of chicken erythrocyte ferrochelatase. Biochem J (1984) 0.88
The binding of reduced nicotinamide adenine dinucleotide-cytochrome b5 reductase to hepatic microsomes. J Biol Chem (1974) 0.88
Expression and characterization of the terminal heme synthetic enzymes from the hyperthermophile Aquifex aeolicus. FEMS Microbiol Lett (2001) 0.88
Identification of the essential cysteine residue of NADH-cytochrome b5 reductase. J Biol Chem (1986) 0.87
The effect of heme binding on the tryptophan residue and the protein conformation of cytochrome b 5 . J Biol Chem (1972) 0.87
Cloning and characterization of Gallus and Xenopus ferrochelatases: presence of the [2Fe-2S] cluster in nonmammalian ferrochelatase. Arch Biochem Biophys (1998) 0.86
The heme-binding properties of prostaglandin synthetase from sheep vesicular gland. J Biol Chem (1981) 0.86
The reactivity of the lysyl residues of cytochrome b5. J Biol Chem (1966) 0.86
Tryptic conversion of cytochrome b 5 reductase to an active derivative containing two peptide chains. J Biol Chem (1972) 0.85
Ferrochelatase from Rhodopseudomonas sphaeroides: substrate specificity and role of sulfhydryl and arginyl residues. J Bacteriol (1986) 0.85
Reconstitution of the two terminal enzymes of the heme biosynthetic pathway into phospholipid vesicles. J Biol Chem (1987) 0.85
The amino acid sequence of the truptic peptides from cytochrome b5. J Biol Chem (1968) 0.84
The role of lysyl residues in the structure and reactivity of cytochrome B5 reductase. J Biol Chem (1968) 0.84
The amino acid sequence of cytochrome b-5. J Biol Chem (1968) 0.84
Covalent cross-linking of the active sites of vesicle-bound cytochrome b5 and NADH-cytochrome b5 reductase. J Biol Chem (1984) 0.84
The homology between cytochrome B-5, hemoglobin, and myoglobin. Proc Natl Acad Sci U S A (1967) 0.84
Erythroid 5-aminolevulinate synthase is required for erythroid differentiation in mouse embryonic stem cells. Blood Cells Mol Dis (1998) 0.83
Yeast ferrochelatase: expression in a baculovirus system and purification of the expression protein. Protein Sci (1992) 0.83