Published in J Med Chem on January 06, 2012
Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase. Bioorg Med Chem (2013) 0.78
Discovery of SCH 900188: A Potent Hepatitis C Virus NS5B Polymerase Inhibitor Prodrug As a Development Candidate. ACS Med Chem Lett (2013) 0.75
Bioconductor: open software development for computational biology and bioinformatics. Genome Biol (2004) 143.19
Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics (2006) 22.61
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature (2005) 15.28
Gene regulation and DNA damage in the ageing human brain. Nature (2004) 9.01
An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays. Cancer Res (2004) 8.86
Highly parallel identification of essential genes in cancer cells. Proc Natl Acad Sci U S A (2008) 7.45
Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis. Cancer Res (2005) 6.93
dChipSNP: significance curve and clustering of SNP-array-based loss-of-heterozygosity data. Bioinformatics (2004) 6.78
Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays. PLoS Comput Biol (2006) 3.39
Genome coverage and sequence fidelity of phi29 polymerase-based multiple strand displacement whole genome amplification. Nucleic Acids Res (2004) 3.37
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Prognostic significance of copy-number alterations in multiple myeloma. J Clin Oncol (2009) 3.21
A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. PLoS Genet (2005) 2.85
Allele-specific amplification in cancer revealed by SNP array analysis. PLoS Comput Biol (2005) 2.84
Pharmaceutical supply chain in China: current issues and implications for health system reform. Health Policy (2010) 2.63
Integration of global SNP-based mapping and expression arrays reveals key regions, mechanisms, and genes important in the pathogenesis of multiple myeloma. Blood (2006) 2.43
Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse. Genome Res (2006) 2.26
Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis. Blood (2003) 2.23
Evolution of the aging brain transcriptome and synaptic regulation. PLoS One (2008) 2.23
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A (2010) 2.10
Loss of heterozygosity and its correlation with expression profiles in subclasses of invasive breast cancers. Cancer Res (2004) 2.05
Genome-wide loss of heterozygosity analysis from laser capture microdissected prostate cancer using single nucleotide polymorphic allele (SNP) arrays and a novel bioinformatics platform dChipSNP. Cancer Res (2003) 1.99
Two-round coamplification at lower denaturation temperature-PCR (COLD-PCR)-based sanger sequencing identifies a novel spectrum of low-level mutations in lung adenocarcinoma. Hum Mutat (2009) 1.97
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells. Cancer Res (2005) 1.94
Comparative analysis of gene sets in the Gene Ontology space under the multiple hypothesis testing framework. Proc IEEE Comput Syst Bioinform Conf (2004) 1.85
The tissue diagnostic instrument. Rev Sci Instrum (2009) 1.82
Molecular diversity of astrocytes with implications for neurological disorders. Proc Natl Acad Sci U S A (2004) 1.76
Dysfunctional homologous recombination mediates genomic instability and progression in myeloma. Blood (2008) 1.76
Genome-wide analysis of neuroblastomas using high-density single nucleotide polymorphism arrays. PLoS One (2007) 1.72
Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nat Biotechnol (2010) 1.71
High-resolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines. Oncogene (2004) 1.69
Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression. J Clin Invest (2011) 1.66
High-affinity peptide against MT1-MMP for in vivo tumor imaging. J Control Release (2011) 1.59
Identification of genes modulated in multiple myeloma using genetically identical twin samples. Blood (2003) 1.56
Characterization of resistance mutations against HCV ketoamide protease inhibitors. Antiviral Res (2007) 1.55
Global gene expression profiling in whole-blood samples from individuals exposed to metal fumes. Environ Health Perspect (2005) 1.54
Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations. J Biol Chem (2005) 1.54
Acquired genomic copy number aberrations and survival in chronic lymphocytic leukemia. Blood (2011) 1.44
Detect and adjust for population stratification in population-based association study using genomic control markers: an application of Affymetrix Genechip Human Mapping 10K array. Eur J Hum Genet (2004) 1.42
Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo. Cell Stress Chaperones (2005) 1.41
A review of HCV protease inhibitors. Curr Opin Investig Drugs (2009) 1.39
MicroRNA-133a, downregulated in osteosarcoma, suppresses proliferation and promotes apoptosis by targeting Bcl-xL and Mcl-1. Bone (2013) 1.36
Converting biomechanical energy into electricity by a muscle-movement-driven nanogenerator. Nano Lett (2009) 1.35
In vitro and in vivo activity of the maytansinoid immunoconjugate huN901-N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine against CD56+ multiple myeloma cells. Cancer Res (2004) 1.31
BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. Mol Cell Biol (2006) 1.29
A plasma biomarker signature of immune activation in HIV patients on antiretroviral therapy. PLoS One (2012) 1.27
SNP array analysis in hematologic malignancies: avoiding false discoveries. Blood (2010) 1.26
Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase. J Med Chem (2007) 1.25
Rescue of mesangial cells from high glucose-induced over-proliferation and extracellular matrix secretion by hydrogen sulfide. Nephrol Dial Transplant (2011) 1.24
Direct magnetic resonance detection of myelin and prospects for quantitative imaging of myelin density. Proc Natl Acad Sci U S A (2012) 1.24
Acquired genomic copy number aberrations and survival in adult acute myelogenous leukemia. Blood (2010) 1.23
Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma. Clin Cancer Res (2004) 1.21
Quantifying cortical bone water in vivo by three-dimensional ultra-short echo-time MRI. NMR Biomed (2011) 1.21
A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo. J Pharmacol Exp Ther (2005) 1.20
Niche conservatism above the species level. Proc Natl Acad Sci U S A (2009) 1.19
Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging. J Exp Med (2006) 1.16
In vivo venous blood T1 measurement using inversion recovery true-FISP in children and adults. Magn Reson Med (2010) 1.15
Clonal evolution, genomic drivers, and effects of therapy in chronic lymphocytic leukemia. Clin Cancer Res (2013) 1.15
Clonal evolution and devolution after chemotherapy in adult acute myelogenous leukemia. Blood (2012) 1.15
Challenges in modern drug discovery: a case study of boceprevir, an HCV protease inhibitor for the treatment of hepatitis C virus infection. Acc Chem Res (2008) 1.14
Comparative linkage analysis and visualization of high-density oligonucleotide SNP array data. BMC Genet (2005) 1.14
Estimation of genotype error rate using samples with pedigree information--an application on the GeneChip Mapping 10K array. Genomics (2004) 1.12
Blocking ion channel KCNN4 alleviates the symptoms of experimental autoimmune encephalomyelitis in mice. Eur J Immunol (2005) 1.10
Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors. Bioorg Med Chem Lett (2007) 1.10
Growth arrest, apoptosis, and telomere shortening of Barrett's-associated adenocarcinoma cells by a telomerase inhibitor. Gastroenterology (2004) 1.10
Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductase. J Biol Chem (2009) 1.08
Clinical resistance to vicriviroc through adaptive V3 loop mutations in HIV-1 subtype D gp120 that alter interactions with the N-terminus and ECL2 of CCR5. Virology (2010) 1.08
Lessons from a decade of integrating cancer copy number alterations with gene expression profiles. Brief Bioinform (2011) 1.08
NF1 inactivation in adult acute myelogenous leukemia. Clin Cancer Res (2010) 1.08
Significant biological role of sp1 transactivation in multiple myeloma. Clin Cancer Res (2011) 1.07
Integrative analysis of gene and miRNA expression profiles with transcription factor-miRNA feed-forward loops identifies regulators in human cancers. Nucleic Acids Res (2012) 1.07
Observation of a charged charmoniumlike structure in e+ e- → π+ π- J/ψ at sqrt[s] = 4.26 GeV. Phys Rev Lett (2013) 1.05
The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment. Cancer Res (2002) 1.04
Identification of small molecule compounds that selectively inhibit varicella-zoster virus replication. J Virol (2003) 1.03
Combined measurement of perfusion, venous oxygen saturation, and skeletal muscle T2* during reactive hyperemia in the leg. J Cardiovasc Magn Reson (2013) 1.02
Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors. J Med Chem (2004) 1.01
Novel pheochromocytoma susceptibility loci identified by integrative genomics. Cancer Res (2005) 1.01
Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays. Blood (2002) 1.01
Temporal genetic program following B-cell receptor cross-linking: altered balance between proliferation and death in healthy and malignant B cells. Blood (2007) 1.01
Kalman/Map filtering-aided fast normalized cross correlation-based Wi-Fi fingerprinting location sensing. Sensors (Basel) (2013) 1.01
Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies. PLoS One (2013) 1.00
Phenotypic and functional effects of heat shock protein 90 inhibition on dendritic cell. J Immunol (2007) 1.00
Bone mineral (31)P and matrix-bound water densities measured by solid-state (31)P and (1)H MRI. NMR Biomed (2014) 0.99
Comparison of primary neuroblastoma tumors and derivative early-passage cell lines using genome-wide single nucleotide polymorphism array analysis. Cancer Res (2009) 0.99
The prognostic significance of various 13q14 deletions in chronic lymphocytic leukemia. Clin Cancer Res (2011) 0.99
Screening for antiviral inhibitors of the HIV integrase-LEDGF/p75 interaction using the AlphaScreen luminescent proximity assay. J Biomol Screen (2008) 0.99
UV-B-induced oxidative damage and protective role of exopolysaccharides in desert cyanobacterium Microcoleus vaginatus. J Integr Plant Biol (2009) 0.99
Abnormal epithelial differentiation and tear film alteration in pinguecula. Invest Ophthalmol Vis Sci (2009) 0.98
RFI-641, a potent respiratory syncytial virus inhibitor. Antimicrob Agents Chemother (2002) 0.97
A global expression-based analysis of the consequences of the t(4;14) translocation in myeloma. Clin Cancer Res (2004) 0.97