Published in Genome Res on February 03, 2006
A high-resolution single nucleotide polymorphism genetic map of the mouse genome. PLoS Biol (2006) 4.57
A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res (2010) 3.81
THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Nat Genet (2008) 3.19
A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome. Nat Genet (2013) 2.59
Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. Proc Natl Acad Sci U S A (2009) 1.95
Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. N Engl J Med (2010) 1.81
Fine mapping in 94 inbred mouse strains using a high-density haplotype resource. Genetics (2010) 1.71
Enhancing genetic mapping of complex genomes through the design of highly-multiplexed SNP arrays: application to the large and unsequenced genomes of white spruce and black spruce. BMC Genomics (2008) 1.57
The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. J Cell Biol (2012) 1.54
Mutation mapping and identification by whole-genome sequencing. Genome Res (2012) 1.51
Identification of a Van der Woude syndrome mutation in the cleft palate 1 mutant mouse. Genesis (2010) 1.48
Genetic variation and population substructure in outbred CD-1 mice: implications for genome-wide association studies. PLoS One (2009) 1.27
Primary ciliary dyskinesia in mice lacking the novel ciliary protein Pcdp1. Mol Cell Biol (2007) 1.26
Four additional mouse crosses improve the lipid QTL landscape and identify Lipg as a QTL gene. J Lipid Res (2009) 1.16
A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus. Hum Mol Genet (2011) 1.13
Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator. J Neurosci (2012) 1.01
Conserved role of unc-79 in ethanol responses in lightweight mutant mice. PLoS Genet (2010) 1.00
A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype. Neural Dev (2011) 0.97
Confirmation of an epilepsy modifier locus on mouse chromosome 11 and candidate gene analysis by RNA-Seq. Genes Brain Behav (2012) 0.96
Interleukin 22 is a candidate gene for Tmevp3, a locus controlling Theiler's virus-induced neurological diseases. Genetics (2007) 0.95
Detection of dental fluorosis-associated quantitative trait Loci on mouse chromosomes 2 and 11. Cells Tissues Organs (2008) 0.94
Genome-wide identification of mouse congenital heart disease loci. Hum Mol Genet (2010) 0.94
SNP2RFLP: a computational tool to facilitate genetic mapping using benchtop analysis of SNPs. Mamm Genome (2008) 0.93
A novel loss-of-function mutation in Npr2 clarifies primary role in female reproduction and reveals a potential therapy for acromesomelic dysplasia, Maroteaux type. Hum Mol Genet (2012) 0.92
Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system. PLoS One (2012) 0.92
174delG mutation in mouse MFRP causes photoreceptor degeneration and RPE atrophy. Invest Ophthalmol Vis Sci (2011) 0.91
The superhealing MRL background improves muscular dystrophy. Skelet Muscle (2012) 0.90
TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues. Development (2011) 0.90
A forward genetic screen in mice identifies mutants with abnormal cortical patterning. Cereb Cortex (2013) 0.88
Multiplex Chromosomal Exome Sequencing Accelerates Identification of ENU-Induced Mutations in the Mouse. G3 (Bethesda) (2012) 0.88
Forward genetics defines Xylt1 as a key, conserved regulator of early chondrocyte maturation and skeletal length. Dev Biol (2013) 0.85
Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis. J Neurosci (2009) 0.85
Mouse forward genetics in the study of the peripheral nervous system and human peripheral neuropathy. Neurochem Res (2008) 0.85
Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo. PLoS Genet (2011) 0.84
Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling. PLoS Genet (2014) 0.84
Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway. Proc Natl Acad Sci U S A (2010) 0.83
A mutation in Tubb2b, a human polymicrogyria gene, leads to lethality and abnormal cortical development in the mouse. Hum Mol Genet (2013) 0.82
An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15. Mamm Genome (2009) 0.82
ENU mutagenesis in mice identifies candidate genes for hypogonadism. Mamm Genome (2012) 0.82
Male hypogonadism and germ cell loss caused by a mutation in Polo-like kinase 4. Endocrinology (2011) 0.82
Chemical mutagenesis: a new strategy against the global threat of infectious diseases. Mamm Genome (2008) 0.81
Description and genetic mapping of Polypodia: an X-linked dominant mouse mutant with ectopic caudal limbs and other malformations. Mamm Genome (2006) 0.81
A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism. Mamm Genome (2010) 0.80
De novo exon duplication in a new allele of mouse Glra1 (spasmodic). Genetics (2006) 0.79
Polymorphisms in toll-like receptor 4 underlie susceptibility to tumor induction by the mouse polyomavirus. J Virol (2012) 0.79
Genetic interactions between chromosomes 11 and 18 contribute to airway hyperresponsiveness in mice. PLoS One (2012) 0.78
Binary trait mapping in experimental crosses with selective genotyping. Genetics (2009) 0.78
Variant mapping and mutation discovery in inbred mice using next-generation sequencing. BMC Genomics (2015) 0.78
ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling. Cell Rep (2014) 0.77
A spontaneous Fatp4/Scl27a4 splice site mutation in a new murine model for congenital ichthyosis. PLoS One (2012) 0.77
ENU Mutagenesis in the Mouse. Curr Protoc Hum Genet (2014) 0.77
The infectious BAC genomic DNA expression library: a high capacity vector system for functional genomics. Sci Rep (2016) 0.75
Grhl2 is required in nonneural tissues for neural progenitor survival and forebrain development. Genesis (2015) 0.75
Angiogenesis QTL on Mouse Chromosome 8 Colocalizes with Differential β-Defensin Expression. J Biomol Tech (2015) 0.75
The Spontaneous Ataxic Mouse Mutant Tippy is Characterized by a Novel Purkinje Cell Morphogenesis and Degeneration Phenotype. Cerebellum (2015) 0.75
MGD: the Mouse Genome Database. Nucleic Acids Res (2003) 10.14
Role of insulin-like growth factors in embryonic and postnatal growth. Cell (1993) 8.22
dChipSNP: significance curve and clustering of SNP-array-based loss-of-heterozygosity data. Bioinformatics (2004) 6.78
The mosaic structure of variation in the laboratory mouse genome. Nature (2002) 6.54
In silico mapping of complex disease-related traits in mice. Science (2001) 4.67
Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nat Genet (2000) 4.66
A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nat Genet (1994) 4.20
Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS Biol (2004) 4.08
An efficient SNP system for mouse genome scanning and elucidating strain relationships. Genome Res (2004) 3.96
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proc Natl Acad Sci U S A (2003) 3.93
Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nat Genet (2002) 2.30
In silico genetics: identification of a functional element regulating H2-Ealpha gene expression. Science (2004) 2.17
Segmental phylogenetic relationships of inbred mouse strains revealed by fine-scale analysis of sequence variation across 4.6 mb of mouse genome. Genome Res (2004) 1.93
Structure and expression of the hairless gene of mice. Proc Natl Acad Sci U S A (1994) 1.85
Efficient localization of mutations by interval haplotype analysis. Mamm Genome (1998) 1.14
Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease. Hum Mol Genet (2005) 1.13
Bioconductor: open software development for computational biology and bioinformatics. Genome Biol (2004) 143.19
A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81
Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A (2002) 25.47
Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics (2006) 22.61
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature (2005) 15.28
Integrated genomic characterization of endometrial carcinoma. Nature (2013) 14.29
Coordinated transcription of key pathways in the mouse by the circadian clock. Cell (2002) 14.07
PRDM16 controls a brown fat/skeletal muscle switch. Nature (2008) 13.08
Obesity and metabolic syndrome in circadian Clock mutant mice. Science (2005) 12.66
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci U S A (2004) 12.43
The somatic genomic landscape of glioblastoma. Cell (2013) 11.73
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science (2010) 9.61
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Gene regulation and DNA damage in the ageing human brain. Nature (2004) 9.01
An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays. Cancer Res (2004) 8.86
LKB1 modulates lung cancer differentiation and metastasis. Nature (2007) 7.80
Molecular components of the mammalian circadian clock. Hum Mol Genet (2006) 7.51
Mammalian circadian biology: elucidating genome-wide levels of temporal organization. Annu Rev Genomics Hum Genet (2004) 7.50
Highly parallel identification of essential genes in cancer cells. Proc Natl Acad Sci U S A (2008) 7.45
Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis. Cancer Res (2005) 6.93
Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nat Genet (2005) 6.91
Circadian integration of metabolism and energetics. Science (2010) 6.86
dChipSNP: significance curve and clustering of SNP-array-based loss-of-heterozygosity data. Bioinformatics (2004) 6.78
Comparative analysis of algorithms for identifying amplifications and deletions in array CGH data. Bioinformatics (2005) 6.44
Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. Nat Genet (2002) 6.29
System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol (2007) 6.23
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. J Clin Invest (2003) 6.04
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature (2010) 5.97
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol (2006) 5.83
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
The meter of metabolism. Cell (2008) 5.71
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science (2009) 5.30
Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. Nat Med (2008) 5.15
Colorectal cancer in mice genetically deficient in the mucin Muc2. Science (2002) 5.08
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A (2002) 4.93
Intercellular coupling confers robustness against mutations in the SCN circadian clock network. Cell (2007) 4.87
Temperature as a universal resetting cue for mammalian circadian oscillators. Science (2010) 4.85
Transcriptional architecture and chromatin landscape of the core circadian clock in mammals. Science (2012) 4.77
Central and peripheral circadian clocks in mammals. Annu Rev Neurosci (2012) 4.73
Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression. Curr Biol (2004) 4.49
Suprachiasmatic nucleus: cell autonomy and network properties. Annu Rev Physiol (2010) 4.38
Landscape of somatic retrotransposition in human cancers. Science (2012) 4.37
Melanopsin is required for non-image-forming photic responses in blind mice. Science (2003) 4.22
Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J Biol Chem (2002) 4.19
Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS Biol (2004) 4.08
cAMP-dependent signaling as a core component of the mammalian circadian pacemaker. Science (2008) 4.02
Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors. J Clin Oncol (2010) 4.01
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci (2005) 4.00
Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell (2007) 3.99
Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A (2007) 3.92
Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell (2011) 3.88
Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial. Genome Biol (2006) 3.75
Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases. Science (2003) 3.70
Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat Methods (2009) 3.68
Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function. J Neurosci (2008) 3.64
A rare penetrant mutation in CFH confers high risk of age-related macular degeneration. Nat Genet (2011) 3.55
PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. J Clin Invest (2007) 3.54
Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome Res (2008) 3.54
A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival. J Neurosci (2007) 3.51
Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays. PLoS Comput Biol (2006) 3.39
Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures. Ann Neurol (2002) 3.37
Genome coverage and sequence fidelity of phi29 polymerase-based multiple strand displacement whole genome amplification. Nucleic Acids Res (2004) 3.37
ChipInfo: Software for extracting gene annotation and gene ontology information for microarray analysis. Nucleic Acids Res (2003) 3.31
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev (2005) 3.25
Prognostic significance of copy-number alterations in multiple myeloma. J Clin Oncol (2009) 3.21
mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol Cell (2008) 3.06
Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation. Proc Natl Acad Sci U S A (2007) 3.06
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature (2002) 3.05
Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc Natl Acad Sci U S A (2005) 2.95
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab (2011) 2.91
A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. PLoS Genet (2005) 2.85
Allele-specific amplification in cancer revealed by SNP array analysis. PLoS Comput Biol (2005) 2.84
Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia. Proc Natl Acad Sci U S A (2007) 2.81
Genetics of circadian rhythms in Mammalian model organisms. Adv Genet (2011) 2.80
Perivascular epithelioid cell neoplasms: pathology and pathogenesis. Hum Pathol (2009) 2.80
Rapid turnover of actin in dendritic spines and its regulation by activity. Nat Neurosci (2002) 2.78
Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent. Proc Natl Acad Sci U S A (2011) 2.73
Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion. Proc Natl Acad Sci U S A (2011) 2.72
mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. J Clin Invest (2011) 2.72
Filter-based hybridization capture of subgenomes enables resequencing and copy-number detection. Nat Methods (2009) 2.71
(CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition. Nat Struct Mol Biol (2005) 2.71
A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo. Proc Natl Acad Sci U S A (2005) 2.67
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature (2012) 2.67
Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. Arch Pathol Lab Med (2013) 2.66
Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system. Proc Natl Acad Sci U S A (2005) 2.65
Genetical genomics: spotlight on QTL hotspots. PLoS Genet (2008) 2.63
Pharmaceutical supply chain in China: current issues and implications for health system reform. Health Policy (2010) 2.63
Differential gene expression following early renal ischemia/reperfusion. Kidney Int (2003) 2.60
Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. J Immunol (2003) 2.59
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A (2008) 2.48
Integration of global SNP-based mapping and expression arrays reveals key regions, mechanisms, and genes important in the pathogenesis of multiple myeloma. Blood (2006) 2.43
Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models. Genes Chromosomes Cancer (2005) 2.42
Dissecting the functions of the mammalian clock protein BMAL1 by tissue-specific rescue in mice. Science (2006) 2.41
Hierarchical model of gene regulation by transforming growth factor beta. Proc Natl Acad Sci U S A (2003) 2.37
The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude. Proc Natl Acad Sci U S A (2006) 2.36
Tuberous sclerosis complex proteins control axon formation. Genes Dev (2008) 2.33