|
1
|
Biological, clinical and population relevance of 95 loci for blood lipids.
|
Nature
|
2010
|
28.21
|
|
2
|
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
|
Nat Genet
|
2010
|
23.08
|
|
3
|
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
Nature
|
2010
|
20.01
|
|
4
|
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
|
Nat Genet
|
2010
|
17.89
|
|
5
|
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
|
Nature
|
2011
|
13.25
|
|
6
|
Genome-wide association study identifies eight loci associated with blood pressure.
|
Nat Genet
|
2009
|
12.44
|
|
7
|
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
|
Nat Genet
|
2008
|
12.32
|
|
8
|
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.
|
Lancet
|
2012
|
12.10
|
|
9
|
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
|
Nat Genet
|
2010
|
7.94
|
|
10
|
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
Nat Genet
|
2012
|
7.59
|
|
11
|
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
|
Nat Genet
|
2010
|
6.49
|
|
12
|
Heritability of adult body height: a comparative study of twin cohorts in eight countries.
|
Twin Res
|
2003
|
6.43
|
|
13
|
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
|
Nat Genet
|
2009
|
6.31
|
|
14
|
A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.
|
Lancet
|
2010
|
6.07
|
|
15
|
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
|
PLoS Genet
|
2009
|
4.97
|
|
16
|
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
Nat Genet
|
2012
|
4.73
|
|
17
|
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.
|
Science
|
2013
|
4.71
|
|
18
|
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|
Nat Genet
|
2012
|
4.37
|
|
19
|
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
Nat Genet
|
2012
|
4.08
|
|
20
|
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
|
Diabetes
|
2010
|
4.07
|
|
21
|
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.
|
N Engl J Med
|
2016
|
3.88
|
|
22
|
Identification of seven loci affecting mean telomere length and their association with disease.
|
Nat Genet
|
2013
|
3.87
|
|
23
|
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
|
Circulation
|
2011
|
3.68
|
|
24
|
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
Nat Genet
|
2013
|
3.25
|
|
25
|
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
|
PLoS Genet
|
2012
|
3.21
|
|
26
|
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
|
Nat Genet
|
2012
|
3.04
|
|
27
|
Geographical structure and differential natural selection among North European populations.
|
Genome Res
|
2009
|
3.03
|
|
28
|
Common variants associated with plasma triglycerides and risk for coronary artery disease.
|
Nat Genet
|
2013
|
2.92
|
|
29
|
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
|
PLoS Genet
|
2013
|
2.83
|
|
30
|
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
|
Nat Genet
|
2011
|
2.73
|
|
31
|
Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies.
|
Int J Epidemiol
|
2010
|
2.44
|
|
32
|
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
|
Aging Cell
|
2011
|
2.37
|
|
33
|
Genetically determined height and coronary artery disease.
|
N Engl J Med
|
2015
|
2.24
|
|
34
|
Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15.
|
Hum Mol Genet
|
2009
|
2.22
|
|
35
|
Metabonomic, transcriptomic, and genomic variation of a population cohort.
|
Mol Syst Biol
|
2010
|
2.17
|
|
36
|
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
|
PLoS Genet
|
2012
|
1.97
|
|
37
|
Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.
|
Am J Hum Genet
|
2009
|
1.81
|
|
38
|
An immune response network associated with blood lipid levels.
|
PLoS Genet
|
2010
|
1.74
|
|
39
|
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
|
Nat Genet
|
2013
|
1.72
|
|
40
|
A genome-wide association search for type 2 diabetes genes in African Americans.
|
PLoS One
|
2012
|
1.72
|
|
41
|
The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis.
|
PLoS Med
|
2013
|
1.70
|
|
42
|
Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis.
|
PLoS Genet
|
2012
|
1.69
|
|
43
|
Common genetic variants, QT interval, and sudden cardiac death in a Finnish population-based study.
|
Circ Cardiovasc Genet
|
2011
|
1.67
|
|
44
|
The interval of linkage disequilibrium (LD) detected with microsatellite and SNP markers in chromosomes of Finnish populations with different histories.
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Hum Mol Genet
|
2003
|
1.66
|
|
45
|
Toward a roadmap in global biobanking for health.
|
Eur J Hum Genet
|
2012
|
1.65
|
|
46
|
The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies.
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BMC Endocr Disord
|
2014
|
1.64
|
|
47
|
Comprehensive catalog of European biobanks.
|
Nat Biotechnol
|
2011
|
1.64
|
|
48
|
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
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Circ Cardiovasc Genet
|
2012
|
1.60
|
|
49
|
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific.
|
Aging Cell
|
2013
|
1.56
|
|
50
|
Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans.
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Am J Hum Genet
|
2007
|
1.51
|
|
51
|
ACE gene and physical activity, blood pressure, and hypertension: a population study in Finland.
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J Appl Physiol (1985)
|
2002
|
1.45
|
|
52
|
Genome scans provide evidence for low-HDL-C loci on chromosomes 8q23, 16q24.1-24.2, and 20q13.11 in Finnish families.
|
Am J Hum Genet
|
2002
|
1.45
|
|
53
|
The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts.
|
Genet Epidemiol
|
2009
|
1.43
|
|
54
|
Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study.
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Aging Cell
|
2013
|
1.33
|
|
55
|
Meta-analysis of genome-wide linkage studies in BMI and obesity.
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Obesity (Silver Spring)
|
2007
|
1.32
|
|
56
|
Gender differences in genetic risk profiles for cardiovascular disease.
|
PLoS One
|
2008
|
1.31
|
|
57
|
MORGAM (an international pooling of cardiovascular cohorts).
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Int J Epidemiol
|
2004
|
1.31
|
|
58
|
Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3.
|
Hum Mol Genet
|
2004
|
1.29
|
|
59
|
Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
|
PLoS Genet
|
2011
|
1.27
|
|
60
|
Within-family outliers: segregating alleles or environmental effects? A linkage analysis of height from 5815 sibling pairs.
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Eur J Hum Genet
|
2008
|
1.25
|
|
61
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Coronary artery wall atherosclerosis in relation to the estrogen receptor 1 gene polymorphism: an autopsy study.
|
J Mol Med (Berl)
|
2002
|
1.24
|
|
62
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The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits.
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PLoS One
|
2011
|
1.18
|
|
63
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Sweet taste preferences are partly genetically determined: identification of a trait locus on chromosome 16.
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Am J Clin Nutr
|
2007
|
1.17
|
|
64
|
Variation in the selenoprotein S gene locus is associated with coronary heart disease and ischemic stroke in two independent Finnish cohorts.
|
Hum Genet
|
2007
|
1.17
|
|
65
|
Evidence of inbreeding depression on human height.
|
PLoS Genet
|
2012
|
1.16
|
|
66
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Lessons from studying monogenic disease for common disease.
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Hum Mol Genet
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2006
|
1.14
|
|
67
|
Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci.
|
Hum Mol Genet
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2011
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1.13
|
|
68
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Risk alleles of USF1 gene predict cardiovascular disease of women in two prospective studies.
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PLoS Genet
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2006
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1.13
|
|
69
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AUTOGSCAN: powerful tools for automated genome-wide linkage and linkage disequilibrium analysis.
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Twin Res Hum Genet
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2005
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1.09
|
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70
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The Three-Factor Eating Questionnaire, body mass index, and responses to sweet and salty fatty foods: a twin study of genetic and environmental associations.
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Am J Clin Nutr
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2008
|
1.07
|
|
71
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Common genetic variants associated with sudden cardiac death: the FinSCDgen study.
|
PLoS One
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2012
|
1.04
|
|
72
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Evaluation of HapMap data in six populations of European descent.
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Eur J Hum Genet
|
2008
|
1.04
|
|
73
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Combined effects of thrombosis pathway gene variants predict cardiovascular events.
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PLoS Genet
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2007
|
1.03
|
|
74
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Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder.
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Hum Mol Genet
|
2003
|
1.02
|
|
75
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OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism.
|
J Mol Med (Berl)
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2009
|
1.02
|
|
76
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Environmental effects exceed genetic effects on perceived intensity and pleasantness of several odors: a three-population twin study.
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Behav Genet
|
2008
|
1.02
|
|
77
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Evaluating whole genome amplification via multiply-primed rolling circle amplification for SNP genotyping of samples with low DNA yield.
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Twin Res Hum Genet
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2005
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0.99
|
|
78
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Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death.
|
J Am Coll Cardiol
|
2003
|
0.98
|
|
79
|
Genome-wide linkage screen for stature and body mass index in 3.032 families: evidence for sex- and population-specific genetic effects.
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Eur J Hum Genet
|
2008
|
0.98
|
|
80
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A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol.
|
PLoS Genet
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2011
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0.97
|
|
81
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Food neophobia in young adults: genetic architecture and relation to personality, pleasantness and use frequency of foods, and body mass index--a twin study.
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Behav Genet
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2010
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0.97
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82
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The molecular genetic architecture of self-employment.
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PLoS One
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2013
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0.96
|
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83
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The functional -374 T/A RAGE gene polymorphism is associated with proteinuria and cardiovascular disease in type 1 diabetic patients.
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Diabetes
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2003
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0.96
|
|
84
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Midlife sleep characteristics associated with late life cognitive function.
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Sleep
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2013
|
0.96
|
|
85
|
Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q.
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Hum Mol Genet
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2004
|
0.96
|
|
86
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A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.
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Twin Res Hum Genet
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2012
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0.95
|
|
87
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C-reactive protein-associated genetic variants and cancer risk: findings from FINRISK 1992, FINRISK 1997 and Health 2000 studies.
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Eur J Cancer
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2010
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0.95
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88
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Genetic and environmental contributions to food use patterns of young adult twins.
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Physiol Behav
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2007
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0.94
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89
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Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals.
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PLoS Genet
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2011
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0.94
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90
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Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging.
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Aging Cell
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2013
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0.93
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91
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European lactase persistence genotype shows evidence of association with increase in body mass index.
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Hum Mol Genet
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2009
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0.91
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92
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Bayesian variable selection in searching for additive and dominant effects in genome-wide data.
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PLoS One
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2012
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0.90
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93
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Genetic component of identification, intensity and pleasantness of odours: a Finnish family study.
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Eur J Hum Genet
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2007
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0.89
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94
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Cohort Profile: the Corogene study.
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Int J Epidemiol
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2011
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0.89
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95
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Midlife alcohol consumption and later risk of cognitive impairment: a twin follow-up study.
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J Alzheimers Dis
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2010
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0.89
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96
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Genome-wide meta-analysis of common variant differences between men and women.
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Hum Mol Genet
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2012
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0.88
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97
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Polymorphisms in the nephrin gene and diabetic nephropathy in type 1 diabetic patients.
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Kidney Int
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2003
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0.88
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98
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Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis.
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Arterioscler Thromb Vasc Biol
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2009
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0.87
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99
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Genetics of maximal walking speed and skeletal muscle characteristics in older women.
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Twin Res Hum Genet
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2008
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0.86
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100
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Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men.
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Atherosclerosis
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2004
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0.86
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101
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Associations of nicotine intake measures with CHRN genes in Finnish smokers.
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Nicotine Tob Res
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2011
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0.86
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102
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Intracranial aneurysm risk locus 5q23.2 is associated with elevated systolic blood pressure.
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PLoS Genet
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2012
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0.85
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103
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Prevalence of arrhythmia-associated gene mutations and risk of sudden cardiac death in the Finnish population.
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Ann Med
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2013
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0.85
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104
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Self-ratings of olfactory function reflect odor annoyance rather than olfactory acuity.
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Laryngoscope
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2008
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0.85
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105
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Midlife cardiovascular risk factors and late cognitive impairment.
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Eur J Epidemiol
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2013
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0.84
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106
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Genome-wide association study of sleep duration in the Finnish population.
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J Sleep Res
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2014
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0.84
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107
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Association analysis of allelic variants of USF1 in coronary atherosclerosis.
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Arterioscler Thromb Vasc Biol
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2008
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0.84
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108
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Locus for quantitative HDL-cholesterol on chromosome 10q in Finnish families with dyslipidemia.
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J Lipid Res
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2004
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0.84
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109
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Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques.
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Atherosclerosis
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2004
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0.83
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110
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Platelet GPIbalpha, GPIV and vWF polymorphisms and fatal pre-hospital MI among middle-aged men.
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J Thromb Thrombolysis
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2007
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0.83
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111
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Genetic variation of the interleukin-1 family and nongenetic factors determining the interleukin-1 receptor antagonist phenotypes.
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Metabolism
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2010
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0.82
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112
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Same genetic components underlie different measures of sweet taste preference.
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Am J Clin Nutr
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2007
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0.82
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113
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Birthplace predicts risk for prehospital sudden cardiac death in middle-aged men who migrated to metropolitan area: The Helsinki Sudden Death Study.
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Ann Med
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2009
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0.82
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114
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Coronary artery calcification is related to functional polymorphism of matrix metalloproteinase 3: the Helsinki Sudden Death Study.
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Atherosclerosis
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2002
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0.82
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115
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ADAM8 and its single nucleotide polymorphism 2662 T/G are associated with advanced atherosclerosis and fatal myocardial infarction: Tampere vascular study.
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Ann Med
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2009
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0.81
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116
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Smoking-dependent association between paraoxonase 1 M/L55 genotype and coronary atherosclerosis in males: an autopsy study.
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2003
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0.81
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117
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Association of variation in the interleukin-1 gene family with diabetes and glucose homeostasis.
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J Clin Endocrinol Metab
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2009
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0.80
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118
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Age-dependent association between hepatic lipase gene C-480T polymorphism and the risk of pre-hospital sudden cardiac death: the Helsinki Sudden Death Study.
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Atherosclerosis
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2006
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0.80
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119
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Dopamine D3 receptor gene polymorphisms, blood pressure and nephropathy in type 1 diabetic patients.
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Nephrol Dial Transplant
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2004
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0.80
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120
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Shared genetic background for regulation of mood and sleep: association of GRIA3 with sleep duration in healthy Finnish women.
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Sleep
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0.80
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121
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Interactions of functional apolipoprotein E gene promoter polymorphisms with smoking on aortic atherosclerosis.
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Circ Cardiovasc Genet
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2008
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0.79
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122
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Myeloperoxidase gene variation as a determinant of atherosclerosis progression in the abdominal and thoracic aorta: an autopsy study.
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Lab Invest
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2003
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0.79
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123
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Birthplace in area with high coronary heart disease mortality predicts the severity of coronary atherosclerosis among middle-aged Finnish men who had migrated to capital area: the Helsinki sudden death study.
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Ann Med
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2010
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0.78
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124
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A common variant near the KCNJ2 gene is associated with T-peak to T-end interval.
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Heart Rhythm
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2012
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0.78
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125
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Mortality rate increases steeply with nonadherence to statin therapy in patients with acute coronary syndrome.
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Clin Cardiol
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2012
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0.78
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126
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Spline methods for the comparison of physical and genetic maps.
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J Comput Biol
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2002
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0.78
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127
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CRP gene variation affects early development of Alzheimer's disease-related plaques.
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J Neuroinflammation
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2011
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128
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Food neophobia shows heritable variation in humans.
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Physiol Behav
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129
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Platelet collagen receptor GPIa (C807T/HPA-5) haplotype is not associated with an increased risk of fatal coronary events in middle-aged men.
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Atherosclerosis
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2002
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0.77
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130
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Thyroid cancer and co-occurring RET mutations in Hirschsprung disease.
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Endocr Relat Cancer
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131
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Genetic contribution to sour taste preference.
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Appetite
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Genetic variation on the BAT1-NFKBIL1-LTA region of major histocompatibility complex class III associates with periodontitis.
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Infect Immun
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133
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Association of the endothelial nitric oxide synthase gene polymorphism with risk of coronary artery disease and myocardial infarction in middle-aged men.
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J Mol Med (Berl)
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Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
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PLoS Genet
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Novel 6p21.3 Risk Haplotype Predisposes to Acute Coronary Syndrome.
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Circ Cardiovasc Genet
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Genome-wide search for QTLs for apolipoprotein A-I level in elderly Swedish DZ twins: evidence of female-specific locus on 15q11-13.
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Eur J Hum Genet
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Genetics of platelet glycoprotein receptors: risk of thrombotic events and pharmacogenetic implications.
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Clin Appl Thromb Hemost
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Association of paraoxonase-1 M55L genotype and alcohol consumption with coronary atherosclerosis: the Helsinki Sudden Death Study.
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Pharmacogenetics
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Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
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PLoS Genet
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140
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Age-dependent interaction of apolipoprotein E gene with eastern birthplace in Finland affects severity of coronary atherosclerosis and risk of fatal myocardial infarction--Helsinki Sudden Death Study.
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