Published in Lancet on October 23, 2010
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat Genet (2011) 5.23
Atherosclerosis: current pathogenesis and therapeutic options. Nat Med (2011) 4.95
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet (2014) 4.60
Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol (2013) 3.89
Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials. Lancet (2015) 3.75
Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease. N Engl J Med (2016) 3.68
Phased whole-genome genetic risk in a family quartet using a major allele reference sequence. PLoS Genet (2011) 3.20
A genetic risk score is associated with incident cardiovascular disease and coronary artery calcium: the Framingham Heart Study. Circ Cardiovasc Genet (2012) 1.81
Personalized medicine: hope or hype? Eur Heart J (2012) 1.80
Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history. Eur Heart J (2015) 1.65
The contributory role of gut microbiota in cardiovascular disease. J Clin Invest (2014) 1.57
Multiple biomarkers for risk prediction in chronic heart failure. Circ Heart Fail (2012) 1.57
Association of a genetic risk score with prevalent and incident myocardial infarction in subjects undergoing coronary angiography. Circ Cardiovasc Genet (2012) 1.54
Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes. Hypertension (2013) 1.52
Genomic prediction of coronary heart disease. Eur Heart J (2016) 1.49
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. Hum Genet (2013) 1.47
The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases. Annu Rev Med (2015) 1.33
Genome-wide association study of coronary artery disease in the Japanese. Eur J Hum Genet (2011) 1.32
Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies. Eur Heart J (2012) 1.30
Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts. Circulation (2015) 1.25
The genetic basis of addictive disorders. Psychiatr Clin North Am (2012) 1.20
Regularized machine learning in the genetic prediction of complex traits. PLoS Genet (2014) 1.15
Genetic markers enhance coronary risk prediction in men: the MORGAM prospective cohorts. PLoS One (2012) 1.13
Matched case-control studies: a review of reported statistical methodology. Clin Epidemiol (2012) 1.13
Genetic risk prediction and a 2-stage risk screening strategy for coronary heart disease. Arterioscler Thromb Vasc Biol (2013) 1.13
Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation. Arterioscler Thromb Vasc Biol (2012) 1.12
Genetic-based prediction of disease traits: prediction is very difficult, especially about the future. Front Genet (2014) 1.12
Genome wide assessment of young onset Parkinson's disease from Finland. PLoS One (2012) 1.09
Gene expression signatures of coronary heart disease. Arterioscler Thromb Vasc Biol (2013) 1.08
Randomized trial of personal genomics for preventive cardiology: design and challenges. Circ Cardiovasc Genet (2012) 1.06
Childhood environmental and genetic predictors of adulthood obesity: the cardiovascular risk in young Finns study. J Clin Endocrinol Metab (2011) 1.06
Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study. Circ Cardiovasc Genet (2011) 1.05
Utility of genetic determinants of lipids and cardiovascular events in assessing risk. Nat Rev Cardiol (2011) 1.04
The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease. Front Physiol (2014) 1.03
Genetics in population health science: strategies and opportunities. Am J Public Health (2013) 1.02
Classical and novel biomarkers for cardiovascular risk prediction in the United States. J Epidemiol (2013) 1.00
Plasma lipid composition and risk of developing cardiovascular disease. PLoS One (2013) 0.99
Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies. Stroke (2014) 0.99
Prediction of Colorectal Cancer Risk Using a Genetic Risk Score: The Korean Cancer Prevention Study-II (KCPS-II). Genomics Inform (2012) 0.99
Genome-wide association studies of chronic kidney disease: what have we learned? Nat Rev Nephrol (2011) 0.98
From genetic discovery to future personalized health research. N Biotechnol (2012) 0.98
Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk Estimates: Effect on Low-Density Lipoprotein Cholesterol Levels (the MI-GENES Clinical Trial). Circulation (2016) 0.97
Implications of discoveries from genome-wide association studies in current cardiovascular practice. World J Cardiol (2011) 0.97
Performance of a genetic risk score for CKD stage 3 in the general population. Am J Kidney Dis (2011) 0.96
A bias-corrected net reclassification improvement for clinical subgroups. Med Decis Making (2012) 0.95
Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease. J Neural Transm (Vienna) (2012) 0.95
Basic concepts and potential applications of genetics and genomics for cardiovascular and stroke clinicians: a scientific statement from the American Heart Association. Circ Cardiovasc Genet (2015) 0.93
Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study. PLoS One (2013) 0.93
Candidate gene association study of BMI-related loci, weight, and adiposity in old age. J Gerontol A Biol Sci Med Sci (2012) 0.93
Genetic variants and blood pressure in a population-based cohort: the Cardiovascular Risk in Young Finns study. Hypertension (2011) 0.91
Assessment of the value of a genetic risk score in improving the estimation of coronary risk. Atherosclerosis (2012) 0.91
Integrating genetics and social science: genetic risk scores. Biodemography Soc Biol (2014) 0.89
Relations of long-term and contemporary lipid levels and lipid genetic risk scores with coronary artery calcium in the framingham heart study. J Am Coll Cardiol (2012) 0.89
Cohort Profile: the Corogene study. Int J Epidemiol (2011) 0.89
Cardiovascular disease risk prediction in women: is there a role for novel biomarkers? Clin Chem (2013) 0.88
Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent. PLoS Med (2016) 0.87
A genetic risk score for hypertension associates with the risk of ischemic stroke in a Swedish case-control study. Eur J Hum Genet (2014) 0.86
Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction. PLoS One (2012) 0.86
Genetic predisposition to coronary heart disease and stroke using an additive genetic risk score: a population-based study in Greece. Atherosclerosis (2012) 0.86
Contribution of genetic background, traditional risk factors, and HIV-related factors to coronary artery disease events in HIV-positive persons. Clin Infect Dis (2013) 0.85
Functional genomics applied to cardiovascular medicine. Circulation (2011) 0.85
Selecting instruments for Mendelian randomization in the wake of genome-wide association studies. Int J Epidemiol (2016) 0.85
Genotype-informed estimation of risk of coronary heart disease based on genome-wide association data linked to the electronic medical record. BMC Cardiovasc Disord (2011) 0.85
Assessment of Parkinson's disease risk loci in Greece. Neurobiol Aging (2013) 0.84
Influence of Genetic Risk Factors on Coronary Heart Disease Occurrence in Afro-Caribbeans. Can J Cardiol (2016) 0.84
Genetic risk score and adiposity interact to influence triglyceride levels in a cohort of Filipino women. Nutr Diabetes (2014) 0.83
Associations of lipid levels susceptibility loci with coronary artery disease in Chinese population. Lipids Health Dis (2015) 0.83
Genetic variants and their interactions in disease risk prediction - machine learning and network perspectives. BioData Min (2013) 0.83
Polygenic Risk Score Identifies Subgroup with Higher Burden of Atherosclerosis and Greater Relative Benefit from Statin Therapy in the Primary Prevention Setting. Circulation (2017) 0.82
Smoking modifies the associated increased risk of future cardiovascular disease by genetic variation on chromosome 9p21. PLoS One (2014) 0.82
Towards a molecular systems model of coronary artery disease. Curr Cardiol Rep (2014) 0.82
Additive influence of genetic predisposition and conventional risk factors in the incidence of coronary heart disease: a population-based study in Greece. BMJ Open (2014) 0.82
Genetic risk and age in Parkinson's disease: Continuum not stratum. Mov Disord (2015) 0.81
Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. Circulation (2015) 0.81
Design of a randomized controlled trial of disclosing genomic risk of coronary heart disease: the Myocardial Infarction Genes (MI-GENES) study. BMC Med Genomics (2015) 0.81
Genetic polymorphisms for estimating risk of atrial fibrillation: a literature-based meta-analysis. J Intern Med (2012) 0.81
Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population. BMC Genet (2015) 0.80
Genetic prediction of common diseases. Still no help for the clinical diabetologist! Nutr Metab Cardiovasc Dis (2012) 0.80
Genetic predictors for cardiovascular disease in hispanics. Trends Cardiovasc Med (2011) 0.80
Improvement in prediction of coronary heart disease risk over conventional risk factors using SNPs identified in genome-wide association studies. PLoS One (2013) 0.80
Multiplex pyrosequencing assay using AdvISER-MH-PYRO algorithm: a case for rapid and cost-effective genotyping analysis of prostate cancer risk-associated SNPs. BMC Med Genet (2015) 0.80
Improved prediction of complex diseases by common genetic markers: state of the art and further perspectives. Hum Genet (2016) 0.80
CVD screening in low-risk, asymptomatic adults: clinical trials needed. Nat Rev Cardiol (2012) 0.80
A clinical approach to inherited premature coronary artery disease. Circ Cardiovasc Genet (2014) 0.79
Systems Biology and Noninvasive Imaging of Atherosclerosis. Arterioscler Thromb Vasc Biol (2016) 0.79
The Role of Genetic Risk Score in Predicting the Risk of Hypertension in the Korean population: Korean Genome and Epidemiology Study. PLoS One (2015) 0.79
Single nucleotide polymorphism rs3774261 in the AdipoQ gene is associated with the risk of coronary heart disease (CHD) in Northeast Han Chinese population: a case-control study. Lipids Health Dis (2016) 0.79
The Metabolic Role of Gut Microbiota in the Development of Nonalcoholic Fatty Liver Disease and Cardiovascular Disease. Int J Mol Sci (2016) 0.78
Circulating, imaging, and genetic biomarkers in cardiovascular risk prediction. Trends Cardiovasc Med (2011) 0.78
Genomic risk prediction. Lancet (2010) 0.78
Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels. Mol Med Rep (2015) 0.78
Susceptibility Loci for Clinical Coronary Artery Disease and Subclinical Coronary Atherosclerosis Throughout the Life-Course. Circ Cardiovasc Genet (2015) 0.78
A colorectal cancer prediction model using traditional and genetic risk scores in Koreans. BMC Genet (2015) 0.77
The evolution and refinement of traditional risk factors for cardiovascular disease. Cardiol Rev (2012) 0.77
Personalized genomes and cardiovascular disease. Cold Spring Harb Perspect Med (2014) 0.77
Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe. PLoS One (2014) 0.77
Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med (2008) 57.29
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Factors of risk in the development of coronary heart disease--six year follow-up experience. The Framingham Study. Ann Intern Med (1961) 12.08
Time-dependent ROC curves for censored survival data and a diagnostic marker. Biometrics (2000) 10.63
Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med (2008) 9.83
Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N Engl J Med (2009) 8.73
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet (2009) 6.83
The limitations of risk factors as prognostic tools. N Engl J Med (2006) 5.90
Novel and conventional biomarkers for prediction of incident cardiovascular events in the community. JAMA (2009) 5.52
The Malmo Diet and Cancer Study. Design and feasibility. J Intern Med (1993) 5.35
New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet (2009) 5.12
Association between a literature-based genetic risk score and cardiovascular events in women. JAMA (2010) 4.46
The validity of the Finnish Hospital Discharge Register and Causes of Death Register data on coronary heart disease. Eur J Cardiovasc Prev Rehabil (2005) 2.78
Reclassification calculations for persons with incomplete follow-up. Ann Intern Med (2010) 2.35
Elevated Lp-PLA2 levels add prognostic information to the metabolic syndrome on incidence of cardiovascular events among middle-aged nondiabetic subjects. Arterioscler Thromb Vasc Biol (2007) 2.21
The validation of the Finnish Hospital Discharge Register and Causes of Death Register data on stroke diagnoses. Eur J Cardiovasc Prev Rehabil (2007) 1.61
Coronary heart disease: from a disease of middle-aged men in the late 1970s to a disease of elderly women in the 2000s. Eur Heart J (2005) 1.44
Genetics of coronary artery disease. Annu Rev Genomics Hum Genet (2010) 1.37
Case-control studies in the genomic era: a clinician's guide. Lancet Neurol (2006) 1.32
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet (2002) 23.18
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet (2008) 20.73
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
The mutational landscape of head and neck squamous cell carcinoma. Science (2011) 16.88
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Metabolite profiles and the risk of developing diabetes. Nat Med (2011) 12.22
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19