PubRank

Jürgen Götz

Author PubWeight™ 90.66‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell 2010 7.52
2 Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease. Nat Rev Neurosci 2010 3.61
3 Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proc Natl Acad Sci U S A 2009 2.04
4 Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils. Proc Natl Acad Sci U S A 2007 1.68
5 Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proc Natl Acad Sci U S A 2008 1.64
6 Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice. J Biol Chem 2005 1.64
7 Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron 2012 1.58
8 Pronuclear injection for the production of transgenic mice. Nat Protoc 2007 1.50
9 Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice. PLoS One 2011 1.45
10 Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice. Neurodegener Dis 2008 1.42
11 Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta. PLoS One 2010 1.37
12 Primary support cultures of hippocampal and substantia nigra neurons. Nat Protoc 2009 1.33
13 Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice. Am J Pathol 2003 1.24
14 Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A 2010 1.24
15 Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice. J Mol Med (Berl) 2008 1.23
16 Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease. PLoS One 2009 1.23
17 Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease. J Biol Chem 2009 1.21
18 Divergent phosphorylation pattern of tau in P301L tau transgenic mice. Eur J Neurosci 2008 1.21
19 beta-Amyloid induces paired helical filament-like tau filaments in tissue culture. J Biol Chem 2003 1.19
20 Convergence of amyloid-beta and tau pathologies on mitochondria in vivo. Mol Neurobiol 2010 1.16
21 Reference genes identified in SH-SY5Y cells using custom-made gene arrays with validation by quantitative polymerase chain reaction. Anal Biochem 2004 1.15
22 Role for glyoxalase I in Alzheimer's disease. Proc Natl Acad Sci U S A 2004 1.12
23 Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β. J Mol Neurosci 2011 1.12
24 Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta. Proc Natl Acad Sci U S A 2011 1.09
25 Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics 2010 1.08
26 MicroRNA networks surrounding APP and amyloid-β metabolism--implications for Alzheimer's disease. Exp Neurol 2011 1.08
27 Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice. Neurobiol Dis 2004 1.02
28 Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice. J Mol Biol 2004 1.01
29 Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia. EMBO J 2003 1.01
30 Why size matters - balancing mitochondrial dynamics in Alzheimer's disease. Trends Neurosci 2013 1.00
31 Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's and Pick's disease. PLoS One 2012 0.97
32 Posttranslational modifications of tau--role in human tauopathies and modeling in transgenic animals. Curr Drug Targets 2004 0.96
33 Glial cells under physiologic and pathologic conditions. Arch Neurol 2002 0.96
34 Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A. Eur J Neurosci 2002 0.96
35 Beta-amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes. Proteomics 2006 0.95
36 Insights into mitochondrial dysfunction: aging, amyloid-β, and tau-A deleterious trio. Antioxid Redox Signal 2012 0.95
37 Decoding the non-coding RNAs in Alzheimer's disease. Cell Mol Life Sci 2012 0.95
38 Brief update on different roles of tau in neurodegeneration. IUBMB Life 2011 0.94
39 Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome. Cell Mol Life Sci 2014 0.94
40 Tau aggregation and its interplay with amyloid-β. Acta Neuropathol 2014 0.93
41 Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures. FEBS Lett 2008 0.93
42 Possibilities for the prevention and treatment of cognitive impairment and dementia. Br J Psychiatry 2007 0.91
43 Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity. Alzheimers Res Ther 2011 0.91
44 Comparing navigation-based in vivo knee kinematics pre- and postoperatively between a cruciate-retaining and a cruciate-substituting implant. Int Orthop 2013 0.91
45 PTL-1 regulates neuronal integrity and lifespan in C. elegans. J Cell Sci 2013 0.90
46 Substrate-specific reduction of PP2A activity exaggerates tau pathology. Biochem Biophys Res Commun 2009 0.90
47 Alzheimer's and Parkinson's disease--overlapping or synergistic pathologies? Trends Mol Med 2002 0.90
48 Transgenic mice expressing the nucleoprotein of Borna disease virus in either neurons or astrocytes: decreased susceptibility to homotypic infection and disease. J Virol 2004 0.90
49 Parkinson's disease: insights from non-traditional model organisms. Prog Neurobiol 2010 0.89
50 A neuroprotective role for the DNA damage checkpoint in tauopathy. Aging Cell 2012 0.89
51 Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation. J Cereb Blood Flow Metab 2013 0.89
52 How it all started: tau and protein phosphatase 2A. J Alzheimers Dis 2013 0.89
53 Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. J Neural Transm (Vienna) 2009 0.89
54 P70 S6 kinase mediates tau phosphorylation and synthesis. FEBS Lett 2005 0.89
55 Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma. Clin Sci (Lond) 2008 0.88
56 Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons. PLoS One 2011 0.87
57 Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice. Biochem Biophys Res Commun 2006 0.87
58 Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. J Neurochem 2014 0.86
59 Navigated cup implantation in hip arthroplasty. Acta Orthop 2009 0.86
60 Functional Genomics meets neurodegenerative disorders Part I: transcriptomic and proteomic technology. Prog Neurobiol 2005 0.84
61 Alzheimer's disease, oestrogen and mitochondria: an ambiguous relationship. Mol Neurobiol 2012 0.84
62 Acquired long QT interval in a recurrent septic female patient with polymorphic ventricular tachycardia due to primary acute adrenal insufficiency. Clin Res Cardiol 2010 0.83
63 Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice. J Neural Transm (Vienna) 2011 0.83
64 Abeta treatment and P301L tau expression in an Alzheimer's disease tissue culture model act synergistically to promote aberrant cell cycle re-entry. Eur J Neurosci 2007 0.83
65 Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice. Neurobiol Aging 2013 0.82
66 MR imaging of the intraarticular disk of the acromioclavicular joint: a comparison with anatomical, histological and in-vivo findings. Skeletal Radiol 2006 0.82
67 Visualizing the microtubule-associated protein tau in the nucleus. Sci China Life Sci 2014 0.81
68 The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells. Sci China Life Sci 2014 0.81
69 Functional Genomics meets neurodegenerative disorders. Part II: application and data integration. Prog Neurobiol 2005 0.81
70 Bisphosphonates or prostacyclin in the treatment of bone-marrow oedema syndrome of the knee and foot. Rheumatol Int 2012 0.80
71 Different tau epitopes define Abeta42-mediated tau insolubility. Biochem Biophys Res Commun 2005 0.80
72 Neuronal protein with tau-like repeats (PTL-1) regulates intestinal SKN-1 nuclear accumulation in response to oxidative stress. Aging Cell 2014 0.80
73 Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice. Mech Dev 2006 0.79
74 Active immunization trial in Abeta42-injected P301L tau transgenic mice. Neurobiol Dis 2005 0.79
75 Neuroproteomics as a promising tool in Parkinson's disease research. J Neural Transm (Vienna) 2008 0.79
76 Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins. Plasmid 2010 0.79
77 Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation. Int J Dev Neurosci 2006 0.79
78 Single nucleotide variants (SNVs) define senescence-accelerated SAMP8 mice, a model of a geriatric condition. J Alzheimers Dis 2013 0.78
79 Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol. PLoS One 2011 0.78
80 ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice. J Biomed Biotechnol 2011 0.78
81 Antiviral CD8 T cells recognize borna disease virus antigen transgenically expressed in either neurons or astrocytes. J Virol 2008 0.78
82 Aging in the nervous system of Caenorhabditis elegans. Commun Integr Biol 2013 0.77
83 Role of hippocalcin in mediating Aβ toxicity. Biochim Biophys Acta 2012 0.77
84 Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice. Brain Res 2012 0.75