Published in J Biol Chem on December 23, 2011
High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol (1987) 43.61
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell (1994) 11.73
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature (1999) 10.36
Notch signaling. Science (1995) 7.22
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science (2001) 7.03
Notch signaling: from the outside in. Dev Biol (2000) 6.06
Notch signaling: control of cell communication and cell fate. Development (2004) 5.95
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol Cell (2000) 5.56
A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol Cell (2000) 5.53
The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Nat Genet (1998) 4.06
Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell (1997) 3.48
Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem (2003) 2.94
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J Biol Chem (2001) 2.89
NeW wrinkles for an old domain. Cell (2000) 2.72
Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J Biol Chem (2001) 2.71
The ins and outs of notch signaling. Mol Cell Neurosci (1997) 2.61
SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Mol Cell Biol (2001) 2.56
The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease. J Clin Invest (2005) 2.51
NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1. Neuron (1999) 2.07
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J Cell Sci (2004) 2.07
The Notch-Hes pathway in mammalian neural development. Cell Res (1999) 2.05
Involvement of Notch1 in the development of mouse mammary tumors. Oncogene (1999) 1.99
Numb regulates post-endocytic trafficking and degradation of Notch1. J Biol Chem (2009) 1.89
Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase. J Biol Chem (2000) 1.88
Mechanisms of tumor suppression by the SCF(Fbw7). Cell Cycle (2005) 1.88
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. J Biol Chem (1999) 1.87
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. J Biol Chem (1999) 1.82
Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain. J Biol Chem (1999) 1.81
kuzbanian-mediated cleavage of Drosophila Notch. Genes Dev (2002) 1.70
Functions of WW domains in the nucleus. FEBS Lett (2001) 1.62
Protein degradation: four E3s for the notch pathway. Curr Biol (2002) 1.55
The FE65 proteins and Alzheimer's disease. J Neurosci Res (2008) 1.51
Notch receptors, partners and regulators: from conserved domains to powerful functions. Curr Top Microbiol Immunol (1998) 1.44
Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate. Curr Biol (1996) 1.41
Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription. J Biol Chem (2002) 1.37
AIP4/Itch regulates Notch receptor degradation in the absence of ligand. PLoS One (2008) 1.35
Notch signaling: direct or what? Curr Opin Genet Dev (1998) 1.23
The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase. Genetics (1999) 1.20
Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET. EMBO Rep (2005) 1.17
Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase. J Cell Sci (2010) 1.15
The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance. Semin Immunol (2007) 1.13
Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein. FEBS Lett (1998) 1.12
Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD. Genes Cells (2006) 1.06
Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch. Nat Cell Biol (2000) 1.04
Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells. J Biol Chem (2008) 1.02
Tip60 histone acetyltransferase acts as a negative regulator of Notch1 signaling by means of acetylation. Mol Cell Biol (2007) 0.92
Expression of the Fe65 adapter protein in adult and developing mouse brain. Neuroscience (2002) 0.91
Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase. Mol Cell Biol (2007) 0.90
Notch1 intracellular domain suppresses APP intracellular domain-Tip60-Fe65 complex mediated signaling through physical interaction. Biochim Biophys Acta (2007) 0.85
Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase. J Cell Sci (2010) 1.15
Notch interferes with the scaffold function of JNK-interacting protein 1 to inhibit the JNK signaling pathway. Proc Natl Acad Sci U S A (2005) 1.08
Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities. J Cell Biol (2003) 0.99
DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1. J Cell Biochem (2010) 0.92
Downregulation by lipopolysaccharide of Notch signaling, via nitric oxide. J Cell Sci (2008) 0.92
Tip60 histone acetyltransferase acts as a negative regulator of Notch1 signaling by means of acetylation. Mol Cell Biol (2007) 0.92
Upstream regulators of the Hippo pathway. Cell Cycle (2012) 0.91
Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase. Mol Cell Biol (2007) 0.90
SAG protects human neuroblastoma SH-SY5Y cells against 1-methyl-4-phenylpyridinium ion (MPP+)-induced cytotoxicity via the downregulation of ROS generation and JNK signaling. Neurosci Lett (2007) 0.89
Beta-catenin modulates the level and transcriptional activity of Notch1/NICD through its direct interaction. Biochim Biophys Acta (2008) 0.88
Presenilin acts as a positive regulator of basal level activity of ERK through the Raf-MEK1 signaling pathway. Biochem Biophys Res Commun (2005) 0.88
The cytoplasmic adaptor protein X11alpha and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement. FASEB J (2009) 0.88
The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase. Exp Cell Res (2011) 0.86
FE65 as a link between VLDLR and APP to regulate their trafficking and processing. Mol Neurodegener (2012) 0.86
Regulation of Notch1 signaling by the APP intracellular domain facilitates degradation of the Notch1 intracellular domain and RBP-Jk. J Cell Sci (2011) 0.86
Wnt5a controls Notch1 signaling through CaMKII-mediated degradation of the SMRT corepressor protein. J Biol Chem (2012) 0.85
Inhibition of Notch1 signaling by Runx2 during osteoblast differentiation. J Bone Miner Res (2011) 0.85
Notch1 intracellular domain suppresses APP intracellular domain-Tip60-Fe65 complex mediated signaling through physical interaction. Biochim Biophys Acta (2007) 0.85
Notch1 modulates oxidative stress induced cell death through suppression of apoptosis signal-regulating kinase 1. Proc Natl Acad Sci U S A (2013) 0.81
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) enhances osteoclast differentiation via the up-regulation of Notch1 protein stability. Biochim Biophys Acta (2012) 0.81
(-)-Epigallocatechin-3-gallate inhibits invasion and migration of salivary gland adenocarcinoma cells. Oncol Rep (2010) 0.80
Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways. PLoS One (2012) 0.80
Zinc-induced downregulation of Notch signaling is associated with cytoplasmic retention of Notch1-IC and RBP-Jk via PI3k-Akt signaling pathway. Cancer Lett (2007) 0.80
Regulation of Notch1 signaling by Delta-like ligand 1 intracellular domain through physical interaction. Mol Cells (2011) 0.80
Indirubin-3'-monoxime, a derivative of a Chinese anti-leukemia medicine, inhibits Notch1 signaling. Cancer Lett (2008) 0.79
5'-Nitro-indirubinoxime induces G1 cell cycle arrest and apoptosis in salivary gland adenocarcinoma cells through the inhibition of Notch-1 signaling. Biochim Biophys Acta (2009) 0.79
Nitric oxide inhibits an interaction between JNK1 and c-Jun through nitrosylation. Biochem Biophys Res Commun (2006) 0.78
TAT-Hsp27 promotes adhesion and migration of murine dental papilla-derived MDPC-23 cells through beta1 integrin-mediated signaling. Int J Mol Med (2010) 0.78
Differential effects of gonadotropin-releasing hormone (GnRH)-I and GnRH-II on prostate cancer cell signaling and death. J Clin Endocrinol Metab (2005) 0.78
Redox regulation of cytosolic glycerol-3-phosphate dehydrogenase: Cys(102) is the target of the redox control and essential for the catalytic activity. Biochim Biophys Acta (2002) 0.78
Presenilin-2 regulates the degradation of RBP-Jk protein through p38 mitogen-activated protein kinase. J Cell Sci (2012) 0.77
Parkin mediates neuroprotection through activation of Notch1 signaling. Neuroreport (2017) 0.75