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Metabolic analysis reveals changes in the mevalonate and juvenile hormone synthesis pathways linked to the mosquito reproductive physiology. Insect Biochem Mol Biol (2014) 0.97

Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One (2014) 0.87

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CLPB variants associated with autosomal-recessive mitochondrial disorder with cataract, neutropenia, epilepsy, and methylglutaconic aciduria. Am J Hum Genet (2015) 0.86

Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. Proc Natl Acad Sci U S A (2014) 0.83

Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria. PLoS One (2014) 0.79

A Mutation in Caenorhabditis elegans NDUF-7 Activates the Mitochondrial Stress Response and Prolongs Lifespan via ROS and CED-4. G3 (Bethesda) (2015) 0.79

A chemical screen to identify inducers of the mitochondrial unfolded protein response in C. elegans. Worm (2015) 0.78

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Plant polyisoprenoids and control of cholesterol level. Arch Immunol Ther Exp (Warsz) (2013) 0.77

Proteomic and metabolomic analysis of the carotenogenic yeast Xanthophyllomyces dendrorhous using different carbon sources. BMC Genomics (2015) 0.76

Loss-of-function Mutation in PMVK Causes Autosomal Dominant Disseminated Superficial Porokeratosis. Sci Rep (2016) 0.75

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Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. Science (1997) 3.30

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature (2006) 3.23

A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span. Dev Cell (2001) 2.90

Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets. Nat Rev Drug Discov (2007) 2.67

Tissue-specific synthesis of yolk proteins in Caenorhabditis elegans. Dev Biol (1983) 2.60

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Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. Genetics (1999) 2.50

SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell (2010) 2.49

Post-prenylation-processing enzymes as new targets in oncogenesis. Nat Rev Cancer (2005) 2.47

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Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme. J Biol Chem (1988) 1.82

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Hormonal signals produced by DAF-9/cytochrome P450 regulate C. elegans dauer diapause in response to environmental cues. Development (2004) 1.70

Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants. PLoS Genet (2009) 1.62

Polyisoprenoids: structure, biosynthesis and function. Prog Lipid Res (2005) 1.60

Enzymes of the mevalonate pathway of isoprenoid biosynthesis. Arch Biochem Biophys (2010) 1.60

Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci U S A (1990) 1.56

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A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans. PLoS Genet (2009) 1.52

A gp330/megalin-related protein is required in the major epidermis of Caenorhabditis elegans for completion of molting. Development (1999) 1.49

Why did high-dose rosuvastatin not improve cardiac remodeling in chronic heart failure? Mechanistic insights from the UNIVERSE study. Int J Cardiol (2010) 1.48

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A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants. Proc Natl Acad Sci U S A (2001) 1.40

Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16. PLoS Biol (2004) 1.34

Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem (1994) 1.29

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Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans. Proc Natl Acad Sci U S A (2009) 1.26

Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase. Biochem Biophys Res Commun (2006) 1.23

Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release. Biochemistry (1995) 1.18

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Involvement of caveolin-1 in meiotic cell-cycle progression in Caenorhabditis elegans. Nat Cell Biol (1999) 1.17

Biosynthesis of N-acetylglucosamine-P-P-dolichol, the committed step of asparagine-linked oligosaccharide assembly. Glycobiology (1991) 1.16

Ras farnesyltransferase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans. Proc Natl Acad Sci U S A (1995) 1.12

Sterol effects and sites of sterol accumulation in Caenorhabditis elegans: developmental requirement for 4alpha-methyl sterols. J Lipid Res (2003) 1.12

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the treatment of central nervous system diseases. Arch Neurol (2010) 1.08

Inhibition of cholesterol biosynthesis by fluorinated mevalonate analogues. Biochemistry (1987) 1.07

Congenital disorders of glycosylation: a booming chapter of pediatrics. Curr Opin Pediatr (2004) 1.05

NCR-1 and NCR-2, the C. elegans homologs of the human Niemann-Pick type C1 disease protein, function upstream of DAF-9 in the dauer formation pathways. Development (2004) 1.05

Role of cholesterol in germ-line development of Caenorhabditis elegans. Mol Reprod Dev (2002) 1.02

Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase. Arch Biochem Biophys (1997) 1.01

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Polyisoprenoids - Secondary metabolites or physiologically important superlipids? Biochem Biophys Res Commun (2011) 1.00

Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins. Mol Cell Proteomics (2007) 0.98

Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor. Mol Endocrinol (2009) 0.96

Purification and properties of geranylgeranyl-diphosphate synthase from bovine brain. J Biol Chem (1994) 0.94

Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria. Genetics (2001) 0.94

Ubiquinone is necessary for Caenorhabditis elegans development at mitochondrial and non-mitochondrial sites. J Biol Chem (2001) 0.94

Hypoglycosylation due to dolichol metabolism defects. Biochim Biophys Acta (2009) 0.93

The sterol modifying enzyme LET-767 is essential for growth, reproduction and development in Caenorhabditis elegans. Mol Genet Genomics (2003) 0.92

Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans. FASEB J (2003) 0.91

Coenzyme Q supports distinct developmental processes in Caenorhabditis elegans. Mech Ageing Dev (2008) 0.89

Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding. J Neurochem (2004) 0.87

Long-term effects of sterol depletion in C. elegans: sterol content of synchronized wild-type and mutant populations. J Lipid Res (2004) 0.86

A circulatory transcriptional regulation among daf-9, daf-12, and daf-16 mediates larval development upon cholesterol starvation in Caenorhabditis elegans. Dev Dyn (2010) 0.85

Statin myopathy: a lipid clinic experience on the tolerability of statin rechallenge. Cardiovasc Ther (2011) 0.83

Isoprenylation of polypeptides in the nematode Caenorhabditis elegans. Biochim Biophys Acta (1998) 0.83

C. elegans knockouts in ubiquinone biosynthesis genes result in different phenotypes during larval development. Biofactors (2005) 0.82

Polyisoprenoid alcohols--recent results of structural studies. Chem Rec (2008) 0.81

Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems. Arch Biochem Biophys (1995) 0.81

Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. Org Lett (2006) 0.80

Isopentenyl-diphosphate isomerase is essential for viability of Caenorhabditis elegans. Mol Genet Genomics (2005) 0.80

Alzheimer disease: statins in the treatment of Alzheimer disease. Nat Rev Neurol (2011) 0.80

Sterol metabolism in the nematodeCaenorhabditis elegans. Lipids (1984) 0.79

Overcoming multidrug-resistance in cancer: statins offer a logical candidate. Med Hypotheses (2009) 0.79

The use of statins in hematopoietic stem cell transplantation. Curr Stem Cell Res Ther (2009) 0.78

Statins exhibit anticancer effects through modifications of the pAkt signaling pathway. Int J Oncol (2011) 0.78

Targeting the mevalonate pathway in multiple myeloma. Leuk Res (2009) 0.77

Multicolor bleach-rate imaging enlightens in vivo sterol transport. Commun Integr Biol (2010) 0.77

Reversal of age-dependent nuclear morphology by inhibition of prenylation does not affect lifespan in Caenorhabditis elegans. Nucleus (2010) 0.77

Manumycin and gliotoxin derivative KT7595 block Ras farnesylation and cell growth but do not disturb lamin farnesylation and localization in human tumour cells. Br J Cancer (1997) 0.77

Monitoring of lipid storage in Caenorhabditis elegans using coherent anti-Stokes Raman scattering (CARS) microscopy. Proc Natl Acad Sci U S A (2007) 2.65

C. elegans feeding defective mutants have shorter body lengths and increased autophagy. BMC Dev Biol (2006) 2.07

Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans. Proc Natl Acad Sci U S A (2009) 1.26

The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway. Proc Natl Acad Sci U S A (2013) 1.26

Developmental genetics of the C. elegans pharyngeal neurons NSML and NSMR. BMC Dev Biol (2008) 1.06

PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. PLoS Genet (2013) 1.00

The adiponectin receptor homologs in C. elegans promote energy utilization and homeostasis. PLoS One (2011) 0.96

An Aphelenchoides sp. nematode Parasitic of Polianthes tuberosa in the Mekong Delta. J Nematol (2007) 0.96

pha-2 encodes the C. elegans ortholog of the homeodomain protein HEX and is required for the formation of the pharyngeal isthmus. Dev Biol (2004) 0.93

C. elegans ten-1 is synthetic lethal with mutations in cytoskeleton regulators, and enhances many axon guidance defective mutants. BMC Dev Biol (2010) 0.89

A genetic analysis of axon guidance in the C elegans pharynx. Dev Biol (2003) 0.89

Maternal and zygotic expression of a nanos-class gene in the leech Helobdella robusta: primordial germ cells arise from segmental mesoderm. Dev Biol (2002) 0.88

A Caenorhabditis elegans model of the myosin heavy chain IIa E706K [corrected] mutation. Ann Neurol (2005) 0.86

ICA69(null) nonobese diabetic mice develop diabetes, but resist disease acceleration by cyclophosphamide. J Immunol (2002) 0.86

The C. elegans M3 neuron guides the growth cone of its sister cell M2 via the Krüppel-like zinc finger protein MNM-2. Dev Biol (2007) 0.84

Caloric restriction and autophagy in Caenorhabditis elegans. Autophagy (2007) 0.83

Misexpression of acetylcholinesterases in the C. elegans pha-2 mutant accompanies ultrastructural defects in pharyngeal muscle cells. Dev Biol (2006) 0.83

Genetics of extracellular matrix remodeling during organ growth using the Caenorhabditis elegans pharynx model. Genetics (2010) 0.82

The twisted pharynx phenotype in C. elegans. BMC Dev Biol (2007) 0.81

Dihydroxyacetone-induced death is accompanied by advanced glycation endproduct formation in selected proteins of Saccharomyces cerevisiae and Caenorhabditis elegans. Proteomics (2007) 0.76

Sustained expression of the novel EBV-induced zinc finger gene, ZNFEB, is critical for the transition of B lymphocyte activation to oncogenic growth transformation. J Immunol (2002) 0.76

Correction: Caenorhabditis elegans PAQR-2 and IGLR-2 Protect against Glucose Toxicity by Modulating Membrane Lipid Composition. PLoS Genet (2016) 0.75