Published in Nat Rev Cancer on May 01, 2005
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Therapeutic intervention based on protein prenylation and associated modifications. Nat Chem Biol (2006) 1.96
Regulation of mTORC1 by PI3K signaling. Trends Cell Biol (2015) 1.54
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Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter. Clin Cancer Res (2012) 1.41
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In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I. Mol Cancer Ther (2009) 1.11
Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors. Biochem Pharmacol (2007) 1.09
Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding. Mol Cell Biol (2013) 1.06
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Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice. J Clin Invest (2011) 1.05
Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1. Nature (2013) 1.05
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The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer. Semin Cell Dev Biol (2012) 1.02
The prenyl-binding protein PrBP/δ: a chaperone participating in intracellular trafficking. Vision Res (2012) 1.02
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The mevalonate pathway in C. elegans. Lipids Health Dis (2011) 0.98
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Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase. Bioorg Med Chem Lett (2006) 0.96
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RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments. Proc Natl Acad Sci U S A (2011) 0.94
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A role for Rac3 GTPase in the regulation of autophagy. J Biol Chem (2011) 0.90
Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. J Biol Chem (2011) 0.90
Downregulation of microRNA-100 enhances the ICMT-Rac1 signaling and promotes metastasis of hepatocellular carcinoma cells. Oncotarget (2014) 0.90
Small GTPases and cilia. Protein Cell (2011) 0.89
Enlarging the scope of cell-penetrating prenylated peptides to include farnesylated 'CAAX' box sequences and diverse cell types. Chem Biol Drug Des (2010) 0.89
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Human guanylate binding protein-1 is a secreted GTPase present in increased concentrations in the cerebrospinal fluid of patients with bacterial meningitis. Am J Pathol (2006) 0.88
The Abi-domain protein Abx1 interacts with the CovS histidine kinase to control virulence gene expression in group B Streptococcus. PLoS Pathog (2013) 0.88
Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation. J Biol Chem (2014) 0.87
Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection. J Exp Med (2013) 0.86
Protein prenylation: unique fats make their mark on biology. Nat Rev Mol Cell Biol (2016) 0.85
Recent discoveries in the genetics of melanoma and their therapeutic implications. Arch Immunol Ther Exp (Warsz) (2007) 0.85
Rho2 palmitoylation is required for plasma membrane localization and proper signaling to the fission yeast cell integrity mitogen- activated protein kinase pathway. Mol Cell Biol (2014) 0.85
Rho GTPases orient directional sensing in chemotaxis. Proc Natl Acad Sci U S A (2013) 0.85
Phosphatase of regenerating liver-3 (PRL-3) is associated with metastasis and poor prognosis in gastric carcinoma. J Transl Med (2013) 0.85
Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitors. Nat Protoc (2011) 0.84
Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation. J Med Chem (2009) 0.84
Insights into the differences between the A- and B-type nuclear lamins. Adv Biol Regul (2012) 0.84
Heterologous expression studies of Saccharomyces cerevisiae reveal two distinct trypanosomatid CaaX protease activities and identify their potential targets. Eukaryot Cell (2009) 0.84
Synthesis of desthio prenylcysteine analogs: sulfur is important for biological activity. Bioorg Med Chem Lett (2005) 0.84
Phosphatase of regenerating liver-3 localizes to cyto-membrane and is required for B16F1 melanoma cell metastasis in vitro and in vivo. PLoS One (2009) 0.84
The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif. J Biol Chem (2014) 0.83
Protein farnesylation and disease. J Inherit Metab Dis (2012) 0.83
The emerging role of Arf/Arl small GTPases in cilia and ciliopathies. J Cell Biochem (2012) 0.83
Rapid analysis of protein farnesyltransferase substrate specificity using peptide libraries and isoprenoid diphosphate analogues. ACS Chem Biol (2014) 0.82
Control of RhoA methylation by carboxylesterase I. J Biol Chem (2013) 0.82
The pro-metastasis tyrosine phosphatase, PRL-3 (PTP4A3), is a novel mediator of oncogenic function of BCR-ABL in human chronic myeloid leukemia. Mol Cancer (2012) 0.82
Regulation of polyisoprenylated methylated protein methyl esterase by polyunsaturated fatty acids and prostaglandins. Eur J Lipid Sci Technol (2011) 0.82
Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease. J Biol Chem (2013) 0.82
The differential palmitoylation states of N-Ras and H-Ras determine their distinct Golgi subcompartment localizations. J Cell Physiol (2015) 0.82
The polybasic region of Rho GTPases defines the cleavage by Yersinia enterocolitica outer protein T (YopT). Protein Sci (2008) 0.81
Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism. Oncogene (2014) 0.80
Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases. J Biol Chem (2015) 0.80
Topology of the yeast Ras converting enzyme as inferred from cysteine accessibility studies. Biochemistry (2013) 0.79
Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria. PLoS One (2014) 0.79
Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization. Bioorg Med Chem (2011) 0.79
Modulation of the inhibitor properties of dipeptidyl (acyloxy)methyl ketones toward the CaaX proteases. Bioorg Med Chem (2010) 0.78
S-carvone suppresses cellulase-induced capsidiol production in Nicotiana tabacum by interfering with protein isoprenylation. Plant Physiol (2013) 0.78
Matrix metalloproteinase-1 contribution to sarcoma cell invasion. J Cell Mol Med (2012) 0.78
Regulation of protein prenyltransferase in central neurons. Commun Integr Biol (2009) 0.77
Synergistic induction of apoptosis by HMG-CoA reductase inhibitor and histone deacetylases inhibitor in HeLa cells. Biochem Biophys Res Commun (2007) 0.77
SmgGDS-558 regulates the cell cycle in pancreatic, non-small cell lung, and breast cancers. Cell Cycle (2014) 0.77
Structural Mechanisms and Drug Discovery Prospects of Rho GTPases. Cells (2016) 0.76
Understanding Protein Palmitoylation: Biological Significance and Enzymology. Sci China Chem (2011) 0.75
Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction. BMC Neurosci (2014) 0.75
N-Acetylglutaminoyl-S-farnesyl-L-cysteine (SIG-1191): an anti-inflammatory molecule that increases the expression of the aquaglyceroporin, aquaporin-3, in human keratinocytes. Arch Dermatol Res (2016) 0.75
Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase. Bioorg Med Chem Lett (2006) 0.75
Novel route to chaetomellic acid A and analogues: serendipitous discovery of a more competent FTase inhibitor. Bioorg Med Chem (2012) 0.75
The O-methyltransferase SrsB catalyzes the decarboxylative methylation of alkylresorcylic acid during phenolic lipid biosynthesis by Streptomyces griseus. J Bacteriol (2012) 0.75
Mutational analysis of the integral membrane methyltransferase isoprenylcysteine carboxyl methyltransferase (ICMT) reveals potential substrate binding sites. J Biol Chem (2014) 0.75
Posttranslational isoprenylation of tryptophan in bacteria. Beilstein J Org Chem (2017) 0.75
A shunt pathway limits the CaaX processing of Hsp40 Ydj1p and regulates Ydj1p-dependent phenotypes. Elife (2016) 0.75
Synthetic isoprenoid analogues for the study of prenylated proteins: Fluorescent imaging and proteomic applications. Bioorg Chem (2015) 0.75
Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms. Oncogene (2017) 0.75
Protein Lipidation As a Regulator of Apoptotic Calcium Release: Relevance to Cancer. Front Oncol (2017) 0.75
Structural basis for catalysis at the membrane-water interface. Biochim Biophys Acta (2016) 0.75
Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Mol Cell (2005) 2.36
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J Mol Biol (2004) 2.15
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev (2007) 1.96
Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function. J Biol Chem (2005) 1.84
Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest (2004) 1.81
Site-specific analysis of protein S-acylation by resin-assisted capture. J Lipid Res (2010) 1.77
Reaction path of protein farnesyltransferase at atomic resolution. Nature (2002) 1.63
A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. Proc Natl Acad Sci U S A (2005) 1.59
Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. Mol Cell Biol (2002) 1.56
The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc Natl Acad Sci U S A (2006) 1.54
A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. J Biol Chem (2006) 1.47
GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. J Clin Invest (2007) 1.47
Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle. J Biol Chem (2004) 1.43
Activation of Rap1 promotes prostate cancer metastasis. Cancer Res (2009) 1.41
Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis. Biochemistry (2007) 1.39
A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity. J Biol Chem (2006) 1.35
A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells. J Biol Chem (2008) 1.32
Structure of mammalian protein geranylgeranyltransferase type-I. EMBO J (2003) 1.28
Androgen receptor activation by G(s) signaling in prostate cancer cells. J Biol Chem (2005) 1.26
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer Cell (2005) 1.23
Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. Proc Natl Acad Sci U S A (2003) 1.17
Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex. Mol Cell Neurosci (2005) 1.16
Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin. J Biol Chem (2002) 1.14
On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy. J Biol Chem (2003) 1.10
MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells. J Biol Chem (2013) 1.07
Role of G12 proteins in oncogenesis and metastasis. Br J Pharmacol (2009) 1.05
Galphaz negatively regulates insulin secretion and glucose clearance. J Biol Chem (2007) 1.03
Selective uncoupling of G alpha 12 from Rho-mediated signaling. J Biol Chem (2005) 1.03
Rho GTPase activity modulates Wnt3a/beta-catenin signaling. Cell Signal (2009) 1.01
Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation. Biochemistry (2003) 1.00
Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt). BMC Biochem (2004) 0.98
Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. J Biol Chem (2009) 0.97
Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells. J Biol Chem (2002) 0.96
Poly adenosine diphosphate-ribose polymerase inhibitor PJ34 abolishes systemic proinflammatory responses to thoracic aortic ischemia and reperfusion. J Am Coll Surg (2006) 0.95
Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Biochemistry (2006) 0.94
High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors. J Biol Chem (2003) 0.94
Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J Pharmacol Exp Ther (2010) 0.92
RHO methylation matters: a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion. Cell Adh Migr (2011) 0.91
A global partnership in medical education between Duke University and the National University of Singapore. Acad Med (2008) 0.91
The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13. Mol Pharmacol (2006) 0.91
Endoscopically assisted fasciotomy: description of technique and in vitro assessment of lower-leg compartment decompression. Am J Sports Med (2002) 0.91
A role for Rac3 GTPase in the regulation of autophagy. J Biol Chem (2011) 0.90
Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. J Biol Chem (2011) 0.90
Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family. Mol Pharmacol (2004) 0.89
Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function. Methods Enzymol (2006) 0.88
Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. Mol Cell Biol (2009) 0.88
A role for G(z) in pancreatic islet beta-cell biology. J Biol Chem (2005) 0.87
Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass. J Biol Chem (2012) 0.87
Growth hormone or insulin-like growth factor-I extends longevity of equine spermatozoa in vitro. Theriogenology (2002) 0.86
The effects of systemic hypothermia on a murine model of thoracic aortic ischemia reperfusion. J Vasc Surg (2010) 0.86
Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. J Biol Chem (2002) 0.86
A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity. J Biol Chem (2010) 0.84
Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation. J Med Chem (2009) 0.84
Analysis of the molecular interaction of the farnesyl moiety of transducin through the use of a photoreactive farnesyl analogue. Biochemistry (2004) 0.83
Time-dependent inhibition of isoprenylcysteine carboxyl methyltransferase by indole-based small molecules. Biochemistry (2007) 0.83
Control of RhoA methylation by carboxylesterase I. J Biol Chem (2013) 0.82
G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion. PLoS One (2011) 0.82
Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork. Invest Ophthalmol Vis Sci (2008) 0.82
Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation. J Biol Chem (2010) 0.82
Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). Eur J Med Chem (2013) 0.80
PJ34, a poly-ADP-ribose polymerase inhibitor, modulates visceral mitochondrial activity and CD14 expression following thoracic aortic ischemia-reperfusion. Am J Surg (2009) 0.80
Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: synthesis and testing of a library of 144 discrete chemicals as potential farnesyltransferase inhibitors. J Comb Chem (2004) 0.78
Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase. J Med Chem (2010) 0.78
Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase. J Biol Chem (2002) 0.78
Interacting targets of the farnesyl of transducin gamma-subunit. Biochemistry (2008) 0.78
The effect of growth hormone (GH) and insulin-like growth factor-I (IGF-I) on in vitro maturation of equine oocytes. Zygote (2011) 0.76
The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. J Biol Chem (2002) 0.76
Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase. Bioorg Med Chem Lett (2006) 0.75
Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10. Methods Enzymol (2004) 0.75