Published in PLoS One on December 27, 2011
Free radical scavengers in anaesthesiology and critical care. Indian J Anaesth (2012) 1.07
Autophagy protein p62/SQSTM1 is involved in HAMLET-induced cell death by modulating apotosis in U87MG cells. Cell Death Dis (2013) 0.95
Risk Factors Associated with Cognitive Decline after Cardiac Surgery: A Systematic Review. Cardiovasc Psychiatry Neurol (2015) 0.94
Mechanistic insights into neurotoxicity induced by anesthetics in the developing brain. Int J Mol Sci (2012) 0.87
General anesthetics inhibit LPS-induced IL-1β expression in glial cells. PLoS One (2013) 0.81
Erythropoietin neuroprotection in neonatal cardiac surgery: a phase I/II safety and efficacy trial. J Thorac Cardiovasc Surg (2012) 0.80
Volatile anesthetics suppress glucose-stimulated insulin secretion in MIN6 cells by inhibiting glucose-induced activation of hypoxia-inducible factor 1. PeerJ (2015) 0.78
Cigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner. Sci Rep (2016) 0.78
Prolonged mechanical ventilation alters the expression pattern of angio-neogenetic factors in a pre-clinical rat model. PLoS One (2013) 0.77
Enhanced brain release of erythropoietin, cytokines and NO during carotid clamping. Neurol Sci (2015) 0.77
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A (1995) 24.77
Astrocytes: biology and pathology. Acta Neuropathol (2009) 8.43
Molecular and cellular mechanisms of general anaesthesia. Nature (1994) 6.94
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci U S A (1993) 6.77
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol (2005) 6.44
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci U S A (1997) 6.11
Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene. Proc Natl Acad Sci U S A (1991) 4.84
Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem (1996) 4.72
Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol (2006) 4.71
Perioperative stroke. N Engl J Med (2007) 4.33
Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. Cancer Cell (2006) 4.01
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1. J Biol Chem (1999) 3.90
Erythropoietin therapy for acute stroke is both safe and beneficial. Mol Med (2002) 3.87
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest (2007) 3.61
Use of anesthetic agents in neonates and young children. Anesth Analg (2007) 3.46
A potential role for erythropoietin in focal permanent cerebral ischemia in mice. J Cereb Blood Flow Metab (1999) 3.25
HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia. FASEB J (2001) 2.73
The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell (2007) 2.58
Acute systemic erythropoietin therapy to reduce delayed ischemic deficits following aneurysmal subarachnoid hemorrhage: a Phase II randomized, double-blind, placebo-controlled trial. Clinical article. J Neurosurg (2009) 2.57
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol (2006) 2.56
Emerging biological roles for erythropoietin in the nervous system. Nat Rev Neurosci (2005) 2.32
Defining safe use of anesthesia in children. N Engl J Med (2011) 2.16
Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model. J Neurosci (2002) 2.05
A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci (2006) 2.04
A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes. J Biol Chem (1994) 2.03
Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases. Biochem Biophys Res Commun (2005) 1.99
Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain. Acta Neuropathol (2001) 1.94
Erythropoietin gene expression in human, monkey and murine brain. Eur J Neurosci (1996) 1.91
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit. Nature (1997) 1.85
Mitochondria and cellular oxygen sensing in the HIF pathway. Biochem J (2008) 1.82
The non-haematopoietic biological effects of erythropoietin. Br J Haematol (2008) 1.81
The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes. J Neurosci (2006) 1.74
Current status of neuroprotection for cerebral ischemia: synoptic overview. Stroke (2008) 1.72
The human erythropoietin receptor gene rescues erythropoiesis and developmental defects in the erythropoietin receptor null mouse. Blood (2001) 1.68
Erythropoietin receptor signalling is required for normal brain development. Development (2002) 1.65
Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy. Pediatrics (2009) 1.62
Potential of xenon to induce or to protect against neuroapoptosis in the developing mouse brain. Can J Anaesth (2008) 1.57
Role of erythropoietin in the brain. Crit Rev Oncol Hematol (2007) 1.50
Erythropoietin and the hypoxic brain. J Exp Biol (2004) 1.37
Reactive oxygen species as mediators of cardiac injury and protection: the relevance to anesthesia practice. Anesth Analg (2005) 1.32
LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner. Antioxid Redox Signal (2008) 1.29
Application of tyramide signal amplification system to immunohistochemistry: a potent method to localize antigens that are not detectable by ordinary method. Pathol Int (1999) 1.29
Effect of N-methyl-D-aspartate receptor epsilon1 subunit gene disruption of the action of general anesthetic drugs in mice. Anesthesiology (2005) 1.22
Calcium signaling stimulates translation of HIF-alpha during hypoxia. FASEB J (2006) 1.22
Hypoxia-induced erythropoietin production: a paradigm for oxygen-regulated gene expression. Clin Exp Pharmacol Physiol (2006) 1.21
Nonrenal regulation of EPO synthesis. Kidney Int (2009) 1.20
Inhibitory effect on cerebral inflammatory agents that accompany traumatic brain injury in a rat model: a potential neuroprotective mechanism of recombinant human erythropoietin (rhEPO). Neurosci Lett (2007) 1.16
Mechanism of ischemic tolerance induced by hyperbaric oxygen preconditioning involves upregulation of hypoxia-inducible factor-1alpha and erythropoietin in rats. J Appl Physiol (1985) (2008) 1.16
Increase of glutamate uptake in astrocytes: a possible mechanism of action of volatile anesthetics. Anesthesiology (1997) 1.05
Contribution of HIF-1alpha or HIF-2alpha to erythropoietin expression: in vivo evidence based on chromatin immunoprecipitation. Ann Hematol (2007) 1.04
Oxygen treatment after experimental hypoxia-ischemia in neonatal rats alters the expression of HIF-1alpha and its downstream target genes. J Appl Physiol (1985) (2006) 1.02
Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm. Anesthesiology (2009) 1.01
Isoflurane preconditioning decreases myocardial infarction in rabbits via up-regulation of hypoxia inducible factor 1 that is mediated by mammalian target of rapamycin. Anesthesiology (2008) 1.01
Isoflurane preconditioning activates HIF-1alpha, iNOS and Erk1/2 and protects against oxygen-glucose deprivation neuronal injury. Brain Res (2008) 1.00
Neuroprotective effects of erythropoietin on glutamate and nitric oxide toxicity in primary cultured retinal ganglion cells. Brain Res (2005) 1.00
Optimal neuroprotection by erythropoietin requires elevated expression of its receptor in neurons. Proc Natl Acad Sci U S A (2009) 0.99
Hypoxia-inducible factor 1, a master transcription factor of cellular hypoxic gene expression. J Anesth (2002) 0.95
Update on neonatal anesthetic neurotoxicity: insight into molecular mechanisms and relevance to humans. Anesthesiology (2009) 0.95
Persisting mild hypothermia suppresses hypoxia-inducible factor-1alpha protein synthesis and hypoxia-inducible factor-1-mediated gene expression. Am J Physiol Regul Integr Comp Physiol (2009) 0.95
Hypoxia-inducible factor 1 and related gene products in anaesthetic-induced preconditioning. Eur J Anaesthesiol (2009) 0.92
Up-regulation of hypoxia inducible factor 1alpha by isoflurane in Hep3B cells. Anesthesiology (2006) 0.92
Autocrine function of erythropoietin in IGF-1-induced erythropoietin biosynthesis. Neuroreport (2008) 0.86
Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane. FEBS Lett (2001) 0.86
The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner. FEBS Lett (2004) 0.85
General anesthetic effects on protein kinase C. Toxicol Lett (1998) 0.85
[Mechanisms of action of ketamine]. Anaesthesist (1997) 0.84
Cerebral adaptations to chronic anemia in a model of erythropoietin-deficient mice exposed to hypoxia. Am J Physiol Regul Integr Comp Physiol (2008) 0.83
The neuroprotective role of erythropoietin in the management of acute ischaemic stroke: from bench to bedside. Acta Neurol Scand (2008) 0.81
The effect of Pa CO2 on the metabolism of ischemic brain in squirrel monkeys. Anesthesiology (1973) 0.81
The volatile anesthetics halothane and isoflurane differentially modulate proinflammatory cytokine-induced p38 mitogen-activated protein kinase activation. J Anesth (2004) 0.81
Changes in ganglioside composition and morphological features during the development of cultured astrocytes from rat brain. Neurosci Res (1989) 0.78
Anesthetic effects on cerebral metabolism. Anesthesiology (1973) 0.76
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia. Nat Genet (2002) 4.06
Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ Res (2003) 3.34
Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol (2003) 3.15
Continuous versus single-injection sciatic nerve block added to continuous femoral nerve block for analgesia after total knee arthroplasty: a prospective, randomized, double-blind study. Reg Anesth Pain Med (2014) 2.07
The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response. Nature (2012) 1.99
Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer. Cancer Res (2007) 1.77
Ketamine suppresses platelet aggregation possibly by suppressed inositol triphosphate formation and subsequent suppression of cytosolic calcium increase. Anesthesiology (2002) 1.75
Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. J Biol Chem (2003) 1.57
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment. Nature (2009) 1.45
Elicitation of sleep-onset REM periods in normal individuals using the sleep interruption technique (SIT). Sleep Med (2002) 1.41
Pulmonary embolism after minor surgery in a patient with low-risk thrombocythemia. J Anesth (2004) 1.39
A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe (2011) 1.31
Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels. Nat Commun (2012) 1.30
LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner. Antioxid Redox Signal (2008) 1.29
Activation of hypoxia-inducible factor 1 during macrophage differentiation. Am J Physiol Cell Physiol (2006) 1.25
Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation. Oncogene (2002) 1.18
Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2010) 1.18
Effect of single-dose dexmedetomidine on emergence agitation and recovery profiles after sevoflurane anesthesia in pediatric ambulatory surgery. J Anesth (2010) 1.14
Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer. Clin Cancer Res (2009) 1.13
Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner. PLoS One (2008) 1.09
Factors related to the occurrence of isolated sleep paralysis elicited during a multi-phasic sleep-wake schedule. Sleep (2002) 1.05
Dynamical pinning of a domain wall in a magnetic nanowire induced by Walker breakdown. Phys Rev Lett (2008) 1.04
The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1. Biochem Biophys Res Commun (2010) 1.02
LPS-induced ROS generation and changes in glutathione level and their relation to the maturation of human monocyte-derived dendritic cells. Life Sci (2005) 1.01
Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling. J Biol Chem (2004) 1.01
Hydrogen sulfide inhibits hypoxia- but not anoxia-induced hypoxia-inducible factor 1 activation in a von hippel-lindau- and mitochondria-dependent manner. Antioxid Redox Signal (2011) 1.00
Pattern of bacterial and fungal infections in the first 3 months after pediatric living donor liver transplantation: an 11-year single-center experience. Liver Transpl (2011) 0.98
Orthostatic intolerance during early mobilization following video-assisted thoracic surgery. J Anesth (2013) 0.98
[Anesthetic management of total aortic arch reconstruction by transluminally placed Inoue endovascular branched stent graft]. Masui (2006) 0.97
Synergistic effect of hypoxia and TNF-alpha on production of PAI-1 in human proximal renal tubular cells. Kidney Int (2005) 0.96
Persisting mild hypothermia suppresses hypoxia-inducible factor-1alpha protein synthesis and hypoxia-inducible factor-1-mediated gene expression. Am J Physiol Regul Integr Comp Physiol (2009) 0.95
Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-gamma in human proximal renal tubular cells. Nephrol Dial Transplant (2007) 0.94
Delayed discharge and acceptability of ambulatory surgery in adult outpatients receiving general anesthesia. J Anesth (2005) 0.92
Redox regulation of the embryonic stem cell transcription factor oct-4 by thioredoxin. Stem Cells (2004) 0.91
A sodium hyaluronate carboxymethylcellulose bioresorbable membrane prevents postoperative small-bowel adhesive obstruction after distal gastrectomy. Surg Today (2010) 0.89
Microglial activation involved in morphine tolerance is not mediated by toll-like receptor 4. J Anesth (2012) 0.89
Successful airway management with use of a laryngeal mask airway in a patient with CHARGE syndrome. J Anesth (2009) 0.88
Two-barrier stability that allows low-power operation in current-induced domain-wall motion. Nat Commun (2013) 0.87
Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions. Kobe J Med Sci (2008) 0.87
Omission of fentanyl during sevoflurane anesthesia decreases the incidences of postoperative nausea and vomiting and accelerates postanesthesia recovery in major breast cancer surgery. J Anesth (2006) 0.87
The intravenous anesthetics barbiturates inhibit hypoxia-inducible factor 1 activation. Eur J Pharmacol (2009) 0.86
The effect of sevoflurane on ciliary motility in rat cultured tracheal epithelial cells: a comparison with isoflurane and halothane. Anesth Analg (2006) 0.86
Monitored anesthesia care with dexmedetomidine of a patient with severe pulmonary arterial hypertension for inguinal hernioplasty. J Anesth (2010) 0.86
The intravenous anesthetic propofol inhibits lipopolysaccharide-induced hypoxia-inducible factor 1 activation and suppresses the glucose metabolism in macrophages. J Anesth (2009) 0.85
The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner. FEBS Lett (2004) 0.85
n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems. Biochem J (2008) 0.85
Activity of the serotonergic system during isoflurane anesthesia. Anesth Analg (2007) 0.85
An effective use of magnesium sulfate for intraoperative management of laparoscopic adrenalectomy for pheochromocytoma in a pediatric patient. Anesth Analg (2002) 0.85
Point-of-care testing system enabling 30 min detection of influenza genes. Lab Chip (2011) 0.84
Exploring the daily activities associated with delayed bedtime of Japanese university students. Tohoku J Exp Med (2010) 0.83
[Morbidly obese patient with a huge ovarian tumor who was intubated while awake using airway scope in lateral decubitus position]. Masui (2010) 0.83
The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway. Biochem Biophys Res Commun (2004) 0.83
Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a μ-opioid receptor-dependent manner. Eur J Pharmacol (2011) 0.83
Duration of vecuronium-induced neuromuscular blockade is shortened during hyperthermic intraoperative intraperitoneal chemotherapy. Br J Anaesth (2003) 0.83
Differential effects of intravenous anesthetics on ciliary motility in cultured rat tracheal epithelial cells. Can J Anaesth (2006) 0.83
SOCS1/JAB likely mediates the protective effect of cardiotrophin-1 against lipopolysaccharide-induced left ventricular dysfunction in vivo. Circ J (2005) 0.82
Inhibitory effect of 6-formylpterin on HIF-1alpha protein accumulation. Biol Pharm Bull (2007) 0.82
Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1. Biochem Biophys Res Commun (2013) 0.81
Two cases of hyperkalemia after administration of hypertonic mannitol during craniotomy. J Anesth (2005) 0.81
The volatile anesthetics halothane and isoflurane differentially modulate proinflammatory cytokine-induced p38 mitogen-activated protein kinase activation. J Anesth (2004) 0.81
Dopamine D2-like receptor in the nucleus accumbens is involved in the antinociceptive effect of nitrous oxide. Anesth Analg (2008) 0.81
Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice. J Anesth (2009) 0.81
Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging. PLoS One (2011) 0.80